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PHARMACEUTICAL TECHNOLOGY B. Amsden CHEE 440 COURSE OBJECTIVES Introduce the fundamentals of preparing dosage forms. Demonstrate the application of engineering and applied science fundamentals to large scale production of dosage forms. Prepare student for an engineering position in the pharmaceutical industry. B. Amsden CHEE 440 COURSE OUTLINE Introduction • the need for delivery systems Principles of Drug Absorption • routes and mechanisms • pharmacokinetics Solid Dosage Forms: Tablets, Capsules • unit operations • drug stability issues Solutions, Suspensions, Emulsions Good Manufacturing Practices B. Amsden CHEE 440 Problem Sets and Tutorials Study problem sets are not marked: to aid in understanding material solutions will be posted weekly Tutorials: • Run by the TA (s) • Problem posed and answered in class B. Amsden CHEE 440 GRADING Midterm Exams (2) 50 % Held during class time (1.5 h each) Midterm 1: Feb 9th, 2012 Midterm 2: March 15th, 2012 Final Exam B. Amsden 50 % CHEE 440 COURSE MATERIALS Recommended textbook Pharmaceutics: The Science of Dosage Form Design, 3rd Ed., M.E. Aulton Editor, 2007. Other useful books: Remington: The Science and Practice of Pharmacy, 21st Ed., 2005 Pharmaceutical Dosage Forms and Drug Delivery Systems, 6th Ed. 1995 Perry’s Chemical Engineers’ Handbook Lecture notes www.chemeng.queensu.ca/courses/CHEE440/lectures/index.php B. Amsden CHEE 440