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Transcript
Pharmacokinetics objective is to describe time vs plasma concentration profile of a drug CHEE 440 evaluate performance of different dosage forms adjust dosage regimens ADME processes modeled by viewing body as a series of interconnected compartments 1 CHEE 440 2 open one-compartment model process of distribution to each compartment is much faster than absorption into blood and elimination drug concentration everywhere in the compartment is equal (CSTR) elimination processes are pseudo-1st order Vd ka D CHEE 440 Cp DB kel Du Dm 3 IV injection dDB k el D B mass balance : dt Cp Cop exp k elt log Cp time, t CHEE 440 4 Extravascular tablets, capsules, transdermal... most drugs absorbed by simple diffusion DA DB DE ka k el DoA k a CP exp kel t exp ka t Vd ka k el CHEE 440 5 Continuous infusion k0 CP 1 exp k el t Vd k el Cp time CHEE 440 6 biological half-life time required to reduce amount of drug in body to 1/2 original dose 0.693 t1 2 k el used to determine fluctuation of plasma concentration between doses persistence of drug in system once drug administration ceases CHEE 440 7 Dosing Schedule MTC Cp MEC time after administration CHEE 440 8