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ABSTRACT MACROSCOPIC, MICROSCOPIC STUDY AND PHYTOCHEMICAL SCREENING OF Marsilea crenata Presl. The examination of taxonomic and phytochemical screening of Marsilea crenata Presl. has been done to identify morphological and anatomical and chemical compound of the plant. The taxonomic include plant identification, classification, and binomial nomenclature based on morphological and anatomical characteristic. The taxonomic study is needed to avoid possible mistakes in taking the plant because Indonesia has too many medicine plants and to avoid possible false crude drug. On the other hand, study of phytochemical screening is needed to know the chemical compounds before studying pharmacological effects. Result showed the characteristic of Marsilea crenata Presl. as a herb, growing on the field, leaves have un umbrella like formation, located at the top of green stipe, consist of four leaf, green, flated or sometimes wades edge, smooth feathers on the surface. Marsilea crenata Presl. has brown stolon and brown roots hairs . Result from microscopical anatomy showed anisocytic stomata with three or more neighbouring cells in different size on upper and lower epidermis, multicelluler trichomes, volatile oil drops, xylem with spiral-form thickening. Whereas stipe and stolon have same microscopical characteristic. There are paracytic stomata exist on epidermis cells, mulicelluler trichomes, volatile oil drops, xylem with spiralform thickening, and type of vascular bundle is amphicribral. On the chemical compound are volatile oil, unsaturated steroid, saponin, and polifenol. Keywords : Marsilea crenata Presl., Morphology, Anatomy, Phytochemical Screening, Chemical compounds.