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The Measurable Difference
BioPhotonic Scanner
lifepak® nano
g3™ Superfruit Blend
The Pharmanex®
BioPhotonic Scanner
Free Radicals & Antioxidants
Health depends on the balance
between free radicals and antioxidants
Free
Radicals
Antioxidants
Antioxidant Health Benefits
Journal of the American Medical Association
“… low levels of the antioxidant vitamins (vitamins A, E, and C)
may increase risk for several chronic diseases. Most people do
not consume an optimal amount of all vitamins by diet alone.”
“It appears prudent for all adults to take vitamin
supplements.”
Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard University
Journal of the American Medical Association 2002; 287: 3127-3129
Pharmanex
BioPhotonic Scanner
Extraordinary Science… Personalized
• Measures your personal antioxidant
protection
• Measure antioxidant effect of
LifePak & G3 in your own body!
• Easy & non-invasive
• Scientifically and clinically validated
• Gold standard – superior to blood
measurement and ORAC testing
Extraordinary Science… Revolutionized
• Invented by Physicists at U. Utah
• Patent rights licensed to Pharmanex
• Measures carotenoid antioxidants in skin
– important group of antioxidants
– part of the antioxidant defense system in the body
– good indicator of your overall antioxidant status
• Based on Raman spectroscopy
“I see a future where the BioPhotonic
Scanner becomes the gold standard
for measuring antioxidant status.”
– Dr. Joseph Chang
President of Pharmanex
February 2003
Carotenoid Correlation Study June 2004
Skin vs. Serum Carotenoids (n = 372)
Raman Intensity, Counts .
60000
50000
40000
r = 0.84
30000
20000
10000
0
0
0.5
1
1.5
2
2.5
3
3.5
4
Total Serum Carotenoids (mcg/ml)
Less variable than gold standard!
Major University clinical study
confirms what we’ve all been waiting for:
Skin carotenoid Score (SCS)
– is an indicator of overall antioxidant status
and oxidative stress in the body
– is a better indicator of fruit and vegetable
intake than blood carotenoids
Cumulative data suggests scanner is
superior to blood testing and ORAC
Double-Blind, Placebo-Controlled
LifePak Supplementation Study
• Question: Does Scanner score reflect increases
of all antioxidants in the body?
• 53 subjects for 6 weeks LifePak or Placebo
• Measure Scanner response and blood antioxidants
16
26000
Supplement
Placebo
15
Raman Intensity
24000
23000
22000
21000
20000
19000
18000
17000
Scanner Response
Ascorbic Acid (mcg/ml)
25000
Day 21
14
13
12
11
p<0.05
10
9
8
7
Blood Vitamin C
6
16000
Day 0
Supplement
Placebo
Day 0
Day 42
Day 21
Day 42
Serum Carotenoids (ng/ml)
Supplement
Placebo
2200
2000
1800
1600
1400
1200
Blood Carotenoids
1000
Alpha-Tocopherol (mcg/ml)
26
2400
24
22
20
Day 21
Day 42
p<0.05
18
p<0.05
16
14
12
10
Day 0
Supplement
Placebo
Blood Vitamin E
Day 0
Day 21
Day 42
Accepted by the Scientific Community
• New York Academy of Sciences, Feb 2003
• Oxygen Club of California, Feb 2003 and Feb 2004
• FASEB/American Society of Nutritional Sciences - April 2003
and April 2004
• Gordon Research Conference, Jan 2004
• American College of Nutrition, October 2004
• Society for Free Radical Research (ISNA-SFRR), June 2005
2005 American Business Awards
Biophotonic Scanner wins in the
Most Innovative Company category
Coming Soon:
The New S2
Extraordinary Science…
Simplified
50 % lighter
60 % smaller
Extraordinary Science…
Simplified
Warm up time
CalibrationScan
time
S1
S2
30 min
5 min
3 min
~2 min
min
4 min
more17people
Calibration steps
scans
3 scans
in more 9places
Weight of scanner
10 lbs
~5 lbs
in no time at all.
Scan time
Temperature range
70 – 75 °F 50 – 95 °F
What is lifepak nano?
A comprehensive nutritional
wellness program delivering
the optimum amounts of all
essential and generally
beneficial nutrients for longterm health and well-being.
lifepak nano: 8 Formulas in 1
Complete, Balanced and
Convenient
Multi
Vitamin
Mineral
>
Antioxidant
Formula
Metabolism
Anti
Aging
Formula
Immune
Nutrient
Formula
Glucose
Formula
Bone
Formula
CardioVascular
Formula
Highly Effective
Minerals
Red Wine
Polyphenols
New
Vitamin E
Nano-CoQ10
NanoNutrients
What is Nanotechnology?
Nano-Switch
iPod nano?
Nanotube Wires
nanotech shirt
A Matter of Size
100 nanometers
Pharmanex Nanotechnology
• To increase intestinal uptake of poorly
absorbed fat-soluble nutrients:
– Carotenoids (lycopene, alpha+betacarotenes, zeaxanthin, astaxanthin)
– Coenzyme Q10
The Nanotechnology Difference
Small nano-particles are easily dispersed and absorbed
The Nanotechnology Difference
CoQ10 Absorption by Human Intestinal Cells
300.0
pmol/mg protein
250.0
5-fold increase in absorption!
200.0
150.0
100.0
50.0
0.0
Chewable A
Chewable B
Chewable C
CoQ10
powder
Nano-CoQ10
powder
lifepak nano: CR-6 LipoNutrients
• New, broader-spectrum nanocarotenoid formula:
–
–
–
–
–
–
alpha-carotene
beta-carotene
lycopene
lutein
zeaxanthin (new): Eye health benefits*
astaxanthin (new): Inflammatory balance*
• plus LipoNutrients (proprietary process)
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Lifepak nano: 60+ Antioxidants
• All 8 forms of natural vitamin E:
– 200 IU a-tocopherol + 75 mg g-toc. + 26 mg other toc. + tocotrienols
• Buffered vitamin C: 500 mg
• Selenium, Copper, Zinc, Manganese (for SOD, GPX)
• 11 Carotenoids, now with astaxanthin and zeaxanthin:
– as found in 5-10 fruits & vegetables per day
• 35 polyphenols:
– green tea (catechins), red wine (resveratrol), grape seed, krill, etc.
• Alpha-Lipoic Acid, Coenzyme Q10, N-Acetyl-L-Cysteine
®
lifepak
nano Study
60+ Antioxidants
Ongoing placebo-controlled clinical study
30000
28000
Raman Intensity
– 57 subjects
– 20 week study
– Better antioxidant
response than
LifePak!
26000
lifepak nano
24000
LifePak
22000
Placebo
20000
18000
16000
Day 0
Day 21
Day 42
lifepak nano: Omega-3 Lipids
• Delivers MarineOmega benefits:
– 600 mg EPA, 400 mg DHA
– Antarctic Krill oil
• Helps normalize omega 6/3 ratio:*
–
–
–
–
helps restores normal inflammatory balance*
promotes cardiovascular health*
promotes healthy joints and cartilage*
supports brain & nervous system*
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Other lifepak nano Innovations
• New high g-tocopherol vitamin E blend
– synergistic antioxidant effects with alpha-tocopherol*
– helps restore normal inflammatory balance*
• New calcium & magnesium sources
– 100 % soluble and organic (GI tolerance)
• Red wine polyphenols
– resveratrol, proanthocyanidins and quercetin
• New 2-chamber packet design
– Improved protection
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
lifepak nano Health Benefits*
Optimum supplementation for general well-being
1. Effectively addresses all nutrient deficiencies
2. Comprehensive cardiovascular benefits
3. Complete bone nutrition
4. Promotes healthy immune function
5. Supports blood sugar metabolism
6. Helps protect eye function
7. Raises your antioxidant defense
8. Protects against the normal symptoms of aging
9. Promotes a healthy balance of pro- and antiinflammatory signals (prostaglandins) in the body
10. Excellent gastro-intestinal tolerance
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
The New Dimension!
• For All Adults
(age 18-121)
• Proprietary
Science
• Broadest Health
Benefits
= gâc fruit + 3 superfruits
= 3 years of Pharmanex research
= 3 Pharmanex research labs
1.
2.
3.
4.
Gâc fruit (Chinese Bitter Cucumber)
Chinese Lycium (Wolfberry)
Cili fruit
Siberian Pineapple (Seabuckthorn)
Gâc - “Fruit From Heaven”
• Indigenous to Southern Asia
Bangladesh, Burma, Cambodia,
China, India, Japan, Laos, Malaysia,
Philippines, Thailand, and Vietnam
• Traditionally used internally
and externally
Topical: wound healing
Internally: eye health, and to
promote growth in children
Antioxidants in Gâc Pulp
• Extraordinarily rich in antioxidants, esp.
– lycopene: 70x more than tomatoes
– beta-carotene: 10x more than carrots
• Unique fatty acids → Lipocarotenes™
– 40% improved bioavailability of carotenoids!
Fruit flesh
Pulp
(mesocarp)
(aril)
Seeds
Gâc Fights Vitamin A Deficiency
• Vitamin A deficiency: Leading cause of
blindness in the world
• In So. Asia, Gâc discovered as potent
indigenous source of highly bioactive
provitamin A (b-carotene)
• 10 years of research by Dr. Le Vuong,
Univ. of California, Davis, Nutrition
Department
*Vuong LT et al., Am J Clin Nutr 2002;75:872-879.
Other
Ingredients
Siberian Pineapple
(sea buckthorn, Hippophae rhamnoides)
• 2000-year history of traditional use in
– Siberia, Tibet, China and Europe
– rejuvenating tonic, for skin health, blood
purifier
• Over 130 modern research studies:
–
–
–
–
–
–
Cardiovascular health*
Healthy liver function*
Periodontal health*
Eye health*
Immunity*
High in vitamins A,C, E, B-vitamins and
minerals, and 190 other actives!
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Other
Ingredients
Chinese Lycium
(Wolfberry; Lycium chinense)
• 2000 years TCM history in China
• Longevity, wellness, vision
• Cellular rejuvenation:
– protects DNA*
– antioxidant (SOD, GPX)*
• Immunity (polysaccharides)*
• Eye health: 40x more zeaxanthin than yellow corn!
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Other
Ingredients
Cili Fruit
(Rosa roxburghii)
• China, esp. Guizhou mountains
• Cardiovascular and antioxidant benefits:
– ↓ oxLDL, ↑ SOD*
• Addresses symptoms of Aging*
• Unique Polyphenols
– Roxburghic Acids
• “King of C”: 60x more vitamin C than oranges!
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Is Catalytically Active
g3 activates SOD and Catalase
– the body's catalytic antioxidant system
– antioxidant protection inside the cell, where
it is needed the most.
SOD: Superoxide Dismutase
– most important antioxidant enzyme
– requires copper, zinc & manganese (LifePak)
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Vulnerable to Oxidation
Betacarotene
Lutein
Lycopene
Vitamin C
Internal Antioxidants
SOD
Catalase
SOD
CAT
- 303 studies
Medline Citations (1966-2005)
350
300
303
250
200
150
100
110
74
50
39
30
0
g3
Mangosteen
Noni
Goji
Acai
Clinical Study
• 34 Subjects consumed for 8 weeks:
– 6 fl oz g3 (maximum recommended intake)
– 6 fl oz Noni Juice (6x’s recommended dose)
– 6 fl oz Xango Juice (2x’s recommended dose)
• Measure antioxidants using BioPhotonic Scanner
Increased Antioxidant Scores
4x More than Xango or Noni
Antioxidant Score
10,000
Noni
Xango
#,
g3
#,
8,000
*
*
6,000
#,
*
4,000
*
2,000
0
Week 0
Week 2
Week 4
*p<0.05 compared to wk 0
Week 6
Week 8
#p<0.05 compared to other juices
Proprietary
• Patent pending, 100%-juice formula
• First juice with Gâc worldwide
The Measurable Difference
You have the 3 most powerful tools of the entire
nutritional supplement industry worldwide:
lifepak nano: The best multi-nutrient supplement.
 : The best functional fruit juice.
BioPhotonic SCANNER: The best consumer test
for antioxidant nutrition.
For More Information
Presentations
www.pharmanexusa.com
My Office  Marketing Tools
Product Resources
www.pharmanexusa.com
www.pharmanexscanner.com
Product Support
E-Mail:
[email protected]
Phone: 1-800-487-1000