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Cancer Genome Landscapes by Bert Vogelstein, Nickolas Papadopoulos, Victor E. Velculescu, Shibin Zhou, Luis A. Diaz, and Kenneth W. Kinzler Science Volume 339(6127):1546-1558 March 29, 2013 Published by AAAS Fig. 1 Number of somatic mutations in representative human cancers, detected by genome-wide sequencing studies. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 2 Genetic alterations and the progression of colorectal cancer. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 3 Total alterations affecting protein-coding genes in selected tumors. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 4 Distribution of mutations in two oncogenes (PIK3CA and IDH1) and two tumor suppressor genes (RB1 and VHL). Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 5 Number and distribution of driver gene mutations in five tumor types. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 6 Four types of genetic heterogeneity in tumors, illustrated by a primary tumor in the pancreas and its metastatic lesions in the liver. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 7 Cancer cell signaling pathways and the cellular processes they regulate. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS Fig. 8 Signal transduction pathways affected by mutations in human cancer. Bert Vogelstein et al. Science 2013;339:1546-1558 Published by AAAS