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Mitosis is cell division in somatic cells. Somatic cells = All the cells in your body that are not sex cells (eggs and sperm) * *Why? * Unicellular organisms use it to reproduce. * *Why? Multicellular organisms use it for growth *Why? Multicellular organisms use it to repair tissues * Muscle and Nerve tissues do not normally do mitosis. * Stem cells are cells that do mitosis, then the daughter cells undergo differentiation to become a specific type of cell in the multicellular organism. Cancer is uncontrolled mitosis with no differentiation. Licentious division - prostate cancer cells during division. A cell’s life: DNA is Packaged into Chromosomes duplicated chromosome chromatin The packaging is impressive – 2 meters of human DNA fit into a sphere about 0.000005 meters in diameter. DNA replication: It happens during INTERPHASE. The Link Between DNA Replication and Chromosome Duplication DNA is Condensed into Visible Chromosomes Only For Brief Periods in the Life of a Cell 95% of the time, DNA is like this. CHROMATIN SISTER CHROMATIDS: Duplicate chromosomes bound together by a centromere. During Mitosis Chromosomes divide. Cytokinesis occurs * 1.Prophase 2.Metaphase 3.Anaphase 4.Telophase interphase Interphase – DNA replication is completed. prophase metaphase Prophase – Chromosomes shorten and thicken, centrioles appear, nuclear membrane disintegrates. Metaphase – chromosomes line up on equatorial plate in middle of cell. Anaphase – chromatids are pulled apart, chromosomes pulled to opposite sides of the cell Telophase – Cytokinesis occurs, cell returns to normal. Mitosis in Action Blue shows DNA, green shows spindle fibers. In Animal Cells, a Cleavage Furrow Forms and Separates Daughter Cells during cytokinesis. Cleave furrow in a dividing frog cell. A cell plate forms between two plant cells to separate them. * http://www.youtube.com/watch?v=VlN7K19QB0