Download 2008 HW1 Part 2

Homework 1
Part 2
Drug Resistance and Malaria
Download “Drug Resistance and Malaria” by Peter
Bloland, published by the World Health Organization:
http://www.who.int/csr/resources/publications/drugresist/
malaria.pdf.
“[T]here is a great disparity between the public health
importance of the disease and the amount of
resources invested in developing new cures.”
Using this reference as your guide, answer the following
questions.
Drug Resistance and Malaria
A)
What three groups of people are most at-risk for
developing severe or fatal malarial illness?
B) Which region of the world is experiencing the most
significant problem with drug resistant Plasmodium
falciparum malaria? (Hint: see Table 3)
Drug Resistance and Malaria
C) What would be the yearly cost of treating every malaria
infection on earth with the least expensive single-agent
antimalarial? (Note: use the WHO’s low-end estimate of
global incidence, and assume that one treatment per
patient will cure the infection; see Table 2)
D) Combination therapy reduces the emergence of drug
resistance. What would be the yearly cost of treating
every malaria infection on earth with the least expensive
combination therapy (assuming every infection is
chloroquine and SP resistant)?
Drug Resistance and Malaria
E) In one sentence each, describe three proposed
strategies to prevent anti-malarial drug resistance.