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Transcript
Alcohol, drugs, and hospitals James Bell February 2014 Why do people use drugs? Why do people use drugs? Drug use is normal behaviour Who develops drug problems? Who develops drug problems 25 Prevalence 20 15 Males (9.0) Females (3.2) 10 5 0 18-24 25-34 35-44 45-54 Age 55-64 65+ Neurobiology of drug use • Drugs of abuse have in common that they act on the “reward pathway” • The reinforcing effect of drugs is reduction in anxiety and creation of a sense of wellbeing • Repeated exposure leads to lasting brain changes, including protracted withdrawal Drug Dependence A maladaptive pattern of substance use leading to impairment or distress Tolerance and Withdrawal Salience Craving Reinstatement after abstinence Persisting use despite harm Communities vulnerable to drug dependence Those without taboos or rewards Especially: - indigenous communities - marginalised communities - deregulated communities Responding to drug problems Distinct area of medicine: • Serious morbidity and mortality • Involves values and choices Simply telling people to stop is of limited value Components of behavioural medicine • • • • Exchange of information Structure Support Relief of symptoms Alcohol and hospitals Alcoholics need not apply Admissions with alcohol problems KCH 2009 CARE_GROUP Elective Emergency Non-Elective Cardiac 44 25 16 Child Health 1 14 1 CSDS 4 Dental 7 26 3 Liver 465 191 109 Medical 8 1716 8 Neurosciences 26 38 49 Renal 15 25 7 Specialist Medicine 3 23 Surgical 67 231 13 Women's Health 3 3 Grand Total 643 2292 206 Total 85 16 4 36 765 1732 113 47 26 311 6 3,141 Questions Hospitalised drug user A heroin user was admitted for hand surgery after a fight - Post-operatively, complaining of pain - When told his next scheduled dose of analgesia was not for several hours, he swore at the nurse and threatened vilence Progress Addiction nurse assessed patient - Opioid withdrawal - Recommended methadone be given, plus analgesia as needed Once withdrawal relieved, addictions nurse suggested apology Patient agreed, situation resolved Why do heroin addicts receive methadone? Opioid Substitution Treatment of Addiction 1. Controlled Supply 2. Stabilization (abolish withdrawal) 3. Diminish reinforcing effects of street heroin 4. Structure – attendance and monitoring 5. Support Prescribing Methadone for admitted patients not on OST FIRST 24 HOURS Prescribe methadone liquid 1mg/ml Dose 1-10mg every 4 hours PRN according to signs of withdrawal Maximum dose 40mg in first 24 hours Always refer these patients to the Substance Misuse Nurse on pager KH3227. Person on methadone (or buprenorphine) admitted 1. Continue medication 2. In addition, usual analgesia, may need titration 3. If head injury / hepatic encephalopathy, may need dose reduction 4. Note drug interactions (anticonvulsants, rifampicin, other CYP inducers) Caution F40 morbidly obese, admitted leg ulcer Mx Methadone 100mg/day, not supervised as she had limited mobility. Methadone prescribed in hospital, administered day1 Day 2 – noted to be drowsy, snoring cyanosed, with pinpoint pupils Party Drugs GBL GABA b agonist, precursor of GHB • Produces confidence, charm, relaxation (“charisma”), sexual disinhibition • In higher doses produces prompt sleep • Narrow therapeutic index – risk of OD • Usage mainly in gay males Why do people use GBL? 1. Socialising 2. Sex 3. Sleep GBL - dependence • Uncommon? • Involves dosing every 1-2 hours • Can develop rapidly (eg after a “long weekend” of partying) • Often occurs when drug is used for sleep • Associated with social withdrawal, emotional blunting, compromised social role GBL withdrawal Onset rapid – 3-4 hours Can occur after awaking from OD May be severe (delirium, agitated psychosis, severe anxiety and insomnia) Several cases required ICU management UK experience – people admitted for elective detox have required ICU transfer (delirium, rhabdomyolysis) GBL withdrawal management • Initiate high dose diazepam (20mg 2nd hourly) early. “Usual” dose 70-90 mg day 1 • Baclofen 10mg tds • Transfer to AAU (more appropriate setting) Further Reading • Bell J & Collins R (2011) Gamma-butyrolactone (GBL) dependence and withdrawal Addiction 106(2); 442-447 • McDonough M, Kennedy N, Glasper A, Bearn J (2004) Clinical features and management of gamma-hydroxybutyrate (GHB) withdrawal: a review Drug and Alcohol Dependence 75; 3–9 • Le Tourneau J, Hagg D, Smith S (2008) Baclofen and gammahydroxybutyrate withdrawal Neurocritical Care 8(3):430-3 Questions [email protected]