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Transcript
1ST ANNUAL
SPRING MEETING
March 31 – April 2, 2016
|
AAHKS
Grand Hyatt Washington
|
Washington, DC
Thank you to the AAHKS
Spring Meeting Program Committee
Craig J. Della Valle, MD
Bryan D. Springer, MD
Thank you to the AAHKS
Spring Meeting Faculty
Matthew P. Abdel, MD
William P. Barrett, MD
Daniel J. Berry, MD
Michael P. Bolognesi, MD
Kevin J. Bozic, MD, MBA
John J. Callaghan, MD
John C. Clohisy, MD
David F. Dalury, MD
Craig J. Della Valle, MD
Stephen T. Duncan, MD
Thomas K. Fehring, MD
Mark I. Froimson, MD, MBA
William L. Griffin, MD
William A. Jiranek, MD
Jay R. Lieberman, MD
Adolph V. Lombardi Jr, MD, FACS
Steven J. MacDonald, MD
R. Michael Meneghini, MD
Mark W. Pagnano, MD
Brian S. Parsley, MD
Javad Parvizi, MD, FRCS
Gregory G. Polkowski II, MD, MSc
Bryan D. Springer, MD
We Need Your Help!
Would you like to volunteer for the 26th AAHKS Annual Meeting?
We are seeking abstract, poster and surgical technique video reviewers. If you are interested,
please contact Sigita Wolfe, AAHKS Director of Education, at [email protected].
Course Description
The First Annual AAHKS Spring Meeting is intended to equip practicing orthopaedic surgeons with state-of-the art information
and cutting-edge strategies aimed at enhancing the care of patients with arthritis and degenerative disease. It combines general
and break-out sessions, emphasizing case-based learning in small group setting for most effective results.
Objectives
• Analyze total hip and knee arthroplasty cases
• Investigate the patterns contributing to effective total hip and knee arthroplasty and revision
• Determine the strategies contributing to optimal perioperative and post-operative care, including complication management
• Consider effective practice management tips and related healthcare policy
• Report the highlights of the 2015 Annual Meeting
CME Accreditation and Credit Designation
The American Association of Hip and Knee Surgeons (AAHKS) is accredited by the Accreditation Council for Continuing Medical
Education (ACCME) to provide continuing medical education for physicians.
The American Association of Hip and Knee Surgeons (AAHKS) designates this live activity for a maximum of 15.5 AMA PRA
Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
First Annual AAHKS Spring Meeting | 1
Spring Meeting Program Schedule
Times and topics are subject to change.
Thursday, March 31, 2016
Time
Session
Room
Faculty
7:00 – 9:00 p.m.
Registration
Declaration Level
7:00 – 9:00 p.m.
Opening Reception
Cabinet Meeting Room
Time
Session
Room
7:00 – 7:50 a.m.
Breakfast and Case
Discussions with Faculty
Constitution Foyer and
Constitution A / B
7:50 – 8:00 a.m.
Welcome and Introduction
Constitution A / B
Jay R. Lieberman, MD
8:00 – 8:30 a.m.
Highlights of the 25th AAHKS
Annual Meeting
Constitution A / B
Moderator: Gregory G. Polkowski II, MD, MSc
Panelists: Brian S. Parsley, MD,
William L. Griffin, MD, Stephen Duncan, MD,
William P. Barrett, MD
8:30 – 9:50 a.m.
Breakout 1: Primary Total Hip
Arthroplasty (THA), Simple
to Complex
Constitution C / D / E,
John Cabin / Arlington or
Wilson / Roosevelt
9:50 – 10:00 a.m.
Break
10:00 – 11:00 a.m.
Symposium I – Perioperative
Optimization
Friday, April 1, 2016
11:00 a.m. – 12:20 p.m. Breakout 2: Primary Total
Knee Arthroplasty (TKA),
Simple to Complex
Constitution A / B
Faculty
Moderator: William A. Jiranek, MD
Panelists: Michael P. Bolognesi, MD,
Steven J. MacDonald, MD,
R. Michael Meneghini, MD
Constitution C / D / E,
John Cabin / Arlington or
Wilson / Roosevelt
12:20 – 1:00 p.m.
Lunch and Advocacy Update
Constitution Foyer and
Constitution A / B
Speaker: Lynn Shapiro Snyder, JD
1:00 – 2:00 p.m.
Symposium II – Periprosthetic
Joint Infection
Constitution A / B
Moderator: Bryan D. Springer, MD
Panelists: Matthew P. Abdel, MD,
Javad Parvizi, MD, FRCS,
Gregory G. Polkowski II, MD, MSc
2:00 – 2:20 p.m.
Break
2:20 – 3:40 p.m.
Breakout 3: Non-arthroplasty
Hip or UKA
Constitution C / D / E, John
Cabin / Arlington (Knee) or
Wilson / Roosevelt (Hip)
3:50 – 4:50 p.m.
Symposium III – Preparing for
the Transition to Value Based
Healthcare
Constitution A / B
Moderator: Kevin J. Bozic, MD, MBA
Panelist: Mark I. Froimson, MD, MBA
4:50 – 5:00 p.m.
Closing Remarks
Constitution A / B
Brian D. Springer, MD
5:00 – 6:30 p.m.
Reception
Constitution Foyer
First Annual AAHKS Spring Meeting | 2
Saturday, April 2, 2016
Time
Session
Room
7:00 – 7:50 a.m.
Breakfast and Case Discussions
with Faculty
Constitution Foyer and
Constitution A / B
7:50 – 8:00 a.m.
Welcome and Introduction
Constitution A / B
Jay R. Lieberman, MD
8:00 – 8:30 a.m.
Highlights of the AAOS, The Hip
Society and The Knee Society
Closed Meetings
Constitution A / B
Moderator: Mark W. Pagnano, MD
Panelists: Thomas K. Fehring, MD,
Daniel J. Berry, MD,
Adolph V. Lombardi Jr., MD, FACS,
John C. Clohisy, MD
8:30 – 9:50 a.m.
Breakout 4: Revision Total
Hip Arthroplasty (THA),
Simple to Complex
Constitution C / D / E,
John Cabin / Arlington or
Wilson / Roosevelt
9:50 – 10:00 a.m.
Break
10:00 – 11:00 a.m.
Symposium IV – The Business
of Orthopaedics
11:00 a.m. – 12:20 p.m. Breakout 5: Revision Total
Knee Arthroplasty (TKA), Simple
to Complex
Constitution A / B
Faculty
Moderator: Mark I. Froimson, MD, MBA
Panelists: Kevin J. Bozic, MD, MBA,
William A. Jiranek, MD,
Jay R. Lieberman, MD
Constitution C / D / E,
John Cabin / Arlington or
Wilson / Roosevelt
12:20 – 1:00 p.m.
Lunch
Constitution Foyer
1:00 – 2:00 p.m.
Symposium V – Perioperative
Care
Constitution A / B
2:00 – 2:20 p.m.
Break
2:20 – 3:40 p.m.
Breakout 6: Managing
Complications in Hip and Knee
Arthroplasty
Constitution C / D / E,
John Cabin / Arlington or
Wilson / Roosevelt
3:50 – 4:50 p.m.
Symposium VI – Step by Step:
Key Choices and Techniques
in the Tough Revision Total Hip
Arthroplasty (THA) and Revision
Total Knee Arthroplasty (TKA)
Constitution A / B
Moderator: Daniel J. Berry, MD
Panelists: John J. Callaghan, MD,
Craig J. Della Valle, MD
4:50 – 5:00 p.m.
Closing Remarks
Constitution A / B
Craig J. Della Valle, MD
Moderator: Jay R. Lieberman, MD
Panelists: David F. Dalury, MD,
Mark W. Pagnano, MD
You can visit our sponsors in the exhibit area:
DePuy Synthes, DJO Global, Medtronic, Pacira Pharmaceuticals, Inc.,
Smith & Nephew, Stryker and Zimmer Biomet
First Annual AAHKS Spring Meeting | 3
First Annual AAHKS Spring Meeting | 4
Session Materials
First Annual AAHKS Spring Meeting | 5
3/16/2016
Highlights of the 25th AAHKS Annual Meeting
3/16/2016
3/16/2016
“Best of the AAHKS 2015 Annual Meeting”
AAHKS 2016 Spring Meeting “Best of the AAHKS 2015 Annual Meeting”
AAHKS 2016 Spring Meeting “Best of the AAHKS 2015 Annual Meeting”
Gregory G Polkowski, MD, MSc
Assistant Professor of Orthopaedic Surgery
Vanderbilt Orthopaedic Institute
AAHKS 2016 Spring Meeting Gregory G Polkowski, MD, MSc
2015 AAHKS Annual Meeting Program Chair
Assistant Professor of Orthopaedic Surgery
Vanderbilt Orthopaedic Institute
2015 AAHKS Annual Meeting Program Chair
Gregory G Polkowski, MD, MSc
Assistant Professor of Orthopaedic Surgery
Vanderbilt Orthopaedic Institute
2015 AAHKS Annual Meeting Program Chair
Disclosures
Disclosures
Disclosures
Something
Something
Something
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
“Best of Symposium”
“Best of Symposium”
Gregory G Polkowski, MD, MSc
Moderator
“Best of Symposium”
Gregory G Polkowski, MD, MSc
Brian Parsley, MD
Moderator
William Griffin, MD
Brian Parsley, MD
William Barret, MD
Gregory G Polkowski, MD, MSc
Moderator
William Griffin, MD
Stephen Duncan, MD
William Barret, MD
Brian Parsley, MD
Stephen Duncan, MD
William Griffin, MD
V A N D E R B I L T Orthopaedic Institute
William Barret, MD
Stephen Duncan, MD
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
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Highlights of the 25th AAHKS Annual Meeting
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2015 AAHKS Annual Meeting
•
•
•
•
•
•
•
•
•
•
2015 AAHKS Annual Meeting
Year for the record books
25th Anniversary
Most abstracts submitted
Year for the record books
– ~1300
25th Anniversary
– 59 papers (4.5% Most abstracts submitted
acceptance rate)
Year for the record books
– th200 posters (15%)
~1300
25 Anniversary
– 59 papers (4.5% Record attendance
Most abstracts submitted
acceptance rate)
2015 AAHKS Annual Meeting
– ~2400 total
~1300
– 200 posters (15%)
• 1600 clinical
– 59 papers (4.5% • Record attendance
• 400 more than 2014
acceptance rate)
– ~2400 total
– 200 posters (15%)
• 1600 clinical
V A N D E R B I L T Orthopaedic Institute
• Record attendance
• 400 more than 2014
– ~2400 total
V A N D E R• B1600 clinical
I L T Orthopaedic Institute
• 400 more than 2014
V A N D E R B I L T Orthopaedic Institute
Pre‐Meeting Courses
• 7th Annual Residents Course
Pre‐Meeting Courses
– Keith Berend and Matt Austin
• 5th Annual Team Member • Course
7th Annual Residents Course
Pre‐Meeting Courses
Keith Berend and Matt Austin
– David Dalury
and Chris Peters
•
• Total Joint Replacement, Course
Surviving and Thriving”
Keith Berend and Matt Austin
– David Dalury
and Chris Peters
• 5
Annual Team Member 1–stth Lawry Barnes and Annual “The Business of Mark Froimson
Course
Total Joint Replacement, – David Dalury and Chris Peters
• Surviving and Thriving”
Industry Symposia
Lawry Barnes and • 1–st 15 Total
Annual “The Business of Mark Froimson
Total Joint Replacement, Surviving and Thriving”
V A•N Industry Symposia
D E R B I L T Orthopaedic Institute
5stth Annual “The Business of Annual Team Member 1
7th Annual Residents Course
– Lawry Barnes and 15 Total
Mark Froimson
V A•N Industry Symposia
D E R B I L T Orthopaedic Institute
– 15 Total
V A N D E R B I L T Orthopaedic Institute
Recognition
• Guest NationsRecognition
– Chilean Hip Society
– Japanese Society for • Guest Nations
Recognition
•
•
•
•
•
•
Replacement Arthroplasty
– Chilean Hip Society
AAHKS Humanitarian Award – Japanese Society for Guest Nations
Recipient
Replacement Arthroplasty
– Chilean Hip Society
– Dr. Adolph Lombardi
AAHKS Humanitarian Award – Japanese Society for AAHKS Presidential Award
Recipient
Replacement Arthroplasty
– Dr. Frank Voss
– Dr. Adolph Lombardi
AAHKS Humanitarian Award AAHKS Presidential Award
Recipient
–
– Dr. Frank Voss
Dr. Adolph Lombardi
V A N D E R B I L T Orthopaedic Institute
• AAHKS Presidential Award
– Dr. Frank Voss
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
First Annual AAHKS Spring Meeting | 7
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Highlights of the 25th AAHKS Annual Meeting
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3/16/2016
2015 Fall Meeting Symposia
• Clinical Practice Difficult Cases
• Outcome • Measures
Clinical Practice Difficult Cases
• Metal Reactions
Outcome • Risk Stratification
Clinical Practice Measures
•• Outpatient Difficult Cases
• Arthroplasty
Metal Reactions
•• Bundled Payments
Outcome Risk Stratification
Measures
Outpatient • FAI
• Arthroplasty
Metal Reactions
• Bundled Payments
Risk Stratification
•
V A N D E R B I L T Orthopaedic Institute
Outpatient •• FAI
Arthroplasty
• Bundled Payments
V A N D E R B I L T Orthopaedic Institute
• FAI
2015 Fall Meeting Symposia
2015 Fall Meeting Symposia
V A N D E R B I L T Orthopaedic Institute
James A. Rand Award Paper
James A. Rand Award Paper
A Randomized Controlled Trial of Oral and IV Tranexamic Acid: James A. Rand Award Paper
The Same Efficacy at Lower Cost?
A Randomized Controlled Trial of Oral and IV Tranexamic Acid: The Same Efficacy at Lower Cost?
A Randomized Controlled Trial of Yale A. Fillingham, MD
Oral and IV Tranexamic Acid: Rush University
The Same Efficacy at Lower Cost?
Yale A. Fillingham, MD
Rush University
Yale A. Fillingham, MD
Rush University
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
A Randomized Controlled Trial of Oral and IV Tranexamic Acid: The Same Efficacy at Lower Cost?
A Randomized Controlled Trial of Yale A Fillingham MD, Erdan Kayupov, MS, Darren Plummer, MD, Mario Moric, MS, Tad Gerlinger, MD, Craig J. Dalla Valle, MD
Oral and IV Tranexamic Acid: A Randomized Controlled Trial of The Same Efficacy at Lower Cost?
Double‐blind, placebo‐controlled, powered, RCT
Yale A Fillingham MD, Erdan Kayupov, MS, Darren Plummer, MD, Mario Moric, MS, Oral and IV Tranexamic Acid: Tad Gerlinger, MD, Craig J. Dalla Valle, MD
1.95 g oral TXA vs 1g iv bolus TXA in TKA
The Same Efficacy at Lower Cost?
Primary outcome: reduction in hemoglobin
Double‐blind, placebo‐controlled, powered, RCT
Yale A Fillingham
MD, Erdan Kayupov, MS, Darren Plummer, MD, Mario Moric, MS, Tad Gerlinger, MD, Craig J. Dalla
Results Valle, MD
1.95 g oral TXA vs 1g iv bolus TXA in TKA
Equivalent Hb
reduction: 3.45 g/dL vs 3.31 g/dL (p<0.001)
Double‐blind, placebo‐controlled, powered, RCT
Primary outcome: reduction in hemoglobin
Equivalent blood loss: 1267 mL vs 1229 mL (p<0.007)
Results
Cost: $14 vs $47—108 1.95 g oral TXA vs 1g iv bolus TXA in TKA
Equivalent Hb reduction: 3.45 g/dL vs 3.31 g/dL (p<0.001)
Primary outcome: reduction in hemoglobin
V A NEquivalent blood loss: 1267 mL vs 1229 mL (p<0.007)
D E R B I L T Orthopaedic Institute
Results
Cost: $14 vs $47—108 Equivalent Hb reduction: 3.45 g/dL vs 3.31 g/dL (p<0.001)
V A NEquivalent blood loss: 1267 mL vs 1229 mL (p<0.007)
D E R B I L T Orthopaedic Institute
Cost: $14 vs $47—108 V A N D E R B I L T Orthopaedic Institute
First Annual AAHKS Spring Meeting | 8
3
3
3/16/2016
Highlights of the 25th AAHKS Annual Meeting
3/16/2016
3/16/2016
A Randomized Controlled Trial of Oral and IV Tranexamic Acid: The Same Efficacy at Lower Cost?
A Randomized Controlled Trial of Yale A Fillingham MD, Erdan Kayupov, MS, Darren Plummer, MD, Mario Moric, MS, Tad Gerlinger, MD, Craig J. Dalla Valle, MD
Oral and IV Tranexamic Acid: The Same Efficacy at Lower Cost?
A Randomized Controlled Trial of Yale A Fillingham MD, Erdan Kayupov, MS, Darren Plummer, MD, Mario Moric, MS, Impact
Oral and IV Tranexamic Acid: Tad Gerlinger, MD, Craig J. Dalla Valle, MD
The Same Efficacy at Lower Cost?
$23 million to $67 million annual savings
Impact
Yale A Fillingham MD, Erdan Kayupov, MS, Darren Plummer, MD, Mario Moric, MS, Tad Gerlinger, MD, Craig J. Dalla Valle, MD
(700,000 TKA/year)
$23 million to $67 million annual savings
Impact
(700,000 TKA/year)
$23 million to $67 million annual savings
V A N D E R B I L T Orthopaedic Institute
(700,000 TKA/year)
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
Lawrence D. Dorr Award
Lawrence D. Dorr Award
Conversion Total Hip Arthroplasty: Is it a Primary or Lawrence D. Dorr Award
Revision Hip Arthroplasty?
Conversion Total Hip Arthroplasty: Is it a Primary or Conversion Total Hip Arthroplasty: Revision Hip Arthroplasty?
Ran Schwarzkopf, MD, MSc
Is it a Primary or NYU Langone
Revision Hip Arthroplasty?
Ran Schwarzkopf, MD, MSc
NYU Langone
V A N D E R B I L T Orthopaedic Institute
Ran Schwarzkopf, MD, MSc
NYU Langone
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
Conversion Total Hip Arthroplasty: Is it a Primary or Revision Hip Arthroplasty?
Conversion Total Hip Arthroplasty: Ran Schwarzkopf, MD and Mahta Baghoolizadeh, BS
Is it a Primary or Conversion Total Hip Arthroplasty: Revision Hip Arthroplasty?
ACS‐NSQIP database dataset (75,000 procedures)
Ran Schwarzkopf, MD and Mahta
Baghoolizadeh, BS
Is it a Primary or Conversion THA vs Revision THA vs Primary THA
Revision Hip Arthroplasty?
Ran Schwarzkopf, MD and Mahta
Baghoolizadeh, BS
Compared 53 pre‐
intra‐ and post‐operative variables
ACS‐NSQIP database dataset (75,000 procedures)
Results
Conversion THA vs Revision THA vs Primary THA
17 variables different Conversion vs Primary (p<0.0003)
ACS‐NSQIP database dataset (75,000 procedures)
Compared 53 pre‐
intra‐ and post‐operative variables
1 variables different Conversion vs Revision (p<0.0003)
Conversion = Revision Conversion ≠ Primary
Results
Conversion THA vs Revision THA vs Primary THA
3 variables different Conversion vs Primary (p<0.0003)
17 variables different Conversion vs Primary (p<0.0003)
Compared 53 pre‐ intra‐ and post‐operative variables
VA N
D EConversion = Revision Conversion ≠ Primary
R B I L T O r t h o p a e d i c IResults
nstitute
1 variables different Conversion vs Revision (p<0.0003)
3 variables different Conversion vs Primary (p<0.0003)
17 variables different Conversion vs Primary (p<0.0003)
1 variables different Conversion vs Revision (p<0.0003)
Conversion = Revision Conversion ≠ Primary
V A N D E R B I L T Orthopaedic Institute
3 variables different Conversion vs Primary (p<0.0003)
V A N D E R B I L T Orthopaedic Institute
First Annual AAHKS Spring Meeting | 9
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4
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Highlights of the 25th AAHKS Annual Meeting
3/16/2016
3/16/2016
Conversion Total Hip Arthroplasty: Is it a Primary or Conversion Total Hip Arthroplasty: Revision Hip Arthroplasty?
Ran Schwarzkopf, MD and Mahta Baghoolizadeh, BS
Is it a Primary or Conversion Total Hip Arthroplasty: Revision Hip Arthroplasty?
Ran Schwarzkopf, MD and Mahta Baghoolizadeh, BS
Is it a Primary or Impact
Revision Hip Arthroplasty?
Conversion = Revision Conversion ≠ Primary
Impact
Ran Schwarzkopf, MD and Mahta Baghoolizadeh, BS
Wrong DRG
Conversion = Revision Conversion ≠ Primary
Impact
Ongoing Discussion with CMS, CJR Implications
Wrong DRG
Conversion = Revision Conversion ≠ Primary
V A N D EOngoing Discussion with CMS, CJR Implications
R B I L T Orthopaedic Institute
Wrong DRG
V A N D EOngoing Discussion with CMS, CJR Implications
R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
AAHKS Clinical Award
AAHKS Clinical Award
Liposomal Bupivacaine and Peri‐articular Injection are Not Superior to Single Shot AAHKS Clinical Award
Liposomal Bupivacaine and Peri‐articular Intra‐articular Injection for Pain Control Injection are Not Superior to Single Shot In Total Knee Arthroplasty
Liposomal Bupivacaine and Peri‐articular Intra‐articular Injection for Pain Control Rajesh K. Jain, MD, MPH
Injection are Not Superior to Single Shot In Total Knee Arthroplasty
Reconstructive Orthopaedics
Intra‐articular Injection for Pain Control Rajesh K. Jain, MD, MPH
Marlton, NJ
In Total Knee Arthroplasty
Reconstructive Orthopaedics
V A N D E R B I L T Orthopaedic Institute
Rajesh K. Jain, MD, MPH
Marlton, NJ
Reconstructive Orthopaedics
V
A N D E R B I L T Orthopaedic Institute
Marlton, NJ
V A N D E R B I L T Orthopaedic Institute
Liposomal Bupivacaine and Peri‐articular Injection are Not Superior to Single Shot Intra‐articular Injection for Pain Control Liposomal Bupivacaine and Peri‐articular In Total Knee Arthroplasty
Injection are Not Superior to Single Shot Rajesh K. Jain, MD, MPH, Scott D. Schoifet, MD, FACS, Manny D. Porat, MD, Gregory Intra‐articular Injection for Pain Control G. Klingenstein, MD, Jeremy J. Reid, MD, Robert E. Post, MD
Liposomal Bupivacaine and Peri‐articular In Total Knee Arthroplasty
Single‐blind, prospective, powered, RCT, 207 TKA
Injection are Not Superior to Single Shot Rajesh K. Jain, MD, MPH, Scott D. Schoifet, MD, FACS, Manny D. Porat, MD, Gregory Intra‐articular Injection for Pain Control G. Klingenstein, MD, Jeremy J. Reid, MD, Robert E. Post, MD
Intra‐articular bupivacaine/morphine vs In Total Knee Arthroplasty
Single‐blind, prospective, powered, RCT, 207 TKA
Rajesh K. Jain, MD, MPH, Scott D. Schoifet, MD, FACS, Manny D. Porat, MD, Gregory Peri‐articular bupivacaine/morphine
Intra‐articular bupivacaine/morphine G. Klingenstein, MD, Jeremy J. Reid, MD, Robert E. Post, MD
Vs
vs Single‐blind, prospective, powered, RCT, 207 TKA
Liposomal bupivacaine (PA)
Peri‐articular bupivacaine/morphine
Intra‐articular bupivacaine/morphine Vs
Primary outcome: VAS Pain & narcotic need (MME)
vs Liposomal bupivacaine (PA)
V A N D E R B I Peri‐articular bupivacaine/morphine
L T Orthopaedic Institute
Primary outcome: VAS Pain & narcotic need (MME)
Vs
Liposomal bupivacaine (PA)
V A N D E R B I L T Orthopaedic Institute
Primary outcome: VAS Pain & narcotic need (MME)
V A N D E R B I L T Orthopaedic Institute
First Annual AAHKS Spring Meeting | 10
5
5
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Highlights of the 25th AAHKS Annual Meeting
3/16/2016
3/16/2016
Liposomal Bupivacaine and Peri‐articular Injection are Not Superior to Single Shot Intra‐articular Injection for Pain Control Liposomal Bupivacaine and Peri‐articular In Total Knee Arthroplasty
Injection are Not Superior to Single Shot Rajesh K. Jain, MD, MPH, Scott D. Schoifet, MD, FACS, Manny D. Porat, MD, Gregory G. Klingenstein, MD, Jeremy J. Reid, MD, Robert E. Post, MD
Intra‐articular Injection for Pain Control Liposomal Bupivacaine and Peri‐articular Single‐blind, prospective, powered, RCT, 207 TKA
In Total Knee Arthroplasty
Injection are Not Superior to Single Shot Rajesh K. Jain, MD, MPH, Scott D. Schoifet, MD, FACS, Manny D. Porat, MD, Gregory Primary outcome: VAS Pain & narcotic need (MME)
G. Klingenstein, MD, Jeremy J. Reid, MD, Robert E. Post, MD
Intra‐articular Injection for Pain Control Results
Single‐blind, prospective, powered, RCT, 207 TKA
In Total Knee Arthroplasty
Rajesh K. Jain, MD, MPH, Scott D. Schoifet, MD, FACS, Manny D. Porat, MD, Gregory IA PAI Lipo
Primary outcome: VAS Pain & narcotic need (MME)
G. Klingenstein, MD, Jeremy J. Reid, MD, Robert E. Post, MD
Mean VAS : 3.95 vs 3.97 vs 3.86 (p=0.94)
Results
Single‐blind, prospective, powered, RCT, 207 TKA
MME/day : 100.7 vs 100.1 vs 98.9 (p=0.97)
IA PAI Lipo
Primary outcome: VAS Pain & narcotic need (MME)
Mean VAS : 3.95 vs 3.97 vs 3.86 (p=0.94)
V A N D E R B I L T O r t h o p a e d i c IResults
nstitute
MME/day : 100.7 vs 100.1 vs 98.9 (p=0.97)
IA PAI Lipo
Mean VAS : 3.95 vs 3.97 vs 3.86 (p=0.94)
V A N D E R B I L T Orthopaedic Institute
MME/day : 100.7 vs 100.1 vs 98.9 (p=0.97)
V A N D E R B I L T Orthopaedic Institute
Liposomal Bupivacaine and Peri‐articular Injection are Not Superior to Single Shot Intra‐articular Injection for Pain Control Liposomal Bupivacaine and Peri‐articular In Total Knee Arthroplasty
Injection are Not Superior to Single Shot Rajesh K. Jain, MD, MPH, Scott D. Schoifet, MD, FACS, Manny D. Porat, MD, Gregory G. Klingenstein, MD, Jeremy J. Reid, MD, Robert E. Post, MD
Intra‐articular Injection for Pain Control Liposomal Bupivacaine and Peri‐articular In Total Knee Arthroplasty
Impact
Injection are Not Superior to Single Shot Rajesh K. Jain, MD, MPH, Scott D. Schoifet, MD, FACS, Manny D. Porat, MD, Gregory G. Klingenstein, MD, Jeremy J. Reid, MD, Robert E. Post, MD
Intra‐articular Injection for Pain Control Cost savings: $4.92 vs $315
In Total Knee Arthroplasty
Impact
Rajesh K. Jain, MD, MPH, Scott D. Schoifet, MD, FACS, Manny D. Porat, MD, Gregory G. Klingenstein, MD, Jeremy J. Reid, MD, Robert E. Post, MD
Also Paper #36, DBRCT Lipo vs PAI
Cost savings: $4.92 vs $315
Impact
Also Paper #36, DBRCT Lipo vs PAI
Cost savings: $4.92 vs $315
V A N D E R B I L T Orthopaedic Institute
Also Paper #36, DBRCT Lipo vs PAI
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
Scientific Sessions (9)
13 RCTs
Scientific Sessions (9)
22% Level 1 Studies
Focus: Clinically Relevant, Practice Changing
13 RCTs
Scientific Sessions (9)
22% Level 1 Studies
Focus: Clinically Relevant, Practice Changing
13 RCTs
22% Level 1 Studies
Focus: Clinically Relevant, Practice Changing
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
First Annual AAHKS Spring Meeting | 11
6
6
3/16/2016
Highlights of the 25th AAHKS Annual Meeting
3/16/2016
3/16/2016
Scientific Session Highlights
Knee
Scientific Session Highlights
#9: Fixed vs Mobile TKA 10 yr
RCT
Knee
No difference
Scientific Session Highlights
#9: Fixed vs Mobile TKA 10 yr
RCT
Knee
#13: Kinematic vs Mechanical Alignment in TKA RCT
No difference
No difference
#9: Fixed vs Mobile TKA 10 yr RCT
#13: Kinematic vs Mechanical Alignment in TKA RCT
No difference
No difference
#13: Kinematic vs Mechanical Alignment in TKA RCT
No difference
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
Scientific Session Highlights
Hip
Scientific Session Highlights
#21: RCT Formal PT vs Independent Ex after THA
Hip
No Difference
Scientific Session Highlights
#21: RCT Formal PT vs Independent Ex after THA
Hip
#22: Michigan Arthroplasty Registry
No Difference
DA vs Post THA Same Dislocation Rates (0.4%)
#21: RCT Formal PT vs Independent Ex after THA
#22: Michigan Arthroplasty Registry
No Difference
#24/25: 13 year f/u XLPE, 28 vs 36 heads
DA vs Post THA Same Dislocation Rates (0.4%)
No difference in Wear Rates or Osteolysis
#22: Michigan Arthroplasty Registry
#24/25: 13 year f/u XLPE, 28 vs 36 heads
DA vs Post THA Same Dislocation Rates (0.4%)
V A N D ENo difference in Wear Rates or Osteolysis
R B I L T Orthopaedic Institute
#24/25: 13 year f/u XLPE, 28 vs 36 heads
V A N D ENo difference in Wear Rates or Osteolysis
R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
Scientific Session Highlights
Infection
Scientific Session Highlights
#27: RCT Oral Abx after 2‐stage PJI Infection
Reduces Reinfection Risk (5% vs 20%)
Scientific Session Highlights
#27: RCT Oral Abx after 2‐stage PJI Infection
#31/32 Injections Prior to TJA Increase Infection Risk
Reduces Reinfection Risk (5% vs 20%)
Risk increases with shorter gap
#27: RCT Oral Abx after 2‐stage PJI #31/32 Injections Prior to TJA Increase Infection Risk
Reduces Reinfection Risk (5% vs 20%)
Risk increases with shorter gap
#31/32 Injections Prior to TJA Increase Infection Risk
Risk increases with shorter gap
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
V A N D E R B I L T Orthopaedic Institute
First Annual AAHKS Spring Meeting | 12
7
7
Breakout 1, Primary Total Hip Arthroplasty (THA): Simple to Complex
Breakout 1, Primary THA: Simple to Complex
Daniel J. Berry, M.D.
Mayo Clinic
Rochester, Minnesota
Challenging Primary THA: Introduction and General Principles
Understand the anatomy and specific technical issues related to the specific anatomic problems posed by
the problem you face. Know what you are up against.
Perform careful, detailed preop planning: Template and have a plan A, plan B, and plan C.
Consider which operative approach will give you all the options you need to solve the problem.
When appropriate, (previous infection, retained hardware) screen for infection.
Prepare for extra blood loss, consider cell saver.
Make sure you have all the special instruments (for example broken screw removal set) and special
implants you need.
First Annual AAHKS Spring Meeting | 13
Breakout 1, Primary Total Hip Arthroplasty (THA): Simple to Complex
Primary THA: Simple to Complex
Berry/Page 2
WHEN FEMORAL FRACTURE FIXATION FAILS: SALVAGE OPTIONS
The Failed Femoral Neck Fracture:
Young patient:
Attempt to preserve patient’s own femoral head. Clinical results reasonably good even if there
are patches of avascular necrosis. Preferred methods of salvage: valgus-producing intertrochanteric
femoral osteotomy: puts the nonunion under compression. Other treatment option: Meyer’s
vascularized pedicle graft.
Older patient:
Most reliable treatment is prosthetic replacement. Decision to use hemiarthroplasty (such as
bipolar) or THA based on quality of articular cartilage, perceived risk of instability problem. In most
patients THA provides higher likelihood of excellent pain relief. Specific technical issues: (1) hardware
removal: usually remove after hip has first been dislocated (to reduce risk of femur fracture); (2) Hip
stability: consider anterolateral approach in older patients at risk. (3) Acetabular bone quality: poor
because it is not sclerotic from previous arthritis; caution when impacting a pressfit cup; low threshold
to augment fixation with screws; don’t overdo reaming; just expose the bleeding subchondral bone.
The Failed Intertrochanteric Hip Fracture:
Young patient:
Attempt to salvage hip joint with nonunion takedown, autogenous bone grafting and internal
fixation. Blade plate usually the favored internal fixation device.
Older patient:
Decision to preserve patient’s own hip with internal fixation versus salvage with hip arthroplasty
should be individualized based on patient circumstances, fracture pattern, bone quality. THA is an
effective salvage procedure for this problem in older patients. If prosthetic replacement is chosen
special considerations include:
1. THA vs. hemiarthroplasty: bipolar better stability; THA more reliable pain relief.
2. Removal of hardware: be prepared to remove broken screws in intramedullary canal.
3. Management of bone loss: bone loss to level of lesser trochanter common. Often requires a calcar
replacement implant. Proximal calcar build up size dictated by bone loss.
4. Length of stem: desirable to bypass screw holes from previous fixation if possible.
5. Stem fixation: cemented or uncemented fixation depending on surgeon preference, bone quality. If
uncemented, consider extensively coated (damaged proximal bone).
First Annual AAHKS Spring Meeting | 14
Breakout 1, Primary Total Hip Arthroplasty (THA): Simple to Complex
Primary THA: Simple to Complex
Berry/Page 3
6. Greater trochanter: often a separate piece, be prepared to fix with wires or cable grip. Residual
trochanteric healing, hardware problems not rare after THA.
7. Bone deformity/heterotopic bone: manage in individual basis.
References
1. Haidukewych GJ, Berry DJ: Hip Arthroplasty for Salvage of Failed Treatment of
Intertrochanteric Hip Fractures. J Bone Joint Surg 85A(5):899-904, May 2003
2. Haidukewych GJ, Berry DJ: Salvage of Failed Treatment of Hip Fractures. J Am Acad Ortho
Surg 13(2):101-9, Mar-Apr 2005.
3. Tabsh I. Waddell JP, Morton J: Total Hip Arthroplasty for Complications of Proximal Femoral
Fractures. J Orthop Trauma 11:166-169, 1997.
SALVAGE OF FAILED ACETABULAR FRACTURES WITH THA
I.
Introduction
A. THA after acetabular fracture presents unique technical challenges.
B. These challenges include bone deformity, bone deficiency, sclerotic or dysvascular bone,
non-united bony fragments, pelvic discontinuity, retained hardware, heterotopic
ossification, previous incisions, and concerns regarding the sciatic nerve.
C. Despite these challenges, with current treatment methods, a high degree of success can be
achieved with modern technology.
II.
Technical Issues
A. Preoperative evaluation for infection
1. In previously operated acetabular fractures, infection is always a concern. Screening
C-reactive protein and sedimentation rate may be performed. If a concern regarding
infection is present, the hip may be aspirated.
B. Incisions
1. In most cases, a previous incision may be utilized. If necessary, an incision may be
extended or a new limb can be created. The hip is less sensitive to multiple incisions
than the knee; nevertheless, attention still should be paid to maintaining optimal skin
bridges.
First Annual AAHKS Spring Meeting | 15
Breakout 1, Primary Total Hip Arthroplasty (THA): Simple to Complex
Primary THA: Simple to Complex
III.
Berry/Page 4
Hardware Removal
A. In cases with a high degree of concern about infection, a staged procedure may be
considered. However, in most cases, hardware removal can be done selectively at the
time of THA surgery. Hardware that does not compromise placement of the THA may be
left in place. Sometimes hardware can be cut off within the acetabulum to minimize
exposure needs.
B. Reconstructive Goals
1. The reconstructive goal is to place the hip center as close as possible to normal hip
center but also to gain good support of the socket on host bone. In most cases, both
goals can be met. When necessary, some compromise in hip center of rotation may be
considered to optimize implant stability on host bone.
C. Bone Deficiencies
1. Most bone deficiencies may be managed with methods similar to revision hip
surgery. However, in the acetabular fracture patient, usually the host femoral head is
available and this can be used as bone graft, either in particulate or bulk form.
2. Most cavitary deficiencies can be dealt with particulate bone graft. Some
superolateral bone deficiencies from posterior wall fractures may be considered for
bone grafting or augmentation techniques.
D. Cup Fixation
1. The principles of revision surgery are followed using uncemented acetabular
components fixed with augmentation screws.
E. Nonunited Fracture
1. Nonunited fractures are not uncommon in these circumstances. Small wall nonunions
may be managed as noted above for bone deficiency. If pelvic discontinuity is
present, it is usually best treated by following the rules established for treatment of
pelvic discontinuity with pelvic plating. Pelvic plating provides a reasonable
likelihood of bone healing in these circumstances when combined with bone grafting
techniques.
F. Heterotopic Ossification
1. Heterotopic ossification is common in previously operated acetabular fractures.
Removal of heterotopic bone at the time of surgery to gain hip motion is routine.
Postoperative measures to reduce the likelihood of bone formation (that is either
shielded radiation or use of a nonsteroid anti-inflammatory agent) may be strongly
considered.
First Annual AAHKS Spring Meeting | 16
Breakout 1, Primary Total Hip Arthroplasty (THA): Simple to Complex
Primary THA: Simple to Complex
Berry/Page 5
G. Nerve Issues
1. The sciatic nerve is at risk during these procedures. In many cases, avoiding the nerve
and the region of the nerve is a reasonable approach. When a lot of work must be
done on the posterior column, the surgeon needs to know exactly where the nerve is
and in such cases the nerve may be exposed distally beneath the gluteus maximus
tendon and followed proximally with careful and judicious dissection.
H. Results
1. Results of total hip arthroplasty after acetabular fracture have varied in the past. More
recent series have shown a high rate of acetabular fixation associated with
uncemented hemispherical implants. Acetabular fracture patients are
disproportionately young and active with unilateral hip disease and, therefore, bearing
surfaces should be chosen accordingly.
References
1. Boardman KP, Charnley J: Low-friction arthroplasty after fracture-dislocation of the hip. J Bone Joint
Surg Br. 1978; 60:495-497.
2. Coventry MB: The treatment of fracture-dislocation of the hip by total hip arthroplasty. J Bone Joint Surg
Am. 1974; 56:1128-1134.
3. Karpos PAG, Christie MJ, Chenger JD: Total hip arthroplasty following acetabular fracture: the effect of
prior open reduction, internal fixation. Orthopaedic Transactions. 1993; 17:589.
4. Malkin C, Tauber C: Total hip arthroplasty and acetabular bone grafting for unreduced fracturedislocation of the hip. Clin Orthop. 1985; 201:57-59.
5. Pritchett JW, Bortel DT: Total hip replacement after central fracture dislocation of the acetabulum.
Orthopedic Review. 1991; 20:607-610.
6. Rogan IM, Weber FA, Solomon L: Total hip replacement following fracture dislocation of the
acetabulum. J Bone Joint Surg Br. 1979; 61:252.
7. Romness DW, Lewallen DG: Total hip arthroplasty after fracture of the acetabulum. J Bone Joint Surgery
Br. 1990; 72:761-764.
8. Waddell JP, Morton J: Total hip arthroplasty following acetabular fracture. Presented at: the Annual
Meeting of the Orthopaedic Trauma Association; 1994; Los Angeles, Calif.
9. Weber M, Berry DJ, Harmsen WS: Total hip arthroplasty after operative treatment of an acetabular
fracture. J Bone Joint Surg Am.1998; 80:1295-1305.
10. Joly JM, Mears DC: The role of total hip arthroplasty in acetabular fracture management. Operative
Techniques in Orthopedics. 1993; 3:80-102.
11. Judet R, Judet J, Letounel E: Fractures of the acetabulum: classification and surgical approaches for open
reduction. J Bone Joint Surg Am.1964; 46:1615.
12. Letournel E: Acetabular fractures: classification and management. Clin Orthop.1980; 151:81-106.
13. Malta JM, Merritt PO: Displaced acetabular fractures. Clin Orthop. 1988; 230:83-87.
14. Mayo KA: Open reduction and internal fixation of fractures of the acetabulum. Clin Orthop.1994;
305:31-37.
15. Row CR, Lowell JD: Prognosis of fractures of the acetabulum. J Bone Joint Surg Am. 1961; 43:30-59.
16. Mears DC, Shirahama M: Stabilization of an acetabular fracture with cables for acute total hip
arthroplasty. J Arthroplasty. 1998; 13:104-107.
First Annual AAHKS Spring Meeting | 17
Breakout 1, Primary Total Hip Arthroplasty (THA): Simple to Complex
Primary THA: Simple to Complex
Berry/Page 6
THA FOR DEVELOPMENTAL HIP DYSPLASIA
I.
Introduction
A. Developmental dysplasia of the hip is among the most common hip diagnoses leading to hip
pain, arthritis and hip surgery in young patients.
B. Advances in treatment have led to more technically straight forward reconstructions, and
better functional results and durability.
II.
Indications for arthroplasty
A. Advanced degenerative disease
B. Anatomy/personality unfavorable for osteotomy
C. Older patient
III.
Classification: Crowe
First Annual AAHKS Spring Meeting | 18
Breakout 1, Primary Total Hip Arthroplasty (THA): Simple to Complex
Primary THA: Simple to Complex
IV.
Berry/Page 7
Treatment Principles
A. Acetabulum
1. Acetabular reconstruction at anatomic position with uncemented implant when possible.
Use screws for extra fixation in most cases.
2. Anterolateral acetabular auto-grafting if needed—fix with screws
3. Accept mild medialization, elevations of hip center to get cup coverage on host bone
4. Reserve high hip center for Crowe II/III patient in whom anatomic hip center would
require socket to mostly be placed on graft
B. Femur
1. Cemented versus uncemented based on patient age, bone quality, anatomy. In most
younger patients uncemented is preferred.
2. Problems: anteversion, length
3. Modular uncemented stems simplify management of excessive anatomic anteversion in
some cases
4. Shortening/derotation subtrochanteric osteotomies in selected cases (see below)
C. Lengthening
1. No definite guidelines for how much is safe but beware if lengthening more than 2 cm
2. Role of intra-operative nerve monitoring
V.
Treatment Based on Classification
A. Crowe I
1. Acetabulum
a. Reconstruction at anatomic hip center using uncemented socket
b. Anterolateral structural graft only if needed (fixation with screws)
2. Femur
a. Uncemented versus cemented bases on anatomy/age/activity/surgeon philosophy
b. If uncemented:
-avoid excessive anteversion of stem (because femur often anteverted)
-in some diaphyseal fixation (extensively coated stem) or modular stems are useful
because of distorted proximal femoral geometry modular stem that allows
anteversion correction and use of uncemented proximally coated fixation is method
of choice for many of these patients
c. If cemented:
-may need CDH stem (valgus medial femur may preclude routine stem)
First Annual AAHKS Spring Meeting | 19
Breakout 1, Primary Total Hip Arthroplasty (THA): Simple to Complex
Primary THA: Simple to Complex
Berry/Page 8
B. Crowe II
1. Acetabulum
a. Reconstruction at anatomic hip center or slightly above anatomic center attempting to
optimize coverage of uncemented socket with native bone
b. Graft if needed (usually do)
2. Femur
a. Same as Crowe I
C. Crowe III
1. Acetabulum
a. Presents the most difficult acetabular problem of DDH cases: severe lateral bone
deficiency
b. Options: -high hip center with small uncemented cup fixed with screws
-anatomic hip center reconstruction beneath large bone graft
2. Femur
a. Same as Crowe I
b. May require femoral shortening if anatomic hip center is chosen (See below for
Crowe IV)
D. Crowe IV
1. Acetabulum
a. Reconstruction at anatomic hip center with extra small uncemented socket
b. Graft usually not needed
c. Technical tip: prepare socket with reverse reaming (expands socket and impacts bone
making it denser)
2. Femur
a. Subtrochanteric osteotomy, femoral shortening
i. advantages: -elegant
-maintains anatomy of femur
-allows uncemented implant use
-avoids trochanteric problems of earlier methods
ii. technical tips: -osteotomy: transverse
-length: preop plan/intraop soft tissue tension
-keep resected segment vascular, split, use as struts
-implant: best to get proximal and distal fixation: fully coated or an
implant with diaphyseal fixation (such as flutes) distally
First Annual AAHKS Spring Meeting | 20
Breakout 1, Primary Total Hip Arthroplasty (THA): Simple to Complex
Primary THA: Simple to Complex
Berry/Page 9
References
1. Crowe JF, Mani VJ, Ranawat CS: Total hip replacement in congenital dislocation and dysplasia of
the hip. J Bone Joint Surg 61A:15, 1979.
2. Ganz R, Klaue K, Vinh TS, Mast JW: A new periacetabular osteotomy for the treatment of hip
dysplasia. Clin Orthop 232:26, 1988.
3. Gerber SD, Harris WH: Femoral head autografting to augment acetabular deficiency in patients
requiring total hip replacement: a minimum five-year and average seven-year followup study. J
Bone Joint Surg 68:1241, 1986.
4. Jaroszynski G, Woodgate I; Saleh K; Gross, A: Total hip replacement for the dislocated hip. J Bone
Joint Surg 83A(2):272, 2001.
5. Jensen JS, Retpen JB, Arnoldi CC: Arthroplasty for congenital hip dislocation and dysplasia:
techniques for acetabular reconstruction. Acta Orthop Scand 60:86, 1989.
6. Sanchez-Sotelo J; Trousdale RT; Berry DJ; Cabanela ME: Surgical Treatment of Developmental Dysplasia
of the Hip in Adults: I. Non-Arthroplasty Options. J Am Academy Orthopaedic Surgeons Vol 10(5):312-333,
Sept/Oct 2002.
7. Sanchez-Sotelo J.; Berry DJ; Trousdale RT; Cabanela ME: Surgical Treatment of Developmental Dysplasia
of the Hip in Adults: II. Arthroplasty Options. J Am Academy Orthopaedic Surgeons Vol 10(5):334-344,
Sept/Oct 2002.
8. Silber DA, Engh CA: Cementless total hip arthroplasty with femoral head bone grafting for hip
dysplasia. J Arthroplasty 5:231, 1990.
9. Trousdale RT, Ekkemkamp A, Ganz R: Periacetabular and intertrochanteric osteotomy for the
treatment of osteoarthritis in dysplastic hips. J Bone Joint Surg 77A:73, 1995.
10. Wiberg G: Relation between congenital subluxation of the hip and arthritis deformans (a
roentgenological study). Acta Orthop Scand 10:351, 1939.
11. Krych AJ; Howard JL; Trousdale RT; Cabanela ME; Berry DJ: Total Hip Arthroplasty with Shortening
Subtrochanteric Osteotomy in Crowe Type-IV Developmental Dysplasia J Bone Joint Surg 91(9):2213-21,
Sept 2009.
12. Krych AJ, Howard JL, Trousdale RT, Cabanela ME, Berry DJ: Total Hip Arthroplasty with Shortening
Subtrochanteric Osteotomy in Crowe Type-IV Developmental Dysplasia: Surgical Technique. J Bone Joint
Surg. Am., 92:176-187, Sept 2010.
First Annual AAHKS Spring Meeting | 21
Breakout 1, Primary Total Hip Arthroplasty (THA): Simple to Complex
Primary THA: Simple to Complex
Berry/Page 10
THA IN PATIENTS WITH PROXIMAL FEMORAL DEFORMITY
Introduction:
Goals of THA in patients with proximal femoral deformity are:
-Avoid letting deformity force suboptimal implant position
-Gain good implant position
-Gain acceptable hip biomechanics
Classification and treatment algorithm: Based on deformity level
-Very proximal (lesser trochanter level or above):
-Subtrochanteric
-Distal: distal to tip of standard THA stem
Management based on Deformity Level:
Distal deformities: Ignore
Proximal deformities: Rx options:
-Remove the deformity and substitute with the implant
-Choose an implant that allows satisfactory position and fixation despite the deformity
Subtrochanteric deformities: The toughest problems to solve (too proximal to ignore; too distal to
bypass). Rx options:
-Resurfacing Hip Arthroplasty: now out of favor due to metal-metal bearings in most cases
-Short stem THA
-Corrective osteotomy with THA: principles: maintain femur vascularity, gain fixation
proximal and distal to osteotomy with optimal implant choice.
Conclusions:
-Majority of proximal femoral deformities in hips requiring THA can be managed in one procedure.
-Main options: Use implant that compensates for deformity; excise the deformity; corrective osteotomy.
References:
Berry, DJ: Total Hip Arthroplasty in Patients with Proximal Femoral Deformity. Clin Orthop Rel Res 369:262272, Dec 1999
First Annual AAHKS Spring Meeting | 22
Breakout 2, Primary Total Knee Arthroplasty (TKA): Simple to Complex
Breakout 2, Primary Total Knee Arthroplasty (TKA): Simple to Complex Outline Pre-­‐operative evaluation Indications Physical Exam Radiographs/Imaging Conservative Treatment to Date The Role of Pre-­‐hab? Evaluation of Risk Factors/Patient Optimization Anesthetic Technique/Pain Management Peri-­‐capsular injections Regional blocks Positioning/Operative Room set up Surgical Approach/Exposure Operative Technique Considerations Alignment-­‐ (neutral, anatomic, kinematic, etc.) Standard Instrumentation CAS Custom guides Other Gap Balancing vs Measured Resection CR vs PS PS (Post vs UC/AS), Mobile bearing Patellar resurfacing Flexion Gap and Extension Gap mismatches First Annual AAHKS Spring Meeting | 23
Breakout 2, Primary Total Knee Arthroplasty (TKA): Simple to Complex
Fixation Cement Cementless Ligament Releases Medial releases Lateral releases Deformity considerations Flexion contracture Varus deformity/Valgus deformity Extra-­‐articular vs Intra-­‐articular Bone loss and management Other considerations Retained hardware Soft tissue defects and previous incisions Previous surgery (HTO, tubercle osteotomy, DFO, patellectomy, etc.) The Role of Intra-­‐articular Drains Blood Management Strategies Wound closure and dressing selection Post-­‐operative management Complications Multi-­‐modal pain management Physical Therapy Discharge Disposition Outpatient follow up routine/schedule References First Annual AAHKS Spring Meeting | 24
Breakout 2, Primary Total Knee Arthroplasty (TKA): Simple to Complex
1) Barrack RL, Booth RE, Lonner JH: Section 1: The knee, in Barrack RL, Booth RE, Lonner JH, McCarthy JC, Mont MA, Rubash HE (eds): Orthopaedic Knowledge Update: Hip and Knee Reconstruction 3. Rosemont, IL, American Academy of Orthopaedic Surgeons, 2006, pp 1-­‐177. 2) Daniels AU, Tooms RE, Harkess JW, Guyton JL: Arthroplasty, in Canale ST (ed): Campbell’s Operative Orthopaedics, ed 9. St. Louis, MO, Mosby, 1998, pp 211-­‐295. 3) Engh GA, Holt BP, Parks NL: A midvastus muscle splitting approach for total knee arthroplasty. J Arthroplasty 1997;12: 322-­‐331. 4) Hofmann AA, Evanich JD, Ferguson RP, Camargo MP: Tento 14-­‐year clinical followup of the cementless natural knee system. Clin Orthop Relat Res 2001;388:85-­‐94. 5) Hofmann AA, Plaster RL, Murdock LE: Subvastus (Southern) approach for primary total knee arthroplasty. Clin Orthop Relat Res 1991;269:70-­‐77. 6) Insall JN: Surgical approaches to the knee, in Insall JN, Scott WN (eds): Surgery of the Knee. New York, NY, Churchill Livingstone, 1984, pp 41-­‐54. 7) Keblish PA: The lateral approach to the valgus knee: Surgical technique and analysis of 53 cases with over two-­‐year follow-­‐up evaluation. Clin Orthop Relat Res 1991;271:52-­‐ 62. 8) McPherson EJ: Adult reconstruction, in Miller MD (ed): Review of Orthopaedics, ed 4. Philadelphia, PA, Saunders 9) Peters CL, Crofoot CD, Froimson MI: Knee reconstruction and replacement, in Fischgrund JS (ed): Orthopaedic Knowledge Update 9. Rosemont, IL, American Academy of Orthopaedic Surgeons, 2008, pp 457-­‐471. 10) Ranawat CS, Flynn WF, Saddler S, et al: Long-­‐term survivorship of the total condylar knee arthroplasty: A 15 year survivorship study. Clin Orthop Relat Res 1993;286:94-­‐102. 11) Rand JA, Ilstrup DM: Survivorship analysis of total knee arthroplasty. J Bone Joint Surg Am 1991;73:397-­‐409. 12) Ritter MA, Herbst SA, Keating EM, et al: Long-­‐term survival analysis of a posterior cruciate-­‐
retaining total condylar total knee arthroplasty. Clin Orthop Relat Res 1994;309:136-­‐145. 13) Scuderi GR, Insall JN: Total knee arthroplasty. Clin Orthop Relat Res 1992;276:26-­‐32. Some Top Testing Facts 1. Care should be taken to avoid placing the tibial component in internal rotation to avoid undesired increases in the Q angle. 2. The patellar component should be placed in a medial and superior position. 3. PCL failure should be considered in a well-­‐functioning PCL-­‐retaining TKA that starts to demonstrate instability, hyperextension, and recurrent effusion. 4. Correction of a gap-­‐balancing mismatch requires equalization of the flexion and extension gap. 5. Successful cementless fixation requires adjunctive peripheral fixation (eg, pegs and screws). First Annual AAHKS Spring Meeting | 25
Breakout 2, Primary Total Knee Arthroplasty (TKA): Simple to Complex
6. Excellent survival outcomes exist for cruciate-­‐retaining and cruciate-­‐substituting TKA designs. 7. The femoral component should be lateralized, parallel to the neutral rotational axis, and externally rotated 3° to 5° to the posterior condylar axis. 8. If a peroneal nerve palsy is suspected following TKA, the patient’s leg should be immediately flexed and all compressive dressings should be removed. First Annual AAHKS Spring Meeting | 26
3/16/2016
Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
Periprosthetic Joint Infection
Periprosthetic
Joint
Infection
AAHKS Spring
Meeting
Symposium
Periprosthetic
Joint Infection
AAHKS Spring Meeting
Symposium
Bryan
D. Springer, MD
AAHKS
OrthoCarolinaSpring
Hip andMeeting
Knee Center
Symposium
Charlotte,
NC
Bryan D. Springer, MD
OrthoCarolina Hip and Knee Center
Charlotte,
NC MD
Bryan
D. Springer,
OrthoCarolina Hip and Knee Center
Charlotte, NC
Disclosure
Stryker Orthopedics
Disclosure
Consultant:
ConvaTec
Speakers
Bureau:Disclosure
Ceramtec
Consultant:
Stryker Orthopedics
Research Support:
Depuy/Wright Medical/Zimmer/Pacira
ConvaTec
Speakers Bureau:
Consultant:
Research
Support:
Editorial Board:
Speakers Bureau:
Ceramtec
Stryker
Orthopedics
Research
Support:
Editorial Board:
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Medical/Zimmer/Pacira
JoA, Arthroplasty
Today
Board of Directors:
Medical Advisor:
Editorial
Board of Board:
Directors:
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Today
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Joint Purification Systems
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AJRRArthroplasty Today
Joint Purification Systems
AJRR
Joint Purification Systems
The Infected TKA
The Infected TKA
• Periprosthetic Joint infection (PJI) is one of
the most challenging and frequent
The Infected
TKA
• complications
Periprosthetic after
Joint TJA
infection (PJI) is one of
the most challenging and frequent
after
Range
from 0.5%
7% ….and
increasing
• complications
Periprosthetic
JointtoTJA
infection
(PJI)
is one of
the most challenging and frequent
aftertoTJA
• complications
Range
from
7%TKA
….and increasing
#1 reason
for0.5%
failure
of
•
••
•
•
•
#3 reason for failure of THA
Range
from
to of
7%TKA
….and increasing
#1 reason
for0.5%
failure
#3 reason for failure of THA
#1 reason for failure of TKA
#3 reason for failure of THA
First Annual AAHKS Spring Meeting | 27
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Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
Projected Incidence of Revision
TJA for Infection
Projected Incidence of Revision
TJA for Infection
Projected Incidence of Revision
TJA for Infection
16.8 % in 2005 to 65.5% in 2030
Kurtz et al JBJS 2007
16.8 % in 2005 to 65.5% in 2030
Kurtz et al JBJS 2007
16.8 % in 2005 to 65.5% in 2030
Kurtz et al JBJS 2007
Periprosthetic Joint Infection worse
than Most Cancers
Periprosthetic Joint Infection worse
than Most Cancers
Periprosthetic Joint Infection worse
than Most Cancers
NEJM July 2014
NEJM July 2014
NEJM July 2014
First Annual AAHKS Spring Meeting | 28
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Symposium II, Periprosthetic Joint Infection
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3/16/2016
Periprosthetic Joint Infection
Periprosthetic Joint Infection
Still remains a tremendous amount of
variation:
• How
to Evaluate
and Diagnose
a of
Still
remains
a tremendous
amount
suspected PJI
variation:
• How to Evaluate and Diagnose a
• suspected
What is thePJI
appropriate Surgical
Management
• What is the appropriate Surgical
Management
Periprosthetic Joint Infection
AGENDA
Periprosthetic Joint Infection
AGENDA
• The Diagnosis of PJI:
Current and Future
– Dr. Javad Parvizi
•• The
of Irrigation
Debridement
The Role
Diagnosis
of PJI: and
Current
and Future
– Dr.
Dr. Matt
–
JavadAbdel
Parvizi
Removal
OneDebridement
Stage or Two ?
•• The
Role of
of Implants:
Irrigation and
–
Polkowski
– Dr.
Dr. Greg
Matt Abdel
• Removal of Implants: One Stage or Two ?
• Interactive Discussion
– Dr. Greg Polkowski
• Interactive Discussion
First Annual AAHKS Spring Meeting | 29
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Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
Diagnosis of Periprosthetic
Joint Infection
Diagnosis of Periprosthetic
Joint Infection
Javad Parvizi MD, FRCS
Diagnosis
of Professor
Periprosthetic
Rothman
Institute
at Thomas Jefferson
Joint
Infection
Javad
Parvizi
MD, FRCS
University,
Philadelphia
Professor
Rothman Institute at Thomas Jefferson
University, Philadelphia
Javad Parvizi MD, FRCS
Professor
Rothman Institute at Thomas Jefferson
University, Philadelphia
Disclosures

Research support:
Disclosures
 Rotation Medical
NIH
 Simplify Medical
 Department of Defense
 Smith and Nephew
 OREF
 Research
support:
 Stelkast
 3M
 Stryker
Orthopedics
Rotation
Medical
 NIH
Aesculap

 Synthes
Simplify Medical
 Department
AO Spine

of Defense
 TissueGene
Smith and Nephew
 OREF
Biomet

 Tornier
 Research
Stelkast
 3M
Cempra support:

 Orthospace
Stryker Orthopedics

CeramTec
 Aesculap

Medical

Zimmer
 Rotation
SynthesBiomet

DePuy
 NIH
AO
Spine

Medical
 Simplify
TissueGene

Department
of
Defense
Integra
 Biomet

Smith
and
Nephew
 Tornier

Myoscience
 OREF
Cempra

 Stelkast
Orthospace
NDRI

 3M
CeramTec

 Stryker
ZimmerOrthopedics
Biomet
Novartis

 Aesculap
DePuy
 Synthes
Pfizer

Spine
 AO
Integra
 TissueGene

 Biomet
Myoscience
 Tornier

 Cempra
NDRI
Rothman Institute of Orthopaedics
at
 Orthospace

Thomas Jefferson University
 CeramTec
Novartis
 Zimmer Biomet

DePuy
 Pfizer
 Integra
 Myoscience
Rothman Institute of Orthopaedics at
 NDRI
Thomas Jefferson University
 Novartis
 Pfizer

Disclosures
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Disclosures






Consultant
 Zimmer Biomet
 Convatech
 TissueGene
 Ceramtec
Consultant
 Zimmer
Medtronics

Biomet
 Convatech
Ethicon

 TissueGene
Theravance


Board Member/Adviser

Journal of Arthroplasty
Eastern Orthopedic Assoc.
Disclosures




3M
JBJS-A
Board
Member/Adviser
 Bone and Joint Journal (British)





Journal
of Arthroplasty
Muller
Foundation
Eastern
Orthopedic Assoc.
Disclosures
United
Healthcare
3M
JBJS-A
Royalty
  Board
Member/Adviser
 Ceramtec
Consultant
 Bone and Joint Journal (British)
Intellectual
 Journal of Arthroplasty
 Zimmer
Medtronics
Elsevier

Biomet
 Muller
Foundation
Property/Ownership
 Eastern Orthopedic Assoc.
 Convatech
Ethicon
 United Healthcare

Wolters Kluwer
 Hip Innovation Technology  3M
 TissueGene
Theravance

 CD Diagnostics
 JBJS-A
 Slack
 Royalty
 Ceramtec
 Bone and Joint Journal (British)
 Corentec
Intellectual
 Medtronics
Jaypee
publishers

Foundation
Muller
Elsevier
 ForMD
Property/Ownership

 United Healthcare
 Ethicon
Alphaeon
 Datatrace
Wolters Kluwer
 Hip Innovation Technology

Theravance
 Joint Purification Systems
 CD Diagnostics
Royalty
Rothman Institute ofOrthopaedics
at
 Slack
 Ceribell
 Corentec
Thomas Jefferson University
Intellectual
 MedAp

Elsevier

Jaypee
publishers

ForMD
Property/Ownership


Kluwer
 Alphaeon
Hip Innovation Technology
 Wolters
Datatrace
 CD
Joint
Purification Systems

Diagnostics

Slack
Rothman Institute of Orthopaedics at
 Corentec
Ceribell

Thomas Jefferson University
 Jaypee publishers
 ForMD
MedAp

 Alphaeon
 Datatrace
 Joint Purification Systems
Rothman Institute of Orthopaedics at
 Ceribell
Thomas Jefferson University
 MedAp

First Annual AAHKS Spring Meeting | 30
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Symposium II, Periprosthetic Joint Infection
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Facts
Facts
The diagnosis of periprosthetic infection has been the subject of Facts
The diagnosis of periprosthetic infection considerable research
has been the subject of The diagnosis of periprosthetic infection considerable research
has been the subject of considerable research
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Background
Background
This research has produced a large number of Background
This research has produced a peer‐reviewed manuscripts
large number of This research has produced a peer‐reviewed manuscripts
large number of peer‐reviewed manuscripts
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Pubmed Publications for PJI by Year
200
180
160
200
Pubmed Publications for PJI by Year
140
180
120
160
200
Pubmed Publications for PJI by Year
100
140
180
80
120
160
60
100
140
40
80
120
0
40
20
0
Obtained using the keyword “periprosthetic joint infection”
1982
1983
1984
1985
1986
1987
1988
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
20
60
Obtained using the keyword “periprosthetic joint infection”
1982
1983
1984
1985
1986
1987
1988
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
0
40
80
1982
1983
1984
1985
1986
1987
1988
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
20
60
100
Obtained using the keyword “periprosthetic joint infection”
First Annual AAHKS Spring Meeting | 31
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Symposium II, Periprosthetic Joint Infection
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3/16/2016
Infected Revisions 2001-2010
Burden
Infected Revisions 2001-2010
Burden
26,000 infected
joints
26,000 infected
joints
26,000 infected
joints
Infected Revisions 2001-2010
Burden
Kurtz, S, Parvizi J JOA 2012
Kurtz, S, Parvizi J JOA 2012
Kurtz, S, Parvizi J JOA 2012
Infected Revisions 2001-2010
Cost
Infected Revisions 2001-2010
Cost
$1 billion
$1 billion
$1 billion
Infected Revisions 2001-2010
Cost
Kurtz, S, Parvizi J JOA 2012
Kurtz, S, Parvizi J JOA 2012
Kurtz, S, Parvizi J JOA 2012
Diagnosis of PJI



Difficult
Difficult
Difficult
Diagnosis of PJI
Diagnosis of PJI
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
First Annual AAHKS Spring Meeting | 32
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Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Intracellular S. aureus in Periprosthetic Tissue
Intracellular S. aureus in Periprosthetic Tissue
Intracellular S. aureus in Periprosthetic Tissue
Parham S et al, Clin Infect Dis 2006
Parham S et al, Clin Infect Dis 2006
Parham S et al, Clin Infect Dis 2006
The Problem
No
The Problem
test with absolute
Problem
accuracyThe
exists
No test with absolute
i.e. no gold standard
accuracy exists
No test with absolute
i.e. no gold
standard
accuracy
exists
i.e.
no gold standard
First Annual AAHKS Spring Meeting | 33
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Symposium II, Periprosthetic Joint Infection
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3/16/2016
Problem Diagnosing PJI
Problem Diagnosing PJI
Sensitivity 87%
Blood
ProblemSpecificity
Diagnosing PJI77%
Sensitivity 87%
Blood
CRP
10CRP
mg/L Specificity 77%
Sensitivity 87%
Blood
10CRP
mg/L Specificity
77%
• Different labs use different units ‐
mg/L vs. mg/dL
10 mg/L
• The lab’s normal range has nothing to do with PJI
• Different labs use different units ‐ mg/L vs. mg/dL
Rothman Institute of Orthopaedics at
Thomas Jefferson University
• The lab’s normal range has nothing to do with PJI
• Different labs use different units ‐ mg/L vs. mg/dL
Rothman Institute of Orthopaedics at
Thomas Jefferson University
• The lab’s normal range has nothing to do with PJI
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Problem Diagnosing PJI
Problem Diagnosing PJI
Synovial Fluid Sensitivity 89%
Problem Specificity
Diagnosing PJI 92%
Synovial Fluid Sensitivity 89%
3000 cells/ul Specificity 92%
Synovial Fluid Sensitivity 89%
3000
cells/ul Specificity 92%
• Problems with automated cell counters?
WBC
WBC
WBC
• The cutoff is about 3000 cells/ul, not 50,000 cells/ul
3000
cells/ul
• Problems with automated cell counters?
Rothman Institute of Orthopaedics at
Thomas Jefferson University
• The cutoff is about 3000 cells/ul, not 50,000 cells/ul
• Problems with automated cell counters?
Thomas Jefferson University
• The cutoff is about 3000 cells/ul, not 50,000 cells/ul
Rothman Institute of Orthopaedics at
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Problems Diagnosing PJI
Problems Diagnosing PJI
Sensitivity
Synovial
Specificity
Fluid Problems Diagnosing PJI
Sensitivity
Synovial
Specificity
Fluid
Sensitivity
Synovial
Specificity
Fluid
52%
95%
52%
95%
Poor Results
52%
95%
Culture
Culture
Culture Poor Results
Year
2006
2008
1999
2012
Year
2014
2006
2008
1999
2012
Year
2014
2006
2008
1999
2012
2014
Author
Journal
Bare et al.
CORR
Gallo et al.
New Microbiol
Spangehl et al.
JBJS
Gomez et al.
J Clin Micro
Rothman Institute of Orthopaedics at
Author
Journal
Shanmugasundaram
et al. University
HSS
Journal
Thomas Jefferson
Bare et al.
CORR
Gallo et al.
New Microbiol
Spangehl et al.
JBJS
Gomez et al.
J Clin Micro
Rothman
at
AuthorInstitute of Orthopaedics
Journal
Shanmugasundaram
et al. University
HSS Journal
Thomas Jefferson
Bare et al.
CORR
Gallo et al.
New Microbiol
Spangehl et al.
JBJS
Gomez et al.
J Clin Micro
Rothman Institute of Orthopaedics at
Shanmugasundaram
et al. University
HSS Journal
Thomas Jefferson
Sensitivity
53%
44%
73%*
64%
Sensitivity
45%
53%
44%
73%*
64%
Sensitivity
45%
53%
44%
73%*
64%
45%
Specificity
94%
94%
94%
97%
Specificity
94%
94%
94%
97%
Specificity
94%
94%
94%
97%
Poor Results
First Annual AAHKS Spring Meeting | 34
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Symposium II, Periprosthetic Joint Infection
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Background
Background
Increasing knowledge has led to many Background
Increasing knowledge official diagnostic recommendations
has led to many Increasing knowledge official diagnostic recommendations
has led to many IDSA
MSIS
ICM
official diagnostic recommendations
AAOS
IDSA
MSIS
AAOS
ICM
IDSA
MSIS
AAOS
ICM
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
AAOS Guidelines
www.aaos.org/guidelines
AAOS Guidelines
www.aaos.org/guidelines
AAOS Guidelines
www.aaos.org/guidelines
•15 recommendations
••15
Majority
strong
recommendations
••15
Review
ofstrong
literature
Majority
recommendations
Review ofstrong
literature
• Majority
• Review of literature
Parvizi et al. JAAOS 2010
Della Valle et al. JAAOS 2010
Parvizi et al. JAAOS 2010
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Della Valle et al. JAAOS 2010
Parvizi et al. JAAOS 2010
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Della Valle et al. JAAOS 2010
Rothman Institute of Orthopaedics at
Thomas Jefferson University
First Annual AAHKS Spring Meeting | 35
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Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
Main Principles
Main Principles
Every painful prosthetic
Main Principles
joint is potentially
infected
• Every painful prosthetic
joint is potentially infected
• Every painful prosthetic
joint is potentially infected
•
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Truly Aseptic?
Truly Aseptic?
• Infection should always be
ruled outTruly Aseptic?
• Infection should always be
• 12% of so called “aseptic”
ruled out
• Infection
should always be
were infected
• 12% of so called “aseptic”
ruled out
Parvizi J , et al CORR 2011
were infected
• 12% of so called “aseptic”
Parvizi J , et al CORR 2011
were infected
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Parvizi J , et al CORR 2011
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
AAOS Guidelines
www.aaos.org/guidelines
AAOS Guidelines
www.aaos.org/guidelines
ESR and CRP
for all patients
AAOS Guidelines
undergoing
revision arthroplasty
www.aaos.org/guidelines
ESR and CRP for all patients
undergoing revision arthroplasty
ESR and CRP for all patients
Aspiration
of joint
before any
undergoing revision
arthroplasty
further
imaging
Aspiration
of joint before any
further
imaging
Aspiration
of joint before any
further imaging
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
First Annual AAHKS Spring Meeting | 36
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3/16/2016
AAOS Guidelines
www.aaos.org/guidelines
AAOS Guidelines
www.aaos.org/guidelines
Patients be off antibiotics
AAOS Guidelines
before
aspiration
(2 weeks)
Patients
be off antibiotics
www.aaos.org/guidelines
before
aspiration
(2diagnosis
weeks)
Patients
be offuntil
antibiotics
No Antibiotics
reached
or refuted
before
aspiration
weeks)
No Antibiotics
until(2diagnosis
reached
refuted gram stain
No role foror
intraoperative
No
Antibiotics
until diagnosis
No role foror
intraoperative
reached
refuted gram stain
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
No role for intraoperative gram stain
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
First Annual AAHKS Spring Meeting | 37
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Symposium II, Periprosthetic Joint Infection
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3/16/2016
AAOS Guidelines
Rec 10: Inconclusive
CT or MRI
- CT or MRI
- CT or MRI
-
AAOS Guidelines
Rec 10: Inconclusive
AAOS Guidelines
Rec 10: Inconclusive
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
AAOS Guidelines
Rec 9: Weak
AAOS
Guidelines
Bone scan
(leukocyte
Rec 9: Weak
labeled)
and
PET
AAOS
Guidelines
Bone scan
(leukocyte
Rec 9: Weak
scan
is anand
option
labeled)
PETfor
Bone scan
(leukocyte
patients
not
scheduled
scan
is an
option
labeled)
and
PETfor
for
reoperation
or
patients
not
scheduled
scan is an
option
for
diagnosis
not
reached
for
reoperation
or
patients
not scheduled
diagnosis
not reached
for reoperation
or
diagnosis not reached
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
First Annual AAHKS Spring Meeting | 38
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Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
International Consensus Meeting
Philadelphia, August 2013
International Consensus Meeting
Philadelphia, August 2013
International Consensus Meeting
Philadelphia, August 2013
New Algorithm
New Algorithm
New Algorithm
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
International Consensus
•
••
•••
•••
••
•
International Consensus
Cell count
International Consensus
Neutrophil
Cell count differential
Culture
Neutrophil
Cell count differential
?Culture
Biomarkers
Neutrophil
differential
?Culture
Biomarkers
? Biomarkers
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
First Annual AAHKS Spring Meeting | 39
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10
3/16/2016
Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
Thresholds (Consensus)
Acute PJI
Thresholds (Consensus)
Acute PJI
 ESR- No threshold
Thresholds
(Consensus)
 CRP > 100 mg/L
(hip and knee)
 ESR- No threshold
Acute PJI
 Synovial WCC = 10,000 cells/ul
 CRP > 100 mg/L (hip and knee)
 ESRNo PMN
threshold
Synovial
>90%
 Synovial WCC = 10,000 cells/ul
 CRP > 100 mg/L (hip and knee)
 Synovial PMN >90%
 Synovial WCC = 10,000 cells/ul
ESR
CRP PMN
 Synovial
>90%
ESR+CRPRothman Institute of Orthopaedics at
Thomas Jefferson University
ESR
CRP
ESR+CRPRothman Institute of Orthopaedics at
Thomas Jefferson University
ESR
CRP
ESR+CRPRothman Institute of Orthopaedics at
Thomas Jefferson University
Definition of PJI
Definition of PJI
CDC
(National
Definition of PJI
CDC
(National
Healthcare
Safety
CDC (National
Healthcare
Safety
Network)
adopts
the
Healthcare
Safety
Network)
adopts
the
MSIS
definition
of
Network)
adopts the
MSIS definition
of
PJI
MSIS definition
of
PJI
PJI
Thresholds (Consensus)
Chronic PJI
Thresholds (Consensus)
 ESR > 30 Chronic
mm/hrPJI
Thresholds (Consensus)
 CRP > 10 mg/L (hip
 ESR > 30 Chronic
mm/hrPJI and knee)
 Synovial WCC > 3,000 cells/ul
 CRP > 10 mg/L (hip and knee)
 ESR > 30 mm/hr
 Synovial PMN >80%
 Synovial WCC > 3,000 cells/ul
 CRP > 10 mg/L (hip and knee)
 Synovial PMN >80%
 Synovial WCC > 3,000 cells/ul
 Synovial
ESR
CRP
Rothman
Institute of Orthopaedics at
ESR+CRP
PMN >80%
Thomas Jefferson University
ESR
CRP
Rothman
Institute of Orthopaedics at
ESR+CRP
Thomas Jefferson University
ESR
CRP
Rothman
Institute of Orthopaedics at
ESR+CRP
Thomas Jefferson University
First Annual AAHKS Spring Meeting | 40
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Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
Premature Treatment
Premature Treatment
• Interferes
with isolation of
infecting
organism
Premature
Treatment
• Interferes
with
isolation of
• Affects cell count
infecting
organism
Interferes
with isolation
of
•• Affects
serological
markers
• Affects
cell count
infecting
Shahi
A et organism
al Clin Orthop 2015
•• Affects
serological
Affects cell count markers
Shahi A et al Clin Orthop 2015
• Affects serological markers
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Shahi A et al Clin Orthop 2015
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Opportunities in
Management of PJI
Era of Biomarkers
Era ofisBiomarkers
here
Era ofisBiomarkers
here
is here
Opportunities in
Management of PJI
Opportunities in
Management of PJI
Biomarkers in Medicine
Biomarkers in Medicine
Biomarkers in Medicine
-hCG
Cardiac
-hCG
Troponin
Cardiac
-hCG
Troponin
Cardiac
Troponin
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
First Annual AAHKS Spring Meeting | 41
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Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016



Diagnosis of PJI
Simple Test
Diagnosis of PJI
UA strips for
leukocyte
Simple
Testesterase
Diagnosis of PJI
UA strips for
leukocyte
Simple
Testesterase
UA strips for leukocyte esterase
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
LE Strips
LE Strips
LE Strips
Results
ProspectiveResults
study
• Rothman Institute
• ProspectiveResults
study
•31 infected / 83 uninfected
• Rothman Institute
• Prospective study
* sensitivity
•31
infected= 81%
/ 83 uninfected
•* Rothman
specificity =Institute
100%
** positive
sensitivity
= 81%
•31
infected
/ 83 uninfected
predictive
value = 100 %
•
** negative
specificitypredictive
= 100% value = 93.3 %
** positive
sensitivity
=
81%Parvizi
et al. JBJS
2011 %
predictive
value
= 100
** negative
specificitypredictive
= 100% value = 93.3 %
Parvizi
et al. JBJS
2011 %
* positive predictive
value
= 100
* negative predictive value = 93.3 %
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Parvizi et al. JBJS 2011
Rothman Institute of Orthopaedics at
Thomas Jefferson University
First Annual AAHKS Spring Meeting | 42
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Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Molecular Markers
Protein Analysis
Cytokines
Proteins
Molecular
Markers
IL-1α, IL-1β, IL1ra, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10,
Protein
IL-12
subunit p40,Analysis
IL-12 subunit p70, IL-15, IL-17, IL-23, IFN-γ,
Category
Adhesion Molecules
Cytokines
Growth Factors
Proteins
Molecular
ICAM-1, Vascular CellMarkers
Adhesion
IL-1α,
IL-1β,
IL1ra, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10,
VEG-F,
BDNF
Protein
Analysis
IL-12 subunit p40, IL-12 subunit p70, IL-15, IL-17, IL-23, IFN-γ,
Category
TNF-α, TNF-β, TNF receptor-like 2
Acute-phase reactants
Category
Complement
cascade
Adhesion
Molecules
Cytokines
Growth Factors
Chemotactic proteins
Acute-phase reactants
Metalloproteinase
Adhesion
Molecules
Complement
compounds cascade
Growth
Factors
Lysis/Destruction
Chemotactic proteins
Acute-phase reactants
Metalloproteinase
Complement cascade
compounds
Other
Lysis/Destruction
Chemotactic proteins
Metalloproteinase
compounds
Other
Lysis/Destruction
Other
CRP
TNF-α, TNF-β, TNF receptor-like 2
Proteins
Complement
C3, α-2
Beta-2-Microglobulin, von
ICAM-1,
Vascular
Cellmacroglobulin,
Adhesion
Willebrand
Factor
VIIIL-6, IL-7, IL-8, IL-10,
IL-1α,
IL-1β,Factor,
IL1ra, Fibrinogen,
IL-2, IL-3, IL-4,
IL-5,
VEG-F, BDNF
IL-12 subunit
p40, IL-12Protein
subunit
IL-15, IL-17, IL-23, IFN-γ,
Monocyte
Chemotactic
1, p70,
Eotaxin-1
TNF-α, TNF-β, TNF receptor-like 2
CRP
MMP-2, MMP-3, MMP-9, TIMP-1
ICAM-1,
Vascular
Cellmacroglobulin,
Adhesion
Complement
C3, α-2
Beta-2-Microglobulin, von
Willebrand
Factor, Fibrinogen, Factor VII
VEG-F, BDNF
Alpha-1-Antitrypsin,
Granulocyte-Macrophage ColonyMonocyte
Chemotactic
Protein 1,Inflammatory
Eotaxin-1
Stimulating
Factor, Macrophage
Protein-1 alpha
CRP
Macrophage
Inflammatory
Protein-1 beta
MMP-2,
MMP-3,
MMP-9, TIMP-1
Complement C3, α-2 macroglobulin, Beta-2-Microglobulin, von
Ferritin, Haptoglobin,
Stem CellFactor
Factor,VII
T-Cell-Specific Protein,
Willebrand
Factor, Fibrinogen,
RANTES, Molecule-1,Granulocyte-Macrophage
Vitamin D-Binding Protein
Alpha-1-Antitrypsin,
ColonyMonocyte Chemotactic Protein 1, Eotaxin-1
Stimulating Factor, Macrophage Inflammatory Protein-1 alpha
Macrophage
Inflammatory
Protein-1 beta
MMP-2,
MMP-3,
MMP-9, TIMP-1
Ferritin, Haptoglobin, Stem Cell Factor, T-Cell-Specific Protein,
RANTES, Molecule-1,Granulocyte-Macrophage
Vitamin D-Binding Protein
Alpha-1-Antitrypsin,
ColonyStimulating Factor, Macrophage Inflammatory Protein-1 alpha
Macrophage Inflammatory Protein-1 beta
Ferritin, Haptoglobin, Stem Cell Factor, T-Cell-Specific Protein,
RANTES, Molecule-1, Vitamin D-Binding Protein
Biomarker Screen
Biomarker Screen
Biomarkers Failing Prescreen Biomarkers Passing Prescreen
•
•
•
PCT
• sFasL
TGFa
• sICAM-1
LL-37, Human, • sVCAM-1
ELISA kit Failing
Biomarkers
Prescreen
• Granzyme
B
LBP
HSP70
•• PCT
•• sFasL
CGRP
IL-1α
•• TGFa
•• sICAM-1
•• Orsomucoid
LL-37, Human, •• IL-10
sVCAM-1
• ELISA
Nibrin kit Failing
Biomarkers
Prescreen
IL-17
•• Granzyme
B
••• TSG6
LBP
MIP-1α
HSP70
PCT
•• sFasL
Plekstrin
••• CGRP
•
MIP-1β
IL-1α
TGFa
• sICAM-1
SOD2 Human, •• sVCAM-1
Orsomucoid
MMP-8
IL-10
••• LL-37,
•• Urokinase
Nibrin kit
ELISA
IL-17
• Granzyme
B
MIF
TSG6
•• LBP
MIP-1α
• HSP70
PAI-1 (total) • IL-1α
Plekstrin
•• CGRP
MIP-1β
sFas
SOD2
•• Orsomucoid
MMP-8
• 45IL-10
Markers
•
•
•
•
•
•
•
•
• IL-1b
• LE Strip
• IL-6
• Lactoferrin
• IL-8
• Lipocalin2/NGAL
Biomarkers
Passing
Prescreen
• TNFa
Neutrophil
G-CSF
•• IL-1b
•• LE
Strip
Elastase-2
IL-1a
•• IL-6
• Lactoferrin
(ELA2)
•• VEGF
IL-8
•• LipocalinResistin
Biomarkers
Passing
Prescreen
2/NGAL
IP-10
•• TNFa
• Thrombospondi
Neutrophil
BFGF (aka
G-CSF
•• IL-1b
•• LE
n-1 Strip
(TSP-1)
Elastase-2
FGF2)
IL-1a
• IL-6
Lactoferrin
(ELA2)
••• HNP1-3,
CRP
VEGF
•• IL-8
Lipocalin• Human
Resistin
,
•• a2M
2/NGAL
IP-10
TNFa
Thrombospondi
kit
SKALP(aka
•• ELISA
Neutrophil
BFGF
•• G-CSF
n-1
(TSP-1)
Elastase-2
• BPI
HNE Enzyme
FGF2)
•• IL-1a
(ELA2)
assay
• HNP1-3,
•• CRP
VEGF
• Resistin
,
a2M
Human
•• IP-10
•
Thrombospondi
ELISA
kit
SKALP(aka
•• BFGF
n-1 (TSP-1)
• BPI
• FGF2)
HNE Enzyme
assay
• HNP1-3,
• CRP
Biomarker Screen
Urokinase
Nibrin
MIF
TSG6
PAI-1 (total)
Plekstrin
sFas
SOD2
Urokinase
MIF
PAI-1 (total)
sFas
• Screened
IL-17
• MIP-1α
• MIP-1β
• 45MMP-8
Markers
Screened
45 Markers
Screened
•
•
•
a2M
SKALP
HNE Enzyme
assay
Human,
•
ELISA kit
BPI
First Annual AAHKS Spring Meeting | 43
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3/16/2016
Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
Genomic
Experiments
Genomic
Biomarker Marathon
Experiments
Genomic
Biomarker Marathon
Experiments
Biomarker Marathon
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Data
Data
Data
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Alpha-Defensin
Alpha-Defensin
Antimicrobial Peptide
Alpha-Defensin
Secreted by Neutrophils
Antimicrobial Peptide
to fight Infection
Secreted by Neutrophils
Antimicrobial Peptide
to fight Infection
Secreted by Neutrophils
to fight Infection
Alpha‐Defensin
Alpha‐Defensin
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Alpha‐Defensin
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
First Annual AAHKS Spring Meeting | 44
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3/16/2016
Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
Overall study data
Overall study data
Gold Standard
Study
N
Institute
Study
Rothman 149
N
MSIS Criteria
Gold Mayo Arizona
Rothman Institute
61
149
MSIS Criteria
MSIS Criteria
Gold Cleveland Clinic
Mayo Arizona
Rothman Institute
Combined
Cleveland Clinic
Mayo Arizona
111
61
149
320
111
61
MSIS Criteria
MSIS Criteria
MSIS Criteria
MSIS Criteria
MSIS Criteria
MSIS Criteria
Combined
Cleveland Clinic
320
111
Thomas Jefferson University
MSIS Criteria
96%
MSIS Criteria
(95%CI: 92‐100%)
Combined
320
Thomas Jefferson University
MSIS Criteria
Study
Sensitivity
Overall study data
N
Standard
Standard
97%
(95%
CI: 86‐100%)
Sensitivity
100%
97%
(95% CI: 79‐100%)
(95% CI: 86‐100%)
Sensitivity
96%
Specificity
96%
(95%
CI: 90‐99%)
Specificity
95%
96%
(95% CI: 83‐99%)
(95% CI: 90‐99%)
Specificity
99%
(95%100%
CI: 82‐99%)
(95% CI: 79‐100%)
97%
(95% CI: 86‐100%)
(95% CI: 93‐100%)
95%
(95% CI: 83‐99%)
96%
(95% CI: 90‐99%)
(95%CI:
92‐100%)
(95%100%
CI: 82‐99%)
(95% CI: 79‐100%)
(95% CI: 93‐99%)
(95% CI: 93‐100%)
95%
(95% CI: 83‐99%)
98%
96%
98%
Rothman Institute of Orthopaedics at
(95% CI: 82‐99%)
98%
Rothman Institute of Orthopaedics at
(95%CI: 92‐100%)
97%
99%
97%
99%
(95% CI: 93‐99%)
(95% CI: 93‐100%)
97%
(95% CI: 93‐99%)
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Prophenoloxidase
Pathway
Beta Glucan (βG)
Fungi
Peptidoglycan (PG)
Prophenoloxidase
Gram & Gram
Pathway
+
-
Prophenoloxidase
Pathway
Peptidoglycan (PG)
Beta Glucan (βG)
Gram+ & GramFungi Pattern Recognition Receptors
Serine Protease Cascade Peptidoglycan (PG)
Beta Glucan (βG)
Pattern Recognition Receptors
Gram+ & GramFungi
Polymerizatio
n of melanin
Melanin clots restrain
and kill microbes.
Basis for this colorimetric method:
Phenoloxidase
Prophenoloxidase
Polymerizatio
Melanin clots restrain
and kill microbes.
Basis for this colorimetric method:
Phenoloxidase
Prophenoloxidase
Polymerizatio
Melanin clots restrain
and kill microbes.
Prophenoloxidase
Phenoloxidase
Serine Protease Cascade
Pattern Recognition Receptors
n ofand
melanin
- Production of melanin is associated with black discoloration
is
Protease
Cascade
indicative of Serine
presence
of PG
or βG.
- Time of reaction can be used to estimate the quantity of PG or βG.
n at
ofand
melanin
- Production of melanin is associated
blackofdiscoloration
is
Rothmanwith
Institute
Orthopaedics
Thomas Jefferson University
indicative of presence of PG or βG.
- Time of reaction can be used to estimate the quantity of PG or βG.
Basis for this colorimetric method:
Rothmanwith
Institute
Orthopaedics atand is
- Production of melanin is associated
blackofdiscoloration
Thomas Jefferson University
indicative of presence of PG or βG.
- Time of reaction can be used to estimate the quantity of PG or βG.
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Preliminary Results












Samples from
8 patients with PJI
and 5 patients
Preliminary
Results
undergoing primary arthroplasty (control group) have
been tested.
Samples from
8 patients with PJI
and 5 patients
Preliminary
Results
In
PJI group,
the pathogens
were
S. aureusgroup)
(4 cases),
undergoing
primary
arthroplasty
(control
have
coagulase
negative
Staphylococcus
(2 cases), Strep.
been tested.
Intermedius and Candida tropicalis.
Samples
fromthe
8 patients
withwere
PJI S.
and
5 patients
In PJI group,
pathogens
aureus
(4 cases),
undergoing
primary
arthroplasty
(control
group)
have
The test was
positive
in all PJI cases
negative
in all
coagulase
negative
Staphylococcus
(2and
cases),
Strep.
been
tested.
control cases.and Candida tropicalis.
Intermedius
In
PJI
group,
the pathogens
were S. aureus
(4aureus)
cases),
The
test
has been
done
(both
S.
The test
was
positive
in on
all two
PJI blood
cases(2and
negative
in all
coagulase
negative
Staphylococcus
cases),
Strep.
and
two
periprosthetic
solid
tissue
samples
(S.
aureus
control cases.and Candida tropicalis.
Intermedius
and Candida tropicalis) at the time of reimplantation
and
positive.
The all
testwere
has been
done on two blood (both S. aureus)
The
test was
positive insolid
all PJI
casessamples
and negative
in all
and two
periprosthetic
tissue
(S. aureus
control
cases.
and Candida tropicalis) at the time of reimplantation
and all were positive.
The test has been done on two blood (both S. aureus)
and two periprosthetic solid tissue samples (S. aureus
and Candida tropicalis) at the time of reimplantation
and all were positive.
First Annual AAHKS Spring Meeting | 45
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Symposium II, Periprosthetic Joint Infection
3/16/2016
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Advantages as
diagnostic method

Directly targets the pathogenic bacteria













Advantages as
diagnostic method
Most of the pathogens in PJI can be detected.
Simple
Directly targetsAdvantages
the pathogenic bacteria
as
 Most of the pathogens
in PJI can
detected.
Inexpensive:
(approximate
costbewill
depend on optimization of
diagnostic
method
the method but
can be less than
20 $ for each experiment)
Simple
Directly
Rapid targets the pathogenic bacteria

pathogens
PJI can30-90
detected.
 Most
Time of
of the
reaction
variesin
between
minutes
and
on the of
Inexpensive:
(approximate
costbewill
depend
ondepends
optimization
quantity
PG/βG.
the
methodofbut
can be less than 20 $ for each experiment)
Simple
Potentially
quantitative
Rapid
Inexpensive:
(approximate
cost
willminutes
depend
ondepends
optimization
 Time of reaction
varies between
30-90
and
on the of
Doable
on
synovial
solid
blood
PG/βG.
thequantity
methodofbut
can fluid,
be less
thantissue
20 $ samples
for each and
experiment)


Easy to perform
Potentially
quantitative
Rapid

quantity
PG/βG. fluid, solid tissue samples and blood
Doable
on of
synovial

Potentially
quantitative
Easy to perform

Doable on synovial fluid, solid tissue samples and blood

Easy to perform




In-hospital
& out-patient
Time
of reaction
varies between 30-90 minutes and depends on the
In-hospital & out-patient
In-hospital & out-patient
Issues

Pathogen

Pathogen

Pathogen



Issues
Parvizi et al JBJS 2013
Issues
Parvizi et al JBJS 2013
Parvizi et al JBJS 2013
Is it really infected?
Is it really infected?
Is it really infected?
First Annual AAHKS Spring Meeting | 46
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Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
Novel Molecular System
Novel Molecular System
PLEX-ID
Novel
1) Amplification
PLEX-ID
Molecular System
 Broad identifiction (3100 species)
2) Amplification
Targeted identification (spectrosray)
1)
PLEX-ID
 Broad identifiction (3100 species)
1) Targeted
Characterization
(high resolution
subtyping and drug
2)
identification
(spectrosray)
1) Amplification
resistance)

Broad identifiction
(3100 species)
Pathogen
status
1) Characterization
(high resolution subtyping and drug
Genomes/Well
2) Targeted
identification (spectrosray)
Confidence
resistance)
 mecA gene
Pathogen
status
Rothman Institute of Orthopaedics at
1) Characterization
(high resolution
and drug
Thomas Jeffersonsubtyping
University
Genomes/Well
Confidence
resistance)
 mecA gene
Pathogen status
Rothman Institute of Orthopaedics at
Genomes/Well Thomas Jefferson University
Confidence
 mecA gene
Rothman Institute of Orthopaedics at
Thomas Jefferson University
IBIS 5000: Step 1
Sample Prep and Broad Range PCR
IBIS 5000: Step 1
Sample Prep and Broad Range PCR
IBIS 5000: Step 1
Sample Prep and Broad Range PCR
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
IBIS 5000: Step 2
MS Analysis and Signal Processing
IBIS 5000: Step 2
MS Analysis and Signal Processing
IBIS 5000: Step 2
MS Analysis and Signal Processing
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
First Annual AAHKS Spring Meeting | 47
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Symposium II, Periprosthetic Joint Infection
3/16/2016
3/16/2016
IBIS 5000: Step 3
Triangulation Using Multiple Primers
IBIS 5000: Step 3
Triangulation Using Multiple Primers
Primer #1 Mass
Base Count
Primer
Set Mass
Base
BlueSet
18234.970
A12Count
GCount
17C17T13
Primer
Mass
Base
Blue
18234.970
A12
G17
C17
Blue
17948.926
ACount
CT
T18
Primer
Set Mass
Base
14G14T
1213
Blue
18234.970
A
G
12
17
17
13
Blue
17948.926
A14
GC
C12
TT
Primer
Set Mass
18610.017 Base
AC
GT
Blue Blue
18234.970
A GCount
1114
19C1518
15
Blue
17948.926
Blue
18610.017
Blue
Blue 18234.970
17936.912
Blue
17948.926
Blue
18610.017
Blue
17936.912
Blue
Blue 17948.926
18877.118
Blue
18610.017
Blue
17936.912
Blue
Blue
Primer18610.017
#1 18877.118
Mass
Blue
17936.912
Blue
Primer
Set18877.118
Mass
Blue
17936.912
BlueSet
18234.970
Blue
18877.118
Primer
Mass
Blue
18234.970
Blue
Blue
17948.926
Primer
Set18877.118
Mass
Blue
18234.970
Blue
17948.926
Primer
Set Mass
Blue
18610.017
Blue
18234.970
Blue
17948.926
Blue
18610.017
Blue
Blue 18234.970
17936.912
Blue
17948.926
Blue
18610.017
Blue
17936.912
Blue
Blue 17948.926
18877.118
Blue
18610.017
Blue
17936.912
Primer
#1
Mass
Blue
18877.118
Blue
18610.017
Blue
17936.912
Primer
Set
Mass
Blue
18877.118
BlueSet
18234.970
Blue
17936.912
Primer
Mass
Blue
18877.118
Blue
18234.970
Blue
17948.926
Primer
Set18877.118
Mass
Blue
Blue
18234.970
Blue
17948.926
Primer
Set Mass
Blue
18610.017
Blue
18234.970
Blue
17948.926
Blue
18610.017
Blue
Blue 18234.970
17936.912
Blue
17948.926
Blue
18610.017
Blue
17936.912
Blue
Blue 17948.926
18877.118
Blue
18610.017
Blue
17936.912
Blue
18877.118
Blue
18610.017
Blue
17936.912
Blue
18877.118
Blue
17936.912
Blue
18877.118
Blue
18877.118
12
A14
G14
C12
T18
A17
GT17
C13
A12
11
19
15
AC
G
CT
T14
13
AG
GC
T1718
11C
1615
14
A17
G17
11
19
15
A14
G12
CT15
T
14 14 1112 17
18 16 14
A AGGCACTGT C T
A GG
C TT
IBIS
5000:
Step 3
A AG GACBase
T C Count
A GC CTCount
T
A AG GBase
CACTGT C T
Base
Count
Triangulation
Using
A
G
A Base
G CACount
TGC CT T Multiple Primers
A G C T
18
15
15 13
11 1119 17
15 16
15 14
18
15
15 13
11 1119 17
15 16
15 14
18 15 15 13
11 17 1612 1417 17 13
18 15 15 13
12
17
17
18 15 1514 1314 1213 18
12
17
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C12
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GT
C13
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15T15
AG
GC
14
14
12
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C13
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11
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AC
GT
C18
AG
GC
1112
17
16T14
14
14
18
A17
G17
C13
T15
11
19
15
A
G
C
T14T
A14
G
C
T
11
17
16
18
A11
G19
C1815
T15
15 13
15
A14
GA12
CG
TC14T
11
17
16
A
G
C
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C1815
T15
15 13
15
C
T
11
17
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14
AG
G
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18CA15
12G15
17C13
17T13
A11AG17
16
14
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GT15
18G
13
12
17
17
AC
GTC
CT
T18
14
14T
1213
A18GA15
C
T
G
C
15
13C 13
12
A14
G14
12
A17
G17
CT
T15
A12
1117
19
1518
17
13
AG
GC
CT
T18
14
14
12
A
G
C
T
A12
G
C
T
11
19
15
A
G
C
T14
A14
G14
C1112
T1718
1615
A17
G17
C13
T15
11
19
15
A
G
C
T
A14
11CT17
16 14
G
18
AG
GC
T15
18C
11
19
A14
GA12
TC1415T13
11
17
1615
AC
GT15
A11AG19
18C
15TC15T13
11
17
1615
14
AG
G15
18C
15C15T13
A11AG17
16T14
18G15C15T13
A18G15C15T13
Base Count
Base Count
Base Count
Base Count
Base Count
Base Count
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Rothman Institute of Orthopaedics at
Thomas Jefferson University
Organisms Profile
Organisms Profile
H. influenzae
[A28 G28 C25 T20]
Organisms Profile
H. influenzae
[A28 G28 C25 T20]
S. pyogenes
[A27 G32 H.
C24
T18]
influenzae
[A28 G28 C25 T20]
S. pyogenes
[A27 G32 C24 T18]
S. pyogenes
[A27 G32 C24 T18]
Thank you
Thank you
Thank you
First Annual AAHKS Spring Meeting | 48
19
Symposium II, Periprosthetic Joint Infection
The Role of I&D:
When, How, and What the
The Role of
I&D:
Literature
Tells
Us
When, How, and What the
The Role of
I&D:
Literature
Tells
Us
When, How, and What the
Literature Tells Us
Matthew P. Abdel, M.D.
Associate Professor of Orthopedic Surgery
Mayo
Clinic,P.Rochester,
MN
Matthew
Abdel, M.D.
Associate Professor of Orthopedic Surgery
Mayo Clinic, Rochester, MN
Matthew P. Abdel, M.D.
Associate Professor of Orthopedic Surgery
Mayo Clinic, Rochester, MN
Disclosures
• Individual Disclosures
Disclosures
• BJJ Editorial Board
• JOR Editorial
Board
• Individual
Disclosures
•• JOT
Editorial Board
Board
BJJ Editorial
Disclosures
•• EJOST
Editorial
Board
JOR Editorial
Board
• Individual
Disclosures
•• Minnesota
Orthopedic
Society Board of Directors
JOT Editorial Board
• BJJ
Editorial Board
EJOST Editorial Board
••JOR
Editorial Board
•
Minnesota Research
Orthopedic
Society Board of Directors
• Institutional
Support
• JOT
Editorial Board
•
DePuy-Synthes, Stryker, and Zimmer-Biomet
• EJOST Editorial Board
• Institutional
Support
• Minnesota Research
Orthopedic
Society Board of Directors
• DePuy-Synthes, Stryker, and Zimmer-Biomet
• Institutional Research Support
• DePuy-Synthes, Stryker, and Zimmer-Biomet
Introduction
• Type I: + intraop
cx after presumed aseptic revision
Introduction
intraop
cx after presumed
aseptic
revision
• Type I:
II:+Acute
postoperative
infection
(< 4 weeks)
Introduction
II:+Acute
postoperative
infection
(<
4 weeks)
•• Type
intraop
cx after
presumed
aseptic
revision
Type I:
III:
Late
acute
hematogenous
(<
4 weeks)
III:Acute
Late acute
hematogenous
(<(<
4 weeks)
•• Type
postoperative
infection
4 weeks)
Type II:
IV:
Chronic
infections
(>
4 weeks)
Type III:
IV: Chronic
infections
(> 4 weeks)
•• Type
Late acute
hematogenous
(< 4 weeks)
• Type IV: Chronic infections (> 4 weeks)
First Annual AAHKS Spring Meeting | 49
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1
Symposium II, Periprosthetic Joint Infection
Introduction
• Type I: + intraop
cx after presumed aseptic revision
Introduction
• Type I:
II:+Acute
postoperative
infection
(< 4 weeks)
intraop
cx after presumed
aseptic
revision
Introduction
intraop
cx after
presumed
aseptic
revision
• Type I:
III:
Late
acute
hematogenous
(<
4 weeks)
II:+Acute
postoperative
infection
(<
4 weeks)
II: Acute
postoperative
4 weeks)
• Type IV:
Chronic
infections
(>infection
4 weeks)
III:
Late acute
hematogenous
(< (<
4 weeks)
III:Chronic
Late acute
hematogenous
(< 4 weeks)
• Type IV:
infections
(> 4 weeks)
• Type IV: Chronic infections (> 4 weeks)
Outline
Outline
Outline
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
Outline
Outline
Outline
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
First Annual AAHKS Spring Meeting | 50
2
2
Symposium II, Periprosthetic Joint Infection
Outline
Outline
Outline
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
Outline
Outline
Outline
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
Outline
Outline
Outline
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
First Annual AAHKS Spring Meeting | 51
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3
Symposium II, Periprosthetic Joint Infection
Case 1
61 YOF, 2 Wks s/p R THR, c/o Fevers
Case 1
61 YOF, 2 Wks s/p R THR, c/o Fevers
Case 1
61 YOF, 2 Wks s/p R THR, c/o Fevers
ESR 54 mm/hr
CRP 121 mg/L
WBC
ESR
5423,795
mm/hr
89%
PMNs
CRP
121
mg/L
Cx: ßWBC
hemolytic
23,795strep
ESR 54 mm/hr
89% PMNs
CRP 121 mg/L
Cx: ß hemolytic strep
WBC 23,795
89% PMNs
Cx: ß hemolytic strep
Case 1
61 YOF, 2 Wks s/p R THR, c/o Fevers
Case 1
61 YOF, 2 Wks s/p R THR, c/o Fevers
Case 1
61 YOF, 2 Cx:
Wks
s/p R THR,
ß hemolytic
strep c/o Fevers

I&D,
Bead Placement,
Cx:
ß hemolytic
strep
Head/Liner Exchange
Preop
Preop
Preop
 I&D, Bead Placement,
Cx: ß hemolytic strep
Head/Liner Exchange
 IV Abx Choice?
 PO Suppression?
 I&D, Bead Placement,
Head/Liner Exchange
 IV Abx Choice?
 PO Suppression?
 IV Abx Choice?
 PO Suppression?
Postop
Postop
Postop
Antibiotics
Type II or III Infections
Antibiotics
Type II or III Infections
Before
Incision
Before
Incision
Before
Incision
Antibiotics
After
Special
Surgery
Circumstances
Type II or III Infections
After
Special
Surgery
Circumstances
After
Surgery
Special
Circumstances
* Mihalko et al. AAOS ICL. 2008
* Leone and Hanssen. AAOS ICL. 2006
* Mihalko et al. AAOS ICL. 2008
* Leone and Hanssen. AAOS ICL. 2006
* Mihalko et al. AAOS ICL. 2008
* Leone and Hanssen. AAOS ICL. 2006
First Annual AAHKS Spring Meeting | 52
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4
Symposium II, Periprosthetic Joint Infection
Antibiotics
Type II or III Infections
Antibiotics
Type II or
III Infections
Before
Incision
Antibiotics
+ Preop Organism
IDor
- Preop Organism ID
Type II
III Infections
Before
Incision
+ Preop Organism ID Before - Preop Organism ID
Incision
Abx (Cx & Sensitivity)
Hold Abx
Rarely cultures
have- returned
+ Preop Organism
ID
Preop Organism ID
Treat with broad spectrum antibiotics (Staph & Strep)
Abx (Cx & Sensitivity)
Hold Abx
Rarely cultures have returned
Treat with broad spectrum antibiotics (Staph & Strep)
Abx (Cx & Sensitivity)
Hold Abx
Rarely cultures have returned
Treat with broad spectrum antibiotics (Staph & Strep)
Antibiotics
Type II or III Infections
Antibiotics
Type II
or III
Infections
After
Surgery
Antibiotics
Tailor to CxType
and II
4-6 weeks of IV Abx
or III
Infections
After
Surgery
Sensitivity
± PO Abx
Tailor to Cx and After Surgery
4-6 weeks of IV Abx
Sensitivity
± PO Abx
Close
coordination
with4-6
ID specialist
Tailor
to Cx
and
weeks of IV Abx
Sensitivity
±et PO
Abx
* Mihalko
al. AAOS
ICL. 2008
* Leone and Hanssen. AAOS ICL. 2006
Close coordination with ID specialist
* Mihalko et al. AAOS ICL. 2008
* Leone and Hanssen. AAOS ICL. 2006
Close coordination with ID specialist
* Mihalko et al. AAOS ICL. 2008
* Leone and Hanssen. AAOS ICL. 2006
Antibiotics
Type II or III Infections
Antibiotics
Type II or
III Infections
Special
Circumstances
Antibiotics
Oral, GI, Type
GU II or
High Risk for MRSA
III Infections
Special
Circumstances
Oral, GI, GU
Special High Risk for MRSA
Circumstances
Include GN Coverage
Add Vancomycin
Oral, GI, GU
High Risk for MRSA
Include GN Coverage
* Mihalko et al. AAOS ICL. 2008
* Leone and Hanssen. AAOS ICL. 2006
Include GN Coverage
* Mihalko et al. AAOS ICL. 2008
* Leone and Hanssen. AAOS ICL. 2006
Add Vancomycin
Add Vancomycin
* Mihalko et al. AAOS ICL. 2008
* Leone and Hanssen. AAOS ICL. 2006
First Annual AAHKS Spring Meeting | 53
5
5
Symposium II, Periprosthetic Joint Infection
Case 1
61 YOF, 2 Wks s/p R THR, c/o Fevers
Case 1
61 YOF, 2 Wks s/p R THR, c/o Fevers
Case 1
61 YOF, 2 Wks s/p R THR, c/o Fevers
ESR 54 mm/hr
CRP 121 mg/L
WBC 23,795
ESR 54 mm/hr
89% PMNs
CRP 121 mg/L
Cx: ß hemolytic strep
WBC 23,795
ESR 54 mm/hr
89% PMNs
CRP 121 mg/L
Cx: ß hemolytic strep
WBC 23,795
89% PMNs
Cx: ß hemolytic strep
Case 1
61 YOF, 2 Wks s/p R THR, c/o Fevers
Case 1
61 YOF, 2 Wks s/p R THR, c/o Fevers
61 YOF,
Preop
Preop
Case 1
PMH: Contralateral THA
BMI = 62 kg/m2
2 Cx:
Wks
s/p R THR,
ß hemolytic
strep c/o
PMH: Contralateral THA
BMI = 62 kg/m2
 I&D, Bead Placement,
Cx: ß hemolytic strep
Head/Liner Exchange
PMH:Contralateral
IV CeftriaxoneTHA
BMI
=
kg/m2

PO62
Duricef
 I&D, Bead
Placement,
Cx: ß hemolytic
strep
Head/Liner Exchange
 IV Ceftriaxone
 Bead
PO Duricef
 I&D,
Placement,
Head/Liner Exchange
 IV Ceftriaxone
 PO Duricef
Preop
Fevers
Postop
Postop
Postop
Case 1
61 YOF, 2 Wks s/p R THR, c/o Fevers
Case 1
61 YOF, 2 Wks s/p R THR, c/o Fevers
61 YOF,
Preop
Preop
Preop
Case 1
PMH: Contralateral THA
BMI = 62 kg/m2
2 Cx:
Wks
s/p R THR,
ß hemolytic
strep c/o
PMH: Contralateral THA
BMI = 62 kg/m2
 I&D, Bead Placement,
Cx: ß hemolytic strep
Head/Liner Exchange
PMH:Contralateral
THA
IV Ceftriaxone
BMI
=
62
kg/m2

PO
Duricef
 I&D, Bead Placement,
Cx: ß hemolytic strep
Head/Liner Exchange
 IV Ceftriaxone
 Bead
PO Duricef
 I&D,
Placement,
Head/Liner Exchange
 IV Ceftriaxone
 PO Duricef
Fevers
2 Years
ESR 3
CRP < 3
2 Years
ESR 3
CRP < 3
2 Years
ESR 3
CRP < 3
First Annual AAHKS Spring Meeting | 54
6
6
Symposium II, Periprosthetic Joint Infection
Outline
Outline
Outline
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
Case 2
52 YOF, 2 Yrs s/p L TKR
Acute Pain, Recent
Case 2Colonoscopy
mm/hr
52 YOF,ESR
2 72
Yrs
s/p L TKR
CRP 333 mg/L
Acute Pain, Recent
Case
2Colonoscopy
WBC 27,598
ESR
72
mm/hr
52 YOF, 70%
2 Yrs
s/p L TKR
PMNs
333 mg/L
Acute Pain,CRP
Recent
Colonoscopy
WBC
ESR
7227,598
mm/hr
70%
PMNs
CRP
333
mg/L
WBC 27,598
70% PMNs
Case 2
52 YOF, 2 Days of Pain, Colonoscopy
Case 2
52 YOF, 2 Days of Pain, Colonoscopy
Case 2
52 YOF, 2 Days of Pain, Colonoscopy
Cx: Enterococcus
Cx: Enterococcus
Preop
Cx: Enterococcus
Preop
Preop
First Annual AAHKS Spring Meeting | 55
7
7
Symposium II, Periprosthetic Joint Infection
Timing
Total Hip Replacement
• Crockarell et al, JBJSTiming
Am, 1988
Total
Hip
Replacement
• Successful
with
head/liner
exchanges
Timing
• Crockarell et al, JBJS
Am, 1988
Total
Hip
Replacement
• Successful with head/liner
exchanges
completed < 2 weeks from onset of symptoms
completed < 2 weeks from onset of symptoms
• Crockarell et al, JBJS Am, 1988
• Successful with head/liner exchanges
completed < 2 weeks from onset of symptoms
Timing
Total Knee Replacement
Timing
• Schoifet and Morrey, JBJS Am, 1990
Totalwith
Knee
Replacement
• 77% failure
I&D and
poly exchange
• All failures in those
with > 28 days of symptoms
Timing
• Schoifet and Morrey, JBJS Am, 1990
Knee Replacement
• 77% Total
failure with I&D and poly exchange
• Brandt et al, Clinical ID, 1997
• All failures in those with > 28 days of symptoms
• > 2 days
failures
rates with S. aureus
• Schoifet
and increased
Morrey, JBJS
Am, 1990
• 77% failure with I&D and poly exchange
• Brandt
et al, Clinical ID, 1997
• All failures
in Clinical
those with
28 days of symptoms
• Marculescu
et al,
ID, >
2006
• > 2 days increased failures rates with S. aureus
• > 8 days increased failure rates
• Brandt et al, Clinical ID, 1997
• Marculescu
al, Clinical ID, 2006
• > 2 daysetincreased
failures rates with S. aureus
• > 8 days increased failure rates
• Marculescu et al, Clinical ID, 2006
• > 8 days increased failure rates
Timing
Acute Hematogenous Infections
Timing
Acute Hematogenous Infections
0 Days
2 Days
14 Days
Timing
0 Days
2 Days
14 Days
Acute Hematogenous Infections
0 Days
S. aureus
2 Days
14Organisms
Days
Gram +
S. aureus
Gram + Organisms
S. aureus
Gram + Organisms
First Annual AAHKS Spring Meeting | 56
8
8
Symposium II, Periprosthetic Joint Infection
Timing
Acute Postoperative Infections
Timing
Acute Postoperative Infections
0 Days
2 Days
14 Days
Timing
28 Days
14 Days
28 Days
Acute Postoperative Infections
0 Days
0 Days
2 Days
S. aureus
2 Days
S. aureus
S. aureus
Days
28 Days
Gram 14
+ Organisms
Index
Gram + Organisms Procedure
Index
Gram + Organisms Procedure
Index
Procedure
Case 2
52 YOF, 2 Yrs s/p L TKR
Acute Pain, Recent
Case 2Colonoscopy
ESR 72 mm/hr
52 YOF,CRP
2 333
Yrsmg/L
s/p L TKR
Acute Pain, Recent
Case
2Colonoscopy
WBC 27,598
ESR 72 mm/hr
52 YOF, 70%
2 Yrs
s/p L TKR
PMNs
333 mg/L
Acute Pain,CRP
Recent
Colonoscopy
WBC
ESR
7227,598
mm/hr
70%
PMNs
CRP 333
mg/L
WBC 27,598
70% PMNs
Case 2
52 YOF, 2 Days of Pain, Colonoscopy
Case 2
52 YOF, 2 Days of Pain, Colonoscopy
52 YOF,
Preop
Preop
Preop
Case 2
PMH: Contralateral TKR
BMI = 59 kg/m2
2 Days
of Pain, Colonoscopy
Cx: Enterococcus
PMH: Contralateral TKR
BMI = 59 kg/m2
 I&D
Poly Exchange
Cx: with
Enterococcus
IV VancomycinTKR
PMH: Contralateral
 PO
BMI
=Amoxicillin
59 kg/m2
Cx: with
Enterococcus
 I&D
Poly Exchange
Postop
 IV Vancomycin
 PO Amoxicillin
 I&D with Poly Exchange
 IV Vancomycin
 PO Amoxicillin
Postop
Postop
First Annual AAHKS Spring Meeting | 57
9
9
Symposium II, Periprosthetic Joint Infection
Outline
Outline
Outline
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
Case 3
78 YOM, 3.5 Weeks s/p L THR, c/o Pain
Case 3
78 YOM, 3.5 Weeks s/p L THR, c/o Pain
Case 3
78 YOM, 3.5 Weeks s/p L THR, c/o Pain
ESR 47 mm/hr
CRP 186 mg/L
ESR 47 mm/hr
CRP 186 mg/L
ESR 47 mm/hr
CRP 186 mg/L
Case 3
78 YOM, 3.5 Weeks s/p L THR, c/o Pain
Case 3
78 YOM, 3.5 Weeks s/p L THR, c/o Pain
Case 3
PMH: DM, RA, smoker
78 YOM, 3.5
s/pstrep
L THR, c/o Pain
Cx:Weeks
ß hemolytic
PMH: DM, RA, smoker
Cx: ß hemolytic strep
PMH: DM, RA, smoker
Cx: ß hemolytic strep
Preop
Preop
Preop
First Annual AAHKS Spring Meeting | 58
10
10
Symposium II, Periprosthetic Joint Infection
Surgical Management
• Antibiotic Suppression (<20%, infirm)
Surgical Management
•• I&D
with Modular
Exchange
Antibiotic
Suppression
(<20%, infirm)
• Open
Surgical
Management
• Arthroscopic
• I&D
with Modular
Exchange
Antibiotic
Suppression
(<20%, infirm)
• Open
• Acute
One-Stage Exchange
• Arthroscopic
• I&D with Modular Exchange
• Open
•• Two-Stage
Exchange
Acute
One-Stage
Exchange
• Arthroscopic
•• Resection
Arthroplasty
Two-Stage
Exchange
Acute One-Stage
Exchange
• Resection
Two-StageArthroplasty
Exchange
• Resection Arthroplasty
Surgical Management
• Antibiotic Suppression
Surgical Management
•• Antibiotic
I&D with Modular
Exchange
Suppression
• Open
Surgical
Management
• Arthroscopic
(limited role; TKA)
• I&D
with Modular
Exchange
Antibiotic
Suppression
• Open
• Acute
One-Stage (limited
Exchange
• Arthroscopic
role; TKA)
• I&D with Modular Exchange
• Open
•• Two-Stage
Exchange
Acute
One-Stage
Exchange
• Arthroscopic
(limited
role; TKA)
•• Resection
Arthroplasty
Two-Stage
Exchange
Acute One-Stage
Exchange
• Resection
Two-StageArthroplasty
Exchange
• Resection Arthroplasty
Surgical Management
• Antibiotic Suppression
Surgical Management
•• Antibiotic
I&D with Modular
Exchange
Suppression
• Open
Surgical
Management
• Arthroscopic
• I&D
with Modular
Exchange
Antibiotic
Suppression
• Open
• Acute
One-Stage Exchange (hip)
• Arthroscopic
• I&D with Modular Exchange
• Open
•• Two-Stage
Exchange
Acute
One-Stage
Exchange (hip)
• Arthroscopic
•• Resection
Arthroplasty
Two-Stage
Exchange
Acute One-Stage
Exchange (hip)
• Resection
Two-StageArthroplasty
Exchange
• Resection Arthroplasty
First Annual AAHKS Spring Meeting | 59
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11
Symposium II, Periprosthetic Joint Infection
Surgical Management
• Antibiotic Suppression
Surgical Management
•• I&D
with Modular Exchange
Antibiotic Suppression
• Open
Surgical Management
• Arthroscopic
•• I&D
with Modular
Exchange
Antibiotic
Suppression
• Open
• Acute
One-Stage Exchange
• Arthroscopic
• I&D with Modular Exchange
• Open Exchange
•• Two-Stage
Acute
One-Stage Exchange
• Arthroscopic
•• Resection
Arthroplasty
Exchange
• Two-Stage
Acute One-Stage
Exchange
•• Resection
Two-StageArthroplasty
Exchange
• Resection Arthroplasty
Surgical Management
• Antibiotic Suppression
Surgical Management
•• I&D
with Modular Exchange
Antibiotic Suppression
• Open
Surgical Management
• Arthroscopic
•• I&D
with Modular
Exchange
Antibiotic
Suppression
• Open
• Acute
One-Stage Exchange
• Arthroscopic
• I&D with Modular Exchange
• Open Exchange
•• Two-Stage
Acute
One-Stage Exchange
• Arthroscopic
•• Resection
Arthroplasty
Exchange
• Two-Stage
Acute One-Stage
Exchange
•• Resection
Two-StageArthroplasty
Exchange
• Resection Arthroplasty
Surgical Management
Total Hip Replacement
Infected
THR
Surgical
Management
Acute (Type II or Type III)
Total
Hip Replacement
Infected
THR
Surgical
Management
Acute (Type II or Type III)Resection Arthroplasty
Total
Hip Replacement
Antibiotic Suppression
Infected THR
Acute (Type II or Type III)Resection Arthroplasty
Antibiotic Suppression
Irrigation & Debridement
+ Head/Liner Exchange
Two-Stage Exchange
Antibiotic Suppression
Irrigation & Debridement
+ Head/Liner Exchange
Irrigation & Debridement
+ Head/Liner Exchange
Resection Arthroplasty
Acute One-Stage
Exchange
Acute One-Stage
Exchange
Acute One-Stage
Exchange
Two-Stage Exchange
* Hansen et al. CORR. 2013
Two-Stage Exchange
* Hansen et al. CORR. 2013
* Hansen et al. CORR. 2013
First Annual AAHKS Spring Meeting | 60
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Symposium II, Periprosthetic Joint Infection
Important Difference
Important Difference
Important Difference
≠
≠
≠
Mode of Fixation
Modecemented
of Fixation
• TKAs: Mostly
Modecemented
of Fixation
• TKAs: Mostly
• TKAs: Mostly cemented
• THAs: Mostly uncemented
• THAs: Mostly uncemented
• THAs: Mostly uncemented
Surgical Management
Total Knee Replacement
Infected
TKR
Surgical
Management
Acute (Type II or Type III)
Total
Knee Replacement
Surgical
Management
Infected
TKR
Acute
(Type II
or Type III)Resection Arthroplasty
Total
Knee
Replacement
Antibiotic Suppression
Infected TKR
Acute (Type II or Type III)
Antibiotic Suppression
Resection Arthroplasty
Irrigation & Debridement
+ Poly Exchange
Antibiotic Suppression
Irrigation & Debridement
+ Poly Exchange
Irrigation & Debridement
+ Poly Exchange
Two-Stage Exchange
Resection Arthroplasty
Acute One-Stage
Exchange
Acute One-Stage
Exchange
Two-Stage Exchange
Two-Stage Exchange
Acute One-Stage
Exchange
First Annual AAHKS Spring Meeting | 61
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13
Symposium II, Periprosthetic Joint Infection
Mayo Protocol
• Favor open I&D with component retention in patients
• Short-livedMayo
symptomsProtocol
• Intact soft tissue envelope
• Favor
open I&Dwell-functioning
with componentjoint
retention
in patients
• Previously
is a must
Protocol
• Short-livedMayo
symptoms
• Intact soft tissue envelope
Favordebridement
open I&D with
component
retention
in
•• Open
allows
for the
exchange
of patients
modular
• Previously
well-functioning
joint
is a must
components
andsymptoms
improved joint access for synovectomy
• Short-lived
• Intact soft tissue envelope
• Open
debridement
allows for thejoint
exchange
of modular
• Previously
well-functioning
is a must
• The
results may
with
the
addition
of Rifampin
components
andimprove
improved
joint
access
for synovectomy
in certain biofilm-producing infections (Staph)*
• Open debridement allows for the exchange of modular
• The
results may
with
theaccess
addition
Rifampin
components
andimprove
improved
joint
for of
synovectomy
in certain biofilm-producing infections
(Staph)*
* Zimmerli W et al. JAMA 1998
• The results may improve with the addition of Rifampin
in certain biofilm-producing infections (Staph)*
* Zimmerli W et al. JAMA 1998
* Zimmerli W et al. JAMA 1998
SURGICAL
TECHNIQUE
SURGICAL
TECHNIQUE
SURGICAL
TECHNIQUE
1. Ellipse Previous Incision
1. Ellipse Previous Incision
1. Ellipse Previous Incision
First Annual AAHKS Spring Meeting | 62
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Symposium II, Periprosthetic Joint Infection
1. Ellipse Previous Incision
1. Ellipse Previous Incision
1. Ellipse Previous Incision
2. Full Thickness Flaps
2. Full Thickness Flaps
2. Full Thickness Flaps
3. Modular Junction Exchange
3. Modular Junction Exchange
HIP
3. Modular Junction Exchange
HIP
HIP
KNEE
KNEE
KNEE
First Annual AAHKS Spring Meeting | 63
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Symposium II, Periprosthetic Joint Infection
4. Five Cultures
Synovium and Peri-Implant Tissue
4. Five Cultures
Synovium and Peri-Implant Tissue
4. Five Cultures
Synovium and Peri-Implant Tissue
Sonication of Removed Hip and Knee
Prostheses for Diagnosis of Infection
Andrej Trampuz, M.D., Kerryl E. Piper, M.S., Melissa J. Jacobson, A.S., Arlen
Sonication
of
Removed
HipR. Osmon,
andM.D.,
Knee
D. Hanssen, M.D.,
Krishnan
K. Unni, M.D., Douglas
Jayawant N. Mandrekar, Ph.D., Franklin R. Cockerill, M.D., James M.
Prostheses
Diagnosis
of
Infection
Steckelberg, M.D.,for
James F.
Greenleaf, Pxh.D., and
Robin
Patel, M.D.
Andrej Trampuz, M.D., Kerryl E. Piper, M.S., Melissa J. Jacobson, A.S., Arlen
Sonication
of
Removed
HipR. Osmon,
andM.D.,
Knee
D. Hanssen, M.D.,
Krishnan
K. Unni, M.D., Douglas
Jayawant N. Mandrekar, Ph.D., Franklin R. Cockerill, M.D., James M.
Prostheses
Diagnosis
of
Infection
Steckelberg, M.D.,for
James F.
Greenleaf, Pxh.D., and
Robin
Patel, M.D.
Andrej Trampuz, M.D., Kerryl E. Piper, M.S., Melissa J. Jacobson, A.S., Arlen
D. Hanssen, M.D., Krishnan K. Unni, M.D., Douglas R. Osmon, M.D.,
N Engl
J Med N. Mandrekar, Ph.D., Franklin R. Cockerill, M.D., James M.
Jayawant
Volume 357(7):654-663
Steckelberg, M.D., James F. Greenleaf, Pxh.D., and Robin Patel, M.D.
August 16, 2007
N Engl J Med
Volume 357(7):654-663
August 16, 2007
N Engl J Med
Volume 357(7):654-663
August 16, 2007
5. Frozen Section
>5 WBC/hpf*
5. Frozen Section
>5 WBC/hpf*
5. Frozen Section
>5 WBC/hpf*
* Feldman et al. JBJS. 1995
* Musso et al. Post Grad Med. 2003
* Feldman et al. JBJS. 1995
* Musso et al. Post Grad Med. 2003
* Feldman et al. JBJS. 1995
* Musso et al. Post Grad Med. 2003
First Annual AAHKS Spring Meeting | 64
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Symposium II, Periprosthetic Joint Infection
6. Complete Debridement
6. Complete Debridement
6. Complete Debridement
7. Inspect Interfaces
7. Inspect Interfaces
7. Inspect Interfaces
8. Irrigation
8. Irrigation
8. Irrigation
* Brown et al. JOA. 2012
* Brown et al. JOA. 2012
* Brown et al. JOA. 2012
First Annual AAHKS Spring Meeting | 65
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Symposium II, Periprosthetic Joint Infection
9. Repeat Debridement
9. Repeat Debridement
9. Repeat Debridement
10. New Instruments, Drain,
and Closure
10. New Instruments, Drain,
and Closure
10. New Instruments, Drain,
and Closure
Infected THAs: Are We Doing
Better with Modern Treatment
Infected THAs: Are We Doing
Better with Modern Treatment
Infected THAs: Are We Doing
Better with Modern Treatment
Andrew J. Bryan, M.D.
Matthew P. Abdel, M.D.
Steven J. Fitzgerald, M.D.
Andrew
J. Bryan, M.D.
Arlen
D. Hanssen,
M.D.
Matthew
Abdel,M.D.
M.D.
Daniel J.P.Berry,
Steven J. Fitzgerald, M.D.
Andrew
J. Bryan, M.D.
Arlen
D. Hanssen,
M.D.
Matthew
Abdel,M.D.
M.D.
Daniel J.P.Berry,
Steven J. Fitzgerald, M.D.
Arlen D. Hanssen, M.D.
Daniel J. Berry, M.D.
First Annual AAHKS Spring Meeting | 66
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Symposium II, Periprosthetic Joint Infection
Infected THA
Questions
Infected THA
• What are modern
Questions
results of I&D?
Infected THA
• What are modern
Questions
results of I&D?
•• Are
we
doing
any
What
are
modern
better than in the
results of I&D?
• past?
Are we doing any
better than in the
• past?
Are we doing any
better than in the
past?
Infected THA
Infected THA
Infected THA
Infected THA
Methods
• All I&D with implant
retention
for deep
Infected
THA
infection after primary
hip replacement at Mayo
Methods
• All I&D with implant
retention
for deep
Infected
THA
after primary
hip replacement at Mayo
• infection
2000-2008
Methods
• All I&D with implant retention for deep
• infection
2000-2008
90 hips after primary hip replacement at Mayo
2000-2008
• 90
hips
• 90 hips
Infected THA
Demographics
Infected THA
• Early postop infection:
73%
Demographics
Infected THA
Early postop
infection:
73%
• Acute
hematogenous:
27%
Demographics
Early postop
infection:
73%
Acute
hematogenous:
27%
•• Treatment
: I&D
 PE liner/head
exchange
Acute hematogenous:
27%
• Treatment
: I&D  PE liner/head
exchange
• Treatment : I&D  PE liner/head exchange
First Annual AAHKS Spring Meeting | 67
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Symposium II, Periprosthetic Joint Infection
Infected THA
Demographics
Infectedafter
THA
• Postop abx suppression
I&D = 84% hips
Demographics
Infected THA
• Postop
abx suppression
Mean followup
= 6 yearsafter I&D = 84% hips
Demographics
•• Postop
abx suppression
Mean followup
= 6 yearsafter I&D = 84% hips
• Mean followup = 6 years
Infected THA
Results
Infected THA
• Overall failureResults
rate for recurrent
Infected THA
infection =
Results
• Overall failure
for recurrent
10%rate
(9/90)*
infection =
• Overall failure
for recurrent
10%rate
(9/90)*
infection =
*Lower10%
than most
previous series
(9/90)*
*Lower than most previous series
*Lower than most previous series
Infected THA
Results
Recurrent Infections
(stratified):
Infected
THA
• Acute postop infection:
Results13% vs.
Infected
THA
Recurrent Infections
(stratified):
•• Acute
hematogenous: 9%
Acute postop infection:
Results13% vs.
Recurrent Infections (stratified):
•• Acute
Acute hematogenous:
postop infection:9%
13% vs.
• Acute hematogenous: 9%
No Significant Difference
No Significant Difference
No Significant Difference
First Annual AAHKS Spring Meeting | 68
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Symposium II, Periprosthetic Joint Infection
Infected THA
Discussion
Infected THA
Why might results be better than previous
series?
Discussion
Infected THA
Why might results be better than previous
Discussion
series? reasons:
• Possible
- Rigorous
criteria
I&Dthan
alone
(MSIS)
Why
might results
be for
better
previous
series?
Most
patients
on
suppressive
antibiotics
• Possible reasons:
-- Improved
antibiotics
(rifampin,
etc)
Rigorous criteria
for I&D
alone (MSIS)
Mid-term
follow-up
- Most patients
• Possible
reasons:on suppressive antibiotics
- Improved
antibiotics
(rifampin,
etc)
Rigorous criteria
for I&D
alone (MSIS)
- Most
Mid-term
follow-up
patients
on suppressive antibiotics
- Improved antibiotics (rifampin, etc)
- Mid-term follow-up
Contemporary Results
I&D with Component Retention
Contemporary Results
I&D with Component Retention
Contemporary Results
• 42 patients
• 76% success at 2 years
I&D
with Component Retention
• 96%
for non-staphylococcal infections
• 42 patients
• 76% success at 2 years
• 96% for non-staphylococcal infections
• 42 patients
• 76% success at 2 years
96%
for non-staphylococcal infections
•• 26
patients
• 77% success at 5 years
• 26 patients
• 77% success at 5 years
• 26 patients
• 77% success at 5 years
Case 3
78 YOM, 3.5 Weeks s/p L THR, c/o Pain
Case 3
78 YOM, 3.5 Weeks s/p L THR, c/o Pain
Case 3
78 YOM, 3.5 Weeks s/p L THR, c/o Pain
ESR 47 mm/hr
CRP 186 mg/L
ESR 47 mm/hr
CRP 186 mg/L
ESR 47 mm/hr
CRP 186 mg/L
First Annual AAHKS Spring Meeting | 69
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Symposium II, Periprosthetic Joint Infection
Case 3
78 YOM, 3.5 Weeks s/p L THR, c/o Pain
Case 3
78 YOM, 3.5 Weeks s/p L THR, c/o Pain
Case 3
PMH: DM, RA, smoker
78 YOM, 3.5
s/pstrep
L THR, c/o Pain
Cx:Weeks
ß hemolytic
PMH: DM, RA, smoker
Preop
Preop
Cx:
Acute
1-Stage Exchange
ß hemolytic
strep
 IV Ceftriaxone
 PO Duricef
PMH: DM, RA, smoker
 Acute 1-Stage Exchange
Cx: ß hemolytic strep
 IV Ceftriaxone
 PO Duricef
1 Year
 Acute 1-Stage Exchange
 IV Ceftriaxone
 PO Duricef
1 Year
Preop
1 Year
Outline
Outline
Outline
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
#1:
Antibiotics
#2: Timing
#3:
Surgical
Treatment
#4: Results
Results
Author
Journal
Year
# of Pts
FU
Success
Koyonos
CORR
2011
136
54 mos
35%
Results
Choi
CORR
2011
32
Odum
Author
Zmistowski
Koyonos
JOA
Journal
JOA
CORR
2011
Year
2011
2011
150
# of Pts
104
136
Choi
Azzam
Odum
Bradbury
Author
Zmistowski
Salgado
Koyonos
CORR
JOA
JOA
JOA
Journal
JOA
CORR
CORR
2011
2010
2011
2009
Year
2011
2007
2011
32
19
150
20of Pts
#
104
20
136
Marculescu
Choi
Azzam
Deirmengian
Odum
Bradbury
Silva
Zmistowski
Salgado
Segawa
Marculescu
Azzam
Wasielewski
Deirmengian
Bradbury
Kramhoft
Silva
Salgado
Teeny
Segawa
Marculescu
Schoifet
Wasielewski
Deirmengian
Kramhoft
Silva
Teeny
Segawa
Schoifet
Wasielewski
Clin ID
CORR
JOA
CORR
JOA
JOA
CORR
JOA
CORR
JBJS
Clin ID
JOA
CORR
JOA
CORR
CORR
JOA
JBJS
Clin ID
JBJS
JOA
CORR
JOA
CORR
JOA
JBJS
JBJS
JOA
2006
2011
2010
2003
2011
2009
2002
2011
2007
1999
2006
2010
1996
2003
2009
1994
2002
2007
1990
1999
2006
1990
1996
2003
1994
2002
1990
1999
1990
1996
99
32
19
31
150
20
530
104
20
10
99
19
10
31
20
27
530
20
21
10
99
31
10
31
27
530
21
10
31
10
Kramhoft
JOA
1994
27
Teeny
JOA
1990
21
4 yrs
29%
Schoifet
JBJS
1990
31
3 yrs
23%
Results
36 mos
FU
54 mos
36 mos
5.7 yrs
Min 2 yrs
FU
54 mos
2 yrs
36
5.7 mos
yrs
4 yrs
Min 2 yrs
3.7 yrs
2 yrs
5.7
yrs
32 months
4 yrs
Min 2 yrs
4 yrs
3.7 yrs
2 yrs
3
32 months
4 yrs
4 yrs
3.7 yrs
3 yrs
32 months
31%
31%
Success
GN = 70%
35%
MSSA = 33%
31%
44%
31%
16%
Success
GN = 70%
33%
35%
MSSA = 33%
60%
31%
44%
35%
31%
16%
33%
GN
33%= 70%
MSSA
50% = 33%
60%
44%
75%
35%
16%
19%
33%
33%
29%
50%
60%
23%
75%
35%
19%
33%
29%
50%
23%
75%
19%
First Annual AAHKS Spring Meeting | 70
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Symposium II, Periprosthetic Joint Infection
Results
Author
Journal
Year
# of Pts
FU
Success
Koyonos
CORR
2011
136
54 mos
35%
Results
Choi
CORR
2011
32
Odum
Author
Zmistowski
Koyonos
JOA
Journal
JOA
CORR
2011
Year
2011
2011
150
# of Pts
104
136
Choi
Azzam
Odum
Bradbury
Author
Zmistowski
Salgado
Koyonos
CORR
JOA
JOA
JOA
Journal
JOA
CORR
CORR
2011
2010
2011
2009
Year
2011
2007
2011
32
19
150
20of Pts
#
104
20
136
Marculescu
Choi
Azzam
Deirmengian
Odum
Bradbury
Silva
Zmistowski
Salgado
Segawa
Marculescu
Azzam
Wasielewski
Deirmengian
Bradbury
Kramhoft
Silva
Salgado
Teeny
Segawa
Marculescu
Schoifet
Wasielewski
Deirmengian
Kramhoft
Silva
Teeny
Segawa
Schoifet
Wasielewski
Clin ID
CORR
JOA
CORR
JOA
JOA
CORR
JOA
CORR
JBJS
Clin ID
JOA
CORR
JOA
CORR
CORR
JOA
JBJS
Clin ID
JBJS
JOA
CORR
JOA
CORR
JOA
JBJS
JBJS
JOA
2006
2011
2010
2003
2011
2009
2002
2011
2007
1999
2006
2010
1996
2003
2009
1994
2002
2007
1990
1999
2006
1990
1996
2003
1994
2002
1990
1999
1990
1996
99
32
19
31
150
20
530
104
20
10
99
19
10
31
20
27
530
20
21
10
99
31
10
31
27
530
21
10
31
10
Kramhoft
JOA
1994
27
Teeny
JOA
1990
21
4 yrs
29%
Schoifet
JBJS
1990
31
3 yrs
23%
Results
36 mos
FU
54 mos
36 mos
5.7 yrs
Min 2 yrs
FU
54 mos
2 yrs
36
5.7 mos
yrs
4 yrs
Min 2 yrs
3.7 yrs
2 yrs
5.7
yrs
32 months
4 yrs
Min 2 yrs
4 yrs
3.7 yrs
2 yrs
3
32 months
4 yrs
4 yrs
3.7 yrs
3 yrs
32 months
31%
31%
Success
GN = 70%
35%
MSSA = 33%
31%
44%
31%
16%
Success
GN = 70%
33%
35%
MSSA = 33%
60%
31%
44%
35%
31%
16%
33%
GN
33%= 70%
MSSA
50% = 33%
60%
44%
75%
35%
16%
19%
33%
33%
29%
50%
60%
23%
75%
35%
19%
33%
29%
50%
23%
75%
19%
Results
Results
Results
Success is ~ 60%
in selected patients
Range of 19% - 83%
Success is ~ 60% in selected patients
Range of 19% - 83%
Success is ~ 60% in selected patients
Range of 19% - 83%
Case 4
56 YOM, 4 Yrs s/p R TKR, 7 Days Pain
H/o Kidney
CaseTransplant
4
ESR 67
56 YOM,
4 mm/hr
Yrs s/p R TKR, 7 Days Pain
H/o
Kidney
CRP
91 mg/L
CaseTransplant
4
WBC
48,494
ESR 67
56 YOM,
4 mm/hr
Yrs s/p R TKR, 7 Days Pain
86%
CRP
91PMNs
mg/L
H/o
Kidney Transplant
Cx:
WBC
48,494
ESR
67MRSA
mm/hr
86%
PMNs
CRP 91 mg/L
Cx: MRSA
WBC
48,494
86% PMNs
Cx: MRSA
First Annual AAHKS Spring Meeting | 71
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Symposium II, Periprosthetic Joint Infection
Case 4
52 YOM, 7 Days of Pain, Transplant, MRSA
Case 4
52 YOM, 7 Days of Pain, Transplant, MRSA
52 YOM, 7
Preop
Case 4
PMH: Kidney Transplant
Immunosuppressed
Days of
Cx:Pain,
MRSA Transplant,
PMH: Kidney Transplant
Immunosuppressed
Cx: MRSA
PMH: Kidney Transplant
Immunosuppressed
Cx: MRSA
MRSA
Preop
Preop
Risk Factors for Failure
I&D with Component Retention
Risk Factors for Failure
I&D with Component Retention
Risk Factors
for Failure
Organism
Other
Host
I&D with Component Retention
Host
Organism
Other
Host
Organism
Other
* Vilchez et al. Clin Microbiol Infect. 2011
* Theis et al. ANZ J Surg. 2007
* Berbari et al. Clin ID. 2006
* Vilchez et al. Clin Microbiol Infect. 2011
* Theis et al. ANZ J Surg. 2007
* Berbari et al. Clin ID. 2006
* Vilchez et al. Clin Microbiol Infect. 2011
* Theis et al. ANZ J Surg. 2007
* Berbari et al. Clin ID. 2006
Risk Factors for Failure
I&DFactors
with Component
Risk
forRetention
Failure
Host
I&D with Component Retention
Risk
Factors for Failure
Non-Modifiable
Modifiable
Host
I&D with Component Retention
Non-Modifiable
Host
Age Immunocompromised
DM
Modifiable
Malnourished
RA
Non-Modifiable
Age Immunocompromised
Modifiable
* Vilchez et
al. Clin Microbiol Infect. 2011
DM
Malnourished
RA
Age
* Vilchez et al. Clin Microbiol Infect. 2011
DM
RA
* Theis et Malnourished
al. ANZ J Surg. 2007
Immunocompromised
* Theis et al. ANZ J Surg. 2007
* Berbari et al. Clin ID. 2006
* Berbari et al. Clin ID. 2006
* Vilchez et al. Clin Microbiol Infect. 2011
* Theis et al. ANZ J Surg. 2007
* Berbari et al. Clin ID. 2006
First Annual AAHKS Spring Meeting | 72
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Symposium II, Periprosthetic Joint Infection
Risk Factors for Failure
I&D with Component Retention
Risk Factors for Failure
I&D with Component
Organism Retention
Risk Factors for Failure
I&D with Component
Organism Retention
S. aureus
Resistant
S. aureus
Organism
MRSA Resistant MRSE
S. aureus
MRSA
* Vilchez etResistant
al. Clin MicrobiolMRSE
Infect. 2011
* Theis et al. ANZ J Surg. 2007
* Berbari et al. Clin ID. 2006
* Parvizi et al. CORR. 2009
* Vilchez et al. Clin MicrobiolMRSE
Infect. 2011
MRSA
* Theis et al. ANZ J Surg. 2007
* Berbari et al. Clin ID. 2006
* Parvizi et al. CORR. 2009
* Vilchez et al. Clin Microbiol Infect. 2011
* Theis et al. ANZ J Surg. 2007
* Berbari et al. Clin ID. 2006
* Parvizi et al. CORR. 2009
Risk Factors for Failure
I&DFactors
with Component
Risk
forRetention
Failure
Other
I&D with Component Retention
Risk
Factors for Failure
Wound Other Sinus
> 2 Weeks I&D Drainage
with Component Tract
Retention Loosening
> 2 Weeks
Wound Other
Drainage
> 2 Weeks
Wound
Drainage
Sinus
Tract
Loosening
Sinus
Tract
Loosening
* Vilchez et al. Clin Microbiol Infect. 2011
* Theis et al. ANZ J Surg. 2007
* Berbari et al. Clin ID. 2006
* Vilchez et al. Clin Microbiol Infect. 2011
* Theis et al. ANZ J Surg. 2007
* Berbari et al. Clin ID. 2006
* Vilchez et al. Clin Microbiol Infect. 2011
* Theis et al. ANZ J Surg. 2007
* Berbari et al. Clin ID. 2006
Case 4
56 YOM, 4 Yrs s/p R TKR, 7 Days Pain
H/o Kidney
CaseTransplant
4
56 YOM,
4 mm/hr
Yrs s/p R TKR, 7 Days Pain
ESR 67
H/o
Kidney
CRP
91 mg/L
CaseTransplant
4
WBC
48,494
ESR
67
mm/hr
56 YOM, 4 Yrs s/p R TKR, 7 Days Pain
86%
CRP
91PMNs
mg/L
H/o
Kidney Transplant
Cx:
WBC
48,494
ESR
67MRSA
mm/hr
86%
CRP
91PMNs
mg/L
Cx: MRSA
WBC
48,494
86% PMNs
Cx: MRSA
First Annual AAHKS Spring Meeting | 73
25
25
Symposium II, Periprosthetic Joint Infection
Case 4
52 YOM, 7 Days of Pain, Transplant, MRSA
Case 4
52 YOM, 7 Days of Pain, Transplant, MRSA
52 YOM, 7
Preop
Preop
Case 4
PMH: Kidney Transplant
Immunosuppressed
Days of
Cx:Pain,
MRSA Transplant, MRSA
PMH: Kidney Transplant
Immunosuppressed
 Two-Stage
Exchange with
Cx: MRSA
Articulating Spacer
PMH:Kidney
Transplant
IV Vancomycin
Immunosuppressed
 Two-Stage
Exchange with
Cx: MRSA
Spacer
Articulating Spacer
 IV Vancomycin
 Two-Stage Exchange with
Articulating Spacer
 IV Vancomycin
Spacer
Spacer
Preop
Summary
• Indications
• Acute postoperative
infection (<4 weeks)
Summary
• Late acute hematogenous infection (<2 weeks)
• Indications
• Acute postoperative
infection (<4 weeks)
• Timing
Summary
Late acute
hematogenous
•• Most
organisms
< 2 weeksinfection (<2 weeks)
• Indications
• S. aureus 48 hours
• Acute postoperative infection (<4 weeks)
• Timing
Late acute
hematogenous
infection (<2 weeks)
•• Most
organisms
2 abx
weeks
• Aggressive
I&D with<IV
(6 wks) ± PO abx
• S. aureus 48 hours
• Timing
•• Success
~60% if without
risk factors
• Mostinorganisms
2 abx
weeks
Aggressive
I&D with<IV
(6 wks) ± PO abx
• S. aureus 48 hours
•• Success
in ~60% if without risk factors
Aggressive I&D with IV abx (6 wks) ± PO abx
• Success in ~60% if without risk factors
Thank You
Thank You
Thank You
First Annual AAHKS Spring Meeting | 74
26
26
Symposium II, Periprosthetic Joint Infection
AAHKS2016SpringMeeting
PeriprostheticJointInfectionSymposium
RemovalofImplants:OneStageorTwo?
GregoryG.Polkowski,MD,MSc
VanderbiltOrthopaedicInstitute
Withtheincreasingburdenofperiprostheticjointinfections(PJI)expectedtoincreaseinthecoming
decades,itisimperativefortheorthopaedisttobewell-versedinthesurgicalmanagementofPJI.While
indicationsfordebridementwithcomponentretentionhavebeenrecognized,inmanycasesremovalof
implantsisessentialforinfectioneradication.FormostsurgeonsintheUnitedStates,thegoldstandard
fortreatmentofchronicandantibiotic-resistantcasesofPJIiswithatwo-stageexchange.However,
orthopaedistsontheglobalstagehaveemployedone-stageproceduresforthemanagementofchronic
PJIundercertaincircumstancesandhavefoundsimilaroutcomecomparedwithtwo-stageprocedures
inmanycaseseries.Inthissymposiumwewilladdresssomeoftheindicationsandcontraindications
betweenone-stageandtwostagetreatmentforPJI.
InJuly,2013,undertheorganizationalassistanceoftheMusculoskeletalInfectionSociety,an
internationalcohortoforthopedicsurgeons,infectiousdiseasemedicalspecialists,radiologists,and
basicscientistswithaninterestinPJIgatheredforthe"InternationalConsensusMeetingon
PeriprostheticJointInfection"inPhiladelphia,PA,USA.TheProceedingsfromtheInternational
ConsensusMeetingwerepublished1andareavailableonthewebsiteoftheMSIS(http://www.msisna.org/international-consensus/).ThemethodologyhasbeenpublishedelThefollowingcriteriaand
considerationsforwhenone-stageandtwo-stagetreatmentforPJIareappropriatearelargelytaken
fromtheopinionsoftheworkgroupasdescribedinthatmeeting.
Definitions:
Onestageexchange:AonestageexchangeisdefinedasthesurgicaltreatmentPJIinwhichthesurgeon
performscompleteremovalofinfectedcomponents,cement,andassociatedhardwarefromthe
infectedjoint,followedbyanextensivesurgicaldebridementofthesynoviumandanyinfectedtissue.
Thisisfollowedbyirrigation,partialwoundclosure,re-preppingtheextremity,newdrapesandclean
instruments,andperformanceofdefinitiverevisionprocedureinthesamesetting.
Two-stageexchange:Atwo-stageexchangeisdefinedasthesurgicaltreatmentPJIinwhichthesurgeon
performscompleteremovalofinfectedcomponents,cement,andassociatedhardwarefromthe
infectedjoint,followedbyanextensivesurgicaldebridementofthesynoviumandanyinfectedtissue.
Thisisfollowedbyirrigationandwoundclosure,usuallyafterplacementofatemporaryantibiotic
impregnatedspacerdeviceformaintenanceofthejointspaceandlocaldeliveryofantibiotics.A
prolongedcourseofintravenousantibioticsensues,whichisfollowedbyanantibiotic“holiday”inwhich
thepatientismonitoredforserologicandclinicalsignsofinfectionrecurrence.Onceinfection
eradicationisdeclared,thepatientisbroughtbacktotheoperatingroomforthesecondstage
procedure:removalofthetemporaryspacer,anddefinitiverevisionjointreplacementsurgerywithreimplantationofcomponents.
Situations/Conditionsinwhichone-stagetreatmentforPJImaybeconsidered:
1. PJIwithknownbacterialspecies(i.e.,positivecultureandantibioticsensitivitiesavailable).
2. Antibioticavailableforsystemictreatment.
3. Ifpossible,antibioticavailableforcementationofcomponentstodeliverlocalantibiotics.
First Annual AAHKS Spring Meeting | 75
Symposium II, Periprosthetic Joint Infection
4. Evolvingindication:Thereisgrowingsupportfortheuseofone-stageexchangeproceduresfor
earlypost-opcementlessTHAPJI2.
Contra-indicationstoconsideringone-stagetreatmentofPJI:
1. Patientwithsystemicsepsis.
2. Unknownorganism,orinfectiousagentunknown(culturenegativeinfection).
3. Presenceofsinustract.
4. Severesofttissuedamagethatmayrequireflapcoverage.
Situations/Conditionsinwhichtwo-stagetreatmentforPJImaybeconsidered:
1. Anyofthecriteriapresentfortreatmentofstageone(anypatientwhoisacandidateforaonestagetreatmentisalsoacandidatefortwo-stagetreatment).
2. Patientswithsystemicsepsis.
3. Infectionwithunknownorganism,orculture-negativeinfection.
4. Preoperativeculturespositiveforhigh-virulenceordrug-resistantorganisms.
5. Severesofttissuecompromise,eitherintheformofachronicsinustractorpoorcoveragethat
mayrequireadditionalflapprocedure.
Otherconsiderations:
1. Thetoutedsuccessoftheone-stageprocessintheinternationalcommunityfrequentlyinvolved
re-implantationwithcementedcomponents,inwhichhighdosesofantibioticsdirectedatthe
infectingorganismwereincludedinthefinalreconstructionconstruct.
2. Mostadvocatesforone-stagetreatmentofPJIsupportperformanceoffairlyaggressivesurgical
debridement,andcitemuchoftheirsuccessonthisstageoftheprocedure.
3. CurrentlytheoperativeimplantchoicesandsurgicaltechniquesintheUSdifferenoughfrom
internationalcommunitysuchthatthetwo-stagetreatmentisstillthemostcommontechnique
employedintheUS.
References:
1. Cats-BarilW,GehrkeT,HuffK,KendoffD,MaltenfortM,ParviziJ.InternationalConsensuson
PeriprostheticJointInfection:DescriptionoftheConsensusProcess.ClinOrthopRelatRes.
2013Dec;471(12):4065-75.
2. HansenE,TetreaultM,ZmistowskiB,DellaValleCJ,ParviziJ,HaddadFS,HozackWJ.Outcome
ofone-stagecementlessexchangeforacutepostoperativeperiprosthetichipinfection.Clin
OrthopRelatRes.2013Oct;471(10):3213-22.
First Annual AAHKS Spring Meeting | 76
Breakout 3, UKA
Breakout 3, Unicondylar Knee Replacement
David F. Dalury M.D.
Unicondylar knee replacements, the replacement of an isolated part of the knee joint, have a long
history in knee surgery. The basic concept is to replace what is worn and retain the more normal
native tissue. There are many theoretical advantages of this approach when compared to a TKR:
less bone resection, a quicker and easier recovery, better knee kinematics, an easier revision if
needed as well as a more cost effective way to manage isolated knee arthritis.
Traditionally, the typical Uni candidate was considered to be an elderly, sedentary, female with
good range of motion and an intact ACL. However, over time there have been many advances in
implant and instrument design, improvements in surgical technique and now, into our 4th decade
of Uni use, longer follow up that has given more confidence to cautiously expand the utilization
of Unis. Use restrictions such as age, weight, activity level and status of the remaining
compartments have all been challenged.
Long term results of Unis now rival those of TKRs in many publications and patients who have
both a Uni and a TKR routinely prefer their Unis. Typically, Unis were utilized in the medial
femoral-tibial articulation but there has been a successful expansion of Unis into the lateral
compartment as well as the patello-femoral joint. Not all designs have equal outcomes and joint
registries have been helpful in detailing that certain devices have superior outcomes compared
with others.
Several controversies still exist such as, how much pre-op deformity is acceptable; how much
disease in other compartments can be tolerated and can Unis be used if the ACL is deficient?
New advances in Uni surgery including concepts such as computer and haptic use, cementless
fixation and improvements in technique and implant design raise the potential for improved
outcomes. The availability of more long term data supporting Uni’s use along with an
increasingly internet savvy patient population raises the probability of an increase in popularity
of Unis.
References:
Biswas D, Pack B, Van Thiel G, Berger RA, Della Valle C. Medial Unicompartmental
Arthroplasty in Patients Less Than 55 Years Old. J Arthroplasty, 29: 101-5, 2014.
Brown NM, Sheth N, Davis K, Berend ME, Lombardi AV, Berend KR, Della Valle CJ. Total
Knee Arthroplasty Has Higher Post-Operative Morbidity than Unicompartmental Knee
Arthroplasty. J Arthroplasty. 27 (8 Suppl), 86-90, 2012.
Foran J, Brown NB, Berger RA, Della Valle CJ, Galante JO. Long Term Survivorship and
Failure Modes of UKA. Clin Orthop Relat Res. 471, 102-8, 2013.
Newman J, Pydisetty RV, Ackroyd C. Unicompartmental or total knee replacement: the 15-year
results of a prospective randomised controlled trial. J Bone Joint Surg Br. 2009
Jan;91(1):52-7
First Annual AAHKS Spring Meeting | 77
Breakout 3, UKA
Parvizi J, Nunley RM, Berend KR, Lombardi AV Jr, Ruh EL, Clohisy JC, Hamilton WG, Della
Valle CJ, Barrack RL. High level of residual symptoms in young patients after total knee
arthroplasty. Clin Orthop Relat Res. 2014 Jan;472(1):133-7.
Berend KR, Berend ME, Dalury DF, Argenson JN, Dodd CA, Scott RD. Consensus Statement
on Indications and Contraindications for Medial Unicompartmental KneeArthroplasty.
J Surg Orthop Adv. 2015 Winter;24(4):252-6.
Dalury DF, Fisher DA, Adams MJ, Gonzales RA. Unicompartmental knee arthroplasty compares
favorably to total knee arthroplasty in the same patient. Orthopedics. 2009 Apr;32(4).
First Annual AAHKS Spring Meeting | 78
Breakout 3, Non-arthroplasty Hip
Breakout 3, Non-Arthroplasty Hip
John C. Clohisy, M.D.
Daniel C. and Betty B. Viehmann Distinguished Professor of Orthopaedic Surgery
Director, Adolescent and Young Adult Hip Service
Chief Adult Reconstructive Surgery
Washington University School of Medicine
St. Louis, MO
Objectives:
1) Review concepts of patient evaluation and selection for joint preservation surgery
2) Present current surgical options in joint preservation hip surgery
Introduction:
Do we really need it? YES.
Should we try to avoid it? YES, if better alternative.
How about alternatives? YES. Early diagnosis and hip joint preservation surgery.
Total hip arthroplasty (THA) is an effective surgical treatment for endstage OA of the hip, yet these
procedures can have limitations in highly active, young patients. In these patients, high-level performance
and long-term survivorship of the implant is the desired result. Nevertheless, bearing surface wear,
osteolysis, aseptic loosening, thigh pain, dislocation, squeaking, mechanical failure, metallosis and activity
limitation are some of the potential drawbacks of prosthetic joint reconstruction. As a result, the concepts
of early diagnosis and hip joint preservation surgery have gained attention. The potential benefits of joint
preservation procedures include symptom relief, enhanced activity, and prolonged survivorship of the
natural hip joint. To obtain these goals the surgeon must be familiar with the etiologies of hip
dysfunction, patient selection criteria, surgical options and anticipated clinical outcomes. These
topics will be discussed.
1) Etiology of premature hip joint failure?
Recent analysis of structural abnormalities associated with endstage hip disease at young age (<50
years) demonstrated the following underlying etiologies:
Osteoarthritis- 56%
Osteonecrosis- 30%
other- 14%
The OA subgroup etiology make-up included:
45% DDH
45% FAI (including Perthes and SCFE)
10% other or not able to classify
Therefore, mechanical hip disease (DDH, FAI, Perthes, SCFE) should be targeted by early
diagnosis and preventive treatment initiatives.
2) Concepts of patient evaluation and selection for joint preservation surgery
Patient selection is a critical component of joint preservation hip surgery. Evaluation of the patient should
focus on the following questions.
a) What is the specific etiology of hip dysfunction (structural anatomy, associated soft tissue
disease, associated muscle dysfunction)?
b) Is the hip disorder surgically correctable?
c) Is the hip joint adequately healthy to respond to joint preservation surgery?
d) Are there significant patient-specific factors (age, BMI, activity level, etc) that will impact
treatment decision-making?
First Annual AAHKS Spring Meeting | 79
Breakout 3, Non-arthroplasty Hip
e) What is the risk-benefit profile for the patient (compared to THA/SRA)?
f) What are the expected outcomes?
3) Current surgical options in joint preservation hip surgery
DDH
FAI
a. Acetabular reorientation (PAO)
b. Proximal femoral osteotomy (PFO)
c. Combined PAO/PFO
a. Anteversion PAO
b. surgical hip dislocation
c. hip scope/limited open
d. hip arthroscopy
Key Points:
1) Premature hip joint osteoarthritis is commonly (90%) associated with underlying structural hip
disease.
2) Careful patient selection is an important component of hip joint preservation surgery.
3) A variety of surgical techniques are required to provide comprehensive hip preservation surgical
care.
4) Clinical outcomes of joint preservation surgery are good to excellent in 80% of patients and should
improve with continued refinement of patient selection criteria and surgical technique.
References:
1. Clohisy JC, St. John LC, Schutz AL. Surgical Treatment of Femoroacetabular Impingement: A
Systematic Review of the Literature. Clin Orthop Relat Res 468(2):255-64, 2010. PMCID:
PMC2806979.
2. Clohisy JC, Schutz AL, St. John LC, Schoenecker PL, Wright RW. Periacetabular Osteotomy: A
Systematic Literature Review. Clin Orthop Relat Res 467(8):2041-2052, 2009. PMCID:
PMC2706361
3. Clohisy JC, Beaule PE, O’Malley A, Safran MR, Schoenecker P. AOA Symposium. Hip Disease in
the Young Adult: Current Concepts of Etiology and Surgical Treatment. J Bone Joint Surg
90(10):2267 - 2281, 2008.
4. Ganz R, Gill TJ, Gautier E, Ganz K, Krugel N, Berlemann U. Surgical dislocation of the adult hip a
technique with full access to the femoral head and acetabulum without the risk of avascular
necrosis. J Bone Joint Surg Br 83(8):1119-24, 2001.
5. Ganz R, Klaue K, Vinh TS, Mast JW. A new periacetabular osteotomy for the treatment of hip
dysplasias. Technique and preliminary results. Clin Orthop Relat Res (232):26-36, 1988.
6. Nwachukwu BU, Rebolledo BJ, McCormick F, Rosas S, HJarris JD, Kelly BT. Arthroscopic Versus
Open Treatment of Femoroacetabualr Impingement: A Systematic Review of Medium- to LongTerm Outcomes. Am J Sports Med [Epub ahead of print June 9, 2015].
7. Steppacher SD, Tannast M, Ganz R, Siebenrock KA. Mean 20-year followup of Bernese
periacetabular osteotomy. Clin Orthop Relat Res Jul;466(7):1633-44, 2008.
8. Matheney T, Kim YJ, Zurakowski D, Matero C, Millis M. Intermediate to long-term results following
the Bernese periacetabular osteotomy and predictors of clinical outcome. J Bone Joint Surg Am
Sep;91(9):2113-23, 2009.
9. Troelsen A, Elmengaard B, Soballe K. Medium-Term Outcome of Periacetabular Osteotomy and
Predictors of Conversion to Total Hip Replacement. J Bone Joint Surg 91(9): 2169-2179, 2009.
First Annual AAHKS Spring Meeting | 80
Symposium III, Preparing for the Transition to Value Based Healthcare
Symposium III, Preparing for the Transition to Value Based Healthcare
Kevin J. Bozic, MD, MBA Professor and Inaugural Chair Department of Surgery and Perioperative Care
Dell Medical School at the University of Texas at Austin
Mark I. Froimson, MD, MBA
President, Euclid Hospital Cleveland Clinic
Challenges Facing the US Healthcare System
1) Emphasis on healthcare, not health
2) Fragmented delivery, payment systems
3) Medical error/defensive medicine
4) “Medical arms race” 5) Moral hazard
Lack of Competition Based on Value
1) Patient choice and competition for patients are powerful forces to encourage continuous improvement
in value and restructuring of care
2) Today’s competition in health care is not aligned with value since the financial success of system
participants is not tied to patient success
Value-Based Healthcare
Primary Goal: Improve Value
1) Value can be defined as patient centered health outcomes per health dollar expended
2) Outcome = Quality (e.g. clinical outcome, safety) + Service (e.g. satisfaction, convenience,
communication)
Keys to Success
1) Empower stakeholders with better information
a) Tools for efficient, real time data collection
b) Transparency of cost, quality (actionable, easy to understand/use, risk adjusted)
2) Reorganize delivery, payment system around patient-centered value (not volume)
a) Align stakeholder incentives around value
b) Increased accountability for providers, patients
3) Leadership from the medical profession
Empowering Patients to Be Better Consumers
1) When rating factors that influenced their selection of provider for elective total joint arthroplasty,
patients chose Physician Manner and Physician Quality as the two most important factors [1]
2) Patients also on average strongly agreed with statements that their choice of surgeon would impact
their outcome and that there are big differences in the quality of care among different surgeons [1]
Quality Measures
1) Need to measure outcomes in order to track improvement
2) Define quality measures for your practice, focusing on outcomes that matter to patients
3) Develop infrastructure to measure outcomes (e.g. clinical data registries)
First Annual AAHKS Spring Meeting | 81
Symposium III, Preparing for the Transition to Value Based Healthcare
4) Use outcomes data for continuous quality improvement, public reporting, value-based payment
a) Increase transparency of cost, outcomes
b) “If I am through learning, I am through.” – John Wooden
Reorganizing the delivery system around value
1) Existing model: care is organized by specialty and discrete service
2) Model organized around value:
a. Staffed by dedicated multidisciplinary team
b. Joint accountability for outcomes and costs
c. Shared information platform
d. Single administrative & scheduling structure
e. Services co-located to the extent possible
3) Train, engage surgeons in Population Health Management
a. Define appropriateness of diagnostic, therapeutic interventions
b. “Downstreaming” care
c. Patient Engagement
d. Patient Activation
i. A measurement of an individual’s propensity to engage in positive health behavior [2]
ii. Patients with higher preoperative activation had better patient-reported outcomes after
TJA [3]
e. Shared decision making
4) Develop patient-centric, disease-based Integrated Practice Units
Role of the Payment System in Improving Value
1) In order to implement value driven healthcare, must identify and eliminate or reduce non-value added
care.
a. Unnecessary care
b. Inappropriate variation in care
c. Avoidable complications/readmissions/reoperations
d. Excess cost due to variation in price
Principles for Successful Implementation of Value-Based Payment
1) Assess culture, operational readiness
a. Risk tolerance
b. Data systems, sharing
c. Trust, alignment
d. Leadership
2) Identify clinical, administrative champions
3) Define the episode for which you accept risk
4) Define performance metrics, gainsharing models
5) Understand care from the patient’s perspective
6) Measure the actual costs of care delivery (e.g. using time-drive activity-based costing)
7) Use data to identify opportunities for improvement
8) Redesign care to improve quality, reduce cost
9) Price/market episode of care program 10) Evaluate results, iterate
First Annual AAHKS Spring Meeting | 82
Symposium III, Preparing for the Transition to Value Based Healthcare
Preparing for Payment System Transformation
1) More granular cost, outcomes measurement
2) Greater integration/alignment across providers
3) Experiment with new payment methodologies
What Do We Have To Lose?
1) Current fee-for-service (RVU, DRG) system:
a. Set up such that as you become a better clinician (fewer complications, etc), your
reimbursement decreases
b. NO consideration of outcomes or value
2) Value based approaches require an up-front investment but can lead to improved provider financial
performance over time
First Annual AAHKS Spring Meeting | 83
Breakout 4, Revision Total Hip Arthroplasty (THA): Simple to Complex
Breakout 4, Revision Total Hip Arthroplasty (THA): Simple to
Complex
S. J. MacDonald, MD, FRCSC
Correspondence: Dr. S. J. MacDonald
London Health Sciences Centre, University Campus
339 Windermere Rd.
London, ON
N6A 5A5
Phone: 519-663-3689
Fax: 519-663-3096
Email: [email protected]
Professor & Chairman of Orthopaedic Surgery,
University of Western Ontario,
London, Ontario, Canada
First Annual AAHKS Spring Meeting | 84
Breakout 4, Revision Total Hip Arthroplasty (THA): Simple to Complex
2
Surgical Exposures
Introduction
There are multiple approaches to the hip in primary total hip arthroplasty
(anterior, antero-lateral, transgluteal, transtrochanteric, posterolateral, multiple miniincision approaches), however in revision total hip arthroplasty there are only 3 that are
employed routinely (transgluteal, transtrochanteric, posterolateral). The advantages and
disadvantages of the approaches will be discussed in this lecture as will the extensile
approaches (femoral osteotomies, controlled perforation, scaphoid window,
retroperitoneal approach) performed in revision procedures.
Revision Approaches: Advantages/Disadvantages
Approach
Direct Lateral
Advantages
Disadvantages
i Dislocation Rate
Extensile exposure g
Superior gluteal
nerve injury
Can be extensile
Notes
Longer period of
postoperative limp
Poor posterior
column access
Transtrochanteric
Extensile
Allows
trochanteric
advancement
Posterolateral
Extensile
h Risk of trochanteric
nonunion
h Risk of dislocation
Posterior column
access
Preservation of
abductors
Specialized Approaches
1)
Extended Trochanteric Osteotomy
• can be performed with either a posterolateral1 or transgluteal2 approach
• indications
- R/O cement, broken implant, ingrown stem
- proximal femoral varus remodeling has occurred preventing straight shot
at femoral canal
- previous trochanteric malunion
- significant trochanteric osteolysis precluding trochanteric osteotomy
First Annual AAHKS Spring Meeting | 85
Breakout 4, Revision Total Hip Arthroplasty (THA): Simple to Complex
3
2)
Controlled Perforation3
• indications – cement removal
• technique
- 7 mm anterior femoral perforation is created with a high-speed burr
- additional perforations, depending on length of cement mantle, performed
5 cm apart
- revision femoral component must bypass most distal perforation by at
least 2 component diameters
3)
Scaphoid Window4
• indications – cement removal
• advantages – allows greater access to femoral canal
• disadvantages – devascularized fragment may be created
4)
Retroperitoneal Approach5
• indications - intrapelvic migration of components/cement
- minimize risk of injury to neurovascular structures
References
1.
Younger TI, Bradford MS, Magnus RE, Paprosky WG: Extended proximal
femoral osteotomy: A new technique for revision arthroplasty. J Arthroplasty
1995;10:329-338.
2.
MacDonald SJ, Cole C, Guerin J, Rorabeck CH, Bourne RB, McCalden RW:
Extended trochanteric osteotomy via the direct lateral approach in revision hip
arthroplasty. Clin Orthop Rel Res 2003;417:210-216.
3.
Head WC, Montgomery WK, Emerson RH:
perforations. Instr Course Lect 1999;48:13-17.
4.
Kerry RM, Masri BA, Garbuz DS, Duncan CP: The vascularized scaphoid
window for access to the femoral canal in revision total hip arthroplasty. Instr
Course Lect 1999;48:9-11.
5.
Rorabeck CH, Partington PF: Retroperitoneal exposure in revision total hip
arthroplasty. Instr Course Lect 1999;48:27-36.
Vastus slide and controlled
First Annual AAHKS Spring Meeting | 86
Breakout 4, Revision Total Hip Arthroplasty (THA): Simple to Complex
4
Acetabular Osteolysis:
When to Graft/Exchange Polyethylene and When to Operate
I.
Introduction
-
-
II.
Assessment of Osteolysis
-
III.
Modular acetabular components in THA have been the component of choice
for more than three decades in North America
While achieving solid bone ingrowth of these components has proved
reproducible with excellent long-term clinical track records, the polyethylene
has been the weak link in the system
Polyethylene wear and osteolysis are seen frequently with long-term followup
The current generation of highly cross-linked polyethylenes will hopefully
reduce the incidence of these complications, but millions of modular
components with non highly cross-linked polyethylenes were performed, and
the issues related to their failure modes, and indications for revision will be
important clinical issues for decades to come
While there are occasional exceptions, in general once osteolysis begins to
develop it will be progressive and can lead to massive bone loss and
acetabular component loosening
Strategies to minimize the complications of massive osteolysis include routine
radiographic review of THA patients (q1-2 years), more frequent reviews
once the presence of osteolysis is established, and earlier rather than later
surgical intervention once progression is seen
In general, plain radiographs tend to underestimate the amount of true bone
loss that is present
Routine imaging may include:
i) AP Pelvis and AP and lateral hip views
ii) Judet views
iii) CT scan
Fundamental Questions to Answer
I) When should I operate?
i) symptomatic patient (however <50% of patients with osteolysis will have
symptoms)
ii) asymptomatic patient with large lesion potentially compromising
component fixation
iii) asymptomatic patient with documented progression of osteolysis on serial
radiographs
First Annual AAHKS Spring Meeting | 87
Breakout 4, Revision Total Hip Arthroplasty (THA): Simple to Complex
5
II) Why has the component failed?
i) specific polyethylene issues
ii) cup design issues
iii) technical issues
iv) related to time in vivo
v) r/o infection (especially if see early osteolysis)
III) Is the acetabular component solid or loose?
i) often difficult to assess preoperatively
- if 50% of shell circumference has osteolysis on AP or lateral xray, have a
suspicion for possible fixation compromise
ii) may be an intraoperative decision – judiciously check acetabular
component fixation intraoperatively
IV) If the acetabular component is solid, can I retain it and either do a liner
exchange or cement in a new polyethylene?
A) Conditions necessary for a liner exchange:
i) Satisfactory component position
ii) Intact locking mechanism
iii) Undamaged acetabular component
iv) Liner of adequate thickness
v) Acceptable track records of components
vi) Ability to achieve intraoperative hip stability
vii) Availability of polyethylene of appropriate shelf life and sterilization
technique
B) Conditions necessary for cementing a liner
i) Satisfactory component position
ii) Adequate acetabular component internal diameter for cement mantle and
polyethylene thickness
iii) match age/demands of patient
IV.
Technical Considerations
A) Liner Exchange
- Remove liner
- Assess component stability
- Assess locking mechanism
- Graft osteolytic lesions either directly, or via a trapdoor technique in the ilium
(note – contraindicated if this compromises the lateral buttress of the pelvis)
- Always be prepared for a full revision with extraction devices and revision
acetabular components and inserts and bone graft
B) Cementing a liner
- The acetabular component needs to be textured by design or by technique
- The polyethylene component needs to be textured by design or by technique
- The cement mantle should be 2-4 mm thick
- Avoid over-sized and uncontained polyethylene
- Performed correctly, cemented liners are equal to modular liners for pushout
strength
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C) Bone grafting
- No data to suggest what technique or material is superior
- Cancellous chips probably most frequently used
- BMPs have been tried by this author as they are osteoinductive, but there is a
significant cost associated with them
V.
Results and Complications
- at this point there are only short-term reports in the literature
- the largest series is from the Norwegian Arthroplasty Register which
demonstrated that isolated liner revisions (318 cases) had a higher re-revision rate
than those cases that underwent revision of their ingrown sockets (398 cases)
- most frequent complication has been postoperative dislocation
- instability complication may be less with direct lateral approach
References
Boucher HR, Lynch C, Young AM, Engh CA, Engh C. Dislocation after polyethylene
liner exchange in total hip arthroplasty. J Arth, 18:654-657, 2003
Claus AM, Engh CA, Sychterz CJ, Xenos JS, Orishimo KF, Engh C. Radiographic
definition of pelvic osteolysis following total hip arthroplasty. J Bone Joint Surg (Am),
85:1519-1526, 2003
Lie SA, Hallan G, Furnes O, Havelin LI, Engesaeter LB. Isolated acetabular liner
exchange compared with complete acetabular component revision in revision of primary
uncemented acetabular components: a study of 1649 revisions from the Norwegian
Arthroplasty Register. J Bone Joint Surg (Br), 89:591-5954, 2007
Lombardi AV Jr, Berend KR. Isolated acetabular liner exchange. J Am Acad Orthop
Surg. 16:243-248, 2008
Maloney WJ, Herzwurm P, Paprosky W, Rubash HE, Engh CA. Treatment of pelvic
osteolysis associated with stable acetabular component inserted without cement as part of
a total hip replacement. J Bone Joint Surg (Am). 79:1628-1634, 1997.
Maloney WJ, Paprosky W, Engh CA, Rubash H. Surgical treatment of pelvic osteolysis.
Clin Orthop, 393: 78-84, 2001
Mehin R, Yuan X, Haydon C, Rorabeck CH, Bourne RB, McCalden RW, MacDonald SJ.
Retroacetabular osteolysis: when to operate? Clin Orthop, 428: 247-255, 2004.
Mehin R, MacDonald SJ. The value of anteroposterior pelvic radiographs for evaluating
pelvic osteolysis. Clin Orthop, 457: 260-261, 2007
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Naudie DDR, Engh CA. Surgical management of polyethylene wear and pelvic osteolysis
with modular uncemented acetabular components. J Arth, 19:124-129, 2004.
O’Brien JJ, Burnett RS, Yuan X, McCalden RW, MacDonald SJ, Bourne RB, Rorabeck
CH. Isolated liner exchange in revision total hip arthroplasty. Clinical results using the
direct lateral surgical approach. J Arth, 19(4): 414-423, 2004.
Restrepo C, Ghanem E, Houssock C, Austin M, Parvizi J, Hozack WJ. Isolated
polyethylene exchange versus acetabular revision for polyethylene wear. Clin Orthop,
467:194-198, 2009
Rubash HE, Sinha RK, Paprosky W, Engh CA, Maloney WJ. A new classification system
for the management of acetabular osteolysis after total hip arthroplasty. Instr Course Lect,
48:37-42, 1999
Stulberg D, Wixson RL, Adams AD, Hendrix RW, Bernfield JB. Monitoring pelvic
osteolysis following total hip replacement surgery: an algorithm for surveillance. J Bone
Joint Surg, 116-122, 2002.
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THE HIP IS NOT STABLE
Introduction
Hip instability continues to be a significant complication following total hip
arthroplasty that is devastating for the patient and frustrating for the arthroplasty surgeon.
Current quoted incidence in the literature remains at approximately 1%. While
dislocations cannot be eliminated, an algorithmic approach to assessing and managing
intraoperative instability will assist the surgeon in addressing the issues intraoperatively
and minimize the probability of postoperative instability.
Preoperative Assessment
Minimizing the risk of intraoperative and postoperative instability actually begins with
the preoperative assessment and identifying the patient at risk and proactively discussing
this with the patient and creating a plan to minimize this event.
Obviously not all patient factors are modifiable, but some are. Patients at an increased
risk include:
1) Morbidly obese
2) Elderly
3) Non compliant (alcohol, substance abuse)
4) Neuromuscular disease
5) DDH
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Intraoperative Assessment
With trials in place the surgeon begins the assessment with first confirming the leg
lengths and offset, assesses component orientation and then takes the hip through a range
of motion assessing for the presence of impingement.;
A) Leg length and offset
It is most helpful to have a reproducible methodology to determine preoperative and
intraop leg length and offset. A fixed device in the pelvis, with another marker of some
description on the femur, is a reliable technique. This is very valuable information in
maximizing the ability to achieve a stable total hip, without the added issue of
lengthening the limb
B) Assess component orientation
Similarly the arthroplasty surgeon should develop an intraoperative technique to
assessing the orientation of both the acetabular and femoral components. There is a great
range of variability in acetabular component placement and malposition increases the
probability of postop dislocation. While correct acetabular component orientation is
critical, minor adjustments can also be made via the use of lipped or face-changing liners.
The role of these liner options is greater in revision, rather than primary, total hip
arthroplasty.
C) Impingement
Impingement can be bone-bone, component-component or bone-component. Removal of
osteophytes and correct component orientation are the keys to minimizing impingement.
Impingement must be carefully assessed for and corrected with trials, or components in
place.
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References
1.
Callanan MC, Jarrett B, Bragdon CR, Zurakowski D, Rubash HE, Freiberg AA,
Malchau H. The John Charnley Award: risk factors for cup malpositioning:
quality improvement through a joint registry at a tertiary hospital. Clin Orthop;
2011,469:319-329.
2.
Elkins JM, Daniel M, Pedersen DR, Singh B, Yack HJ, Callaghan JJ, Brown TD.
Morbid obesity may increase dislocation in total hip patients: a biomechanical
analysis. Clin Orthop; 2013,471:971-980.
3.
Kalteis T, Sendtner E, Beverland D, Archbold PA, Hube R, Schuster T,
Renkawitz T, Grifka J. The role of the transverse acetabular ligament for
acetabular component orientation in total hip replacement: an analysis of
acetabular component position and range of movement using navigation software.
JBJS(Br);2011,93(8):1021-1026.
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Evaluation of the Symptomatic &
Asymptomatic Metal on Metal THA
The Metal on Metal Hip
II.
II
Introduction
-
Metal on metal bearings, in both a total hip and resurfacing application, saw an
increase in global utilization over the past several years
-
This peaked in 2008 in the US, with approximately 35% of bearings being hard on
hard (metal on metal, or ceramic on ceramic)
-
Beginning in 2008, reports in the orthopaedic literature began to surface re local soft
tissue reactions and hypersensitivity to metal on metal bearings
-
A major implant manufacturer recalled a resurfacing device in 2010 after national
joint registries demonstrated higher than expected revision rates
-
Patients with painful metal on metal bearings presenting to the orthopaedic surgeon
are a difficult diagnostic challenge
-
The surgeon must go back to basic principles, perform a complete history and
physical exam, obtain serial radiographs and basic bloodwork (ESR,CRP) to rule out
common causes of pain and determine if the pain is related to the bearing, or not
The Asymptomatic MoM Arthroplasty
-
Patients will present for either routine followup, or because of concerns re their
bearing
-
It is important to emphasize that at this point the vast majority of patients with a
MoM bearing are indeed asymptomatic and their bearings are performing well
-
The surgeon must take into account:
a) which specific implant are they dealing with and what is its track record
b) what is the cup position
c) when do perform metal ion testing
d) when to perform further soft tissue imaging (MARS MRI, Ultrasound)
e) when to discuss possible surgery
-
A simple algorithm for both painless and painful MoM Arthroplasties has been
developed and is presented below
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III.
Painful MoM THA causes not related to the bearing couple
A) Extrinsic to the hip
-spine (radiculopathy, stenosis)
-vascular
-metabolic
-malignancy
B) Intrinsic to the hip
i) Extracapsular
-iliopsoas tendonitis
-trochanteric bursitis
ii) Intracapsular
-sepsis
-loosening
-thigh pain
-prosthetic failure
IV.
Painful MoM THA causes related to the bearing couple
There are now described a number of possible clinical scenarios and causes of pain that relate to
the metal on metal bearing couple itself:
A) Local hypersensitivity reaction without a significant soft tissue reaction
B) Local hypersensitivity reaction with a significant soft tissue reaction
0
C) Impingement and soft tissue pain 2 to large head effect
V.
Factors related to a hypersensitivity reaction
Some patients, and prosthesis, seem to be at a higher risk of developing issues following a metal
on metal bearing, although our understanding of the interplay of these factors is still in evolution:
A) Patient
- female gender
- smaller component sizes
B) Implant
-some implants have higher wear rates and perhaps are more prone to corrosion
-large heads and monoblock shells
C) Technique
0
-high cup inclination angles > 50
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VI.
Special tests
There is ongoing confusion related to the relative value of the various special tests that patients
with a painful MoM undergo.
A) Metal Ions
- obtaining serum, or whole blood, cobalt and chromium levels is recommended as a baseline test.
However there is no established cutoff level to determine with certainty if a patient is having a
hypersensitivity reaction. A 7 parts per billion cutoff has been suggested. This gives high
specificity, but poor sensitivity. Metal ions therefore can be used as a clue, and one more test in
the workup, but cannot be relied upon in isolation to make a diagnosis.
B) MARS (Metal Artifact Reduction Sequence) MRI
- a useful tool for demonstrating soft tissue involvement, but there are many painless, well
functioning MoM implants that have soft tissue reactions, that don’t require a revision. In the
painful MoM hip an MRI, or ultrasound, is recommended to look for soft tissue destruction or a
fluid-filled periprosthetic lesion (pseudotumour). Significant soft tissue involvement is
concerning and is commonly an indication for revision in the painful MoM hip
C) CT imaging
- can be utilized to help determine cup position and combined anteversion, however plain
radiographs can give a rough estimate of this as well, so routine CT scan evaluations are not
currently recommended
VII.
Treatment
Management of the painful MoM hip is directly related to the etiology of the pain. Unique to
MoM bearing is the issue of pain secondary to a local hypersensitivity reaction. All above test
should be utilized to help determine the best course of action in any individual patient.
The painful MoM bearing, that is demonstrating significant soft tissue involvement is a
concerning scenario. Earlier revision, to prevent massive abductor damage, would seem prudent
for these patients. The painful MoM bearing with no significant soft tissue changes can probably
be followed and reviewed at regular intervals. If the pain persists and is felt to be secondary to a
hypersensitivity reaction, then revision is really the only option, although the patient must be
cautioned regarding the unpredictable nature of the pain relief.
References
Blumenfeld TJ, Bargar WL, Campbell PA
A painful metal-on-metal total hip
arthroplasty: a diagnostic dilemma.
J Arthroplasty, 25(7):1168, 2010.
Cobb JP, Davda K, Ahmad A, Harris SJ,
Masjedi M, Hart AJ
Why large-head metal-on-metal hip replacements are painful: the anatomical basis of psoas
impingement on the femoral head-neck junction.
J Bone Surg (Br), 93(7);881-885, 2011.
Hart AJ, Sabah S, Henckel J, Lewis A, Cobb J, Sampson B, Mitchell A, Skinner JA
The painful metal-on-metal hip resurfacing.
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J Arthroplasty, 26(1):71-76, 2011
2012 Australian National Joint registry at www.aoa.org.au/docs
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J Bone Surg (Br), 91;738-744, 2009.
Kwon Y-M, Jacobs JJ, MacDonald SJ, Potter HG, Fehring TK, Lombardi AV
Evidence-based understanding of management perils for metal-on-metal hip arthroplasty patients.
J Arthroplasty, 27(8):20-25, 2012.
Sabah SA, Mitchell AW, Henckel J, Sandison A, Skinner JA, Hart AJ
Magnetic resonance imaging findings in painful metal-on-metal hips: a prospective study.
J Arthroplasty, 26(1):71-76, 2011
2012 Australian National Joint registry at www.aoa.org.au/docs
Management of the Infected THA
Management of the Infected THA
Defining the Problem
In total hip replacement surgery, the incidence of infection has ranged from 1.6-2.6 %
Defining
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complication of infection leads to significant morbidity for the patient, opens the doors to
further complications as a result of further surgery, as well as adding substantial costs to
the care of the patient.
Management of the Infected THA
Defining the Problem
In total hip replacement surgery, the incidence of infection has ranged from 1.6-2.6 %
after the advent of pre-operative antibiotics, to as low as 0.39% in high volume centres
using special ORs and all precautions. Infection in the prosthesis is a significant problem
and has been shown to decrease the outcome and benefit for the patient. The serious
complication of infection leads to significant morbidity for the patient, opens the doors to
further complications as a result of further surgery, as well as adding substantial costs to
the care of the patient.
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An approach to the prevention, diagnosis and treatment of infection is therefore critical to
the arthroplasty reconstructive surgeon.
A) Prevention
I - Patient Factors
The general pre-operative health of the patient is an important factor to consider. Patients
with multiple comorbidities (ASA class III or more) are at higher risk for infection.
While clearly some factors can’t be modified (ie, previous surgery), many others can be
optimized.
i) Diabetes
- Patients with poor sugar control and higher HbA1C concentrations are at higher risk for
infection. Glucose control should be optimized prior to surgery. Post-operatively tighter
glucose control has also been shown to decrease the rate of infection and other
complications, although the data is primarily from post-cardiac surgery.
ii) Obesity
-Controversy exists re the relative risk of obesity and deep infection post TKA, however
clearly there is a higher risk of prolonged drainage in these hips, which increases the risk
of surgical site infection. For the morbidly obese, weight loss counseling and
gastroplasty consultation is recommended.
iii) Rheumatoid Arthritis
-Often patients coming for joint arthroplasty are on a cocktail of drugs:
a) NSAIDs - weak anti-platelet effect and should be stopped if possible pre-operatively,
especially aspirin with its non-reversible effect on platelets (10 days)
b) Steroids - powerful effect on the inflammatory cascade, and depression of the immune
system. If possible, steroid use should be tapered pre-operatively to minimum levels, and
if the patient remains on supra-physiologic doses of over 5 mg daily, intravenous steroids
should be administered peri-operatively to avoid adrenal insufficiency crisis. Recent
literature indicates that the relatively high doses of intravenous hydrocortisone (100 mg
every 8 hours) are not necessary, and for total joints 25 mg every 12 hours for three doses
is adequate, with no need for prolonged therapy beyond this.
c) Methotrexate – variable historical recommendations, however 2 recent publications
have shown no increased complications maintaining, rather than stopping it
d) Leflunomide - one of the new DMARDs has shown a significant increase in infection
rate post-operatively when not stopped
e) TNF blockers (infliximab, adalimumab, etanercept) - have not been definitively
demonstrated to be harmful in the peri-operative context from multiple studies
iv) Immunocompromised
-HIV, hemophilia, previous organ transplantation, skin disorders (psoriasis)
v) Previous hip surgery
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II - Intraoperative Factors
i) Antibiotic Prophylaxis
-administered <60 minutes prior to surgical incision (critical point)
-Cefazolin routinely, or Vancomycin/Clindamycin in allergic patient
-no evidence for extended use >24 hrs in routine primary THA
ii) OR suite
-high airflow turnover room (doesn’t have to be laminar flow necessarily)
-vertical laminar flow improves air quality
-ultra-violet light also effective
-no convincing evidence for body exhaust suits
iii) Sterile technique
-breaks in sterile technique are more common than considered
-change to new gloves prior to handling implants
iv) Length of Operating Time
- increased OR time is associated with increased infection rates and this has been
confirmed in several papers and registry data
v) Antibiotic cement
- national joint registries clearly demonstrate reduced infection rates with its routine use
- approved for routine use in many countries (not the US – only for 2nd stage revision
procedures)
III – Postoperative Factors
i) Drain use
- no evidence that a drain either increases or decreases the infection rates
ii) VTE prophylaxis
- no evidence that the routine postop use of low mw heparin increases the infection rates
- evidence that preop use does increase infection rates
iii) Prolonged wound drainage
- should have a low threshold for returning to the OR in a patient who has had wound
drainage for longer than 7-10 days, particularly in a patient with further risk factors such
as obesity, diabetes, previous surgical scars in the area, poor vascularity, ongoing need
for anti-coagulation, or evidence of wound edge necrosis
iv) Antibiotic prophylaxis for dental work
- beyond 2 years postop - joint statement from the AAOS and American Dental
Association advocated its’ use only in at risk patients
- if patients tolerate the antibiotics, we discuss option of prophylaxis indefinitely
B) Diagnosis
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i) History
- key – have a high index of suspicion in all failed and painful THAs
- look for – wound healing problems with index procedure
- “always painful/ never right”
- recent systemic illness (ask about recent/current Ab use,dental procedures,etc)
- rest pain and nocturnal pain
ii) Physical exam
- often normal
- local skin changes
iii) Imaging
a) plain radiographs – most commonly normal, although may see periosteal
b) nuclear imaging – role is ill-defined, useful to evaluate the painful hip with all tests
being negative to look for incomplete boney ingrowth
iv) Blood tests
- ESR and CRP should be obtained on every patient assessed for a painful THA
- if both are normal, probability of infection is very low
- if one or both are elevated, further investigate with an aspiration
v) Aspiration
- confirm patient has been off all antibiotics for at least 2 weeks
- performed in all cases with abnormal bloodwork, and send for:
a) Cell count
- indicative of infection if > 3000 WBC/mm (if both ESR and CRP elevated)
- indicative of infection if > 9000 WBC/mm (if only one of ESR or CRP elevated)
b) Cell count differential
- be suspicious of infection if > 80% WBC count
- very indicative of infection if > 90% WBC count
c) Culture
- send for aerobic, anaerobic and fungal and TB infections in some cases (previous
cultures negative when clinical suspicion is high)
vi) Intraoperative Evaluation
a) Frozen section
- results are pathologist specific
-average of 5-10 PMNs per high powered field is normally the cut-off, although again
this varies between pathologists
- we have found the best approach is to speak directly with our pathologist and have them
determine – is this consistent with chronic or acute inflammation
b) Gram stain
- can see both false positives and false negatives
- can be used as a guide to determine which postoperative antibiotic to use, but can’t be
used as the only method to diagnose an infection
- in many institutions no longer available as a stat test
- always take at least 3, if not more, independent culture swabs to help guide postop Rx
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There is not one widely accepted gold standard test for diagnosing the infected THA. It is
a clinical judgment based on many factors, particularly in the face of negative cultures.
C) Treatment
Historically infected THAs have been classified into 4 broad categories based on the
timing of presentation: an unexpected positive intraoperative culture, acute infection,
chronic infection and acute hematogenous infection. It must be emphasized that it is often
not entirely clear which category a given patient falls into, so treatment recommendations
based on the categories should be viewed as general guidelines only.
i) Positive intraoperative culture
- in this scenario one or more of the intraoperative cultures taken at the time of a revision
THA come back as positive
- there is no strong evidence based medicine to guide the surgeon in this case
- our routine is to involve Infectious Disease in the process and our strong leaning is to
treat all of these cases with 6 weeks of IV antibiotics (although some authors would argue
that if only one positive culture and no others signs of infection, those patients do not
require prolonged antibiotic coverage)
- we would not take the patient back to the operating room and perform a first stage
revision
ii) Acute postoperative infection
- historically this has been defined as an infection occurring within the first 6 weeks
following THA
- however more recently authors are beginning to discuss this in terms of within the 3-4
weeks of the index procedure
- while it seems intuitive that the longer the infection has been present the lower the
success rate will be with an I&D and polyethylene exchange, there is actually very little
published to guide the surgeon as to when to make the transition and perform component
removal and antibiotic spacer insertion
- in general, we use the cut-off of 4 weeks, but this has to be individualized to patient and
in particular the organism cultured
- staph infections are much harder to eradicate and will have a higher failure rate for
I&D’s, strept infections on the other hand are more amenable to that intervention
- Rx – in summary, patients presenting with acute infections should undergo:
1) an operative intervention with a formal I&D with removal of the polyethylene insert so
that that interface can be accessed
2) multiple intraoperative cultures should be obtained
3) a postop ID consult
4) 6 weeks of IV Abs
5) some authors are actually recommending chronic oral suppression for these cases,
however again there is no evidence based medicine to give clear guidelines
iii) Chronic postoperative infection
- divergent literature re one-stage versus two-stage procedure
- majority of North American centres perform two-stage
- I&D’s are not successful and simply delay ultimate treatment
- a two-stage revision has an approx 90% success rate and includes:
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i) 1st stage: a) thorough meticulous debridement of involved soft tissue
b) removal of all components and cement if present
c) pulsatile lavage irrigation with 9L (at minimum)
d) use of an antibiotic spacer
Spacers
- there are two types of antibiotic spacers, static and articulating. Spacers allow for the
local delivery of antibiotics. Current recommendations are for the use of 3 doses of
Vancomycin and 3 doses of Tobramycin per bag of cement (if the patient has any
underlying urine clearance or kidney issues we reduce the dosage). This amount of
antibiotic will create a very thick doughy cement that is hard to mix so we routinely add
another ½ vial of the monomer. It must be emphasized that this amount of Ab in the
cement will reduce the mechanical properties of the cement so is only recommended for
spacers knowing that they will be converted to THA’s at the time of the second stage
revision
- there is no literature to suggest that the success rate for static vs articulating spacers is
any different, however articulating spacers do offer some advantages: prevent the limb
shortening allowing an easier exposure at the 2nd stage, perhaps improved functionality.
One disadvantage is the risk of dislocation. In cases of severe bone loss they are difficult
to use and there is the possibility for increased bone loss with movement between the
articulating spacer and host bone.
ii) Interval between stages
- patient receives 6 weeks of IV antibiotics, guided by intra-operative cultures (in
consultation with Infectious disease)
- some authors recommend very frequent ESR and CRP checks. Our routine is to do this
bloodwork at 6 weeks when they are seen in clinic and their antibiotics are stopped and
then again 3 weeks later when they are seen in the preadmission clinic and have a repeat
aspiration that same day.
- approx 10% of patient will fail the first attempt at infection eradication and will need to
have a repeat 1st stage and spacer insertion
iii) 2nd stage:
a) repeat the debridement and obtain multiple samples for cultures and frozen
section. Controversial re what constitutes ongoing infection – at our site our
pathologists will tell us if samples are consistent with acute or chronic
inflammation
b) if evidence of ongoing infection – proceed to spacer insertion
c) if no evidence of ongoing infection – proceed to definitive implants
d) keep patient on IV Abs until cultures back
iv) Acute hematogenous infection
- by history, this is a well functioning THA that acutely changes
- this source of infection is often never determined
- look for recent dental procedures, any infections (ie, UTIs), skin ulcers in diabetics, etc
- patient presents with very short direction of ++pain, perhaps decreased ROM, difficulty
ambulating, occasionally a fever
- Rx is identical to that for acute postoperative infection:
1) an operative intervention with a formal I&D with removal of the polyethylene insert so
that that interface can be accessed
2) multiple intraoperative cultures should be obtained
3) a postop ID consult
4) 6 weeks of IV Abs
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5) some authors are actually recommending chronic oral suppression for these cases,
however again there is no evidence based medicine to give clear guidelines
References
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
Advisory statement. Antibiotic prophylaxis for dental patients with total joint
replacements. American Dental Association; American Academy of Orthopaedic
Surgeons. J Am Dent Assoc., 128(7): 1004-8, 1997.
Amin AK, P. J., Cook RE, Brenkel IJ.: Does obesity influence the clinical
outcome at five years following total knee replacement for osteoarthritis? J Bone
Joint Surg Br., 88(3): 335-40, 2006.
Asensio A, R. A., Múñez E, Vilanova JL, Torrijos P, García FJ.: Preoperative low
molecular weight heparin as venous thromboembolism prophylaxis in patients at
risk for prosthetic infection after knee arthroplasty. Infect Control Hosp
Epidemiol., 26(12): 903-9, 2005.
Azzam KA, Seeley M, Ghanem E, Austin MS, Purtill JJ, Parvizi J.: Irrigation and
debridement in the management of prosthetic infection: traditional indications
revisted. J Arthoplasty, 25(7);1022-1027, 2010.
Block JE, S. H.: Reducing the risk of deep wound infection in primary joint
arthroplasty with antibiotic bone cement. Orthopedics., 28(11): 1134-45, 2005.
Coursin DB, W. K.-. Corticosteroid supplementation for adrenal insufficiency.
JAMA, 287: 236-40, 2002.
den Broeder AA, C. M., Fransen J, de Jong E, de Rooij DJ, Wymenga A, de
Waal-Malefijt M, van den Hoogen FH: Risk factors for surgical site infections
and other complications in elective surgery in patients with rheumatoid arthritis
with special attention for anti-tumor necrosis factor: a large retrospective study.
Nat Clin Pract Rheumatol. , 3(8): 432-3, 2007.
Der Tavitian J, O. S., Taub NA, Taylor GJ: Body-exhaust suit versus occlusive
clothing. A randomised, prospective trial using air and wound bacterial counts. J
Bone Joint Surg Br., 85(4): 490-4, 2003.
Esler CN, B. C., Fiddian NJ.: The use of a closed-suction drain in total knee
arthroplasty. A prospective, randomised study. J Bone Joint Surg Br., 85(2): 2157, 2003.
Fuerst M, M. H., Baumgärtel K, Rüther W: Leflunomide increases the risk of
early healing complications in patients with rheumatoid arthritis undergoing
elective orthopedic surgery. Rheumatol Int., 26(12): 1138-42, 2006.
Grennan DM, G. J., Loudon J, et al: Methotrexate and early postoperative
complications in patients with rheumatoid arthritis undergoing elective orthopedic
surgery. Ann Rheum Dis, 60(3): 214-7, 2001.
Hanssen, A.: Evaluation and treatment of infection at the site of a total hip or knee
arthroplasty. Instr Course Lect 48(111), 1999.
Johnson AJ, Daley JA, Zywiel MG, Delanois RE, Mont MA.: Preoperative
chlorhexidine preparation and the incidence of surgical site infections after hip
arthroplasty. J Arthoplasty, 25(6):98-102, 2010.
Knobben BA, E. Y., Neut D, van der Mei HC, Busscher HJ, van Horn JR.:
Intraoperative contamination influences wound discharge and periprosthetic
infection. J Hosp Infect., 62(2): 174-80, 2006.12.
Malone, D. G., T; Tracy, JK; Gannon, C; Napolitano, LM;: Surgical site
infections: reanalysis of risk factors. J Surg Res, 103(1): 89-95, 2002.
First Annual AAHKS Spring Meeting | 103
Breakout 4, Revision Total Hip Arthroplasty (THA): Simple to Complex
21
16.
Marchant MH Jr, Viens NA, Cook C, Vail TP, Bolognesi MP.: The impact of
glycemic control and diabetes mellitus on perioperative outcomes after total joint
arthroplasty. J Bone Joint Surg Am., 91(7):1621-1629, 2009.
17.
Murata K. Yasuda T, I. H., Yoshida M, Shimizu M, Nakamura T: Lack of
increase in postoperative complications with low-dose methotrexate therapy in
patients with rheumatoid arthritis undergoing elective orthopedic surgery. Mod
Rheumatol., 16(1): 14-9, 2006.
18.
Murphy E, Spencer SJ, Young D, Jones B, Blyth MJ: MRSA colonisation and
subsequent risk of infection despite effective eradication in orthopaedic elective
surgery. J Bone Joint Surg Br., 93(4): 548-551, 2011.
19.
Oussedik SI, Dodd MB, Haddad FS: Outcomes of revision total hip replacement
for infection after grading according to a standard protocol. J Bone Joint Surg Br.,
92(9): 1222-1226, 2010.
20.
Patel VP, W. M., Sehgal B, Preston C, DeWal H, Di Cesare PE.: Factors
associated with prolonged wound drainage after primary total hip and knee
arthroplasty. J Bone Joint Surg Am. , 89(1): 33-8, 2007.
21.
Peersman, G.: Infection in total knee replacement: a retrospective review of 6489
total knee replacements. Clin Orthop Relat Res., Nov. 2001(392): 15-23, 2001.
22.
Schinsky MF, Della Valle CJ, Sporer SM, Rosenberg AG, Jacobs JJ, Paprosky
WG.: Perioperative testing for sepsis in revision total hip arthroplasty. J Bone
Joint Surg Am. , 90:1869-1875, 2008.
23.
Småbrekke A, E. B., Havelin LI, Furnes O.: Operating time and survival of
primary total hip replacements: an analysis of 31,745 primary cemented and
uncemented total hip replacements from local hospitals reported to the Norwegian
Arthroplasty Register Acta Orthop Scand., 75(5): 524-32, 2004.
24.
Spangehl MJ, Masterson E, Masri BA, O’Connell JX, Duncan CP.: The role of
intraoperative gram stain in the diagnosis of infection during revision total hip
arthroplasty. J Arthoplasty, 14;952-956, 1999
25.
Spangehl MJ, Masri BA, O’Connell JX, Duncan CP.: Prospective analysis of
preoperative and intraoperative investigations for the diagnosis of infection at the
sites of two hundred and two revision total hip arthroplasties. J Bone Joint Surg
Am, 81:672-683, 1999.
26.
Tannenbaum DA, M. L., Grady-Benson JC.: Infection around joint replacements
in patients who have a renal or liver transplantation. J Bone Joint Surg Am., 79(1):
36-43, 1997.
27.
Willis-Owens CA, Konyves A, Martin DK: Factors affecting the incidence of
infection in hip and knee replacement: an analysis of 5277 cases. J Bone Joint
Surg Br., 92(8): 1128-1133, 2010.
28.
Wolf CF, Gu NY, Doctor JN, Manner PA, Leopold SS: Comparison of one and
two stage revision of total hip arthroplasty complicated by infection: a Markov expectedutility decision analysis. J Bone Joint Surg Am., 93(7): 631-639, 2011
First Annual AAHKS Spring Meeting | 104
Symposium IV, The Business of Orthopaedics
Symposium IV, The Business of Healthcare
Mark Froimson, MD, MBA
Trinity Health
Healthcare in general, and joint replacement in particular, has come under fire for being of
uneven quality and cost, without a direct correlation between the two. As a result, payers and
regulators are attempting to correct this perceived deficiency by incentivizing providers, that is
physicians and health systems, to focus on the value of the care provided. While there is general
agreement that both quality improvement and cost reduction are tandem paths to value creation,
there is less agreement on the best models for achieving one or both of these. Waste and
unnecessary interventions are commonly cited reasons for excess cost and lack of quality.
Duplication of services occurs when there is lack of communication and coordination and when
practitioners attempt to ply their craft in traditional silos. The move to alternative payment
models has begun to shed light on the importance of care coordination and transitions of care, in
eliminating redundancy and ensuring compliance with prescribed treatments. Such seamless care
requires that providers know one another, that there are common and accepted pathways across
the continuum, that communication is fostered, that follow up is assured and that complications
and deviations from the expected course are managed by those with the most knowledge of the
patient. Although such care can occur in a virtual network of providers who are well known to
each other, there is increasing evidence that the most reliable way to ensure such quality and
efficiency is through the creation of integrated delivery systems. Such systems can take the form
of a unified entity with a single business model, but can also exist in the form of a clinically
integrated network that is linked by shared agreements between independent entities. It is the
degree of integration that matters more than the financial ties of the parties delivering the care.
One additional conclusion is clear, in order for the healthcare system to be redesigned and
optimized for better care deliver and better health, physicians will need to play a more central
role in the leadership of such efforts. Whether in private practice, group practice, in academic
medicine or as employees, physicians, and surgeons in particular, will need to understand the
legislative and regulatory landscape, and, importantly, how they can either impact it or adapt to
it. Change is rapid on all fronts, but what is immutable is the value that patients see in the doctor
First Annual AAHKS Spring Meeting | 105
Symposium IV, The Business of Orthopaedics
patient relationship. It is imperative that surgeons get educated on the non clinical drivers of the
system, both financial and regulatory. Only by empowering themselves with knowledge will
they be able to influence teams, build systems, eliminate waste and lay claim to the value that
these activities create.
References:
Bhatt, Purvi B., Forster Kevin, Walter Terri L., Survive or Thrive?, Healthcare Financial
Management, July 2015, p62-67.
Carlin Caroline S., Dowd Bryan, Feldman Roger, Changes in Quality of Health Care Delivery
after Vertical Integration, Health Services Research, August 2015, p. 1043-1069.
Hwang Wenke, PhD, Chang Jongwha, PhD, LaClair Michelle, MPH, Paz Harold, MD, MS,
Effects of Integrated Delivery System on Cost and Quality, The American Journal of Managed
Care, May 2013, Vol 19, No. 5, e175-e184.
Jacquin Laura, A Strategic Approach to Healthcare Transformation, Healthcare Financial
Management, April 2014, p.74-79.
May, Ellen Lanser, Achieving Physician-Led Clinical Integration, Healthcare Executive, Jan/Feb
2015, p11-17.
Moore, Keith D., Eyestone, Katherine M., Coddington Dean C., The Integration Aspiration,
Healthcare Financial Management, June 2014, p56-59.
Sharan Alok D., MD, MHCDS, Schroeder Gregory D., MD, West, Michael E., MBA, CPA,
Vaccaro Alexander R., MD, PhD, MBA, Business of Medicine, Spinal Disord Tech, Vol 00,
Number 00, 2015, p1-3.
First Annual AAHKS Spring Meeting | 106
Symposium IV, The Business of Orthopaedics
Squazzo Jessica D., The Journey to Value-based Care for Population Health, Healthcare
Executive, Jan/Feb 2015, p28-35.
Teisberg Elizabeth O., Phd, Wallace Scott, JD, MBA, Creating a High-Value Delivery System
for Health Care, Semin Thorac Cardiovasc Surg 21, 2009, p.35-42.
First Annual AAHKS Spring Meeting | 107
Breakout 6, Managing Complications in Hip and Knee Arthroplasty
Breakout 6, Complications after THA and TKA:
Current Strategies for Diagnosis and Treatment
Moderators:
Craig J. Della Valle, MD
Rush University Medical Center, Chicago, IL
Jay Parvizi, MD
The Rothman Institute at Thomas Jefferson University, Philadelphia, PA
Greg Polkowski, MD
Vanderbilt University Medical Center, Nashville, TN
Diagnosis and Treatment of Infection in the Early Post-Operative Period
Diagnosis can be extremely difficult in the early post-operative period secondary to
normal post-operative pain, edema and peri-incisional erythema that make the appearance
of the wound and normal cues to diagnosis unreliable.
While the ESR, CRP, synovial fluid WBC count and differential have been found to be
useful in the diagnosis of chronic infection, one would expect that they would be elevated
in the early post-operative period and potentially unreliable.
We performed a retrospective review of 6,033 consecutive primary total hip
arthroplasties performed by (3) surgeons to determine the utility of the ESR, CRP and
synovial fluid WBC count with differential in the early post-operative period; 73 patients
(1.2%) underwent early re-operation within the first 6 weeks.
ESR (mm/hr)
CRP (mg/L)
Synovial Fluid WBC Count
Differential (% PMN)
Mean Infected (N=36)
69 (6-140)
192 (5-395)
Mean Not Infected (N=37)
46 (8-80)
30 (5-68.7)
P-Value
0.016
<0.001
84,954
(1,400-455,322)
91% (64%-99%)
2,291
(260-12,680)
63% (19%-96%)
< 0.001
<0.0001
We determined the following optimal cut-off values
- C-Reactive Protein: 93mg/L (normal < 8 mg/L)
- Synovial Fluid WBC count : 12,800 WBC/uL
- Differential: 89%
These numbers are similar to our experience with the diagnosis of infection in the early
postoperative period following TKA (see Bedair et. Al CORR 2011)
How do we use this in oury own practices?
- If there is ANY question regarding the wound appearance, we get a CRP.
First Annual AAHKS Spring Meeting | 108
Breakout 6, Managing Complications in Hip and Knee Arthroplasty
Early Complications THA
-
2
If the CRP is near or > 100mg/L, we aspirate the hip (or knee)
If the synovial fluid WBC is > 10,000 and differential is > 90%, the hip is very
likely infected.
If you are still unsure, you can wait for the culture results
Treatment of Infection in the Early Post-Operative Period
Although the most common treatment for an acute post-operative infection is irrigation
and debridement (I+D) with exchange of the modular bearing surface, the validity of this
approach has recently been questioned given a high rate of failure.
- Particularly bad results with any type of a staphyloccal infection
- Or with a resistant organism
Alternative options include a 1-stage exchange or a 2-stage exchange. We performed a
decision analysis to compare quality of life outcomes among irrigation and debridement,
one and two-stage exchange (Bedair et. al, CORR 2011).
- Based on this analysis, if the rate of eradication of infection with a 1-stage
exchange exceeds 69%, it is the preferred treatment option;
- I+D with a bearing surface change is only preferred if the success rate is > 60%.
- Advantages of a one-stage exchange include
o Relative ease of cementless component removal in the early post-operative
period
o Greater exposure and access for debridement of the bony surfaces
o Removal of colonized implants, which may harbor bacterial biofilm.
Early experience with 1-Stage Exchange in the early postoperative period following THA
- Multi-center study (Rush, Jefferson, University College Hospital in London)
- 28 Hips; all had cementless components at index arthroplasty and all exchanged to
cementless implants
- 71% implant retention at mean 41 months
- Hansen et. al, CORR 2013
Based on the published results of an isolated I+D, the decision analysis and the early
clinical results of a 1-stage exchange, it seems reasonable to consider a 1-stage exchange
for the treatment of the acute infected THA.
Suggested Reading
1. Bedair H, Ting N, Moric M, Saxena A, Jacovides C, Parvizi J, Della Valle CJ.
Diagnosis of infection in the early post-operative period following primary total
knee arthroplasty. Clin Orthop Relat Res. 2011, 469:34-40.
2. Bedair H, Ting N, Bozic KJ, Della Valle CJ, Sporer SM. Treatment of Early
Infections after THA: A Decision Analysis. CORR 2011, 469:3477-85.
3. Bradbury T, Fehring TK, Taunton M, et. al. The fate of acute methicillin-resistant
staphylococcus aureus periprosthetic knee infections following debridement and
retention of components. J Arthroplasty. 2009 (Suppl): 101-4.
First Annual AAHKS Spring Meeting | 109
Breakout 6, Managing Complications in Hip and Knee Arthroplasty
Early Complications THA
3
4. Della Valle C, Parvizi J, et. al. AAOS clinical practice guideline on the diagnosis
of PJI. J Bone Joint Surg Am. 2011 Jul 20;93(14):1355-7.
5. Hansen E, Zmistowski B, Della Valle C, Parvizi J, Haddad FS, Hozack WJ.
Outcome of One Stage Cementless Exchange for Acute Postoperative
Periprosthetic Hip Infection. Clin Orthop, 471:3214-22, 2013.
6. Tetreault M, Wetters N, Aggarwal VK, Moric M, Parvizi J, Huddleston JI, Segreti
J, Della Valle C. Should draining wounds be cultured prior to revision hip and
knee arthroplasty? J Arthroplasty, 28 (8 Suppl):133-6, 2013.
Management of the Unstable THA
Recurrent dislocation following total hip arthroplasty (THA) is a complex, multifactorial
problem that has been shown to be the most common indication for revision THA. At
our center, we have tried to approach the unstable hip by identifying the primary cause of
instability and correcting that at the time of revision surgery.
Type
1
2
3
Reason for Instability
Malposition Acetabulum
Malposition Femoral
Component
4
Abductor Deficiency
Soft Tissue/Bony
Impingement
5
6
Late Polyethylene Wear
Unable to identify cause
Treatment
Revision acetabular component; upsize femoral head
Revision femoral component; upsize femoral head
Constrained liner or dual mobility bearing; optimize
component position
Remove sources of impingement; upsize femoral
component and optimize component position
Exchange of acetabular liner; upsize femoral head and
optimize component position
Constrained liner or dual mobility bearing
The most common etiologies of instability in our experience include cup malposition
(Type 1) and abductor deficiency (Type 3)
We reviewed 75 hips revised for instability and at a mean 35.3 months 11 re-dislocations
occurred (14.6%). Acetabular revisions were protective against re-dislocation (p<0.015).
The number of previous operations (p=0.0379) and previously failed constrained liners
(p<0.02) were risk factors for failure. The highest risk of failure was in patients with
abductor insufficiency with revisions for other etiologies having a success rate of 90%.
Although instability can be multifactorial, by identifying the primary cause of instability,
a rational approach to treatment can be formulated. In general the poorest results were
seen in patients with abductor deficiency. Given the high rate of failure of constrained
liners (9 of the 11 failures were constrained), we currently are exploring alternatives such
as dual mobility articulations.
Suggested Reading
First Annual AAHKS Spring Meeting | 110
Breakout 6, Managing Complications in Hip and Knee Arthroplasty
Early Complications THA
4
Wera GD, Ting NT, Moric M, Paprosky WG, Sporer SM, Della Valle CJ. Classification
and management of the unstable total hip arthroplasty.J Arthroplasty,27: 710-5,
2012.
Leg Length Inequality
Total hip arthroplasty provides an effective operative solution in managing patients with
joint failure. Leg length inequality is a cause of patient morbidity with serious medicolegal implications. Management relies on an accurate understanding of the cause of LLI
and is usually conservative. Revision surgery for managing LLI is occasionally required
and often very successful.
Suggested Reading
1. Ranawat CS; Rodriguez JA. Functional leg-length inequality following total hip
arthroplasty. J Arthroplasty. 1997 Jun;12(4):359-64.
2. Gurney B; Mermier C; Robergs R; Gibson A; Rivero D. Effects of limb-length
discrepancy on gait economy and lower-extremity muscle activity in older adults.
J Bone Joint Surg Am. 2001 Jun;83-A(6):907-15.
3. Jones HW; Harrison T; Clifton R; Akinola B; Tucker K. The Relationship
between abduction contracture and leg length discrepancy following total hip
replacement.. Journal of Bone & Joint Surgery, British Volume. 2010 July 1,
2010;92-B(SUPP III):389.
4. Maloney WJ; Keeney JA. Leg length discrepancy after total hip arthroplasty. J
Arthroplasty. 2004 Jun;19(4 Suppl 1):108-10.
5. Clark CR; Huddleston HD; Schoch EP, 3rd; Thomas BJ. Leg-length discrepancy
after total hip arthroplasty. J Am Acad Orthop Surg. 2006 Jan;14(1):38-45.
6. Parvizi J; Sharkey PF; Bissett GA; Rothman RH; Hozack WJ. Surgical treatment
of limb-length discrepancy following total hip arthroplasty. J Bone Joint Surg
Am. 2003 Dec;85-A(12):2310-7
Periprosthetic Fractures: Early
With the popularity of cementless stems in primary total hip arthroplasty (THA) we have
seen a concomitant rise in the prevalence of intra-operative and early postoperative
fractures of the femur. While initial press-fit fixation is a requirement for
osseointegration to occur, there is a fine balance between optimizing initial stability and
overloading the strength of the proximal femur. Hence, the risk of intra-operative
fractures is intimately related to the design of the femoral component utilized
(metaphyseal engaging, wedge shaped designs having the highest risk) and the strength
of the bone that it is inserted into (elderly females being at highest risk).
If a fracture is identified, typically during or immediately after implant insertion, the stem
should be removed and the fracture examined to determine its extent; most are nondisplaced after removal of the implant. At this time, the surgeon can either place a
cerclage wire or cable and re-insert the stem or switch to a femoral component that gains
fixation primarily in the diaphysis. Recognition intra-operatively is preferable as
First Annual AAHKS Spring Meeting | 111
Breakout 6, Managing Complications in Hip and Knee Arthroplasty
Early Complications THA
5
unrecognized fractures can lead to early femoral component subsidence and/or displaced
fractures that in our experience are challenging to manage.
These fractures typically are associated with a loose femoral component and require
revision to a stem that gains primary fixation distally. We have found a high risk of
complications and problems when treating these fractures in the early postoperative
period with a high risk of infection, heterotopic ossification and the requirement for
subsequent surgery.
Periprosthetic Fractures: Late
The Vancouver Classification is based on the location of the fracture, the fixation of the
implant and the quality of the surrounding host bone. The most common pitfall in
treatment is mistaking a B2 fracture (stem loose) for a B1 (stem stable); treatment of a
loose implant with ORIF alone will necessarily fail.
Type
Fracture Location
Implant
A
Per-Trochanteric
Stable
B
B1
B2
Around the stem
B3
C
Well distal to stem
Stable
Loose
Treatment
ORIF of the trochanter; concomitant bearing surface
exchange if associated with osteolysis
Loose
ORIF; typically long locked plate of whole femur
Femoral component revision to distally fixed stem
As for B2 but surrounding bone stock poor;
typically little isthmus for distal fixation; may
require proximal femoral replacement
Stable
ORIF; typically long locked plate of whole femur
Suggested Reading
1. Berend KR, Lombardi AV, Jr, Mallory TH, Chonko DJ, Dodds KL, Adams JB.
Cerclage wires or cables for the management of intraoperative fracture associated
with a cementless, tapered femoral prosthesis: results at 2 to 16 years. J
Arthroplasty. 2004;19(Suppl 2):17–21.
2. Berry DJ. Management of periprosthetic fractures: the hip. J Arthroplasty.
2002;17: 11–13.
3. Brady OH, Garbuz DS, Masri BA, Duncan CP. Reliability and Validity of the
Vancouver Classification of femoral fractures after hip repalcement. J
Arthroplasty. 2000; 15: 59-62.
4. Sheth N, Brown NB, Moric M, Berger RA, Della Valle CJ. Operative Treatment
of Early Peri-Prosthetic Femur Fractures Following Primary Total Hip
Arthroplasty. J Arthroplasty. 28, 286-91, 2013
First Annual AAHKS Spring Meeting | 112
Symposium VI, Step by Step: Key Choices and Techniques in the Tough Revision Total Hip Arthroplasty (THA)
and Revision Total Knee Arthroplasty (TKA)
Symposium VI, Step by Step: Key Choices and Techniques in the Tough
Revision Total Hip Arthroplasty (THA) and Revision Total Knee Arthroplasty
(TKA)
Daniel J. Berry, M.D.
Mayo Clinic
Rochester, Minnesota
I.
Revision THA
A. Exposure
1. When do you perform an ETO?
B. Acetabular bone loss/reconstruction
1. What is role of cancellous graft?
2. What is role of structural graft?
3. When do you use metal augments?
4. When do you need something more than a hemispheric shell?
5. Do you always use a highly porous/high friction cup surface?
6. Indications for cup-cage; triflange cup?
C. Femoral bone loss
1. What percent of cases are uncemented?
2. What category of uncemented stem do you usually use?
a. Fluted/tapered
b. Fully coated
3. Is there still a role for impaction grafting?
4. Is there still a role for proximal femoral allografts?
D. Instability
1. What head size do you use in most revisions?
2. What is the role of dual mobility implants?
3. What is the role of dual mobility constrained cups?
II.
Revision TKA
A. Exposure
1. In a revision TKA, how often do you use a quadriceps snip?
2. In a revision TKA, how often do you use a tibial tubercle osteotomy?
B. Implant removal
1. What is your favorite way to take out a well-fixed femur?
2. What is your favorite way to take out a well-fixed tibia?
3. Any tricks to take out well-fixed stems?
First Annual AAHKS Spring Meeting | 113
Symposium VI, Step by Step: Key Choices and Techniques in the Tough Revision Total Hip Arthroplasty (THA)
and Revision Total Knee Arthroplasty (TKA)
Key Choices and Techniques in the Tough Revision THA and TKA
C. Bone loss
1. Tibia
a. What is the role of cancellous bone graft?
b. What is the role of structural bone graft?
c. What is the role of sleeves?
d. What is the role of highly porous cones?
2. Femur
a. What is the role of cancellous bone graft?
b. What is the role of structural bone graft?
c. What is the role of sleeves?
d. What is the role of highly porous cones?
3. Stems
a. What percent of your stems are cemented?
b. What percent of your stems are uncemented?
c. How do you decide how long to go with the stems?
D. Constraint
1. What percentage of your revision TKA’s are posterior stabilized?
2. What percentage of your revision TKA’s are constrained condylar?
3. What percentage of your revision TKA’s are hinged?
4. What are your indications for hinged implant in 2016?
First Annual AAHKS Spring Meeting | 114
Berry/Page 2
Public Disclosure Information
Planners and Faculty
Matthew P. Abdel, MD
No financial relationships with
commercial interests to disclose
Stephen T. Duncan, MD
Biomet; Mitek; Morph;
Smith & Nephew
William P. Barrett, MD
DePuy, A Johnson & Johnson Company
Thomas K. Fehring, MD
DePuy, A Johnson & Johnson Company
Daniel J. Berry, MD
DePuy, A Johnson & Johnson Company
Mark I. Froimson, MD, MBA
Medical Compression Systems
Michael Bolognesi, MD
Amedica; Biomet; DePuy, A Johnson &
Johnson Company; Kinamed; Zimmer
William L. Griffin, MD
DePuy, A Johnson & Johnson
Company; Zimmer
Kevin J. Bozic, MD, MBA
No financial relationships with
commercial interests to disclose
William A. Jiranek, MD
Cayenne Medical; DePuy, A Johnson
& Johnson Company; Johnson &
Johnson; Lifenet Health, Inc.; Stryker
John J. Callaghan, MD
DePuy, A Johnson & Johnson Company
John C. Clohisy, MD
Microport Orthopedics; Pivot Medical;
Smith & Nephew; Zimmer
Jay R. Lieberman, MD
DePuy, A Johnson & Johnson
Company; Hip Innovation Technology
David F. Dalury, MD
DePuy, A Johnson & Johnson
Company; Johnson & Johnson
Adolph V Lombardi Jr, MD
Innomed; Kinamed; Orthosensor;
Pacira Pharmaceuticals, Inc.;
Surgical Technology International;
Zimmer Biomet
Craig J. Della Valle, MD
Biomet; CD Diagnostics; DePuy,
A Johnson & Johnson Company;
Smith & Nephew; Stryker
Steven J. MacDonald, MD
DePuy, A Johnson & Johnson
Company; Hip Innovations Technology;
JointVue; Smith & Nephew; Stryker
AAHKS Staff
Sigita Wolfe
No financial relationships with
commercial interests to disclose
First Annual AAHKS Spring Meeting | 115
R. Michael Meneghini, MD
Stryker
Mark W. Pagnano, MD
DePuy, A Johnson & Johnson
Company; Pacira; Stryker
Brian S. Parsley, MD
Conformis; DePuy, A Johnson &
Johnson Company; Nimbic Systems
Javad Parvizi, MD, FRCS
3M; CD Diagnostics; Cempra;
CeramTec; DePuy, A Johnson &
Johnson Company; Hip Innovation
Technology; PRN; Smith & Nephew;
StelKast; Stryker; Zimmer
Gregory G. Polkowski, II MD
No financial relationships with
commercial interests to disclose
Bryan D. Springer, MD
Convatec; Polaris; DePuy, A Johnson
& Johnson Company; Ceramtec;
Joint Purification Systems; Stryker
First Annual AAHKS Spring Meeting | 116
Call for Submissions
ABSTRACT SUBMISSIONS
Submit high-quality scientific and socioeconomic
abstracts by June 1, 2016 for consideration as
podium or poster presentations. Abstracts are blind
reviewed by the AAHKS Program Committee review
team. If you are interested in serving on the review
team, contact meeting @ aahks.org.
SYMPOSIUM PROPOSALS
Submit proposals by May 2, 2016 covering all
aspects of arthroplasty and health policy. Proposals
are reviewed by the AAHKS Program Committee.
VIDEO PROPOSALS
Submit proposals for surgical technique videos that
are high-quality, clinically relevant and have high overall
educational value. Deadline is May 2, 2016.
Submit proposals and abstracts
online at www.AAHKS.org
Save the Date
AAHKS
26th Annual Meeting
November 10 – 13, 2016
NEW LOCATION!
Hilton Anatole
Dallas, Texas, USA
Thank you to our Sponsors
DePuy Synthes
DJO Global
Medtronic
Pacira Pharmaceuticals, Inc.
Smith & Nephew
Stryker
Zimmer Biomet
See you at the
AAHKS
26th ANNUAL MEETING
November 3 - 6, 2016 | Hilton Anatole, Dallas
9400 West Higgins Rd., Suite 230,
Rosemont, IL USA 60018
847 – 698 – 1200 | www.AAHKS.org