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MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA
PROGETTO NEGOZIALE F.I.R.B.
Identification and functional analysis of the gene
expression profiles characterizing hormone-responsive
breast cancer
AIMS:
1.
Identification of new panels of molecular markers to
better prognostic evaluation of breast cancer lesions,
with respect to prediction of the degree of hormone
responsiveness and clinical evolution of the disease;
2.
Generating a publicly available list of annotations on
genes and gene networks relevant to mammary gland
and breast cancer biology and to ovarian hormone
action;
3.
Training in post-genomics and technological
dissemination.
MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA
PROGETTO NEGOZIALE F.I.R.B.
Identification and functional analysis of the gene
expression profiles characterizing hormone-responsive
breast cancer
AIMS:
1.
Identification of new panels of molecular markers to
better prognostic evaluation of breast cancer lesions,
with respect to prediction of the degree of hormone
responsiveness and clinical evolution of the disease;
2.
Generating a publicly available list of annotations on
genes and gene networks relevant to mammary gland
and breast cancer biology and to ovarian hormone
action;
3.
Training in post-genomics and technological
dissemination.
MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA
PROGETTO NEGOZIALE F.I.R.B.
Identification and functional analysis of the gene
expression profiles characterizing hormone-responsive
breast cancer
AIMS:
1.
Identification of new panels of molecular markers to
better prognostic evaluation of breast cancer lesions,
with respect to prediction of the degree of hormone
responsiveness and clinical evolution of the disease;
2.
Generating a publicly available list of annotations on
genes and gene networks relevant to mammary gland
and breast cancer biology and to ovarian hormone
action;
3.
Training in post-genomics and technological
dissemination.
MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA
PROGETTO NEGOZIALE F.I.R.B.
Identification and functional analysis of the gene
expression profiles characterizing hormone-responsive
breast cancer
AIMS:
1.
Identification of new panels of molecular markers to
better prognostic evaluation of breast cancer lesions,
with respect to prediction of the degree of hormone
responsiveness and clinical evolution of the disease;
2.
Generating a publicly available list of annotations on
genes and gene networks relevant to mammary gland
and breast cancer biology and to ovarian hormone
action;
3.
Training in post-genomics and technological
dissemination.
Identification and functional analysis of the gene expression
profiles characterizing hormone-responsive breast cancer
Work Packages breakdown:
Workpackage 4
• Activity 1-5: Cellular models
Coordination: Second Univ. Napoli
Workpackage 2
• Activity 1-4: Proteomics
•Coordination: ISA-Natl Res. Council
Workpackage 3
Activity 1: Animal models
Coordination: Univ. Milano
Workpackage 4
• Activity 1-3: Tumor profiling and clinical studies
Coordination: Univ. Torino
Workpackage 5
• Activity 1-4: Bioiformatics
Coordination: Second Univ. Napoli
Identification and functional analysis of the gene expression
profiles characterizing hormone-responsive breast cancer
FUNCTIONAL
CHARACTERIZATION
MOLECULAR
PROFILING
VALIDATION
functional genomic and
proteomic analyses in
experimental models
gene expression profiling of
tumor samples
‘in situ’ analyses
(tissue arrays and LCM)
Clinical data
(hormone responsiveness)
Identification and functional analysis of the gene expression
profiles characterizing hormone-responsive breast cancer
MOLECULAR
PROFILING
FUNCTIONAL
CHARACTERIZATION
UniNa2
IRCC-To
UniTo
IEO-Mi
UniFe
IDI-Rm
UniMi (in vivo)
IST-Ge (in vivo)
ISA-CNR (proteomics)
functional genomic and
proteomic analyses in
experimental models
IRCC-To
UniFe
UniNa2
ISA-CNR (proteomics)
gene expression profiling of
tumor samples
VALIDATION
UniFe
IRCC-To
UniNa2
UniFe
IRCC-To
‘in situ’ analyses
(tissue arrays and LCM)
clinical studies
BIOINFORMATICS
UniNa2
IST-Ge
UniTo
CINECA-Bo
ISA-CNR
IEO-Mi
IRCC-To
UniFe
Identification and functional analysis of the gene expression profiles
characterizing hormone-responsive breast cancer
http://www.hrbc-genomics.net/
Alessandro Weisz
Dipartimento di Patologia generale
Seconda Università degli Studi di Napoli
[email protected]