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Organic Chemistry, 6th edition Paula Yurkanis Bruice Chapter 25 The Organic Chemistry of the Coenzymes, Compounds Derived from Vitamins Brian L. Groh Minnesota State University, Mankato Mankato, MN Bruice: Organic Chemistry, © 2011 Pearson Education, Inc. 25 Which of the following is not true of cofactors or coenzymes? A. They assist in catalyzing a variety of reactions. B. They can be metal ions. C. They may be organic molecules which are then called coenzymes. D. All vitamins function as coenzymes. E. They may function as reducing or oxidizing agents. Bruice: Organic Chemistry, © 2011 Pearson Education, Inc. 25 Which of the following is not true of cofactors or coenzymes? A. They assist in catalyzing a variety of reactions. B. They can be metal ions. C. They may be organic molecules which are then called coenzymes. D. All vitamins function as coenzymes. E. They may function as reducing or oxidizing agents. Except vitamin C all water soluble vitamins and vitamin K are cofactors. The others are not. Bruice: Organic Chemistry, © 2011 Pearson Education, Inc. 25.2 What enzyme is used in the following reaction? CO 2SH A. B. C. D. E. SH CO2- FAD S S Succinate dehydrogenase Dihydrolipoyl dehydrogenase Thiol dehydrogenase Amino acid oxidase FADH2 dehydrogenase Bruice: Organic Chemistry, © 2011 Pearson Education, Inc. + FADH2 25.2 What enzyme is used in the following reaction? CO 2SH SH A. B. C. D. E. CO2- FAD S S + FADH2 Succinate dehydrogenase Dihydrolipoyl dehydrogenase Thiol dehydrogenase Amino acid oxidase FADH2 dehydrogenase There is no enzyme called thiol dehydrogenase. Bruice: Organic Chemistry, © 2011 Pearson Education, Inc. 25.5 Pyridoxal phosphate (PLP) is required by enzymes that catalyze transformations including: A. B. C. D. E. Decarboxylation Transamination Racemization Alpha- and beta-eliminations and cleavages All of the above Bruice: Organic Chemistry, © 2011 Pearson Education, Inc. 25.5 Pyridoxal phosphate (PLP) is required by enzymes that catalyze transformations including: A. B. C. D. E. Decarboxylation Transamination Racemization Alpha- and beta-eliminations and cleavages All of the above Bruice: Organic Chemistry, © 2011 Pearson Education, Inc. 25.1, Which of the following coenzymes is used in 25.2, oxidations reactions? 25.7 A. THF B. FADH2 C. NADH D. NAD+ E. All of these Bruice: Organic Chemistry, © 2011 Pearson Education, Inc. 25.1, Which of the following coenzymes is used in 25.2, oxidations reactions? 25.7 A. THF NAD+ acts as a hydride B. FADH2 acceptor. NADP+ is C. NADH another similar D. NAD+ oxidizing agent. E. All of these Bruice: Organic Chemistry, © 2011 Pearson Education, Inc. 25.1, Which of the following coenzymes is not used in 25.2, reduction reactions? 25.8 A. Dihydrolipoate B. FADH2 C. NADH D. Vitamin KH2 E. None. All of these are reducing agents. Bruice: Organic Chemistry, © 2011 Pearson Education, Inc. 25.1, Which of the following coenzymes is not used in 25.2, reduction reactions? 25.8 A. Dihydrolipoate B. FADH2 C. NADH D. Vitamin KH2 E. None. All of these are reducing agents. All of these coenzymes are hydrogen donors. Bruice: Organic Chemistry, © 2011 Pearson Education, Inc. 25.225.8 Which of the following enzymes is used in the transfer of a single carbon? A. B. C. D. E. Vitamin KH2 Thiamine pyrophosphate (TPP) Tetrahydrofolate (THF) Pyridoxal phosphate (PLP) Flavin mononucleotide (FMN) Bruice: Organic Chemistry, © 2011 Pearson Education, Inc. 25.225.8 Which of the following enzymes is used in the transfer of a single carbon? A. B. C. D. E. Vitamin KH2 Thiamine pyrophosphate (TPP) Tetrahydrofolate (THF) Pyridoxal phosphate (PLP) Flavin mononucleotide (FMN) THF is used in the transfer of groups containing only one carbons such as –CH3, –CH2, and –HC=O. Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.