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CARDIOVASCULAR DISEASE 心血管疾病总论 王建安 浙江大学医学院附属第二医院 IMPACT OF CARDIOVASCULAR DISEASE • More than 70 million Americans are estimated to have one or more types of cardiovascular disease (CVD) • 65 million have hypertension • 13 million have coronary heart disease (CHD) • 5.4 million have had a stroke • More than 8 million Americans have peripheral artery disease (PAD) • Overall, about one in four Americans currently have some forms of CVD IMPACT OF CARDIOVASCULAR DISEASE • CVD contributes to about 1.4 million deaths annually in the United States, or 40% of all deaths • Approximately 32% of CVD deaths occur prematurely (i.e., in persons <75 years old) • Each year, about 1.2 million Americans have a new or recurrent myocardial infarction (MI), and more than 40% of these events are fatal • The annual incidence of new or recurrent stroke is about 700,000 per year, and about 275,000 Americans die from a stroke each year Epidemiology Risk Factors CHD Stroke PAD Advanced age +++ ++++ ++++ Male gender ++ + + Cigarette smoking +++ + ++++ Hypertension ++ ++++ ++ High LDL cholesterol ++ + + Low HDL cholesterol +++ + +++ Triglycerides ++ + +++ Diabetes mellitus +++ + ++++ Homocysteine ++ ++ +++ Fibrinogen ++++ ++ +++ C-reactive protein ++++ ++ ++ Lp(a) ++ ++ +++ Chlamydia pneumoniae ++ + ++ ESTABLISHED NEWER SYMPTOMS OF CARDIOVASCULAR DISEASE • Chest pain or discomfort • Dyspnea, orthopnea, paroxysmal nocturnal dyspnea, wheezing • Palpitations, dizziness, syncope • Cough, hemoptysis • Fatigue, weakness • Pain in extremities with exertion (claudication) History matters! Chest pain • Provocative and Palliative factors: What makes better or worse? • Quality: Visceral vs. somatic • Region and Radiation: Central, left, or right To Back, neck, arm • Severity: Scale of 1-10 • Timing: Gradual or sudden onset • Associated symptoms: SOB, sweating, nausea Complete medical history • A thorough review of systems • Family history – premature atherosclerosis – familial abnormalities, such as the long QT syndrome or hypertrophic cardiomyopathy • Social history – cigarette smoking – alcohol intake – use of illicit drugs • Past medical history PHYSICAL EXAMINATION Chest X-ray 胸片 • 心影大小 Pulmonary edema 肺水肿 ELECTROCARDIOGRAPHY (ECG)心电图 Ambulatory ECG (Holter) 动态心电图 Indications: to diagnose arrhythmia • Patients with unexplained syncope,near syncope, or episodic dizziness in whom the cause is not obivious. • Patients with unexplained recurrent palpitation • To assess antiarrhythmic drug response. To diagnose silent myocardial ischemia • Transient ST segment depression Treadmill ECG stress testing 活动平板检查 Mainly used to estimate the likelihood and extent of coronary artery disease. 主要用于诊断冠心病 Exercise protocol: 运动方案 • Standard Bruce protocol • Modified Bruce protocol Designed for older patients whose exercise capacity is limited by cardiac disease. …… Treadmill ECG stress testing 活动平板检查 Test result 检查结果 • Positive 阳性 运动中出现典型心绞痛,心动图提示ST段 水平型或下斜型压低>=0.1mv(J点后6080ms)持续2分钟为运动试验阳性标准 • False positive 假阳性 • Negative 阴性 • False negative 假阴性 ECHOCARDIOGRAPHY (ECHO) 超声心动图 • • • • • • Transthoracic echocardiography (TTE) Transesophageal echocardiography (TEE) Handheld echocardiography Contrast echocardiography Three-dimensional echocardiography Stress echocardiography NUCLEAR CARDIOLOGY 核素检查 COMPUTED TOMOGRAPHY ANGIOGRAPHY (CTA) CARDIOVASCULAR MAGNETIC RESONANCE IMAGING 心血管磁共振 Coronary Angiography (CAG) 冠状动脉造影 THANKS