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Jesse Cook: Chemistry & Biochemistry
Mentor: Mary Cloninger -- Chemistry & Biochemistry
Lactose-functionalized PAMAM Dendrimer Effects on Cancer cell Aggregation
The interaction of galectin-3 with a lactose-functionalized PAMAM dendrimer is monitored through aggregation assays
with the human cancer cell lines HT-1080 and A-549. It is hypothesized and shown that the generation-2 dendrimer
(relatively small) will inhibit aggregation (Figure 3.6 a). Also hypothesized is that the larger dendrimers will induce
aggregation by aiding in cross-linking of cells (Figure 3.6 b), but results are inconclusive.
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