Download YANG Daiwen

Daiwen YANG
Department of Biological Sciences
14 Science Drive 4
National University of Singapore
Singapore 117543
Tel: 65-6516-1014
Email: [email protected]
URL: http://yangdw.science.nus.edu.sg/
http://yangdw.science.nus.edu.sg/
MAJOR RESEARCH INTERESTS
Our research interests lie in development and application of NMR methodology for protein
structure determination, protein dynamics, and drug discovery. Current projects include
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Structure determination of biologically important proteins such as cell-cell adhesion
proteins, tumor suppressors, RNA binding proteins, and lipid binding proteins.
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Development of novel NMR methods for the study of large proteins (>40 kDa)
Functionally relevant dynamics on microsecond-millisecond and picosecond-nanosecond
timescales
Identification and design of phosphatase inhibitors using fluorescence and NMR-based
methods
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RECENT REPRESENTATIVE PUBLICATIONS
1. Z. Lin, S. Sriskanthadevan, H. Huang, C.H.Siu, D. W. Yang, Solution structures of the
adhesion molecule DdCAD-1 reveal new insights into Ca2+-dependent cell-cell adhesion,
Nat. Struct. Mol. Biol., 13, 1016-22 (2006).
2. Y. Q. Xu, Y. Zheng, J.S. Fan, D.W. Yang, A novel strategy for structure determination of
large proteins without deuteration, Nature Methods , 3, 931-937 (2006).
3. X. Zhang, X. Sui, D. W. Yang*, Probe methyl dynamics from 13C autocorrelated and crosscorrelated relaxation, J. Am. Chem. Soc., 128, 5073-5081 (2006).
4. X. Sui, Y. Xu, J. L. Giovannelli, N. T. Ho, C. Ho & D. W. Yang, Mapping Protein-Protein
Interfaces on the Basis of Proton Density Difference, Angew. Chem. Int. Ed. Engl., 44, 51415144 (2005).
5. Y. Zheng & D. W. Yang, STARS: Statistics on inter-atomic distances and dihedral angles in
protein secondary structures, Bioinformatics, 21, 2925-2926 (2005).
6. X.Y. Ran, H. H. Miao, F.S. Sheu & D.W.Yang, Structural and Dynamic Characterization of
a Neuron-specific Protein Kinase C Substrate, Neurogranin, Biochemistry, 42, 5143-5150
(2003).