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The Measurable Difference BioPhotonic Scanner lifepak® nano g3™ Superfruit Blend The Pharmanex® BioPhotonic Scanner Free Radicals & Antioxidants Health depends on the balance between free radicals and antioxidants Free Radicals Antioxidants Antioxidant Health Benefits Journal of the American Medical Association “… low levels of the antioxidant vitamins (vitamins A, E, and C) may increase risk for several chronic diseases. Most people do not consume an optimal amount of all vitamins by diet alone.” “It appears prudent for all adults to take vitamin supplements.” Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard University Journal of the American Medical Association 2002; 287: 3127-3129 Pharmanex BioPhotonic Scanner Extraordinary Science… Personalized • Measures your personal antioxidant protection • Measure antioxidant effect of LifePak & G3 in your own body! • Easy & non-invasive • Scientifically and clinically validated • Gold standard – superior to blood measurement and ORAC testing Extraordinary Science… Revolutionized • Invented by Physicists at U. Utah • Patent rights licensed to Pharmanex • Measures carotenoid antioxidants in skin – important group of antioxidants – part of the antioxidant defense system in the body – good indicator of your overall antioxidant status • Based on Raman spectroscopy “I see a future where the BioPhotonic Scanner becomes the gold standard for measuring antioxidant status.” – Dr. Joseph Chang President of Pharmanex February 2003 Carotenoid Correlation Study June 2004 Skin vs. Serum Carotenoids (n = 372) Raman Intensity, Counts . 60000 50000 40000 r = 0.84 30000 20000 10000 0 0 0.5 1 1.5 2 2.5 3 3.5 4 Total Serum Carotenoids (mcg/ml) Less variable than gold standard! Major University clinical study confirms what we’ve all been waiting for: Skin carotenoid Score (SCS) – is an indicator of overall antioxidant status and oxidative stress in the body – is a better indicator of fruit and vegetable intake than blood carotenoids Cumulative data suggests scanner is superior to blood testing and ORAC Double-Blind, Placebo-Controlled LifePak Supplementation Study • Question: Does Scanner score reflect increases of all antioxidants in the body? • 53 subjects for 6 weeks LifePak or Placebo • Measure Scanner response and blood antioxidants 16 26000 Supplement Placebo 15 Raman Intensity 24000 23000 22000 21000 20000 19000 18000 17000 Scanner Response Ascorbic Acid (mcg/ml) 25000 Day 21 14 13 12 11 p<0.05 10 9 8 7 Blood Vitamin C 6 16000 Day 0 Supplement Placebo Day 0 Day 42 Day 21 Day 42 Serum Carotenoids (ng/ml) Supplement Placebo 2200 2000 1800 1600 1400 1200 Blood Carotenoids 1000 Alpha-Tocopherol (mcg/ml) 26 2400 24 22 20 Day 21 Day 42 p<0.05 18 p<0.05 16 14 12 10 Day 0 Supplement Placebo Blood Vitamin E Day 0 Day 21 Day 42 Accepted by the Scientific Community • New York Academy of Sciences, Feb 2003 • Oxygen Club of California, Feb 2003 and Feb 2004 • FASEB/American Society of Nutritional Sciences - April 2003 and April 2004 • Gordon Research Conference, Jan 2004 • American College of Nutrition, October 2004 • Society for Free Radical Research (ISNA-SFRR), June 2005 2005 American Business Awards Biophotonic Scanner wins in the Most Innovative Company category Coming Soon: The New S2 Extraordinary Science… Simplified 50 % lighter 60 % smaller Extraordinary Science… Simplified Warm up time CalibrationScan time S1 S2 30 min 5 min 3 min ~2 min min 4 min more17people Calibration steps scans 3 scans in more 9places Weight of scanner 10 lbs ~5 lbs in no time at all. Scan time Temperature range 70 – 75 °F 50 – 95 °F What is lifepak nano? A comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for longterm health and well-being. lifepak nano: 8 Formulas in 1 Complete, Balanced and Convenient Multi Vitamin Mineral > Antioxidant Formula Metabolism Anti Aging Formula Immune Nutrient Formula Glucose Formula Bone Formula CardioVascular Formula Highly Effective Minerals Red Wine Polyphenols New Vitamin E Nano-CoQ10 NanoNutrients What is Nanotechnology? Nano-Switch iPod nano? Nanotube Wires nanotech shirt A Matter of Size 100 nanometers Pharmanex Nanotechnology • To increase intestinal uptake of poorly absorbed fat-soluble nutrients: – Carotenoids (lycopene, alpha+betacarotenes, zeaxanthin, astaxanthin) – Coenzyme Q10 The Nanotechnology Difference Small nano-particles are easily dispersed and absorbed The Nanotechnology Difference CoQ10 Absorption by Human Intestinal Cells 300.0 pmol/mg protein 250.0 5-fold increase in absorption! 200.0 150.0 100.0 50.0 0.0 Chewable A Chewable B Chewable C CoQ10 powder Nano-CoQ10 powder lifepak nano: CR-6 LipoNutrients • New, broader-spectrum nanocarotenoid formula: – – – – – – alpha-carotene beta-carotene lycopene lutein zeaxanthin (new): Eye health benefits* astaxanthin (new): Inflammatory balance* • plus LipoNutrients (proprietary process) *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Lifepak nano: 60+ Antioxidants • All 8 forms of natural vitamin E: – 200 IU a-tocopherol + 75 mg g-toc. + 26 mg other toc. + tocotrienols • Buffered vitamin C: 500 mg • Selenium, Copper, Zinc, Manganese (for SOD, GPX) • 11 Carotenoids, now with astaxanthin and zeaxanthin: – as found in 5-10 fruits & vegetables per day • 35 polyphenols: – green tea (catechins), red wine (resveratrol), grape seed, krill, etc. • Alpha-Lipoic Acid, Coenzyme Q10, N-Acetyl-L-Cysteine ® lifepak nano Study 60+ Antioxidants Ongoing placebo-controlled clinical study 30000 28000 Raman Intensity – 57 subjects – 20 week study – Better antioxidant response than LifePak! 26000 lifepak nano 24000 LifePak 22000 Placebo 20000 18000 16000 Day 0 Day 21 Day 42 lifepak nano: Omega-3 Lipids • Delivers MarineOmega benefits: – 600 mg EPA, 400 mg DHA – Antarctic Krill oil • Helps normalize omega 6/3 ratio:* – – – – helps restores normal inflammatory balance* promotes cardiovascular health* promotes healthy joints and cartilage* supports brain & nervous system* *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Other lifepak nano Innovations • New high g-tocopherol vitamin E blend – synergistic antioxidant effects with alpha-tocopherol* – helps restore normal inflammatory balance* • New calcium & magnesium sources – 100 % soluble and organic (GI tolerance) • Red wine polyphenols – resveratrol, proanthocyanidins and quercetin • New 2-chamber packet design – Improved protection *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. lifepak nano Health Benefits* Optimum supplementation for general well-being 1. Effectively addresses all nutrient deficiencies 2. Comprehensive cardiovascular benefits 3. Complete bone nutrition 4. Promotes healthy immune function 5. Supports blood sugar metabolism 6. Helps protect eye function 7. Raises your antioxidant defense 8. Protects against the normal symptoms of aging 9. Promotes a healthy balance of pro- and antiinflammatory signals (prostaglandins) in the body 10. Excellent gastro-intestinal tolerance *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The New Dimension! • For All Adults (age 18-121) • Proprietary Science • Broadest Health Benefits = gâc fruit + 3 superfruits = 3 years of Pharmanex research = 3 Pharmanex research labs 1. 2. 3. 4. Gâc fruit (Chinese Bitter Cucumber) Chinese Lycium (Wolfberry) Cili fruit Siberian Pineapple (Seabuckthorn) Gâc - “Fruit From Heaven” • Indigenous to Southern Asia Bangladesh, Burma, Cambodia, China, India, Japan, Laos, Malaysia, Philippines, Thailand, and Vietnam • Traditionally used internally and externally Topical: wound healing Internally: eye health, and to promote growth in children Antioxidants in Gâc Pulp • Extraordinarily rich in antioxidants, esp. – lycopene: 70x more than tomatoes – beta-carotene: 10x more than carrots • Unique fatty acids → Lipocarotenes™ – 40% improved bioavailability of carotenoids! Fruit flesh Pulp (mesocarp) (aril) Seeds Gâc Fights Vitamin A Deficiency • Vitamin A deficiency: Leading cause of blindness in the world • In So. Asia, Gâc discovered as potent indigenous source of highly bioactive provitamin A (b-carotene) • 10 years of research by Dr. Le Vuong, Univ. of California, Davis, Nutrition Department *Vuong LT et al., Am J Clin Nutr 2002;75:872-879. Other Ingredients Siberian Pineapple (sea buckthorn, Hippophae rhamnoides) • 2000-year history of traditional use in – Siberia, Tibet, China and Europe – rejuvenating tonic, for skin health, blood purifier • Over 130 modern research studies: – – – – – – Cardiovascular health* Healthy liver function* Periodontal health* Eye health* Immunity* High in vitamins A,C, E, B-vitamins and minerals, and 190 other actives! *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Other Ingredients Chinese Lycium (Wolfberry; Lycium chinense) • 2000 years TCM history in China • Longevity, wellness, vision • Cellular rejuvenation: – protects DNA* – antioxidant (SOD, GPX)* • Immunity (polysaccharides)* • Eye health: 40x more zeaxanthin than yellow corn! *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Other Ingredients Cili Fruit (Rosa roxburghii) • China, esp. Guizhou mountains • Cardiovascular and antioxidant benefits: – ↓ oxLDL, ↑ SOD* • Addresses symptoms of Aging* • Unique Polyphenols – Roxburghic Acids • “King of C”: 60x more vitamin C than oranges! *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Is Catalytically Active g3 activates SOD and Catalase – the body's catalytic antioxidant system – antioxidant protection inside the cell, where it is needed the most. SOD: Superoxide Dismutase – most important antioxidant enzyme – requires copper, zinc & manganese (LifePak) *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Vulnerable to Oxidation Betacarotene Lutein Lycopene Vitamin C Internal Antioxidants SOD Catalase SOD CAT - 303 studies Medline Citations (1966-2005) 350 300 303 250 200 150 100 110 74 50 39 30 0 g3 Mangosteen Noni Goji Acai Clinical Study • 34 Subjects consumed for 8 weeks: – 6 fl oz g3 (maximum recommended intake) – 6 fl oz Noni Juice (6x’s recommended dose) – 6 fl oz Xango Juice (2x’s recommended dose) • Measure antioxidants using BioPhotonic Scanner Increased Antioxidant Scores 4x More than Xango or Noni Antioxidant Score 10,000 Noni Xango #, g3 #, 8,000 * * 6,000 #, * 4,000 * 2,000 0 Week 0 Week 2 Week 4 *p<0.05 compared to wk 0 Week 6 Week 8 #p<0.05 compared to other juices Proprietary • Patent pending, 100%-juice formula • First juice with Gâc worldwide The Measurable Difference You have the 3 most powerful tools of the entire nutritional supplement industry worldwide: lifepak nano: The best multi-nutrient supplement. : The best functional fruit juice. BioPhotonic SCANNER: The best consumer test for antioxidant nutrition. For More Information Presentations www.pharmanexusa.com My Office Marketing Tools Product Resources www.pharmanexusa.com www.pharmanexscanner.com Product Support E-Mail: [email protected] Phone: 1-800-487-1000