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Be a Champion 2005 Workshop Richard Higbee Vice President Global Marketing Our Promise • We promise you will leave with . . . • A Clear Understanding of the Pharmanex Vision and Strategy • A Conviction That Pharmanex Products Change Lives • Key Message Points That Will Help You Build Your Business “Business Take-aways” The Pharmanex Strategy Our strategy is to leverage science in order to create the most innovative sponsoring products in the dietary supplement and functional foods industry. Joseph Chang, Ph.D. President of Pharmanex Michael Chang, Ph.D. Chief Scientific Advisor, Pharmanex Fellow First Pharmanex office Homestead A Victory for CholestinTM and 57 Million Americans Cholestin, Good News for Better Health. Here’s some very good news for the estimated 57 million Americans who want a safe and 100% natural way to promote and maintain healthy cholesterol levels* – Cholestin is not a drug. A recent federal court ruling said that Cholestin meets all criteria as a dietary supplement. This distinction means that you can continue to enjoy direct access to this remarkably effective product, giving you an extremely strong weapon in the fight for better health. Research Confirms Cholestin Works. Cholestin’s benefits have been supported by over 30 clinical studies, all of which produced impressive results. Most recently, a double-blind, placebo-controlled study of Cholestin’s patented form of red yeast rice, was conducted by the UCLA School of Medicine and published by the American Journal of Clinical Nutrition. The studies measured the effects on cholesterol levels before and after supplementation with Cholestin. It was proven that Cholestin was effective compared to the placebo group. USA Today Circa 1997 Pharmanex® = “Pharma-Next” “Next Generation Pharmaceutical” I See a Future… I See a Future… • You as ambassadors of good health I See a Future… • You as ambassadors of good health • The world knowing their antioxidant score Extraordinary Science… Personalized Revolutionized Simplified Extraordinary Science… Personalized Revolutionized Simplified Body Fat and Antioxidant Protection 35,000 Antioxidant Score 30,000 29,236 25,000 25,612 20,000 20,835 15,000 10,000 16,603 < 25 25-29 30-39 Body Mass Index > 40 Breaking News: Landmark Scanner Study Skin Carotenoid Score = Antioxidant Protection Extraordinary Science… Personalized Revolutionized Simplified Lighter – Smaller – Faster S1 S2 Warm up time 30 min 5 min Calibration time 17 min 4 min Calibration steps 9 scans 3 scans Weight of scanner 10 lbs ~5 lbs Scan time 3 min ~2 min 70 – 75 °F 21 – 24 °C 50 – 95 °F 10 – 35 °C Temperature range Global Rollout • China, Europe, US Markets – February 2006 • Other markets soon after! • Learn more in your regional meeting I See a Future… • A Winning Strategy I See a Future… • A Winning Strategy • Simplicity Extraordinary Science… Personalized Revolutionized Simplified Now is the time to Scan the World! 10 Million People by 2007 Michael’s Business Take-aways • Original Pharmanex Slogan: “Pharmaceutical companies improve health with medicines, Pharmanex improves health without medicine” • Pharmanex is derived from “Pharma-next” or “Next Generation Pharmaceutical” Joe’s Business Take-aways • 10M by 2007 • The scanner is the gold standard for overall antioxidant protection • We must “SCAN THE WORLD” Major Accomplishments • Global Product Rollout – – – – • • • • BioPhotonic Scanner TRA Marine Omega Estera Stevie Award; NBJ Award Product Certifications China Manufacturing Scanner “Oxidative Stress” Study Science & Tradition Mark R. Bartlett Ph.D. Sr. Director Pharmanex New Product Development Fruit Phytonutrients • At least 1,000 phytochemicals identified with cell protective effects • Very few (25) studied • Fruits and vegetables – more than meets the eye • We don’t eat enough fruits and vegetables 3 years ago… Pharmanex began Searching the World for Superfruits – R&D evaluated hundreds of fruits for… • • • • • Extraordinary antioxidant power (Scanner) Extraordinary nutritional contents Quality of scientific efficacy data Impeccable safety data History of traditional folklore usage Why the long search and Why the long list? Free Radicals Sources • Environmental pollution (smog, ozone, NO2) • Radiation exposure: – sunlight (UV-light), X-rays, etc. • Smoking: – 10,000,000,000,000,000 free radicals/cigarette! • Eating and Breathing: mitochondria metabolism in your Mitochondria – The Energy Furnaces of the body Free Radicals SOD CAT Pharmanex Research Centers were involved… 1.Provo R&D Center 2.Shanghai R&D Center 3.Beijing R&D Center years of searching –Almost all failed Selection criteria –All but Four (g+3) very special fruits Gâc - “Fruit From Heaven” • Indigenous to Southern Asia Bangladesh, Burma, Cambodia, China, India, Japan, Laos, Malaysia, Philippines, Thailand, and Vietnam • Traditionally used internally and externally Topical: wound healing Internally: eye health, and to promote growth in children Antioxidants in Gâc Pulp • Extraordinarily rich in antioxidants, esp. lycopene, beta-carotene, vitamin E • Unique fatty acids → Lipocarotenes™ Fruit flesh Pulp (mesocarp) (aril) Seeds Pharmanex Research Centers 3 Years of Searching and R&D 3 +1 Superfruits 1. Gâc fruit (Chinese Bitter Cucumber) 2. Chinese Lycium (Wolfberry) 3. Cili fruit 4. Siberian Pineapple (Seabuckthorn) Gac Fruit Lycopene Content 2500 2227 2000 1500 70 x more than tomatoes! 1000 500 0 31 Tomato 54 41 Watermelon Guava mcg/g wet weight Ishida et al., J Agric Food Chem 52:274, 2004 Gac aril Gac Fruit Beta-Carotene Content 800 718 700 600 500 10 x more than carrots! 400 300 200 100 48 79 76 0 Spinach Carrot Sw.Potato mcg/g wet weight Ishida et al., J Agric Food Chem 52:274, 2004 Gac aril Gâc Fights Vitamin A Deficiency • …a Leading cause of blindness in the world • In So. Asia, Gâc discovered as potent indigenous source of highly bioactive provitamin A (b-carotene) • 10 years of research by Dr. Le Vuong, Univ. of California, Davis, Nutrition Department *Vuong LT et al., Am J Clin Nutr 2002;75:872-879. Zeaxanthin in Chinese Lycium Fruit 1000 900 800 700 600 500 400 300 200 100 0 800 40 x more than yellow corn! 18 Yellow Corn mcg/g wet weight Ch.Lycium Vitamin C in Cili Fruit 2500 2500 2000 60 x more than oranges! 1500 1000 500 0 30 Mandarin mg/100g wet weight 45 Orange 71 Kiwi Cili ™ Lipocarotenes • Nature’s unique nutrient delivery system in • Gâc – contain fatty acids (unique among fruits) – with carotenoids & vitamin E pre-dissolved – Gâc carotenes: 40 % improved uptake* *compared to beta-carotene powder. Vuong LT et al., Am J Clin Nutr 2002;75:872-879. Vulnerable to Oxidation Betacarotene Lutein Lycopene Vitamin C Internal Antioxidants SOD Catalase SOD CAT Proprietary • Patent pending, 100%-juice formula • First juice with Gâc worldwide • Pharmanex bought world supply of Gâc & Cili (2004/2005 season) will increase your scanner score! – 4,000 – 7,000 units @ 4 fl oz / day (8 weeks) – 12,000 – 20,000 units with LifePak® Use to take LifePak®! EFFECT OF AND OTHER JUICES ON ANTIOXIDANT STATUS AS MEASURED BY THE BIOPHOTONIC SCANNER Purpose: • To compare the effects of , XanGo™ and Tahitian Noni® juices on antioxidant status Study Design • Subjects (N=34) were randomly assigned to 1 of 3 groups • Subjects consumed 3 fluid oz twice per day, with breakfast and with dinner for 8 weeks • Comparable Daily Intakes – 6 fl oz (Maximum recommended intake) – 6 fl oz Tahitian Noni® (6x’s Recommended dose) – 6 fl oz XanGo™ (2x’s Recommended dose) Increased Antioxidant Network Scores ~9,500 in 8 Weeks Antioxidant Network Score 50,000 1 2 3 4 5 6 7 8 9 10 11 40,000 30,000 20,000 10,000 Week 0 Week 8 Lipocarotenes™ in are More Bioavailable Antioxidant Score 10,000 8,000 6,000 4,000 2,000 0 Other Carotenes g3 Lipocarotenes Increased Antioxidant Scores 4x’s More than XanGo™ or Noni Antioxidant Score 10,000 Noni XanGo™ #, g3 #, 8,000 * * 6,000 #, * 4,000 * 2,000 0 Week 0 Week 2 *p<0.05 compared to wk 0 Week 4 Week 6 Week 8 #p<0.05 compared to other juices Conclusions†: • dramatically increases antioxidant scores. • Lipocarotenes™ in g3 are 55% more easily absorbed. • has 4x’s the antioxidant potential of either XanGo™ or Tahitian Noni® Juice. †Preliminary, unpublished data. Thanks to Angela Mastaloudis, Ph.D. Associate Senior Scientist Mark’s Business Take-aways • Scanner Developed: was developed because of the scanner • SCS Certified: Guaranteed to Increase • • • • Antioxidant Score Superfruit: A fruit that contains unusually high amounts of antioxidants Lipocarotenes™: Natures unique delivery system First to Market: Proprietary, Patent Pending, 100% Juice, World supply of Gâc and Cili Tahitian Noni® & XanGo™ Lose: Noni and XanGo™ lose to g3 in scanner study The Power of Nanotechnology Carsten R. Smidt, Ph.D., FACN Vice President, Global R&D What is Nanotechnology? Example: Nano-Electronics Nano-Switch Nanotube Wires A Matter of Size 100 nanometers What is Nanotechnology? 1. A Matter of Size: 1 -100 nanometers – Most molecules are 1 to 100 nm in size 2. Function at the Molecular Level – Nanotechnology is the science of manipulating substances at the molecular level Pharmanex Nanotechnology • To increase intestinal uptake of poorly absorbed fat-soluble nutrients: – Carotenoids (lycopene, alpha+betacarotenes, zeaxanthin, astaxanthin) – Coenzyme Q10 Reasons for Poor Absorption • Poor intestinal solubility • Requires fat for dissolution (e.g., Lipocarotenes) • Aggregation into large particles – not easily digested and absorbed The Nanotechnology Difference Small nano-particles are easily dispersed and absorbed ™ NanoCoQ10 What is CoQ10? • Coenzyme Q10, CoQ10, or ubiquinone – fat-soluble, vitamin-like nutrient that catalyzes energy production in cells* – found in all cell membranes, nuclei and mitochondria – produced in the body—decreasing with age *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. CoQ10 Health Benefits* • Helps produce cellular energy, ATP • Provides powerful protection against free radical damage inside the cell (mitochondria) • Strengthens heart muscle - supports circulation • Maintains existing normal blood pressure • Skin health (anti-aging benefits) *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Regular CoQ10 Products • Not easily absorbed into the body • High dose needed to achieve meaningful benefits • NanoCoQ10™ uses molecular nanoencapsulation to significantly improve absorption CoQ10 Absorption by Human Intestinal Cells pmol/mg protein 300.0 250.0 5-fold increase in absorption!* 200.0 30 mg ≈ 150 mg 150.0 100.0 50.0 0.0 Chewable A Chewable B Chewable C CoQ10 powder *Preliminary, laboratory data Nano-CoQ10 powder Summary • Breakthrough nanotechnology • Highly bioavailable CoQ10 • Heart protection* • Helps produce cellular energy* • Antioxidant protection* • Use with Celltrex® CoQ10 Complete • CoQ10 PowerPack • More at the Nu Skin workshop! *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Introducing Highly Effective Minerals Red Wine Polyphenols New Vitamin E Nano-CoQ10 NanoNutrients lifepak® nano: Nano-Antioxidants Nano-CoQ10 Nano-Carotenoids? lifepak®nano: Nano-Antioxidants • New, broader-spectrum nanocarotenoid formula: – – – – – – alpha-carotene beta-carotene lycopene lutein zeaxanthin (new): Eye health benefits* astaxanthin (new): Immune response* • plus LipoNutrients (proprietary process) *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. lifepak®nano: Omega-3 Lipids • Delivers MarineOmega benefits: – 600 mg EPA, 400 mg DHA – Antarctic Krill oil • Helps normalize omega 6/3 ratio in diet: – helps maintain normal inflammatory response* – promotes cardiovascular health* – supports brain & nervous system* *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. lifepak®nano: Vitamin E Formula • Gamma-tocopherol: – synergistic antioxidant effects with alpha-tocopherol (neutralizes different free radicals)* – helps maintain normal inflammatory response* • New vitamin E formula in lifepak® nano: – – – = 200 IU alpha-tocopherol (134 mg) 75 mg gamma-tocopherol 26 mg beta- and delta-tocopherols 235 mg total vitamin E (201 mg in LifePak® Prime) *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. lifepak® nano: Mineral Sources • 600 mg Calcium, with new patented dicalcium malate (soluble, organic Ca) • 300 mg Magnesium, 100% amino acid chelate • Plus 6 other bone nutrients: D, K, P, B, Si, resveratrol* • Advantage: More efficient absorption and better GI tolerance than Ca and Mg in LifePak® Prime or LifePak® Women *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. lifepak® nano: Red Wine Actives • “1-2 glasses of red wine a day keep the doctor away” (French Paradox) • Cardiovascular benefits attributed to red wine polyphenols:* – Resveratrol – Proanthocyanidins – Quercetin • lifepak® nano = 2 glasses red wine a day! *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. New Packet Design • Unique 2-chamber design – Separates soft-gels from hard shell capsules for optimum stability – New film with stronger protection and oxygen barrier (as in LifePak® Japan) Phytonutrients Minerals Vitamins proprietary CR-6 LipoNutrients New Health Benefits* • Helps maintain a healthy balance of pro- and antiinflammatory signals (prostaglandins) in the body – Cardiovascular health (designed to lower C-reactive protein) – Joint health and mobility • Expanded cell rejuvenation & anti-aging benefits • • • • – CR6-LipoNutrients™, red wine benefits, 60+ antioxidants, incl. nano-antioxidants Complete bone support (8 nutrients) New eye health benefits (lutein & zeaxanthin) Improved gastro-intestinal tolerance plus the benefits of LifePak® Prime *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. ® lifepak nano Study 60+ Antioxidants Ongoing placebo-controlled clinical study 30000 28000 Raman Intensity – 57 subjects – 20 week study – Better antioxidant response than LifePak®! lifepak nano 26000 24000 LifePak 22000 Placebo 20000 18000 16000 14000 12000 10000 Day 0 Day 21 Day 42 Highly Effective Minerals Red Wine Polyphenols New Vitamin E Nano-CoQ10 NanoNutrients For All Adults (age 18-121) Cutting-Edge Science! Broadest Health Benefits! The New Dimension! The Power of Nanotechnology Visit our PRODUCT SHOWCASE! Win an iPod nano with lifepak® nano! Purchase CoQ10 PowerPack and g3™! Carsten’s Business Take-aways • Nano Technology means increased absorption • CR6-LipoNutrients™ Technology is proprietary and patent-pending • Gentle to the stomach • Guaranteed to increase antioxidant score • Do You NANO? Now is the Time “The FUTURE is literally in your hands and in the hands of the people you scan” Joe Chang Be a Champion 2005 Workshop