Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Genomica nutrizionale e approccio sperimentale Go et al., 2003 La metilazione dei dinucleotidi 5’CpG3’ nei promotori modula l’espressione dei geni Mantenimento del pattern di metilazione durante la duplicazione del DNA L’acetilazione degli istoni Nutrienti, attività genica e tumore Ross et al., 2003 Componenti nutrizionali bio-attivi Cancer prevention – the potential for diet to modulate molecular signalling Trends in Molecular Medicine, Manson, 2002 Manson, 2002 Depending on the circumstances, dietary compounds such as curcumin, epigallocatechin gallate (EGCG), resveratrol and indole-3-carbinol (I3C) can upor down-regulate signalling to induce stress-response genes, or growth arrest and apoptosis Manson, 2002 Different chemopreventive agents can suppress the activity of IKK, PI3K and/or PKB, inhibit the translocation of NF-kB to the nucleus, or upregulate PTEN Manson, 2002 Chemopreventive agents, such as indole-3-carbinol and epigallocatechin gallate, can downregulate the expression or activity of CDKs and cyclins, and upregulate CDK inhibitors such as p21 and p27, thereby causing cell-cycle arrest in G1 . Manson, 2002 Induction of stress-response genes by chemopreventive chemicals Manson, 2002 Restrizione calorica Regime dietetico a basso contenuto calorico in assenza di sottonutrizione o malnutrizione Allungamento della sopravvivenza del 50% in lievito, nematodi, roditori e scimmie Mattson, 2003 Mattson, 2003 Mattson, 2003 Koubova et al., 2003 Koubova et al., 2003 Pathways metabolici modificati dalla restrizione calorica Koubova et al., 2003 Restrizione calorica e stress ossidativo Hyon Jeen Kim et al., 2002 Possibile meccanismo attraverso cui la CR migliora la funzionalità neuronale Restrizione calorica e invecchiamento Barja, 2002 CR manipulates the membrane fatty acid components as an adaptive measure against agerelated peroxidizability — an efficient and smart strategy to resist oxidative stress. Barja, 2002 Shelke et al., 2003 Exercised CR animals are shown to have an additional extended mean life span of ~10% beyond their nonexercised CR counterparts. Suppression of microsomal production of reactive oxygen species by CR. AS, ad libitumfed, sedentary; AE, ad libitum-fed, exercising; RS, CR, sedentary; RE, CR, exercising; DCF = 2'7'-dichlorodihydrofluorescin Yu et al., 2003 ARC (apoptosis repressor) levels in the brain of adult (12AD), old (26AD), and old caloric restricted (26CR) Fischer 344 male rats determined by Western blot analysis Reduction of the incidence of tumors following reduction of food intake An even more remarkable example of CR’s ability to resist irradiation is shown in the work of Gross and Dreyfuss, who challenged mice with gamma irradiation to induce tumorigenesis. They not only show a clear-cut tumor suppression by CR (TABLE) but also that CR rats had a far better capability of resisting one of the most deleterious forms of stressors. Shelke et al., 2003 Shelke et al., 2003 Lee et al., 1999