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Chapter 20: Antimicrobial Drugs
History
Antimicrobials
Mode of
Action
Resistance
Today and
the Future
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FINAL ROUND
© 2013 Pearson Education, Inc.
Topic 1: History
$100 Question
The birth of modern chemotherapy is credited
to the efforts of
a.
b.
c.
d.
Alexander Fleming.
Paul Ehrlich.
Robert Koch.
Louis Pasteur.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: History
$100 Answer
The birth of modern chemotherapy is credited
to the efforts of
a.
b.
c.
d.
Alexander Fleming.
Paul Ehrlich.
Robert Koch.
Louis Pasteur.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: History
$200 Question
In 1928, who observed that the growth of bacteria
was inhibited on a Petri plate contaminated by a
mold?
a.
b.
c.
d.
Alexander Fleming
Robert Koch
James Watson
Francis Crick
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: History
$200 Answer
In 1928, who observed that the growth of bacteria
was inhibited on a Petri plate contaminated by a
mold?
a.
b.
c.
d.
Alexander Fleming
Robert Koch
James Watson
Francis Crick
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: History
$300 Question
What was the first antibiotic discovered?
a.
b.
c.
d.
tetracycline
erythromycin
streptomycin
penicillin
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: History
$300 Answer
What was the first antibiotic discovered?
a.
b.
c.
d.
tetracycline
erythromycin
streptomycin
penicillin
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: History
$400 Question
In World War II, which of following made it clear
that antimicrobial agents could be effective against
systemic bacterial infections?
a.
b.
c.
d.
sulfa drugs
penicillin
tetracycline
erythromycin
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: History
$400 Answer
In World War II, which of following made it clear
that antimicrobial agents could be effective against
systemic bacterial infections?
a.
b.
c.
d.
sulfa drugs
penicillin
tetracycline
erythromycin
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: History
$500 Question
More than half of our antibiotics are produced by
species of
a.
b.
c.
d.
Mycobacterium.
Streptomyces.
Clostridium.
Bacillus.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 1: History
$500 Answer
More than half of our antibiotics are produced by
species of
a. Mycobacterium.
b. Streptomyces.
c. Clostridium.
d. Bacillus.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 2: Antimicrobials
$100 Question
Which of the following are the easiest to treat with
antimicrobial agents?
a.
b.
c.
d.
viruses
fungi
bacteria
protozoa
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 2: Antimicrobials
$100 Answer
Which of the following are the easiest to treat with
antimicrobial agents?
a.
b.
c.
d.
viruses
fungi
bacteria
protozoa
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 2: Antimicrobials
$200 Question
One disadvantage to using broad-spectrum
antibiotics is
a.
b.
c.
d.
superinfection.
selective toxicity.
toxicity.
inhibition.
ANSWER
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© 2013 Pearson Education, Inc.
Topic 2: Antimicrobials
$200 Answer
One disadvantage to using broad-spectrum
antibiotics is
a.
b.
c.
d.
superinfection.
selective toxicity.
toxicity.
inhibition.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 2: Antimicrobials
$300 Question
Practically all antibiotic-producing microbes have
the ability to produce a(n)
a.
b.
c.
d.
exotoxin.
spore.
endotoxin.
capsule.
ANSWER
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© 2013 Pearson Education, Inc.
Topic 2: Antimicrobials
$300 Answer
Practically all antibiotic-producing microbes have
the ability to produce a(n)
a.
b.
c.
d.
exotoxin.
spore.
endotoxin.
capsule.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 2: Antimicrobials
$400 Question
If a microbial drug prevents microbes from
growing, its action is termed
a. bactericidal.
b. selectively toxic.
c. bacteriostatic.
d. toxic.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 2: Antimicrobials
$400 Answer
If a microbial drug prevents microbes from
growing, its action is termed
a. bactericidal.
b. selectively toxic.
c. bacteriostatic.
d. toxic.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 2: Antimicrobials
$500 Question
Which of the following antimicrobials has the
broadest spectrum of activity?
a.
b.
c.
d.
streptomycin
isoniazid
penicillin G
tetracycline
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 2: Antimicrobials
$500 Answer
Which of the following antimicrobials has the
broadest spectrum of activity?
a.
b.
c.
d.
streptomycin
isoniazid
penicillin G
tetracycline
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Mode of Action
$100 Question
How many major modes of action are utilized by
antimicrobial drugs?
a.
b.
c.
d.
four
five
three
six
ANSWER
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© 2013 Pearson Education, Inc.
Topic 3: Mode of Action
$100 Answer
How many major modes of action are utilized by
antimicrobial drugs?
a.
b.
c.
d.
four
five
three
six
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Mode of Action
$200 Question
Eukaryotes have 80S ribosomes, and prokaryotes
have _____ ribosomes.
a.
b.
c.
d.
90S
60S
80S
70S
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Mode of Action
$200 Answer
Eukaryotes have 80S ribosomes, and prokaryotes
have _____ ribosomes.
a.
b.
c.
d.
90S
60S
80S
70S
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Mode of Action
$300 Question
Some antimicrobial agents demonstrate
competitive inhibition, as is represented by the
relationship of sulfanilamide and
a.
b.
c.
d.
peptidoglycan.
para-aminobenzoic acid.
teichoic acid.
muramic acid.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Mode of Action
$300 Answer
Some antimicrobial agents demonstrate
competitive inhibition, as is represented by the
relationship of sulfanilamide and
a. peptidoglycan.
b. para-aminobenzoic acid.
c. teichoic acid.
d. muramic acid.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Mode of Action
$400 Question
The mode of action of chloramphenicol is to
a.
b.
c.
d.
inhibit cell wall synthesis.
inhibit nucleic acid synthesis.
injure the plasma membrane.
inhibit protein synthesis.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Mode of Action
$400 Answer
The mode of action of chloramphenicol is to
a.
b.
c.
d.
inhibit cell wall synthesis.
inhibit nucleic acid synthesis.
injure the plasma membrane.
inhibit protein synthesis.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Mode of Action
$500 Question
The antifungal drug amphotericin combines with
sterols to disrupt the activity of the fungus. Its
mode of action is to
a.
b.
c.
d.
inhibit the synthesis of essential metabolites.
injure the plasma membrane.
inhibit nucleic acid synthesis.
inhibit cell wall synthesis.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 3: Mode of Action
$500 Answer
The antifungal drug amphotericin combines with
sterols to disrupt the activity of the fungus. Its
mode of action is to
a.
b.
c.
d.
inhibit the synthesis of essential metabolites.
injure the plasma membrane.
inhibit nucleic acid synthesis.
inhibit cell wall synthesis.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Resistance
$100 Question
Bacteria that are resistant to large numbers of
antibiotics are popularly termed
a.
b.
c.
d.
superbugs.
superinfections.
MRSA.
synergism.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Resistance
$100 Answer
Bacteria that are resistant to large numbers of
antibiotics are popularly termed
a.
b.
c.
d.
superbugs.
superinfections.
MRSA.
synergism.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Resistance
$200 Question
If one measures a large zone of inhibition in a
disk-diffusion test, one can assume that the
bacteria are
a.
b.
c.
d.
sensitive to the antibiotic.
resistant to the antibiotic.
unaffected by the antibiotic.
bactericidal.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Resistance
$200 Answer
If one measures a large zone of inhibition in a
disk-diffusion test, one can assume that the
bacteria are
a.
b.
c.
d.
sensitive to the antibiotic.
resistant to the antibiotic.
unaffected by the antibiotic.
bactericidal.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Resistance
$300 Question
Which of the following is NOT a method of
antibiotic abuse?
a.
b.
c.
d.
prescribing antibiotics for the common cold
adhering to the dose regimen
using outdated antibiotics
using antibiotics in animal feed
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Resistance
$300 Answer
Which of the following is NOT a method of
antibiotic abuse?
a.
b.
c.
d.
prescribing antibiotics for the common cold
adhering to the dose regimen
using outdated antibiotics
using antibiotics in animal feed
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Resistance
$400 Question
What was the first penicillinase-resistant drug to
be developed?
a.
b.
c.
d.
vancomycin
penicillin G
methicillin
clavulanic acid
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Resistance
$400 Answer
What was the first penicillinase-resistant drug to
be developed?
a.
b.
c.
d.
vancomycin
penicillin G
methicillin
clavulanic acid
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Resistance
$500 Question
The main mechanism for resistance of MRSA to
methicillin is
a. a new inactivating enzyme.
b. rapid ejection of the antibiotic.
c. modifying the penicillin-binding protein (PBP)
on the cell’s membrane.
d. restriction of the absorption through porins.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 4: Resistance
$500 Answer
The main mechanism for resistance of MRSA to
methicillin is
a. a new inactivating enzyme.
b. rapid ejection of the antibiotic.
c. modifying the penicillin-binding protein
(PBP) on the cell’s membrane.
d. restriction of the absorption through porins.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Today and the Future
$100 Question
Assessing the risks and benefits when
administering drugs is termed
a.
b.
c.
d.
therapeutic index.
assessment index.
therapeutic management.
assessment management.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Today and the Future
$100 Answer
Assessing the risks and benefits when
administering drugs is termed
a.
b.
c.
d.
therapeutic index.
assessment index.
therapeutic management.
assessment management.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Today and the Future
$200 Question
The largest arsenal of drugs is against
a.
b.
c.
d.
viruses.
protozoa.
bacteria.
helminths.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Today and the Future
$200 Answer
The largest arsenal of drugs is against
a.
b.
c.
d.
viruses.
protozoa.
bacteria.
helminths.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Today and the Future
$300 Question
The treatment of bacterial endocarditis is much
more effective when both penicillin and
streptomycin are used together than when taken
alone. This is an example of
a.
b.
c.
d.
symbiosis.
commensalism.
synergism.
antagonism.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Today and the Future
$300 Answer
The treatment of bacterial endocarditis is much
more effective when both penicillin and
streptomycin are used together than when taken
alone. This is an example of
a.
b.
c.
d.
symbiosis.
commensalism.
synergism.
antagonism.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Today and the Future
$400 Question
All of the following represent new and future
targets for antimicrobial activity EXCEPT
a.
b.
c.
d.
use of protein synthesis inhibition.
use of antimicrobial peptides.
targeting virulence factors.
use of phage therapy.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Today and the Future
$400 Answer
All of the following represent new and future
targets for antimicrobial activity EXCEPT
a.
b.
c.
d.
use of protein synthesis inhibition.
use of antimicrobial peptides.
targeting virulence factors.
use of phage therapy.
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Today and the Future
$500 Question
Which antimicrobial has existed for an indefinite
time without significant development of
resistance?
a.
b.
c.
d.
methicillin
β-lactam
vancomycin
magainins
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
Topic 5: Today and the Future
$500 Answer
Which antimicrobial has existed for an indefinite
time without significant development of
resistance?
a.
b.
c.
d.
methicillin
β-lactam
vancomycin
magainins
BACK TO GAME
© 2013 Pearson Education, Inc.
FINAL ROUND Question
Russian scientists are currently experimenting
with phage therapy as a method to treat
infections of
a.
b.
c.
d.
viruses.
bacteria.
fungi.
protozoa.
ANSWER
BACK TO GAME
© 2013 Pearson Education, Inc.
FINAL ROUND Answer
Russian scientists are currently experimenting
with phage therapy as a method to treat
infections of
a.
b.
c.
d.
viruses.
bacteria.
fungi.
protozoa.
BACK TO GAME
© 2013 Pearson Education, Inc.