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Managing Innovation Evista Case Morgane … Maël Bourguignon Jonathan Calvet Axel Caborderie Summary I. INTRODUCTION – II. Background MARKET CONSTRAINTS AND PROBLEMATIC – Threats : Generics / « Me too » – Environmental constraints : Formularies / Laws – Problematic III. DEVELOPMENT PROCESS AND ORGANIZATION – Development process / Time to Market – « Heavyweight » management approach IV. CONCLUSION : – To go Further Background 1876. Creation of ELI LILLY and Company by Colonel Eli Lilly, pharmaceutical chemist and Civil war veteran. Background 1930-80. ELI LILLY continued to develop insulin product family and treatment of endocrine diseases. Background 1920. First Blockbuster for treatment of diabetes: Insulin Background 1950s. Development of Ceclor : top-selling antibiotic of the world. Background 1980. Introduction of Humilin using recombinant DNA technology : improve diabetes treatment. Background 1986. Commercialisation of Prozac : drug for central nervous system. Background 1996. Zyprexa : Anti-psychotic for treatment of schizophrenia. Background 1990-97. Restructuring and focus on fighting cancer and cardiovascular diseases : Launch of ReoPro, anti-platelet agent and Gemzar, oncology product. Background 2005. Eli Lilly registered 14,6 billion $ of global revenues The problematic Considering the increasing threats within the pharmaceutical industry, How can Eli Lilly remain competitive? Conclusion • Time to market : a better approach taking into account the market constraints. • « Heavyweight » approach: give the priority to the future potential blockbuster. Conclusion • To go further : – Should we apply this approach to the commercialization of new drugs ? – On which criterions ? – For which costs ? – Should we have to delay or stop other projects ?