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Drugs and Our Society How Drugs Work in the Body and the Mind Pharmacology of Drugs 1. Pharmacology relates to the way drugs are: - administered to the body - how they are absorbed - how distributed through the body - how metabolized by the body - and how excreted from the body 2. There are 4 primary routes through which drugs are administered - oral / inhalation / injection / absorption Administration of Drugs 3. Ingesting drugs (oral) produces different effects from inhaling - smoking marijuana has a different effect from ingesting it - chewed tobacco is absorbed differently from smoked tobacco - the effects of injected narcotics are more intense than other forms 4. Not all drugs can be injected, such as marijuana - resin and water don’t mix Admin of Drugs, cont - it is less likely to be abused than narcotics and opiates - which can be injected 5. Cocaine is more likely to be abused than caffeine - the effects of cocaine are much more powerful - it takes effect more quickly. Depending on administration - injected more powerful than snorting Admin of Drugs, cont 6. Alcohol is metabolized in the liver - primary absorption site is the small intestine - removed through exhaling / sweat / urination - rate of 3/4th ounce per hour 7. Snort cocaine - mucous membranes in nose absorb drug quickly - effects are felt within minutes Admin of Drugs, cont 8. Amphetamines taken orally - produce peak effects in 2 to 3 hours - eliminated in 2 to 3 days - effect of injected amphetamines is 5 minutes 9. Caffeine effects is between 15 to 45 minutes - metabolized in the liver - removed by the kidneys Admin of Drugs, cont 10.Marijuana smoked allows half of the THC to be absorbed through lungs - before entering the bloodstream - the liver initially detoxifies the THC - it is removed primarily through feces Oral Administration 1. Ingesting by mouth is the oldest and easiest way - digesting / then absorbing into the bloodstream 2. Absorption time is longer after ingestion - between 5 and 30 minutes - not complete until after 6 to 8 hours 3. Gastrointestinal system consists of the esophagus, stomach / intestines - enables body to absorb nutrients - and remove waste Oral Administration, cont 4. Interior of stomach is highly acidic - drugs can be impacted by acidity - this can weaken effect of morphine / heroin / cocaine - which are highly alkaline drugs 5. From small intestine to bloodstream - drugs then processed by the liver - liver “metabolizes” the drug - enzymes break the drug down Oral Administration, cont 6. A larger dosage is needed when taken orally 7. 200 drugs show increase in enzyme activity - Phenobarbital has effect and duration decreased - valium and marijuana the active metabolites produce similar effects to the parent drug and prolongs the effect considerably Oral Administration, cont 8. Ingesting drugs on a full stomach or an empty stomach - does make a difference in the effect drugs will have on the body Injection 1. Parenteral drug use refers to the injection of drugs - injected drugs reach the brain quickly - the fastest means of injection is intravenous (IV): within a vein - it is called “mainlining” - with prolonged use, the vein wall loses strength and elasticity - and the vein can collapse Injection 2. Heroin injected into the forearm - 10 to 15 seconds to the heart / lung / and brain - blood vessel walls are relatively insensitivity - irritating material can also be injected - it is possible to deliver high concentrations of a drug 3. Another method is intramuscular - which is injection into a muscle 4. Muscle tissue serves as a filter, so the absorption time is slower Injection, cont 5. Example: - onset of euphoria after injecting heroin intravenously is 7 to 8 seconds - intramuscular the euphoric onset is 5 to 8 minutes - the more blood vessels the muscle has, the faster the absorption - deltoid muscle injections are faster than the buttocks Injection, cont 6. Subcutaneous injection - injecting just below the layers of the skin - the drug is absorbed less evenly and slowly - it is also referred to as a “skin pop” or “skin popping” Inhalation 1. This is where drugs are absorbed into the bloodstream via the lungs 2. Speed and efficiency are quite high - due to the accessibility of capillary walls - from the lungs, drugs go directly to the brain in 5 to 8 seconds - effects usually are brief 3. Smoking tobacco / marijuana / crack - ‘huffing’ glue, paint, other inhalants Absorption Through Skin or Membranes 1. Quick absorption - 15 to 20 seconds 2. Mucous membranes - found in the nose / mouth / rectal / and vaginal areas - drug adheres to membrane - dissolves into bloodstream 3. Intranasal - sniff / snort a drug such as cocaine - in dust or powder form Absorption Through Skin or Membranes 4. Transdermal application - ointment applied to skin - patch placed directly on the skin How Drugs Exit the Body 1. The body has a fairly efficient system to rid itself of unwanted substances - gases and solvent vapors can be eliminated in exhaled breath - small amounts can be eliminated through sweat / saliva / or feces - but primarily through urine 2. The major job of elimination is the liver and kidneys - the “dynamic duo” of excretion Kidneys 1. Two organs about the size of a fist - located on either side of the spine 2. Primary functions: - maintain balance between water and salt in body fluids - and the excretion of excess water in the form of urine 3. It functions as a complex filtering system - the kidneys physically remove certain substances from the blood Kidneys, cont 4. - it filters everything out - then selectively reabsorbs what is required 5. The kidney can make urine acidic or basic - the pH value can be manipulated - pH value refers to the acidity of a solution Liver 1. A large organ located high in the stomach under the diaphragm 2. Function - compare it to a chemical factory - molecules are modified to form new useful substances - toxic molecules are changed into less harmful substances 3. Changes made by molecules are called ENZYMES - depending on the drug / liver can create additional enzymes Liver, cont - metabolizes (breaks down) the molecules - the product of metabolism is metabolites, which are more useful and less toxic - they breakdown drugs into less active forms, called detoxification 4. Metabolites of certain drugs can be more active than the original (active metabolites) - good examples are THC and psilocybin Rate of Excretion 1. Kidneys operate most efficiently with high concentrations of the drug in the blood 2. Concentration falls - kidneys cannot filter out the drug at the same rate 3. Rate of excretion can be described in terms of ‘half-life’ - time for the body to eliminate half - of a given blood level of drug Rate of Excretion, cont 4. Half the original blood level is eliminated in 30 minutes - 30 minutes later, level is 25% - 30 minutes later, level is 12.5% 5. Every 30 minutes the body gets rid of half the drug circulating in the blood - so the half-life of the drug is 30 minutes 6. Half-life equals 1 hour - 50% / 25% / 12.5% / 6.25% / etc.