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Introduction
Advanced Course on Bioinformatics and
Comparative Genome Analysis
Fredj Tekaia
Institut Pasteur
[email protected]
Advanced Course on Bioinformatics and
Comparative Genome Analysis
June 30 - July 12, 2008
Universidade Federal de Santa Catarina, Florianopolis,
Brazil
Organizers/Contact:
• Alberto M.R. Davila, Instituto Oswaldo Cruz, FIOCRUZ, Rio, Brazil;
• Edmundo Grisard, Universidade Federal de Santa Catarina,
Florianopolis, Brazil;
• Hugo Naya, Institut Pasteur Montevideo, Uruguay;
• Fredj Tekaia, Institut Pasteur Paris, France.
Course web page: http://www.pasteur.fr/~tekaia/ACBCGA.html
Financial support
CNPq/QUADTRYP/FINEP
Why this course ?
672
53
Tree of life
94
http://www.genomesonline.org/
Complete genomes
3823 projects
• 819 published
(12-06-08)
• 1848 Bacteria
• 90 Archaea
• 936 eukaryotes
• 130 metagenomes
• 3 phylogenetic
domains;
• Lifestyles:
mesophiles;
(hyper)thermophiles;
psychrophiles;
extreme conditions,...
Number of complete genomes
Number of available completely sequenced genomes
900
850
800
750
700
650
600
550
500
450
400
350
300
250
200
150
100
50
0
819
700
3823 projects
471
323
224
165
116
2
5
12
19
24
95
96
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99
42
00
71
01
02
Years
03
04
05
06
07
06-2008
08
Completely sequenced Genomes that span the three
domains of life are growing at a rapid rate
List and references
GOLD
Genome studies show that:
• Access to entire genome sequences is revolutionizing our
understanding of how genetic information is stored and
organized in DNA, and how it has evolved over time.
• The sequence of a genome provides significant details of
the gene catalogue within a species.
• Comparisons of complete genome sequences show the
acceleration in the understanding of species organisation,
links between genes, functions of the genes, evolution of
genes, genomes and species.
=> Beyond fundamental biological and methodological interests,
Expected applications include: Drug, Medical and Agricultural,…
discoveries.
• Few scientists are involved in generating data
and much more are involved in data analyses
Genomics
Is the study of genomes.
(including the study of their genes, proteins,
their sequences, functions, evolution,....)
Bioinformatics is needed to transform the
flood of raw data (sequences) into scientific
knowledge.
Mathematics
Statistics
Bioinformatics
Nucleotide & protein
sequences and related
informations
Biology
Informatics
Bioinformatics and Comparative Genome
Analysis
The main objectives of the course are to
familiarize you with bioinformatics and large scale
genome data analyses skills by introducing:
1- advanced fundamental algorithms in
Bioinformatics;
2- their application in genome analyses;
3- recent knowledge acquired from genomes studies
and their perspectives.
• We hope that this course will motivate some of
you
to continue their involvement in these
fascinating domains:
Bioinformatics and Genomics.
Enjoy
this exiting program
and
your stay in Florianopolis.