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Section F
Lung Cancer
Carcinogenic Process
73
Tobacco use in the US, 1900-2000
Per Capita Cigarette Consumption
5000
4000
100
Per capita
cigarette
consumption
90
80
Men
3000
2000
70
60
Lung cancer
death rates
50
40
30
1000
Age-Adjusted Lung Cancer Death Rates
40 YEARS
Women
0
*Per 100.000, age-adjusted to 2000 US standard population.
Sources: Death rates: US Mortality Public Use Tapes, 1960-2000, US Mortality Volumes, 1930-1959,
National Center for Health Statistics, Centers for Disease Control and Prevention, 2002.
Cigarette consumption: US Department of Agriculture, 1900-2000.
20
10
0
Chemicals in Tobacco Smoke
Carcinogen
Probably Carcinogen
Possibly Carcinogen
IARC Monographs on the Evaluation
of Carcinogenic Risks to Humans,
Volume 83 (2004). Tobacco Smoke and
Involuntary Smoking. http://monographs.iarc.fr/
ENG/Monographs/vol83/index.php
75
Chemicals in Side stream Tobacco Smoke
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 83 (2004)
Tobacco Smoke and Involuntary Smoking. http://monographs.iarc.fr/ENG/Monographs/vol83/index.php
76
Key Points – Section F
  It takes 40 years for a decrease in tobacco
use to be followed by a decline in tobaccorelated cancer
  Tobacco smoke contains many initiators
and promoters
  Biomarkers for exposure to tobacco smoke
include cotinine and PAH adducts
  Most cancer is, in theory, preventable
78