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Some human GPCRs involved in aging and certain age-related pathologies LOGO 3-D Pie Chart Text2 Text1 orthosteric site Text3 (the VFT module) Text4 Text5 allosteric site (the heptahelical domain) LOGO www.themegallery.com Such compounds might soon prove to be excellent drugs to treat various diseases including anxiety Parkinson’s disease depression drug addiction schizophrenia(精神分裂症) osteoporosis(骨质疏松症) new taste enhancers LOGO Limitations of the approach 1 2 pharmacological bridge Text 3 4 LOGO 2 Contents LOGO 1 No consensus has been reached 2 The patients have no respond 3 Drugs may be indirect to pathogenesis 4 Drug’s action is unexpected to its feature Contents LOGO 1 No consensus has been reached 2 The patients have no respond 3 Drugs may be indirect to pathogenesis 4 Drug’s action is unexpected to its feature Contents LOGO 1 No consensus has been reached 2 The patients have no respond 3 Drugs may be indirect to pathogenesis 4 Drug’s action is unexpected to its feature Contents LOGO 1 No consensus has been reached 2 The patients have no respond 3 Drugs may be indirect to pathogenesis 4 Drug’s action is unexpected to its feature Perspective It is to be hoped that an admixture of new techniques and strategies of genomics, proteomics, which enable to work together with the ‘‘old’’ biochemical approaches. multi-marker biological treatment monitoring large scale automated measures biological differential diagnostic system LOGO LOGO Lunch time !!! and don’t forget the importance of GPCRs Made by jason_wjb