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Legal Drugs
What They ‘Forgot’ To Tell You
-Greg Hryniewicki
PART ONE
The Pain Killers…
#1
Oxycodone
(opiates)
 Average Dose: 5–15 mg oral every 4 to 6 hours
or 10 mg controlled release every 12 hours.
 Average Deadly Dose: 30mg/kg (with no
tolerance)
 Side Effects: Constipation, fatigue, dizziness,
nausea, vomiting dry mouth, anxiety, itching,
and sweating, loss of appetite, nervousness,
abdominal pain, diarrhea, urine retention,
dyspnea, and hiccups.
 Dependence and Withdrawal: Anxiety, panic
attack, nausea, insomnia, muscle pain, muscle
weakness, fevers, and other flu-like symptoms.
 Cancer: Is not proven to increase risk of
cancer. This medication is usually given
to cancer patients who suffer from
severe pain.
 Pregnancy: Withdrawal symptoms have
been reported in newborns whose
mothers had been exposed to
oxycodone during pregnancy.
 Worldwide Deaths: 27.2 people for every
one million people per year.
 USA Deaths: 14,800+/- per year.
#2: Advil (ibuprofen)
 Average Dose: 400mg every 6 hours.
 Average Deadly Dose: 636mg/kg.
 Side Effects: nausea, dyspepsia,
gastrointestinal ulceration/bleeding, raised
liver enzymes, diarrhea, constipation,
epistaxis, headache, dizziness, priapism,
rash, salt and fluid retention, hypertension
and it is also associated with hearing loss.
 Dependence and Withdrawal: If taking
more than 1,200mg per day and
discontinuing; minor joint pain may be felt.
Cancer: 51% increase in
developing kidney cancer.
Pregnancy: Taking while
pregnant increases chance of
miscarriage by 240%.
Worldwide Deaths: unknown.
USA Deaths: 16,500+/(estimate) per year.
#3 NyQuil (OTC cocktail)
Acetaminophen, Dextromethorphan and
Doxylamine succinate
 Average Dose: 30ml shot that contains:




Alcohol (10%)
Acetaminophen (650 mg/30 ml) (pain reliever/fever reducer)
Dextromethorphan (30 mg/30 ml) (cough suppressant)
Doxylamine succinate (12.5 mg/30 ml) (antihistamine/hypnotic)
 Average Deadly Dose: Acetaminophen would
be the first chemical in this ‘drug cocktail’ to kill
you. The needed dose would be 338mg/kg, so
about thirty-seven shots for the average
American.
 Side Effects: Nausea, vomiting, sweating,
diarrhea, yellow skin or eyes, body rash,
dizziness, closed-eye hallucinations, difficulty
breathing, dry mouth, ataxia, urinary retention,
drowsiness, memory problems, inability to
concentrate, hallucinations, psychosis, and a
marked increased sensitivity to external stimuli.
 Dependence and Withdrawal: There are no
physical withdrawal symptoms if following the
recommended dosage but there is strong evidence
that suggests a psychological dependency
possibly developing since it is such an effective
sleep aid.
 Cancer: If you use it four or more times a week,
your chance of developing cancer in general
doubles, especially in the liver and thyroid.
 Pregnancy: The various ingredients cause an
overall increased risk of a miscarriage and birth
defects.
 Worldwide Deaths: unknown.
 USA Deaths: 460+/- per year.
PART TWO
“You’re Not Normal… Take
These!”
[methylphenidate is Ritalin]
#4: Adderal (amphetamine)
 Average Dose: 5-60mg daily (depending on tolerance).
 Average Deadly Dose: 200-300mg (with no tolerance and a
weight of 80kg/176lbs (average weight of an American).
 Side Effects: anorexia, hyperactivity, dilated pupils, flushing,
restlessness, dry mouth, headache, tachycardia,bradycardia,
tachypnea, hypertension, hypotension, hyperthermia,
diaphoresis, diarrhea, constipation, blurred vision, dizziness,
twitching, insomnia, numbness, palpitations, arrhythmias,
tremors, dry and/or itchy skin, acne, pallor, euphoria, anxiety,
increased libido, alertness, concentration, increased energy,
increased self-esteem, self-confidence, sociability, irritability,
aggressiveness, psychosomatic disorders, psychomotor
agitation, dermatillomania, delusions of grandiosity,
hallucinations, excessive feelings of power and invincibility,
repetitive and obsessive behaviors, paranoia, and with
chronic and/or high doses, amphetamine psychosis,
convulsions, heart attack and stroke can occur.
 Dependence and Withdrawal: mental fatigue, mental
depression, increased appetite, anxiety, agitation, excessive
sleep, vivid or lucid dreams, deep REM sleep and suicidal
ideation.
 Cancer: Using recreational doses (30mg+) once
every three to five days increased the chance of
developing Kaposi's sarcoma (KS), Lymphoma and
cervical cancer by 500%.
 Pregnancy: Use during pregnancy increases chance
of heart defects, gastroschisis and small intestinal
atresias, cleft lip and palate, reduction in birth
weight, prematurity, postpartum hemorrhage, and
retained placenta. Babies can have an increase in
jitteriness, drowsiness, and respiratory distress,
suggesting an amphetamine withdrawal syndrome.
 Worldwide Deaths: unknown.
 USA Deaths: unknown.
 Deaths unknown probably due to people mixing the
amphetamine with different substances, such as
alcohol, cocaine, ect; which are deadly combinations
and cause of death was probably pointed at the
other drugs instead.
#5: Aripiprazole
(Abilify)
Designed to
treat:
schizophrenia,
bipolar disorder,
major depressive
disorder
 Average Dose: 2-30mg (Depending
on tolerance and specific disorder)
 Average Deadly Dose: unknown
(overdose starts at 90-120mg)
 Side Effects: nausea, vomiting,
constipation, headache, dizziness,
inner sense of restlessness/need to
move (akathisia), anxiety insomnia,
increased appetite, weight gain
restlessness, diabetes, mellitus.
 Dependence and Withdrawal: nausea, emesis,
lightheadedness, diaphoresis, dyskinesia,
orthostatic hypotension, tachycardia,
nervousness, dizziness, headache, excessive
non-stop crying, and anxiety.
 Cancer: is not known to increase chance of
caner.
 Pregnancy: Increases chance of miscarriage
and will transfer though Brest-feeding, making
the baby become dependent if exposed.
 Worldwide Deaths: unknown.
 USA Deaths: 27+/- per year (mostly suicides).
#6:
Zoloft
(SSRI’s)
 Average Dose: 25-200mg
(Depending on tolerance and
specific disorder)
 Average Deadly Dose: 1327mg/kg
 Side Effects: nausea, ejaculation,
insomnia, diarrhea, dry mouth,
somnolence (drowsiness),
dizziness, tremors, and decreased
libido.
 Dependence and Withdrawal: withdrawal symptoms
of irritability, agitation, dizziness, headache,
nervousness, crying, emotional lability, bad dreams
and anger can occur for more than two weeks
following discontinuation.
 Cancer: increased chance of developing breast
cancer by 91%.
 Pregnancy: Using this drug during pregnancy will
cause the baby to suffer severe from withdrawal
upon being born. Respiratory distress, cyanosis,
apnea, seizures, temperature instability, feeding
difficulty, vomiting, hypoglycemia, hypotonia,
hypertonia, hyperreflexia, tremor, jitteriness,
irritability, and constant crying will all be things the
baby will go though during his/her withdrawal.
 Worldwide Deaths: unknown.
 USA Deaths: 1,125+/- per year (mostly from
suicide).
PART THREE
The Classics
Funded By:
Companies
&
#7: Nicotine
 Average Dose per Cigarette: 1mg
 Average Deadly Dose: 30–60 mg (0.5–
1.0 mg/kg)
 Side Effects: Increased heart rate & blood
pressure plus multiple others listed on next
slide.
 Dependence and Withdrawal: Interferes with
reward pathway by releasing dopamine.
Lack of nicotine will cause down regulation
as brain tries to compensate. Very addictive
because it increases reward pathway
sensitivity, opposed to heroine and cocaine,
which decrease reward pathway sensitivity,
making it more addictive than the two.
 Cancer: Increases cholinergic signaling,
which inhibits apoptosis, promoting tumor
growth.
 Pregnancy: Use in the first twelve weeks of
pregnancy increases the chance of birth
defects by 60%. Also increases chance of
child developing ADHD later on in life by
250%.
 Worldwide Deaths: 6,000,000+/- (1st Hand)
/ 600,000+/- (2nd Hand) [estimates] per
year.
 USA Deaths: 440,000+/- (1st Hand) /
49,000+/- (2nd Hand) per year.
#8:
Caffeine
 Average Dose: 100mg (1 cup of coffee)
 Average Deadly Dose: 3,000-20,000mg
(depending on body weight and tolerance)
 Side Effects: Reduce physical fatigue and restores
alertness when drowsiness occurs. Increases
heart rate and blood pressure. Reduces fine motor
movements, stimulation of urination, possible
nausea.
 Dependence and Withdrawal: headache, irritability,
inability to concentrate, drowsiness, insomnia, and
pain in the stomach, upper body, and joints. May
appear within 12 to 24 hours after discontinuation
of caffeine intake, peak at roughly 48 hours, and
usually last from 2 to 9 days.
 Cancer: Caffeine increases chance of
pancreatic and bladder cancer but reduces
the risk of oral, esophageal,
and pharyngeal cancer.
 Pregnancy: Is only safe to consume up to
200mg (two cups of coffee) per day while
pregnant. Exceeding this amount will
increase the chance of a miscarriage or
preterm birth.
 Worldwide Deaths: 200,000-300,000
(estimate) per year.
 USA Deaths: 12,000+/- (estimate) per year.
ONE CUP OF COFFEE
4-5 Cups
#9: Alcohol
 Average Dose: 0.05-0.1% BAC (When drunk, your
20-25% down the road to possible death)
 Average Deadly Dose: 0.4-0.55% BAC
 Side Effects: Euphoria, talkativeness, relaxation,
central nervous system depression, nausea,
possible vomiting, impaired motor and sensory
function, impaired cognition.
 Dependence and Withdrawal: Discontinuing use
after several years of heavy drinking can be fatal.
Alcohol withdrawal can cause anxiety, autonomic
dysfunction, seizures, and hallucinations. Delirium
tremens is a condition that requires people with a
long history of heavy drinking to undertake
an alcohol detoxification regimen.
 Cancer: Alcohol increases the chance of mouth,
esophagus, pharynx, larynx, breast, liver, lung,
stomach, endometrial, gallbladder, ovarian, prostate
and small intestine cancer.
 Pregnancy: Physical defects can develop in a fetus in
association with high levels of alcohol consumption
during pregnancy. Alcohol crosses the placental
barrier and can stunt fetal growth or weight, create
distinctive facial stigmata, damage neurons and brain
structures, which can result in psychological or
behavioral problems, and cause other physical
damage. Fetal alcohol exposure is the leading known
cause of mental retardation in the Western world.
 Worldwide Deaths: 2,500,000+/- (estimate) per year.
 USA Deaths: 75,754 in 2012.
2010 study by the Independent Scientific
Committee on Drugs, led by David Nutt, Leslie
King and Lawrence Phillips