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Download Activation of transposon mutagenesis in Etv6+
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Modeling the evolution of ETV6-RUNX1–induced B-cell precursor acute lymphoblastic leukemia in mice by Louise van der Weyden, George Giotopoulos, Alistair G. Rust, Louise S. Matheson, Frederik W. van Delft, Jun Kong, Anne E. Corcoran, Mel F. Greaves, Charles G. Mullighan, Brian J. Huntly, and David J. Adams Blood Volume 118(4):1041-1051 July 28, 2011 ©2011 by American Society of Hematology Generation of the Etv6-RUNX1 transposase knockin allele (Etv6+/RUNX1). Louise van der Weyden et al. Blood 2011;118:1041-1051 ©2011 by American Society of Hematology Activation of transposon mutagenesis in Etv6+/RUNX1 mice. Louise van der Weyden et al. Blood 2011;118:1041-1051 ©2011 by American Society of Hematology Etv6+/RUNX1 mice with “second hits” develop a pre-B ALL recapitulating features of the human disease. Louise van der Weyden et al. Blood 2011;118:1041-1051 ©2011 by American Society of Hematology Hierarchical clustering of the leukemias and their mutated genes based on common insertion sites. Louise van der Weyden et al. Blood 2011;118:1041-1051 ©2011 by American Society of Hematology Insertions in the Ebf1 gene. Louise van der Weyden et al. Blood 2011;118:1041-1051 ©2011 by American Society of Hematology
