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Psych 30 Glossary Terms (Chapter 5) acute -- immediate or short-term effects after taking a single drug dose addiction -- generally refers to the psychological attachment to a drug(s); addiction to "harder" drugs such as heroin results in both psychological and physical attachment to the chemical properties of the drug, with the resulting satisfaction (reward) derived from using the drug in question additive interactions -- effects created when drugs are similar and actions are added together antagonistic interactions -- effects created when drugs cancel one another biotransformation -- process of changing the chemical properties of a drug, usually by metabolism blood-brain barrier -- selective filtering between the cerebral blood vessels and the brain chronic -- long-term effects, usually after taking multiple drug doses cross-dependence -- dependence on a drug can be relieved by other similar drugs cross-tolerance -- development of tolerance to one drug causes tolerance to related drugs cumulative effect -- buildup of a drug in the body after multiple doses taken at short intervals dependence -- physiological and psychological changes or adaptations that occur in response to the frequent administration of a drug dose-response -- correlation between the amount of a drug given and its effects drug interaction -- presence of one drug alters the action of another drug dysphoric -- characterized by unpleasant mental effects; the opposite of euphoric half-life -- time required for the body to eliminate and/or metabolize half of a drug dose intramuscular (IM) -- drug injection into a muscle intravenous (IV) -- drug injection into a vein margin of safety -- range in dose between the amount of drug necessary to cause a therapeutic effect and that needed to create a toxic effect mental set -- the collection of psychological and environmental factors that influence an individuals’ response to drugs metabolism -- chemical alteration of drugs by body processes metabolites -- chemical products of metabolism pharmacokinetics -- the study of factors that influence the distribution and concentration of drugs in the body placebo effects -- effects caused by suggestion and psychological factors independent of the pharmacological activity of a drug plateau effect -- maximum drug effect, regardless of dose potency -- amount of drug necessary to cause an effect psychological dependence -- dependence that results because a drug produces pleasant mental effects rebound effect -- form of withdrawal; paradoxical effects that occur when a drug has been eliminated from the body reverse tolerance -- enhanced response to a given drug dose; opposite of tolerance side effects -- unintended drug responses subcutaneous (SC) -- drug injection beneath the skin synergism -- ability of one drug to enhance the effect of another; also called potentiation teratogenic -- something that causes physical defects in the fetus threshold dose -- minimum drug dose necessary to cause an effect tolerance -- changes in the body that decrease response to a drug even though the dose remains the same toxicity -- capacity of one drug to damage or cause adverse effects in the body withdrawal -- unpleasant effects that occur when use of a drug is stopped