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Swiss-Prot group activities www.uniprot.org www.expasy.org Swiss Institute of Bioinformatics – Geneva in collaboration with the UniProt Consortium The main focus of the Swiss-Prot group is to provide the scientific community with the most accurate protein sequences associated with a high level of functional annotation, in an user friendly format allowing easy data retrieval and analysis. The group is involved in the production of the manually curated UniProtKB/Swiss-Prot knowledgebase (www.uniprot.org), the ENZYME nomenclature database (http://www.expasy.org/enzyme) , the protein families and domains PROSITE database (http://www.expasy.org/prosite) and the taxonomy database (http://www.uniprot.org/taxonomy/) Protein Annotation Programs - Vertebrates (CD2) Bacteria and Archae (HAMAP) Plants (PPAP) Fungi (FPAP) Viruses Dictyostelium discoideum Drosophila and C.elegans Toxins (Tox-Prot) - Controlled vocabulary (GO annotation) Post-translational modifications (PTMs) Integration of proteomic data Integration of 3D structure information Human polymorphisms and diseases Quality Assurance Software development Research - Annotation platform development and maintenance - UniProtKB/Swiss-Prot release - ExPASy and UniProt websites Service, education and popular science - Calipho Computer Analysis and Laboratory Investigation of Proteins of Human Origin - Phylogeny - User support - Courses and tutorials (e-Proxemis) - Master in Proteomics and Bioinformatics - Doctoral school (SIB) - Text mining - Sequence analysis tool development - Knowledge management of human variants Contact Swiss-Prot group Swiss Institute of Bioinformatics Centre Médicale Universitaire 1 Michel Servet 1211 Geneva 4 Phone: + 41 22 379 50 50 Fax: + 41 22 379 58 58 [email protected] - Protein Spotlight (www.expasy.org/spotlight/) - Protéines à la ‘Une’ (www.expasy.org/prolune/) Electronic publications The team Amos Bairoch and Lydie Bougueleret (group leaders) 50 annotators (life science background), 13 programmers, 8 reseachers, 15 persons involved in system administration, service/education and administration. The Swiss-Prot group is part of the Swiss Institute of Bioinformatics (SIB) and of the UniProt Consortium. Swiss-Prot group activities are supported by the Swiss Federal Government through the Federal Office of Education and Science and by the National Institutes of Health (NIH) grant 2 U01 HG02712-04. Additional support comes from the European Commission contract FELICS (021902RII3) and from the PATRIC BRC (NIH/NIAID contract HHSN 266200400035C). Swiss Institute of Bioinformatics (SIB) European Bioinformatics Institute (EMBL-EBI) Protein Information Resource (PIR) www.uniprot.org