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Transcript
29th November 2012 Allicin - Nature’s Antibiotic From the heart of garlic What’s in garlic that makes it so powerful? Garlic contains a wide range of vitamins and minerals a sulphur compound called “alliin” and an enzyme called “alliinase” When harvested garlic has no smell but it contains a very potent defence mechanism that starts when garlic is cut, cooked, boiled, chopped, fried or mechanically processed in any way Now for the smelly bit! Let’s make some Allicin Crush some fresh garlic Allicin produced from fresh garlic ALLIIN ALLINASE ALLICIN Allicin the “Mother” substance ALLICIN AJOENE DATS DADS THIOSULPHINATE COMPOUNDS FORMED WHEN ALLICIN BREAKS DOWN ARE ALSO BODY ACTIVE Historical properties of garlic that can be attributed to allicin Anti-bacterial - wide spectrum of sensitive bacteria both gram positive and negative Anti-viral (including common cold virus) Anti-fungal (more effective than many drugs) Anti-cancer (IOWA women’s study) Anti-cholesterol (substantial data) Anti-blood pressure (substantial data) May reduce blood sugar levels May help to reduce fat build up and lead to loss of weight Types of Garlic supplement Garlic oil capsules – no allicin potential Aged garlic extract – no allicin potential Garlic macerates – some allicin potential? Garlic powder – potential depends on processing Garlic powder easily inactivated by stomach acid Allicin powder supplements like AllicinMax have now been available for 7 years Active supplement manufactured by Allicin International Limited Preventing the Common Cold A double blind placebo controlled survey with 146 volunteers Antiviral: How “common” is a cold? In the Western World we see 2-5 colds on average per person per year Over 200 different cold virus types Viral disease is an excellent traveller The common cold costs National economies enormous sums of money in lost working days Prevention is always better than cure Results Active supplement with the optimum dose of allicin is found ONLY in AllicinMax Results - Number of colds Placebo 65 Active P<0.05 24 0 20 40 60 80 Results - Average symptom duration (days) Placebo 5.01 Active p<0.001 1.52 0 1 2 3 4 5 6 Repeat infections Placebo 16 Active 2 0 p<0.001 5 10 15 20 Conclusions AllicinMax can prevent the Common Cold Reduction of severity of symptoms Re-infection less likely with AllicinMax Could represent huge savings for the UK economy Product is well tolerated and may offer other advantages according to volunteer reports Manufacturer’s recommended dose was used Addition of various vitamins or minerals or herbs is a logical combination Allicin as a modern anti-bacterial Known as “Nature’s antibiotic” Broad spectrum of activity No resistance has ever been recorded Allicin prevents bacterial enzyme production Problem infections can be resolved with allicin Allicin is natural, safe and effective MIC (ppm allicin) for some problem bacteria Streptococcus pyogenes Staphylococcus aureus Listeria monocytogenes Escherichia coli 0157 Salmonella typhimurium Clostridium perfringens Helicobacter pylori 16 16 16 32 32 64 16 ppm ppm ppm ppm ppm ppm ppm Staphylococcus aureus Involved in 95% of simple cases of eczema Leads to worsening of clinical symptoms Causes secondary infection Prevents topical steroids from working Present in most cases of acne Prevalant bacterium in psoriasis Staphylococcus aureus The “Golden” Bacterium Where it all began with real patients Debra’s wounds - open on the right but after treatment on the left both long standing wounds had closed and no further procedures were required Human Volunteer Studies Allicin kills Staph. aureus Work completed at The University of East London 30 bacterial strains were tested 12 were resistant to pharmaceutical antibiotics ALL strains were sensitive to Allicin Published in June 2004 in The Journal of Biomedical Science AllicinMax vs MUPIROCIN (a pharmaceutical antibiotic) Case history – before treatment Female, 14 yrs old 2 pins inserted wounds failed to heal for 18 months. Patient had several courses of antibiotics with no effect. Surgeons were keen to readmit her and replace the pins and deal with the infection. We tested her as ++MRSA sensitive to allicin Case history after treatment Treatment was 10 AllicinMAX daily in divided doses (AllicinMAX only) for a period of 4 weeks. No creams or spray were needed in this case. Swabs post treatment showed no MRSA infection present in the healed area, groin or nasal cavity What does this mean to patients? You get your life back! Is allicin really stable? Purity of Allicin using HPLC Mass Spectrometric Analysis of Allicin Allicin 1 mg/ml (Lawson) O 163 100 (M+H+) CH S CH2 CH2 CH2 CH2 S CH Allicin(162) Relative Intensity (%) 75 Mass 73 121 163 50 Intensity 40,128 54,038 162,051 121 25 73 180 (M+NH4+) 0 100 150 200 250 m/z 300 350 400 Topical use of Alliderm Gel™ Headlice Herpes cold sores Warts (upstairs and downstairs) Acne, eczema, psoriasis, rosacea Toe nail and finger nail fungus Mouth ulcers, tooth abcess, gingivitis Molluscum contagiosum Cuts, bruises, bites, wounds and stings Hand washing experiments T 0hr Both hands at the start of the test loaded with germs Hand washing experiments T+1hr untreated Alliderm™treated Both hands were washed and one had Alliderm™ applied Hand washing experiments T +2hr untreated treated No growth on the hand treated with Alliderm™ applied Summary Alliderm™ Gel can be used topically or internally for a very wide range of conditions Alliderm™ Gel can be used to protect your hands (and other exposed skin surfaces) from infectious organisms Alliderm™ Gel heals wounds very quickly and helps to prevent scarring Alliderm™ Gel is safe and easy to use and does not contain alcohol so will not damage your skin Allimax™ and Alliderm Gel™ Summary A unique opportunity to capitalise on the long established properties of garlic’s active mother substance ALLICIN. Only now is this 21st century molecule available in a form that the human race can really feel the benefit. Antiviral, Antibacterial, Antifungal, Antihistamine Antiparasite, Anticholesterol, Antihypertensive