Download Guidelines for the Use of Taxotere in Mice (per ULAM) 1.0 Purpose

SOP-BCR6.10
1.0
Guidelines for the Use
of Taxotere in Mice
(per ULAM)
Author: S. Clouthier
Rev:
Issued: 07/02/09
0
Revised: 07/02/09
Approved: M. Wicha
Purpose
The purpose of SOP 6.10 is to provide information on proper procedure for rodents
administered Chemotherapeutic agents.
2.0
Scope
SOP 6.10 is intended to cover all resources, personnel and equipment in the BCR laboratory.
3.0 Materials
No.
1.0
Name
Taxotere
Description
Chemotherapy Agent
4.0 Procedure
4.1 Any mouse cage that contains animals receiving Taxotere or other chemotherapy agent
should be clearly identified. A green dissolvable sticker should be applied to the outside of
the cage and it should indicate the drug and date that chemotherapy administration begins.
4.2 Three days after the last dose of chemotherapy (if the mice will receive no further
chemotherapy treatments) the mice should be moved to a clean cage without a green label.
4.3 When a green labeled cage is emptied of mice, place all caging (including bedding) into a
plastic bag on the floor inside the animal cubicle. ULAM staff will discard the bedding and
sterilize the caging in a mode compliant with OSEH Haz Mat procedures.
 Notify Chris Binkley: Animal Care Supervisor, [email protected] 6-3946 of
any carcasses that are generated within three days of Taxotere administration.
These carcasses will require biohazard containment. Mice which survive beyond
three days administration will have metabolized the drug such that they can be
disposed of according to standard mouse disposal procedures.
5.0 Applicable References
ULAM website [ http://www.ulam.umich.edu/ ]
6.0 Change Description
Revision
Date
Reference
Description of Change
Page 1