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Application of Conditioning to the Study of Drug Addiction Conditioned Place Preference with drugs of abuse uses Pavlovian conditioning procedures CS * UCS CS e.g. Light Stimulus*Drug Light Stimulus R R approach response approach response Self-Administration of drugs of abuse uses Instrumental conditioning procedures R e.g. Lever press response SR drug delivery Conditioned Place Preference stay Drug-injected Not Drug-injected don’t stay Pre-conditioning Preference Tests Days 1 and 2 Conditioning Sessions Days 3-10 Post-conditioning Preference Tests Days 11 and 14 Intravenous Cocaine Self-Administration Some drugs that are self-administered by laboratory animals Stimulants Narcotics Cocaine Fentanyl Anxiolytics Chlordiazepoxide Other Phencyclidine (PCP) d-Amphetamine Heroin Diazepam Nicotine Methylphenidate Codeine Pentobarbital Ethanol Methamphetamine Methadone Morphine Ketamine D 9 THC Self-Administration Model of Relapse incorporates both Instrumental and Pavlovian Conditioning No Cocaine and No Cues Cocaine Cues Alone Cocaine + Cocaine Cues Cue-Induced Relapse to Cocaine-Seeking Behavior Childress et al 1999 Cocaine Cue-Induce Craving Front of Brain Amygdala not lit up Amygdala activated Back of Brain Nature Video Cocaine Video Grant et al 1996 Cocaine Cue-Induce Craving In the laboratory...... • Study the brain sites that mediate conditioned relapse-like behavior • Determine the molecules that give rise to conditioned relapse-like behavior (e.g., genes; proteins) • Test medications that may reduce conditioned relapse-like behavior • Study the consequences of conditioned drug use (e.g., neurocognitive; brain plasticity changes)
