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™ Somnolin Support for Deep, Restful Sleep & Daytime Alertness◆ Patient Benefits: • A natural approach to deep, restful, and recuperative sleep to feel refreshed and alert during the day◆ • Helps to fall asleep and stay asleep by promoting balanced levels of neurotransmitters◆ • Promotes an alert, relaxed state during the day◆ • Convenient and easy to use, supplying clinically effective levels of 5-HTP and theanine in just one tablet daily◆ Special Features: • Provides optimal clinical outcomes with Suntheanine®—an extensively researched source of theanine—and a plant source of 5-HTP (5-hydroxytryptophan)◆ • Supplies neuroactive forms of folate (L-5-methyl tetrahydrofolate) and vitamin B12 (methylcobalamin) to provide support where it counts◆ • Features an exclusive, scientifically designed blend of ingredients available only through Metagenics 60 MILLION AMERICANS suffer from occasional sleeplessness— characterized by less than optimal daily functioning. ™ Somnolin Rest Assured with Somnolin 10 Signs of Occasional Sleeplessness Millions of Americans experience some form of occasional sleeplessness without knowing it. Occasional difficulty sleeping and staying awake are actually two sides of the same coin, and many people show subtle signs of sleep issues, such as: • Difficulty falling asleep occasionally • Difficulty waking up in the morning or waking up tired • Microsleeps—very brief episodes of sleep, such as “nodding off”, when otherwise awake • “Zoning out” in the middle of a conversation or task • Difficulty concentrating, making simple decisions, or doing math calculations • Feeling emotional, crabby, or volatile for no apparent reason • Altered memory or judgment • Clumsy and/or slower reaction times than normal • Routinely falling asleep within 5 minutes after lying down All-Natural Support For Restful Sleep and Daytime Alertness Somnolin is an exclusive, unique approach to promoting deep, restful, and recuperative sleep at bedtime while supporting wakefulness and alertness during the day by delivering a variety of specially selected, well-researched ingredients:◆ Suntheanine—the source of theanine for scientific research—influences the generation of alpha brain waves associated with a relaxed, calm state. It also plays a role in the formation of gamma amino butyric acid (GABA) and dopamine neurotransmitters key for maintaining a sense of calmness.◆ 5-Hydroxytryptophan (5-HTP) from the plant Griffonia simpicifolia positively influences levels of serotonin, a neurotransmitter that helps regulate occasional sleeplessness and nervous tension.◆4 Neuroactive B Vitamins—including Metagenics' exclusive source of bioavailable folate (L-5-methyl tetrahydrofolate) and methylcobalamin—cross the blood-brain barrier to provide support where it counts. Along with vitamin B6, these nutrients support a positive mood and healthy mental function.◆ Somnolin™ Each Tablet Supplies: L-5-Hydroxytryptophan (L-5-HTP from Griffonia simplicifolia) ......................................100 mg Theanine† ........................................................................100 mg Vitamin B6 ........................................................................20 mg Vitamin B12 (as methylcobalamin) ..........................250 mcg L-5-methyl tetrahydrofolate†† ....................................200 mcg Recommendations: One tablet daily or as directed. May be taken during the day and/or one hour before bedtime. Form: 30 Tablet Bottle † As Suntheanine® †† As Metafolin® U.S. Patent Nos. 5,997,915; 6,254,904. Caution: Because this product contains ingredients that influence neurotransmitter levels, patients taking certain prescriptive medications (including MAO inhibitors and other antidepressants) should avoid use. If pregnant or nursing, or taking medications, consult your healthcare practitioner before use. Use with caution when driving or operating References 1. National Library of Medicine. Sleep Disorders. Available at http://www.nlm.nih.gov/medlineplus/tutorials/sleepdisorders/hr24910 1.html. Accessed June 30,2004. 2. National Institute of Neurological Disorders and Stroke. Available at http:www.ninds.nih.gov/health_and_medical/pubs/understanding_sle ep_brain_basic.htm. Accessed July 21, 2004. 3. Juneja LR, Chu DC, Okubo T, Nagato Y, Yokogoshi H. L-theanine—a unique amino acid of green tea and its relaxation effect in humans, Trends in Food Science and Technology 1999;10:199-204. 4. Meyers S. Use of neurotransmitter precursors for treatment of depression. Alt Med Rev 2000;5(1):64-71. 5. Jacob RA. Folate, DNA methylation, and gene expression: factors of nature and nurture. Am J Clin Nutr 2000 Oct;72(4):903-04. 6. Mayer G, Kroger M, Meier-Ewert K. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharmacology 1996;15(5):456-64. machinery, may cause drowsiness. ◆ These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. www.metagenics.com ©2003 Metagenics, Inc. MET1029 7/04