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Matthew Kilmurry, M.D. St. Mary’s General Hospital Grand River Hospital I have no conflicts of interest The problem 2003 numbers for Ontario 7500 new cases 6300 deaths Only 25% of cases are surgically resectable Breast cancer in 2007 was 8000 new cases and 2000 deaths Causes Smoking Radon exposure Asbestos exposure Second hand smoke Genetics Types of Lung Cancer Primary Secondary Colonic mets Other primaries Resection of pulmonary mets Several prognostic factors Disease free interval Number of mets Resectability 30% long term survival Do not assume it is a met Old study suggests 73% of pulmonary nodules in patients with previous cancer will be new primary Primary lung cancer Small cell Non small cell Accounts for 75-80 % of primary lung tumors Screening No accepted screening method Studies using CT, CXR and sputum High index of suspicion smokers Staging Stage I: no lymph node involvement Stage II: lymph nodes involved or tumor invading into chest wall Stage III: mediastinal nodal involvement or bad tumour factors Stage IV: metastatic disease Nodal stations Surgical Approach Diagnosis: Is this cancer? Metastases: Is there spread? Suitability: Is the patient healthy enough for surgery? Diagnosis History and physical Chest X-ray CT scan Percutaneous biopsy Bronchoscopy Metastases History and physical Upper abdominal imaging Bone scan and CT head PET scan Mediastinoscopy Nodal stations Suitability History and physical PFT’s Cardiac investigations 2D echo Stress test Nuclear medicine CPET Quantitative V/Q scan Treatment Stage I and II are generally offered surgery with stage II getting post op chemo Some stage III can be offered surgery – usually after chemoradiotherapy Rare stage IV patients can be offered surgery Solitary brain mets Treatment Lobectomy preferred approach Limited resection has higher recurrence and worse long term suvival Stage survival, 5 years Stage I – 60-70% Stage II – 40-50% Stage III – 15-25% Stage IV – 0-10% Case # 1 65 year old male previous smoking history Chest X-ray done as part of annual health exam CT confirmed mass in LUL Small lesion also noted in RUL Case # 1 Case # 1 Bronchoscopy and mediastinoscopy showed no evidence of mets Thoracotomy confirmed diagnosis and had lobectomy Right upper lobe nodule unchanged over two years Case # 2 68 year old woman had pneumonia like symptoms which led to chest X-ray Smoker of 1 pack per day for 45 years Case # 2 Case # 2 CT chest showed large tumour with no evidence of mets Biopsy shows NSCLC PET scan shows no evidence of metastatic disease Case # 2 Mediastinoscopy showed metastatic disease in lymph nodes Referred for chemoradiotherapy Possible candidate for surgery Palliation Majority of work with chemo and radiotherapy Pain and symptom management vital Surgery sometimes required Pleural effusions Endobronchial tumours Thoracic DAU Run through Grand River Cancer Center Multidisciplinary clinic with respirologists and thoracic surgeons Referrals accepted through GRCC Main criteria is newly abnormal chest X-ray Thoracic Program Combined thoracic surgery at St. Mary’s General Hospital CCO pushing to eliminate low volume thoracic centers Working to keep thoracic surgery in Kitchener-Waterloo Conclusions Lung cancer is a major health concern in Ontario Surgery offers best chance for cure in resectable cases Multidisciplinary care required and available in our region