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CHMI 2227E Biochemistry I Proteins: - Tertiary structure CHMI 2227 - E.R. Gauthier, Ph.D. 1 Tertiary structure CHMI 2227 - E.R. Gauthier, Ph.D. 2 Tertiary structure Collagen myoglobin CHMI 2227 - E.R. Gauthier, Ph.D. 3 Tertiary structure http://butane.chem.uiuc.edu/cyerkes/chem104A_S07/Lecture_Notes_104/lect28c.html Interaction forces Check this one out: http://www.elmhurst.edu/~chm/vchembook/567tertprotein.html 4 CHMI 2227 - E.R. Gauthier, Ph.D. Tertiary structure A CHMI 2227 - E.R. Gauthier, Ph.D. B 5 Tertiary structure Folding motifs - 1 CHMI 2227 - E.R. Gauthier, Ph.D. 6 Tertiary structure Folding motifs - 2 CHMI 2227 - E.R. Gauthier, Ph.D. 7 Tertiary structure Protein domains – Pyruvate kinase Domain 1 Domain 2 Domain 3 CHMI 2227 - E.R. Gauthier, Ph.D. 8 Tertiary structure 1. Myoglobin b-turn b-turn Proline CHMI 2227 - E.R. Gauthier, Ph.D. 9 Tertiary structure 1. Myoglobin Hydrophilic amino acids: Blue Hydrophobic amino acids: Yellow CHMI Cross-sectional 2227 - E.R. Gauthier, Ph.D. view 10 Tertiary structure 2. Porin – a membrane-bound protein Hydrophilic amino acids: Blue Hydrophobic amino acids: Yellow CHMI 2227 - E.R. Gauthier, Ph.D. 11 Tertiary structure Chaperones CHMI 2227 - E.R. Gauthier, Ph.D. 12 Tertiary structure Protein denaturation Check this one out: http://www.elmhurst.edu/~chm/vchembook/568denaturation.html 13 CHMI 2227 - E.R. Gauthier, Ph.D. Tertiary structure Protein denaturation CHMI 2227 - E.R. Gauthier, Ph.D. 14 Examples of proteins 1. Green fluorescent protein CHMI 2227 - E.R. Gauthier, Ph.D. 15 Examples of proteins 1. Green fluorescent protein Light! CHMI 2227 - E.R. Gauthier, Ph.D. 16 Examples of proteins 1. Green fluorescent protein Nucleus CHMI 2227 - E.R. Gauthier, Ph.D. Golgi apparatus 17 Examples of proteins 1. Green fluorescent protein CHMI 2227 - E.R. Gauthier, Ph.D. 18 Examples of proteins 2. Prion proteins Toxic form = PrPsc Normal form = PrPc http://en.wikipedia.org/wiki/Image:Prion.gif CHMI 2227 - E.R. Gauthier, Ph.D. 19 Examples of proteins 2. Prion proteins Fiber aggregation CHMI 2227 - E.R. Gauthier, Ph.D. 20 Important web site: http://www.pdb.org/pdb/home/home.do CHMI 2227 - E.R. Gauthier, Ph.D. 21
