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Poisonous Plants Dr. Jennifer Frick-Ruppert ACEE Executive Director Associate Professor of Ecology and Environmental Studies 1 Poisonous and Medicinal Just a matter of degree! Nicotine is a great example: Cigarettes are smoked because the nicotine is a stimulant; it is also addictive Nicotine is extremely toxic; on par with cyanide, heroin, atropine. LD50 is less than 5 mg per kg of body weight. Average lethal dose is 7 drops of pure nicotine. Nicotine content of cigarettes is regulated to a maximum of 1 mg per cigarette. Average human is 155 lbs or 70 kg; therefore the LD50 for a 70 kg human is about 350 mg or 350 cigarettes. 2 Some Types of Plant Poisons Alkaloids Derived from amino acids; basic (alkali) Most affect the nervous system because they mimic or block the action of nerve transmitters Glycosides Sugar-based with attached subgroup; it is the subgroup that determines toxicity Cyanogenic glycosides release cyanide; Glucosinolates occur in mustard family; Cardiac glycosides act on heart Oxalic acid Crystalline structure is irritating; like glass shards Rhubarb (Rheum rhabarbarum), Beets (Beta vulgaris), Sorrels (Oxalis spp., Rumex spp.), Purslane (Portulaca oleracea); also Arum family Phenols Acidic compounds Toxicodendron/Rhus species: Poison Ivy, Oak, and Sumac 3 Edible plants and toxins Potato! Solanum tuberosum; Nightshade Family Solanine, a bitter alkaloid Present in green parts of leaves, sprouts and tubers; ancestral forms even dark tubers Don’t eat green potatoes! Taro, Elephant’s Ears Colocasia esculenta; Arum Family Staple food of the Pacific Islands Contain oxalic acid crystals Prepared by washing and pounding to make poi 4 Passage through Food Chain Milk sickness Cattle eat White Snakeroot (Eupatorium rugosum) Milk from these cows sicken people Common disease in eastern states; Lincoln’s mother, my neighbors! Several compounds including glycosides and a complex alcohol (tremetol) Turtles and poisonous mushrooms Turtles unaffected; humans that eat the turtles can be sickened 5 Fungal Pathogens on Food Ergot poisoning Fungus (Claviceps spp.) growing on Rye or Wheat or other grasses; humans eat the flour Ascomycete fungus; makes a hard black elongated structure Grain containing more than 0.3% ergot is prohibited from sale Over 40 alkaloids present; related to lysergic acid Symptoms include irritable digestive tract, loss of balance, convulsions, drowsiness Witch-hunts of Salem and other towns Aflatoxins/Mycotoxins Contaminants of grain or other foods Penicillium, Aspergillus, Monascus commonly Confusion between plant toxicity and mold toxicity 6 Foxglove Digitalis purpurea; Figwort Family Native to England and Europe; naturalized in USA; planted in gardens Contains a cardiac glycoside Used to treat “dropsy:” massive fluid retention caused by poor heart function Now used in controlled dosages to correct heart beat irregularities, improve circulation, relieve fluid buildup, help kidney function 7 Mayapple Podophyllum peltatum; Barberry Family Natives used as emetic and worm expellent; also for syphilis Strongly irritating to skin and poisonous Contains lignans with anti-cancer and anti-viral properties Used today to treat venereal warts and testicular cancer 8 Buckeye Aesculus spp.; Horse Chestnut Family Main toxin is a saponin glycoside (aesculin) All parts of plant toxic Natives used ground leaves to kill fish 9 Cherries, Peaches, Plums, Prunus spp. Rose Family Leaves, bark, and seeds (but not fruits) are toxic Contain a cyanogenic glycoside (amygdalin) resulting in cyanide poisoning if ingested Almonds are the seeds of a species of Prunus that produces low levels of toxin 10 Poison Ivy, Oak, Sumac Toxicodendron or Rhus spp. Cashew Family Variable growth form; climbing or bushy Leaflets in 3 on compound leaves; alternate leaves Contains an oleoresin (urushiol) in sap; pollen or smoke also irritating Poison Sumac has alternate, pinnately compound leaves Don’t confuse with Virginia Creeper 5-parted leaves 11 Dolls-Eyes or Baneberry Actaea pachypoda and A. rubra; Buttercup Family All parts toxic, especially berries and roots Undetermined toxin, probably a glycoside Used by natives as emetic 12 Bloodroot Sanguinaria canadensis; Poppy Family Contains several alkaloids including sanguinarine; very toxic Used to induce glaucoma in laboratory animals 13 False Hellebore Veratrum parviflorum and others; Lily Family Contain several alkaloids including veratridine Can be mistaken for other plants, including edible Ramps Used to treat high blood pressure 14 Poison Hemlock Conium maculatum and Cicuta spp.; Umbel Family NOT the Hemlock tree (Tsuga canadensis) Resembles wild carrot, but has smooth leaves Used to poison Socrates European weed, now naturalized USA Contains toxic alkaloids related to nicotine 15 Pokeweed Phytolacca americana; Pokeweed Family Several toxic compounds, mostly saponins, but recently a mitogen that damages blood cells Young stalks commonly eaten after boiling in several waters No longer recommended 16 References NJ Turner and AF Szczawinski. 1991. Common Poisonous Plants and Mushrooms of North America. Timber Press, Oregon. S Foster and JA Duke. 1990. Peterson Field Guides Eastern/Central Medicinal Plants.Houghton Mifflin Company, Boston. A Krochmal and C Krochmal. 1984. A Field Guide to Medicinal Plants. Random House, NY. Most of the photos in this presentation were from these references or from various internet sites. Do not distribute them. 17