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Understanding Cancer and Related Topics Understanding Nanodevices Developed by: Jennifer Michalowski, M.S. Donna Kerrigan, M.S. Jeanne Kelly Brian Hollen Explains nanotechnology and its potential to improve cancer detection, diagnosis, and treatment. Illustrates several nanotechnology tools in development, including nanopores, quantum dots, and dendrimers. These PowerPoint slides are not locked files. You can mix and match slides from different tutorials as you prepare your own lectures. In the Notes section, you will find explanations of the graphics. The art in this tutorial is copyrighted and may not be reused for commercial gain. Please do not remove the NCI logo or the copyright mark from any slide. These tutorials may be copied only if they are distributed free of charge for educational purposes. What Is NanoBiotechnology? Water molecule Nanodevices Nanopores Dendrimers Nanotubes Quantum dots Nanoshells White blood cell A period Tennis ball Designing Nanodevices for Use in the Body Too Small Too Big Manufacturing Nanodevices X-ray beam Crystal Crystal Scattered X-rays Detector Nanodevices Atoms in crystal White blood cell Nanodevices Are Small Enough to Enter Cells Cell Nanodevices Nanodevices Water molecule White blood cell Nanodevices Can Improve Cancer Detection and Diagnosis NanoBiotechnology Imaging Physical Exam, Symptoms Nanodevices Can Improve Sensitivity Nanodevices could potentially enter cells Precancerous cells Normal cells and determine which cells are cancerous or precancerous. Precancerous cells Normal cells Nanodevices Can Preserve Patients’ Samples Traditional Tests Cells from patient Cells altered Active state lost Nanotechnology Tests Cells from patient Cells preserved Active state preserved Additional tests Nanodevices Can Make Cancer Tests Faster and More Efficient Patient A Patient B Cantilevers Can Make Cancer Tests Faster and More Efficient Cancer cell Antibodies with proteins Antibodies Bent cantilever Water molecule White blood cell Nanodevices Cantilevers Nanopores Single-stranded DNA molecule A T C G Nanopore Singlestranded DNA molecule A Nanopore T Nanopore Single-stranded DNA molecule Water molecule Nanodevices Nanopores White blood cell Quantum Dots Ultraviolet light off Quantum dot bead Water molecule Ultraviolet light on Quantum dots Nanodevices Quantum dots Quantum dots emit light White blood cell Quantum Dots Can Find Cancer Signatures Quantum dot beads Cancer cells Healthy cells Cancer cells Quantum dot beads Healthy cells Improving Cancer Treatment Traditional Treatment Drugs Nanotechnology Treatment Toxins Nanodevices Cancer cells Cancer cells Noncancerous cells Dead cancer cells Dead noncancerous cells Toxins Noncancerous cells Dead cancer cells Intact noncancerous cells Nanoshells Near-infrared light off Nanoshell Near-infrared light on Gold Nanoshell absorbs heat Water molecule Nanodevices Nanoshells White blood cell Nanoshells as Cancer Therapy Nanoshells Nanoshells Cancer cells Cancer cells Healthy cells Healthy cells Near-infrared light Dead cancer cells Intact healthy cells Nanodevices as a Link Between Detection, Diagnosis, and Treatment Traditional Cancer Treatment NanoBiotechnology Cancer Treatment Cancer cell Cancer cell Nanodevice Drug Imaging Reporting Detection Targeting Dendrimers Cancer cell Dendrimer Water molecule Nanodevices Dendrimer White blood cell Dendrimers : Highly Branched Dendritic Macromolecules Poly (amido amine) Dendrimers ● Characteristics Monodisperse macromolecule Globular (Spherical) Facile surface bio-functionalization Similar molecular size to biomolecules (Glucose oxidase 65.27.7 nm) ● Applications Vehicles for delivery of genes and drugs 4.5 nm G4 Poly(amidoamine) Dendrimer Biomimetic catalysts (Peptides-, Glycodendrimers) Medical applications (MRI contrast enhancer) Molecular carriers for chemical catalysts (Core, Peripheral) Dendrimers as Cancer Therapy Therapeutic agent Cancer detector Cell death monitor Reporter Water molecule Nanodevices Dendrimer White blood cell NanoBiotechnologies in Patient Care Today 2020 We would like to hear from you . . . If you have questions about this tutorial’s content, suggestions for new topics, or other feedback on the Web site, please send an e-mail to [email protected]. If you have questions about this tutorial’s artwork or want permission to use it, please send an e-mail to [email protected].
