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29th November 2012
Allicin - Nature’s Antibiotic
From the heart of garlic
What’s in garlic that makes
it so powerful?
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Garlic contains a wide range of vitamins and
minerals a sulphur compound called “alliin”
and an enzyme called “alliinase”
When harvested garlic has no smell but it
contains a very potent defence mechanism
that starts when garlic is cut, cooked, boiled,
chopped, fried or mechanically processed in
any way
Now for the smelly bit!
Let’s make some Allicin
Crush some fresh garlic
Allicin produced from fresh garlic
ALLIIN
ALLINASE
ALLICIN
Allicin the “Mother” substance
ALLICIN
AJOENE
DATS
DADS
THIOSULPHINATE COMPOUNDS
FORMED WHEN ALLICIN BREAKS
DOWN ARE ALSO BODY ACTIVE
Historical properties of garlic that
can be attributed to allicin
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Anti-bacterial - wide spectrum of sensitive
bacteria both gram positive and negative
Anti-viral (including common cold virus)
Anti-fungal (more effective than many drugs)
Anti-cancer (IOWA women’s study)
Anti-cholesterol (substantial data)
Anti-blood pressure (substantial data)
May reduce blood sugar levels
May help to reduce fat build up and lead to
loss of weight
Types of Garlic supplement
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Garlic oil capsules – no allicin potential
Aged garlic extract – no allicin potential
Garlic macerates – some allicin potential?
Garlic powder – potential depends on
processing
Garlic powder easily inactivated by stomach
acid
Allicin powder supplements like AllicinMax
have now been available for 7 years
Active supplement manufactured
by Allicin International Limited
Preventing the Common Cold
A double blind placebo controlled
survey with 146 volunteers
Antiviral:
How “common” is a cold?
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In the Western World we see 2-5 colds on
average per person per year
Over 200 different cold virus types
Viral disease is an excellent traveller
The common cold costs National economies
enormous sums of money in lost working
days
Prevention is always better than cure
Results
Active supplement with the
optimum dose of allicin is found
ONLY in AllicinMax
Results - Number of colds
Placebo
65
Active
P<0.05
24
0
20
40
60
80
Results - Average symptom
duration (days)
Placebo
5.01
Active
p<0.001
1.52
0
1
2
3
4
5
6
Repeat infections
Placebo
16
Active
2
0
p<0.001
5
10
15
20
Conclusions
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AllicinMax can prevent the Common Cold
Reduction of severity of symptoms
Re-infection less likely with AllicinMax
Could represent huge savings for the UK
economy
Product is well tolerated and may offer other
advantages according to volunteer reports
Manufacturer’s recommended dose was used
Addition of various vitamins or minerals or
herbs is a logical combination
Allicin as a modern anti-bacterial
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Known as “Nature’s antibiotic”
Broad spectrum of activity
No resistance has ever been recorded
Allicin prevents bacterial enzyme production
Problem infections can be resolved with allicin
Allicin is natural, safe and effective
MIC (ppm allicin) for some
problem bacteria
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Streptococcus pyogenes
Staphylococcus aureus
Listeria monocytogenes
Escherichia coli 0157
Salmonella typhimurium
Clostridium perfringens
Helicobacter pylori
16
16
16
32
32
64
16
ppm
ppm
ppm
ppm
ppm
ppm
ppm
Staphylococcus aureus
Involved in 95% of simple cases of
eczema
 Leads to worsening of clinical symptoms
 Causes secondary infection
 Prevents topical steroids from working
 Present in most cases of acne
 Prevalant bacterium in psoriasis
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Staphylococcus aureus The “Golden” Bacterium
Where it all began
with real patients
Debra’s wounds - open on the
right but after treatment on the left
both long standing wounds had
closed and no further procedures
were required
Human Volunteer Studies
Allicin kills Staph. aureus
Work completed at The University of
East London
 30 bacterial strains were tested 12 were
resistant to pharmaceutical antibiotics
 ALL strains were sensitive to Allicin
 Published in June 2004 in The Journal
of Biomedical Science
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AllicinMax vs MUPIROCIN
(a pharmaceutical antibiotic)
Case history – before treatment
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Female, 14 yrs old 2 pins inserted wounds failed to heal for 18
months. Patient had several courses of antibiotics with no effect.
Surgeons were keen to readmit her and replace the pins and deal
with the infection. We tested her as ++MRSA sensitive to allicin
Case history after treatment
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Treatment was 10 AllicinMAX daily in divided doses (AllicinMAX only)
for a period of 4 weeks. No creams or spray were needed in this
case. Swabs post treatment showed no MRSA infection present in
the healed area, groin or nasal cavity
What does this mean to patients?
You get your life back!
Is allicin really stable?
Purity of Allicin using HPLC
Mass Spectrometric Analysis of Allicin
Allicin 1 mg/ml (Lawson)
O
163
100
(M+H+)
CH
S
CH2
CH2
CH2
CH2
S
CH
Allicin(162)
Relative
Intensity
(%)
75
Mass
73
121
163
50
Intensity
40,128
54,038
162,051
121
25
73
180 (M+NH4+)
0
100
150
200
250
m/z
300
350
400
Topical use of Alliderm Gel™
Headlice
 Herpes cold sores
 Warts (upstairs and downstairs)
 Acne, eczema, psoriasis, rosacea
 Toe nail and finger nail fungus
 Mouth ulcers, tooth abcess, gingivitis
 Molluscum contagiosum
 Cuts, bruises, bites, wounds and stings
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Hand washing experiments T 0hr
Both hands at the start of the test loaded with germs
Hand washing experiments
T+1hr
untreated
Alliderm™treated
Both hands were washed and one had Alliderm™ applied
Hand washing experiments T
+2hr
untreated
treated
No growth on the hand treated with Alliderm™ applied
Summary
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Alliderm™ Gel can be used topically or
internally for a very wide range of conditions
Alliderm™ Gel can be used to protect your
hands (and other exposed skin surfaces) from
infectious organisms
Alliderm™ Gel heals wounds very quickly and
helps to prevent scarring
Alliderm™ Gel is safe and easy to use and
does not contain alcohol so will not damage
your skin
Allimax™ and Alliderm Gel™
Summary
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A unique opportunity to capitalise on
the long established properties of
garlic’s active mother substance
ALLICIN. Only now is this 21st century
molecule available in a form that the
human race can really feel the benefit.
Antiviral, Antibacterial, Antifungal, Antihistamine
Antiparasite, Anticholesterol, Antihypertensive