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For Infornation: Andrs Jowers lvlanager, News Bureau (619)457-8290, 455-8133 FOR IMI{EDIATE RM,E,ASE #82388-4 Scripps Cl-inic resuunes clinical of experimental Lunq cancer treatrent IA ,JOLLA,Aug. 23 -resuning its trial clinical Scrilps trial and Research Foundation is Clinic of an experirental phase of the trial, Like the initial this treatment for lung cancer. stage is confined to with non-snall celI lung cancer - the npst conunontype, accounting lntients for threequarters of the l-50,000 cases diagnosed each year in this country. Patients Itre trial interested will conjugate Monoclonal- antibodies out and bind to specific anLibody used in this antibody-drug killing are antibodies rade in the laboratory that seek cells - in this case, lung cancer celIs. Itre study is ctrsnically &ug, cells of a in hurnns. combined with the Once injected' methotrexate. conjugate should deliver nalignant (619)455-8860. continue to evaluate the safetv and effect nronocl"onal antibody-drug chsnotherapeutic in the stuQy should call the monoclornl the drug directly without daneging nornal tissue. (l'iore) to the twror, thus Page 2 Aug. 23' 1988 #82388-4 The antibody used in the trial Institute of Scripps Clinic I KSI/ , was discovered by Research investigators. The antibodlz and antibody-drug conjugates $/ere produced by Brunswick Technetics, quantities for hunnn trials. and tLre initial Prelininary director oncology division; Research Institute in the laboratory and Dr. Leslie of Scripps Clinic. oncology, henatology and director of the ctrest and critical Walker, immunology dj.vision, Dr. Darlene Elias, formerly of the San Francisco, Cardiovascular Research Institute, the Scripps Clinic on this out the stuQy include Dr. Robert clinical Dr. Iawrence Kline, UniversiQr of California, a ceinvestigator carrying of experimental care medicine division; has joined investigations hunan safety studies have been prcrnising. The team of investigators Dillnnn, San Diegor in sufficient chest and critical project. ### care redicine division as