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LEARNING MODULE FOR CARE OF THE TUNNELED HEMODIALYSIS CENTRAL VENOUS CATHETER POST-ENTRY LEVEL COMPETENCY FOR RNS AND LPNS (CC 50-050) Developed: June 1998 Revision Date: April 2014 This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 2 of 33 TABLE OF CONTENTS Learning Objectives and Method ………………………………... …………………………………………………….….. References ……………………………………………………. Self Test ………………………………………………………. Answers ………………………………………………… Proficiency Skills Checklists ……………………………………. Theory Page 3 3 22 24 26 27 (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 3 of 33 LEARNING OBJECTIVES & METHOD Following the completion of this learning module, the RN or LPN will: 1. Discuss the indications for use of the tunneled hemodialysis Central Venous Catheter (CVC). 2. Discuss the advantages of the tunneled hemodialysis CVC. 3. Discuss the components and placement of this device. 4. Discuss the nursing interventions required pre and post insertion of the line. 5. Describe the theory and procedure related to assessing patency, flushing, blood withdrawal, instillation of lock solution, luer lock cap and dressing changes. 6. Demonstrate the ability to: assess patency, flush catheter lumens, blood withdrawal, instillation of lock solution (alteplase or antibiotic locking solution instillation is to be performed by an RN only), luer lock or TEGO connector cap and dressing changes. 7. Discuss complications associated with the tunneled hemodialysis CVC and nursing actions to prevent and treat these complications. 8. Discuss required patient teaching components in relation to the tunneled hemodialysis CVC. In order to be deemed competent in the care of the tunneled hemodialysis CVC, the RN or LPN must: 1. Review the Policy and Procedure & Learning Module associated with the tunneled hemodialysis CVC. 2. Complete the self-test. 3. Practice the procedures and demonstrate skills to clinical educator, preceptor or delegate. 4. Maintain a record of competence. 5. Conduct a yearly self-assessment of competency level and develop a plan in conjunction with the unit manager to meet ongoing needs. THEORY 1. The tunneled hemodialysis CVC is subcutaneously tunneled on the chest wall and the external catheter exits on the chest usually above the nipple line near the sternal border. The preferred site is the right internal jugular vein with the catheter tip adjusted to the level of the caval atrial junction or into the right atrium. The catheter can also be placed in the external jugular, subclavian or femoral vein; however, the right internal jugular is the preferred site as: 1.1. the internal jugular permits easier catheter tip positioning in the right atrium, (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 4 of 33 1.2. use of subclavian vein is associated with thrombus formation and stenosis 1.3. the femoral vein is typically only used when chest wall insertion is not possible Tunneled cuffed double-lumen central venous catheter inserted in the right internal jugular vein. Vascular Access for Dialytic Therapies Tordoir, Jan H.M., Comprehensive Clinical Nephrology, CHAPTER 87, 1031-1042 Copyright © 2010 Copyright © 2010, 2007, 2003, 2000 by Saunders, an imprint of Elsevier Inc. The tunneled hemodialysis catheter contains two (dual) lumens. (pictured above). The catheter tip design varies with each brand. The tip design will help to minimize blood recirculation during dialysis. The catheters are usually made of polyurethane material (please refer to manufacturers product instructions for further information about specific catheter brands). Polyurethane is soft and flexible but can rupture if excessive pressure is applied such as when using syringes less than 10mL (i.e. the smaller the syringe the more pounds per square inch pressure applied to the catheter). Attached to the outside of the tunneled CVC is a thin band of felt material. When the catheter is in place, this cuff sits about 3-5 cm from the exit site (under the skin in the subcutaneous tunnel). The cuff's primary purpose is to promote fibrin growth, which helps to anchor the catheter in place. Fibrin growth usually occurs within a few days - several weeks of the catheter insertion. The cuff also helps to minimize bacteria from migrating along the catheter. Each of the catheter lumens has an in-line clamp and typically each lumen is color-coded (red for “arterial” outflow of blood and blue for “venous” return). (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 5 of 33 Like other central venous access devices (CVADs), tunneled hemodialysis lines are chosen for patients with kidney disease when long- term venous access is required and a creation of an A/V fistula or graft has failed or is not matured for cannulation. The tunneled CVC allows for repeated access for hemodialysis and related blood sampling and IV administration. The CVC tip location may be in the right atrium or at the level of the caval atrial junction. This position will maximize hemodilution and potentially decreases venous irritation from medications known to cause thrombophlebitis when infused in peripheral IV sites. Nursing Practice Statements Preinsertion Care 1. Provide and document patient teaching. Include the following: purpose, placement, insertion procedure and post insertion care including what symptoms to report to the nurse. 2. Blood work to be drawn as per physician or NP’s orders. Profile (platelet count), INR, and PTT within seven days prior to the procedure 3. The patient may have clear fluids after midnight the day before the procedure and until the procedure has been completed. Discussion will need to be had with the physician or NP regarding adjustments to insulin or oral hypoglycemic medications. The procedures are usually scheduled for the morning and it suggested to bring the hypoglycemic medications to the hospital and take the medication after the procedure is completed. 4. Patients on warfarin who meet low risk criteria for arterial or venous thromboembolism may be managed using the PPO (0400MR) Anticoagulation Pre/Post Radiology Intervention. Patients on warfarin who do not meet low risk criteria for arterial or venous thromboembolism may require a consult to Anticoagulation clinic or admission to hospital for anticoagulation management. 5. Take all other medications as usual except for hypoglycemic medications and warfarin as mentioned above. 6. Outpatients are to arrange for someone to accompany them and to drive them home after the procedure as the patient usually receives IV conscious sedation. Insertion and Nursing Care The patient usually is admitted to Medical Day Unit (VGH site) or Minor Procedure (HI site). A health history is completed, intravenous access initiated and hospital gown is provided. The patient will then be transported to the Interventional Radiology suite - approximate time one hour. A radiologist in the radiology department inserts tunneled hemodialysis CVC. The procedure takes approximately an hour and usually requires IV conscious sedation. This is a sterile procedure (a gown, gloves and mask will be worn, the skin at the insertion site will be cleansed with a disinfectant and sterile equipment will be used). An incision is made in (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 6 of 33 the chest wall usually above the nipple line and near the sternal border. This is known as the exit site because it is where the catheter exits the body. From the exit site, the catheter is tunneled subcutaneously to the jugular vein. Here another incision is made and the catheter is entered into the jugular vein. This is known as the venotomy (insertion) site. The catheter is then advanced until the tip is in the correct location. The line is flushed with normal saline and then instilled/locked with prescribed solution. The CVC may be stabilized by sutures and/or by steri-strips at the exit site and at the insertion site. A gauze dressing is placed over the insertion site and exit site for the first 24-48 hours (gauze dressing is required if drainage and/or redness noted). Post Insertion Nursing Care Immediately and for the first two hours post insertion the patient should be assessed for bleeding complications, pain and access problems. Frequent vitals and bed rest may be ordered for an inpatient. An outpatient may be monitored in the Medical Day Unit /Minor Procedure unit. The patient may eat and drink post procedure. The patient's level of comfort and any abnormal sensations at the site should be assessed post insertion and during the monitoring recovery period. Any abnormal sensations should be reported to the physician or NP immediately. These symptoms may include pain upon inspiration, burning or throbbing. Care of the small incision line (venotomy site) is managed like other routine incision care; the sutures and steri-strips (if applicable) are to be removed approximately 10-14 days post procedure as ordered by the physician or NP. The exit site steri-strips (if applicable) are to be removed 7-10 days post procedure. Often, an anchor suture is places in close proximity to the exit site for up to 6 weeks and requires a physician or NP’s order for removal. A review of the insertion procedure documentation is to be assessed and recorded on the patient’s hemodialysis kardex. Prior to catheter use, the RN or LPN must verify that correct catheter tip placement has been documented by the radiologist. Each time a catheter is used it is assessed for the following: - Catheter lumen volumes, size, integrity and patency - Kinks - Suture integrity - Insertion site (presence of redness, drainage etc.) (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 7 of 33 All patients should be aware of safety precautions and signs and symptoms to report to the health care professionals. Refer to the Capital Health Patient Guide- Tunneled Hemodialysis Catheter (WQ85-1032) Nursing Approach to Patient Teaching: 1. start teaching as early as possible, involve a family member if able; 2. assess patient’s readiness to learn; 3. assess most effective method of learning for patient (i.e., pictures, booklet, demonstration, discussion); 4. design a teaching schedule so others may reinforce and add to what has been taught; 5. explain procedures in terms appropriate for the individual patient; 5.1. consistently evaluate effectiveness of teaching; 5.2. refer to Capital Health Patient Guide- Tunneled Hemodialysis Catheter (WQ851032) as an introduction. Care and Maintenance As discussed earlier there are several indications and benefits to patients with use of a tunneled hemodialysis CVC. There are many potential complications that may also occur. This section reviews specific complications; causes; preventative actions and management. Occlusion/Dysfunction Flushing of the tunneled hemodialysis CVC is required to prevent or delay catheter occlusion related to fibrin formation or drug precipitate. This is accomplished by withdrawing 5 mL of discard blood from each lumen to remove the locking solution from the lumen and flushing of the catheter lumens with 10 mL of 0.9% normal saline followed by instillation with locking solution. (The preferred locking solution is 4% sodium citrate. Heparin; antibiotic lock, or Alteplase may be ordered by physician or NP).The flushing and locking of the CVC is required q 48-72 hours and whenever the catheter is accessed (i.e. for hemodialysis). When TEGO connector is not in use positive pressure is used to prevent the backflow of blood into the catheter, which could lead to clotting of blood in the catheter lumen and at the tip of the catheter. Methods to Maintain Positive Pressure 1. Close the clamp as the last 0.5mL of solution is injected (when TEGO connector not in use). 2. Close the clamp to IV tubing (i.e. if giving antibiotics) before closing the catheter lumen clamp (when TEGO connector not in use). 3. Post dialysis - administer blood back to patient by attaching the saline line to the arterial bloodline and allowing the blood pump to return the blood. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 8 of 33 Infection Systemic and local infections are possible complications of a tunneled hemodialysis CVC. The most common source of infection is the catheter lumens but other potential causes include: migration of skin flora up the catheter tract and/or CVC bifurcation, hematogenous seeding from another site of infection, catheter related thrombus and rarely contaminated infusate. When performing catheter care it is important that the catheter does not touch the skin as this increases the chance of infection from skin organisms. To decrease the risk of infection from the catheter, aseptic-no touch technique is used at all times. Hand washing is critical before performing any aspect of line care. Sterile gloves (for dressing changes), clean gloves (for catheter access) and mask (both patient and nurse) are to be worn for catheter dressing changes or anytime the catheter is to be accessed. TEGO connectors are to be used as locking caps for hemodialysis catheters The TEGO connector is a closed system device that potentially can reduce the risk of catheter related infections resulting from repeat opening and manipulation of the CVC lumen(s). The preferred skin antiseptic for hemodialysis catheters and exit site care is 2% chlorhexidine gluconate/70% isopropyl alcohol. This is due to its rapid (30 second) and persistent antimicrobial activity (up to 48 hours). In an effort to achieve maximal effectiveness the solution must be applied to the skin using friction to the skin and cleaning in a horizontal (side to side) plane extending 5cm from the catheter exit site, then cleaning in a vertical (up and down) plane, then cleaning the skin beginning at the insertion site with a circular motion (middle to outward) extended in a 5cm radius, for 30 seconds, with up to 2 minutes drying time. The sterile exit site dressing is changed once a week or anytime the dressing is loose and/or wet. If the exit site is draining, red and/or sore, then sterile gauze and transparent dressings are to be used. Gauze dressings are to be changed every hemodialysis treatment (48 to 72 hours) and prn. If the exit site is well healed and free of drainage/redness then transparent exit site dressings can be used. Along with the exit site, the catheter bifurcation must be covered with the transparent dressing. Transparent dressings are to be changed every 7 days (on hemodialysis days) or prn. TEGO connector caps are to be changes every 7 days and prn. Luer lock caps are to be changed every 48-72 hours or if the line is accessed (i.e. for blood sampling). Signs and symptoms of infection may include elevated temperature (although this symptom may be absent), elevated WBC's, site discomfort, redness, swelling and/or drainage. These signs and symptoms must be reported to the physician or NP. The exit site is to be swabbed for C&S. Blood cultures (via the catheter and peripheral) may be ordered prior to initiating antibiotic therapy and a catheter change may be indicated. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 9 of 33 CVC related infections are associated with significant morbidity, mortality and treatment costs. Since 2002, there have been several studies addressing the benefits of using antibiotic and heparin lock solutions to help prevent/reduce catheter related infections. However, relatively few clinical trials have addressed the overall efficacy and most effective concentration of gentamicin. Therefore, gentamicin levels may need to be monitored and resistance to gentamicin may need to be monitored when this CVC locking approach is used. Venous Air Embolism To prevent venous air embolus and decrease the risk of infection, open the system only when it is absolutely necessary. Lines must always be clamped when they are not in use. All lines must be clamped before the system is opened. Removal of the Tunneled CVC Removal of the tunneled CVC is performed by a physician. Consideration may be given to removal of the locking solution from the CVC lumens prior to removal. Blunt edge dissection or surgical cut down to dissect the fibrosed cuff may be required. Patients should lie flat during removal procedure. Patients are asked to perform the Valsalva maneuver, or exhale, hold their breath and bear down while the line is removed and they may feel a slight burning sensation as the line is dislodged from the tissue. Slight pressure is applied to both the catheter venotomy site and catheter exit site post removal. To prevent venous air embolism, an airtight dressing using Vaseline or betadine ointment gauze occlusive dressing must be applied post removal to the exit site until the site has healed and forms a scab. As well, if a cut down procedure (performed by the physician) is required to help free the catheter from the subcutaneous tract than a suture may be inserted. The suture should be removed in 7 days post procedure and requires a physician’s order. An airtight dressing using a Vaseline or betadine ointment gauze dressing must be applied post removal to the cut down site until the site has healed and forms a scab. The RN or LPN is to assist the physician in the removal of the tunneled CVC as follows: Position the patient in supine position. Instruct the patient on Valsalva maneuver or if Valsalva maneuver is contraindicated, have patient hold breath. Hold slight pressure to the catheter exit site and venotomy site as indicated by the physician. Instruct patient to again perform Valsalva maneuver or hold his/her breath while applying Vaseline or Betadine ointment gauze occlusive dressing. Instruct patient to leave dressing in place for 72 hours. Provide education to the patient as to the signs and symptoms of air embolism, bleeding and to seek appropriate emergency medical attention if these or other complications related to the removal of the CVC occur. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 10 of 33 If a suture has been inserted, instruct patient to seek medical attention for removal of the suture 7 days post procedure. As per CC 02-008 LPN Skills, the condition of the patient may be defined as complex, acute or predictable and the unit’s Charge RN is to assign the caregiver most appropriate for the level of care required by the patient.to perform this skill. If the patient’s condition changes from predictable to Complex or Acute, the Charge RN is to provide assistance and/or take over the care of the patient as appropriate. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 SIGNS AND SYMPTOMS Bleeding from the catheter Excessive bleeding for more than 2448 hours after insertion is unusual. Page 11 of 33 POSSIBLE CAUSES NURSING ACTIONS PREVENTION/RATIONALE Bleeding may occur if the patient - Has some form of coagulopathy. Is on an anti- coagulant. Is taking over the counter medications which affect platelet count. Has undergone a traumatic insertion procedure. Has been extremely active post insertion. Use of a large bore catheter. Has had heparin post insertion or catheter exchange. The heparin may have been infused systemically. Identify the source of the bleeding (is it the venotomy site or is the bleeding occurring within the subcutaneous tunnel). Thorough patient assessment to determine the presence of factors which may cause bleeding post insertion (i.e. bleeding disorders, abnormal clotting blood levels). If bleeding is excessive, notify the physician or NP. The line may have to be removed and direct pressure applied to the insertion site. If bleeding occurs immediately post insertion at the venotomy site, apply sterile gelfoam and gauze (using aseptic technique) to the bleeding site. A suture (if absent) may be required at the site. DO NOT leave gelfoam on bleeding site after bleeding has resolved (potential source of infection if left on site for a prolonged period of time). More frequent dressing changes as well as mild pressure may be needed to control bleeding. The initial dressing should have gauze above the insertion site to absorb the drainage. If not contraindicated, attempt to sit the patient up while applying pressure to the bleeding site. Rationale: this will help to reduce venous bleeding by reducing venous pressure within the vessel. A PTT may be ordered if the heparin has been administered systemically. Careful venipuncture technique performed by a competent clinician. Locking solution of heparin 1000 units/mL or 4% sodium citrate is ordered for instillation of lumens for at least the first three catheter access procedures following a catheter insertion or a catheter exchange. Do not overfill the catheter lumens (instil the correct amount of anticoagulant as per the lumen volume). Rationale: 4% sodium citrate does not cause systemic anticoagulation effects as compared with heparin. As well, there is little evidence in the literature to support the practice of catheter lumen overfill as a means to prevent lumen dysfunction. Furthermore, attempts to locate (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 SIGNS AND SYMPTOMS POSSIBLE CAUSES Page 12 of 33 NURSING ACTIONS PREVENTION/RATIONALE literature refuting the use of 4% sodium citrate or heparin 1000 units/mL for newly inserted or exchanged catheter lumen instillation has not been located. Incorporation of these practices (no overfill; 4% sodium citrate or heparin 1000 units/mL) should help reduce the chance of significant interdialytic systemic heparinization and associated bleeding complications. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 13 of 33 SIGNS AND SYMPTOMS POSSIBLE CAUSES NURSING ACTIONS Catheter related sepsis -- May or may not have rise in temperature, increased pulse, chills, malaise, drainage or redness from the insertion site, elevated white blood cell count. Infection present in the catheter and blood most commonly caused by coagulase- negative staphylococci, staphylococcus aureus, aerobic gram- negative bacilli and candida albicans. (Mermel, 2001) Monitor patient for signs of infection (i.e. increased temperature, chills). Use aseptic technique during all aspects of care. Notify the physician or NP. Another topical antibiotic or betadine ointment may be prescribed in place of the Polysporin triple ung for the exit site if the site is reddened and draining. Wash hands thoroughly with antibacterial soap or use alcohol based hand rub (ABHR ) and wear gloves and mask before caring for the tunneled CVC or dressings. Contamination of the catheter lumens leading to colonization of the lumen interior is the most common route of infection. (Mermel, 2001) The decision to remove the catheter depends upon the causative organism, the type of catheter and the condition of the patient. The physician or NP may order 2 sets of blood samples for culture and sensitivity, one from the line and one peripherally. If drainage is noted from insertion site - send a swab for culture and sensitivity. If the tunneled CVC is removed, send catheter tip (with an order) for Culture and Sensitivity (C & S). Two modes of treatment prescribed by the physician or NP -(1) (2) Leave catheter in place, treat with antibiotics Treat with an initial dose of antibiotics, remove the catheter, insert another tunneled central line (different site or exchange over guidewire). PREVENTION Access and change dressings, and adapters as outlined in Nursing Policy and Procedure. The use of an antibiotic lock solution (example: heparin/gentamicin solution) Rationale: CVC related infections are associated with significant morbidity, mortality and treatment costs. Since 2002 there have been several studies addressing the benefits of using antibiotic and heparin lock solutions to help prevent/reduce catheter related infections. Relatively few clinical trials have addressed the overall efficacy and most effective concentration of gentamicin. Therefore, if a gentamicin lock solution is ordered, gentamicin (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 SIGNS AND SYMPTOMS POSSIBLE CAUSES Page 14 of 33 NURSING ACTIONS PREVENTION levels, and resistance to gentamicin may need to be monitored. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 SIGNS AND SYMPTOMS Catheter tip migration referred pain in the jaw, ear or teeth; - distended veins on the side of the tunneled central line; - the length of the catheter from the insertion site is lengthened. - pain during infusion or flushing. - sluggish drip rate during infusion. - inability to aspirate blood. - dyspnea, cyanosis, chest pain, hypotension and shock. POSSIBLE CAUSES Movement of the catheter either internally or externally .The catheter may become looped, tip may move out of the correct location, the tip may erode the vasculature or myocardium. Some movement of the tip is normal with changes in the patient’s position, however misdirected hemodialysis treatment, fluid infusions may lead to cardiac tamponade, extravasation, pleural effusions and death. Page 15 of 33 NURSING ACTIONS PREVENTION Measure the initial length of the catheter (measure from exit site to end of catheter hub) post insertion and document in the nursing kardex. Medicate conditions which could cause nausea and vomiting, severe bouts of coughing. Assess for signs and symptoms of catheter migration (see signs and symptoms). Teach patients to avoid pulling on the catheter and to avoid any activity that incorporates a lot of upper body movement which could dislodge the catheter. Teach the patient to observe for these and notify nurse if present. If these are present, notify the physician or NP. An x-ray to verify catheter tip placement may be required. Proper insertion technique. **Do not attempt to reinsert** Patients at an increased risk include: Patients who experience frequent nausea and vomiting, patients who are physically active, patients who have severe bouts of coughing and patients with left sided catheters. A pull on the tunneled CVC could cause dislodgement of the catheter. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 SIGNS AND SYMPTOMS Occlusion/Dysfunctional CVC -Inability to aspirate blood and/or flush catheter lumen or sluggish blood return. High venous and arterial dialysis pressures during therapy. IV medication will not infuse. POSSIBLE CAUSES Catheter lumen or hemodialysis line clamped. Precipitate or clot in hemodialysis bloodline or CVC lumen. Dressing or suture placed too tightly. Catheter tip lying against the side of the vessel wall. Hemodialysis line, IV tubing or catheter lumen kinked. Clamp on IV tubing closed. Volume depletion. Page 16 of 33 NURSING ACTIONS Check all tubing/ lines and tunneled hemodialysis CVC for kinks - correct kinks if present. PREVENTION Verify CVC locking solution. Check clamps to see if closed - release if closed. Preferred locking solution is 4% sodium citrate. Check to see if dressing is too tight over the tunneled central line. Preferred locking solution is 4% sodium citrate. If blood return is absent, rule out positional problems by: -Asking the patient to deep breathe, cough and change position -Attach 10 ml syringe and attempt aspiration - Assess TEGO connector for possible dysfunction. -- If these measures are not successful, notify physician or NP. Rationale: There have been a few small studies and one large study comparing heparin 5000 units/mL to 4% sodium citrate. These studies, for the most part, demonstrated that citrate was comparable to heparin in terms of maintaining catheter patency. Additionally, a prospective cohort study concluded that the use of citrate for CVC lumen locking has equivalent or better outcomes in terms of alteplase use, need for CVC exchange and access-related hospitalizations when compared with heparin. Exceptions for Hemodialysis: - If ordered, RN is to follow Hemodialysis CVC Dysfunction Protocol - Prior to hemodialysis, if unable to aspirate 5 mL of discard blood when the catheter lumens are locked with 4% sodium citrate then the RN or LPN may push the sodium citrate into the catheter. The LPN will notify the RN accordingly and the nephrologists will be made aware of this at some point in the patient’s hemodialysis treatment and the dialysis RN (educated in care of the use of the Hemodialysis CVC Dysfunction Protocol) will assess the patient’s catheter for dysfunction and intervene accordingly. Flush CVC with saline before and after medication to prevent clogging from drug precipitates. Follow schedules for locking of CVC lumens as outlined in Policy and Procedure for Maintaining Catheter Patency (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 SIGNS AND SYMPTOMS POSSIBLE CAUSES Page 17 of 33 NURSING ACTIONS PREVENTION If able to withdraw 5 mL of discard blood, draw up 10 mL of normal saline, attach syringe to catheter lumen of the tunneled hemodialysis CVC, aspirate gently for blood return, if blood return confirmed, inject normal saline and attempt to aspirate again. Use good dressing technique to prevent kinking. Check IV tubing and tunneled CVC for presence of precipitate. Immediately withdraw 6-10mL of blood, flush with 10 mL normal saline and change IV tubing. Assess for volume depletion (low albumin, below ideal body weight, nausea/vomiting). Leaking or Broken catheter -- Blood or fluid leaking from the tunneled CVC or signs and symptoms of venous air embolism. Tear or hole in the catheter or lumen caused by: Clamping the tunneled central line with instruments (i.e. hemostats). Clamping devices (as above) should never be used on tunneled CVC because they may cause tears. Accidental cut with a sharp instrument during a dressing change. Improper dressing change (i.e. catheter is left exposed). If noted -- Have patient hold breath or bear down. Clamp the tubing between the break and the skin. Apply occlusive tape over the hole Notify physician or NP and coordinate catheter repair. Obtain catheter repair kit for physician. Ensure dressing or suture is not applied tightly as to occlude the CVC. Be certain to flush after taking blood samples. Do not let IV lines run dry Never use any type of clamping device on the CVC. Do not use sharp instruments or scissors during dressing changes. Use 10 mL syringes to prevent too much catheter pressure during flushing or instilling procedures. Exception: When using 5 mL pre-filled 4% sodium citrate syringes (as ordered) instil each catheter lumen with the solution over 15 seconds so as to prevent an increase in catheter pressure. Use dressing to secure the CVC. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 SIGNS AND SYMPTOMS POSSIBLE CAUSES Page 18 of 33 NURSING ACTIONS PREVENTION Rupture caused by use of a small syringe. Fluid Leaking from the luer lock cap/IV connection of the tunneled CVC or from around the hemodialysis bloodline. Loose tubing connection. Tighten adaptor and IV tubing or dialysis lines. If CVC was locked the catheter will have to be accessed (withdraw 5 mL of blood), flushed (10 mL of normal saline) and locked again (according to physician or NP’s order). Use leur lock connectors. Ensure luer lock connectors are secured to the catheter lumens of the CVC. Ensure hemodialysis bloodline is secured to the catheter lumens every 1 hour. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 SIGNS AND SYMPTOMS POSSIBLE CAUSES Deep vein thrombosis of the subclavian vein or internal jugular vein Swelling in the arm, distension of the veins of the arm and neck on the side in which the CVC is located. High venous and arterial pressure during hemodialysis treatment or the IV solution may not infuse and may have pain in the neck, scapula, arm or ear. Injury to the intima of the wall of the vein. Venous Air Embolism - Chest pain, dyspnea, tachycardia, cyanosis, decreased blood pressure, nausea, confusion When 10-20mL of air is trapped in the vein it is carried quickly to the right ventricle. Here it blocks the flow of blood from the ventricles into the pulmonary arteries thus the heart overfills. The right ventricle forcefully contracts in an attempt to eject the blood. However, this causes the air bubble to break into smaller air bubbles, which cause more obstruction and pulmonary hypoxia. Page 19 of 33 NURSING ACTIONS PREVENTION Notify the physician or NP. Obstructed blood flow by clot formation. Changes in composition of the blood. Assess IV system, dialysis bloodlines are secure. Clamp the hemodialysis bloodlines and catheter lumens Disconnect the patient from the hemodialysis treatment and recirculate the blood. If signs and symptoms are noted, place on the left side with feet above the heart (this allows air to enter the right atrium and disperse via the pulmonary artery). Notify the physician or NP. Monitor vital signs. Oxygen by mask is usually required. Avoid use of instruments which may puncture catheter (i.e. hemostats, scissors, safety pins). Ensure hemodialysis bloodlines are free of air and foam and that the venous line is "in situ” correctly. Remove all air from IV tubing prior to use. When changing luer lock cap or TEGO connectors - close clamp of CVC. Keep the catheter insertion site at or below the (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 SIGNS AND SYMPTOMS POSSIBLE CAUSES Pulmonary hypoxia causes vasoconstriction in the lung. This leads to an even greater workload for the right ventricle. Eventually, left ventricular filling is reduced and cardiac output drops, shock and death rapidly occur. May occur on insertion and removal. Page 20 of 33 NURSING ACTIONS PREVENTION level of the heart. Stay with the patient. Advise patient to avoid activities which could dislodge or remove the CVC. Closely watch confused patients to ensure they do not disconnect the tubing or dislodge the catheter. Catheter is punctured. Accidental removal of catheter. Opening of the system during luer lock cap change. Air not removed from IV tubings. The tunneled CVC is accidentally removed Accidental pulling on the catheter. Tell the patient to call immediately for the nurse. Teach patient to: Place gauze over the exit site and hold in place for 20 minutes. Avoid pulling on the catheter. Then apply Vaseline or betadine ointment gauze and an air tight dressing. Not engage in activities which could dislodge the catheter. Call the physician or NP. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 SIGNS AND SYMPTOMS POSSIBLE CAUSES Page 21 of 33 NURSING ACTIONS PREVENTION Assess for venous air embolism and take nursing actions listed for this if signs are noted. At Home, instruct patient to: 1. Hold breath or bear down as if having a bowel movement until pressure is applied as stated below. 2. Apply pressure with a gauze, clean face cloth or hand over exit site and hold in place. 3. Call 911 or have someone take them to the emergency department to be assessed. Internal Catheter Fracture- Partial or complete breakage of catheter internally, possibly leading to catheter embolism. Swelling of the chest wall, or feeling of fullness in the chest when IV infusing or during hemodialysis therapy. New chest pain cough or palpitations. Mechanical friction caused by shoulder movements when catheter is placed in the subclavian vein medial to the mid-clavicalar line between the clavicle and st 1 rib. Notify the physician or NP. Chest X-ray maybe ordered because it can demonstrate catheter pinch off. Correct placement in radiology. Teach patients to avoid activities with a lot of shoulder movement. Avoid CVC placement in the subclavian vein. May be preceded by catheter pinch off as indicated by difficulty aspirating blood or infusing fluids when patients are seated upright. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 22 of 33 REFERENCES: Alberta Health Services (2009). CVC: Sodium citrate 4% lock post hemodialysis policy. Southern Alberta Renal Program. ANNA Core Curriculum for Nephrology Nursing. (2008). Vascular access for hemodialysis. In ANNA, American nephrology nurses association, (5th ed., pp. 748-751). Anonymous (2011). Retrieved from: http://www.nursingtimes.net/nursing-practice/clinical-zones/iv-therapy/avoiding-airembolism-when-removing-cvcs/5037174.article Berns, J., S., Tokars, J., I. (2002). Preventing bacterial infections and antimicrobial resistance in dialysis patients. American Journal of Kidney Disease, 40(5). Bestul, M., B., VandenBussche, H., L. (2005). Antibiotic lock technique: Review of the literature. Pharmacotherapy, 25(2), pp. 211-227. Dogra, G., K. et al. (2002). Prevention of tunnelled hemodialysis catheter-related infections Using catheter-restricted filling with gentamicin and citrate : A randomized controlled study. Journal of American Society of Nephrology, 13, pp. 2133-2139. Healthmark (2006). Citralock Product Monograph. MedXL Inc, Montreal, Canada. Kim, S., H. (2004). Prevention of uncuffed hemodialysis catheter-related bacteremia using an antibiotic lock technique: A prospective, randomized clinical trial. International Society of Nephrology, 69, pp. 161-164. Krishnasami A, Carlton D, Bimbo L et al (2002). Management of hemodialysis catheterrelated bacteremia with an adjunctive antibiotic lock solution. Kidney International, 61, pp.1136-41. MacRae, J., Dojcinovic, I., Djurdjev, O., Jung, B., Shalansky, S., Levin, A., & Kiaii, M. (2007). Citrate 4% versus heparin and the reduction of thrombosis study (CHARTS). American Society of Nephrology 3: 369-374. McIntyre, C., W. et al. (2004). Locking of tunnelled hemodialysis catheters with gentamicin and heparin. Kidney International, 66, pp. 801-805. Mermel L., A. et al. (2001). Guidelines for the management of intravascular catheter-related infections. Journal of Intravenous Nursing, 24(3), pp.180-205. Molzahan, Anita (Ed.) (2006).Contemporary Nephrology Nursing: Principles and Practice, 2nd ed. American nephrology nurses’ association, Pitman, NJ. Pp.569-572. National Kidney Foundation. KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for 2006 Updates: Hemodialysis Adequacy, Peritoneal Dialysis Adequacy and VascularAccess. Am J Kidney Dis 48:S1-S322, 2006 (suppl 1). (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 23 of 33 Pierre, C., Allan, J., Hindmarsh, T., Jones, G., & Delisle, S. (2000). The effects of sodium citrate in arterial catheters on acid-base and electrolyte measurements. Journal of the Society of Critical Care Medicine, 28(5), pp. 1388-1392. Registered Nurses’ Association of Ontario. (2008). Care and maintenance to reduce vascular access complications. Retrieved January 31, 2014, from http://rnao.org/Storage/39/3381_Care_and_Maintenance_to_Reduce_Vascular_Access_C omplications._with_2008_Supplement.pdf Safer Healthcare Now (2007). Getting started kit: Prevent central line infections how to guide. Quebec Campaign. Saxena, A., K., Panhotra, B., R., Naguib, M. (2002). Sudden irreversible sensory-neural hearing loss in a patient with diabetes receiving amikacin as an antibiotic-heparin lock. Pharmacotherapy, 22(1), pp. 105-108. Solumed Product Monograph (2006). Your Preoperative Antisepsis Solutions. www.solumed.biz. TEGO Connector (Date?). Directions for Use. ICU Medical Inc. Thomas et al., (2006). Recommendations for central venous catheter management in hemodialysis patients. CANNT Journal, 16(1), pp 13-17. Vercaigne, L.M., Sitar, D.S., Penner, S.B., et al. (2000) Antibiotic-heparin lock: in vitro antibiotic stability combined with heparin in a central venous catheter. Pharmacotherapy, 20, pp.394-9. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 24 of 33 Tunneled Central Venous Catheter (External) Self Test 1. Double lumen catheters are the most commonly used central venous catheters for hemodialysis: a) True b) False 2. If the catheter venotomy site contains a suture, how long is the suture typically left in place: a) 7-10 days b) 10-14 days c) 24-48 hours d) Up to 6 weeks 3. Reason(s) why the right internal jugular is the preferred site for hemodialysis catheter insertion is: a) the internal jugular permits easier catheter tip positioning in the left atrium b) the use of subclavian vein is associated with thrombus formation and stenosis c) the internal jugular permits easier catheter tip positioning in the right atrium d) a, b and c e) b and c 4. At Capital Health, how often are tunneled hemodialysis catheters flushed? a) q 48-72 hours b) q 24-48 hours c) whenever the hemodialysis catheter is accessed (i.e. blood sampling, medication administration) d) a and c 5. 6. Which is the preferred routine locking solution to maintain CVC lumen patency? a) heparin 5,000 units/mL b) 4% sodium citrate c) heparin 10,000 units/mL d) heparin 1,000 units/mL Name 3 ways to prevent an air embolism: ________________________________________________ ________________________________________________ ________________________________________________ (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 25 of 33 (LM table of contents) 7. Nursing observation of exit/insertion site includes: ____________________________________________ ____________________________________________ ____________________________________________ 8. Gauze dressings should be changed every ____________ to _________ hours and prn. 9. Transparent dressings should be changed every __________ days and prn. 10. Match the descriptions with the correct signs/symptoms a. Catheter occlusion _______ inability to flush (central) catheter or inability to withdraw blood b. Exit site infection _______ edema or tenderness in neck, shoulder or arm c. Air embolism _______ redness, tenderness, swelling and discharge at site _______ SOB, chest pain, tachycardia and cyanosis d. Venous thrombosis (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 26 of 33 SELF TEST ANSWERS 1. a 2. b 3. e 4. d 5. b 6. 7. 1. Ensure hemodialysis bloodlines are free of air and foam and that the venous line is "in situ" correctly 2. When changing luer lock cap and/or when flushing the catheter - close clamp of tunneled central line lumen. 3. Remove all air from IV tubing prior to use 1. Assess for redness/soreness/edema 2. Assess for drainage 3. Assess for catheter displacement and/or damage 8. 48 to 72 hours 9. 7 days 10. a. Catheter occlusion a inability to flush (central) catheter or inability to withdraw blood b. Exit site infection d edema or tenderness in neck, shoulder or arm c. Air embolism b redness, tenderness, swelling and discharge at site d. Venous thrombosis c SOB, chest pain, tachycardia and cyanosis (LM table of contents) (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 27 of 33 Capital Health Proficiency Standards Skills Checklist TITLE: MAINTAINING PATENCY – TUNNELED HEMODIALYSIS CVC Name: ________________________ Unit: ______________________________ Evaluator: _____________________ Date: ______________________________ Critical Behaviours Performed 1. Masks (patient and nurse) and washes hands. Yes 2. Wipes normal saline injection port with 2% chlorhexidinegluconate/70% Isopropyl alcohol swab and uses separate swab to wipe locking solution injection port (as applicable). Allows to air dry completely. 3. Draws up 10mL normal saline x 2 and prescribed locking solution or obtains 4% sodium citrate pre-filled syringes.. 4. Applies non-sterile gloves. 5. Opens gauze around catheter lumens and places sterile 4x8 under lumens while removes old gauze. Places sterile 4x8 on top of lumens. 5.1. Places prescribed antiseptic on 4x4. Cleans surrounding skin and under lumens as outlined in policy. Allows to dry completely. 5.2. Removes gloves, washes hands. Applies new non sterile gloves. 5.3. Removes 4x8s from catheter lumens. Places sterile barrier under lumens. 6. Cleans CVC lumen TEGO connector with 2% chlorhexidine gloconate/70% Isopropyl alcohol swab(s). Allow to dry completely. 6.1. Attaches syringe by holding TEGO and rotating collar of syringe onto TEGO until it stops (do not over tighten). 6.2. Opens the clamp and withdraws 5 mL of discard blood. Disconnects syringe from TEGO by grasping TEGO and twisting syringe away from TEGO until loose. Closes the lumen clamp. 6.3. Cleans CVC lumen TEGO connector as per 6 a). Allows to air dry completely. 7. Attaches the normal saline syringe (as per step 6). 7.1. Opens the clamp, verifies blood return and flushes with 10mL of normal saline. Disconnects syringe (as per step 6.1). Closes clamp. 8. Attaches syringe containing locking solution, opens the clamp and instils the prescribed locking solution (as outlined in the Maintaining Catheter Patency Procedure). Removes the syringe. Closes clamp. Alteplase or heparin/gentamicin instillation is performed by RN only. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. No Care of the Tunneled External CVC Learning Module CC 50-050 Page 28 of 33 9. Repeats steps 6-8 for other lumen. 10. Uses no touch technique throughout access procedure. 11. Wraps the catheter lumens with sterile gauze and tape. 12. Documents accordingly. Labels and dates CVC with locking solution name and dose used for instillation. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 29 of 33 Capital Health Proficiency Standards Skills Checklist TITLE: CHANGING THE TUNNELED HEMODIALYSIS CVC DRESSING & TEGO CONNECTOR(S) Name: ________________________ Unit: ______________________________ Evaluator: ________________________Date: ______________________________ Critical Behaviours Performed Ye s 1. Masks (patient and nurse) and washes hands. 2. Wears non-sterile gloves and carefully loosens the old dressing. Tries to minimize pulling or tugging of the dressing from around the exit site. 3. Opens gauze around catheter lumens. 3.1. Places sterile 4x8 under catheter lumens and exit site while removes old gauze dressing. Places sterile 4x8 on top of lumens and exit site. 3.2. Places prescribed antiseptic on 4x4. Cleans surrounding skin and under lumens as outlined in procedure. Allows to dry completely. 4. Removes gloves and washes hands. Sets up the sterile dressing tray; adds supplies. 4.1. Removes top 4x8 gauze from lumens. Puts on sterile gloves. 4.2. Places sterile barrier under the lumens. 5. Scrubs exit site using friction to the skin and cleaning in a horizontal (side to side) plane extending 5cm from the catheter exit site, then cleaning in a vertical (up and down) plane, then cleaning the skin beginning at the insertion site with a circular motion (middle to outward) extended in a 5cm radius for 30 seconds, with up to 2 minutes drying time. Allows to dry completely. 5.1. Wraps and cleans catheter bifurcation with 2% chlorhexidine gluconate/70% Isopropyl alcohol moistened gauze. Air dry completely before applying dressing. 6. Wraps and cleans each catheter lumens and TEGO connector with cleansing solution moistened gauze. Removes gauze. Allows to air dry. 6.1. Ensures CVC lumen clamp is closed. Then using aseptic technique, removes TEGO connector from CVC lumen and (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. No Care of the Tunneled External CVC Learning Module CC 50-050 Page 30 of 33 Critical Behaviours Performed Ye s attaches new TEGO connector to CVC lumen. 6.2. Applies a thin film of Polysporin® triple ointment to exit site (as prescribed). 7. Applies a transparent or gauze dressing (as applicable) to cover the catheter exit site and hub. Ensures the catheter exit site and hub are visualized in the transparent window of the dressing. Secures the mepore segment of the tegaderm dressing under both catheter lumens by overlapping the mepore edges. Reinforces the mepore segment under the catheter lumens with the reinforcement mepore strips provided with the dressing. Applies to the catheter hub the second mepore reinforcement strip over the top of the transparent dressing at the hub. 7.1. Uses no touch technique throughout the procedure. 8. Wraps the catheter lumens with sterile gauze and tape. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. No Care of the Tunneled External CVC Learning Module CC 50-050 Page 31 of 33 (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. Care of the Tunneled External CVC Learning Module CC 50-050 Page 32 of 33 Capital Health Proficiency Standards Skills Checklist TITLE: BLOOD WITHDRAWAL FROM A TUNNELED HEMODIALYSIS CVC Name: ________________________ Unit: ______________________________ Evaluator: ________________________Date: ______________________________ Critical Behaviours Performed Yes 1. Masks (patient and nurse) and washes hands. 2. Wipes normal saline injection port with 2% chlorhexidine gluconate/70% Isopropyl alcohol swab and uses separate swab to wipe locking solution injection port (as applicable). Allows to air dry completely. 3. Draws up 10 mL of normal saline and prescribed locking solution or obtains 4% sodium citrate pre-filled syringes. Applies non-sterile gloves. 4. Opens gauze around catheter lumens and places sterile 4x8 under lumens while removes old gauze. Places sterile 4x8 on top of lumens. 4.1. Places prescribed antiseptic on 4x4. Cleans surrounding skin and under lumens as outlined in procedure. Allows to dry completely. 4.2. Removes gloves, washes hands. Applies new non sterile gloves. 4.3. Removes 4x8s from catheter lumens. Places sterile barrier under lumens. 5. Cleans CVC lumen TEGO connector with 2% chlorhexidine gluconate/70% Isopropyl alcohol swab(s). Allow to air dry completely. 5.1. Attaches syringe by holding TEGO and rotating collar of syringe onto TEGO until it stops (do not over tighten) 5.2. Opens the clamp and withdraws 5 mL of discard blood. Disconnects syringe from TEGO by grasping TEGO and twisting syringe away from TEGO until loose. Closes the lumen clamp. 6. Attaches BD Vacutainer device to TEGO. Opens clamp. Inserts Blood tube and engages device to fill blood tube. After filling complete, removes blood tube, inverts tube as per CC 85-079 Venipuncture for Blood Specimen/Blood Culture Collection (See related document – Venipuncture Order of Draw). Removes BD Vacutainer device from TEGO. Closes clamp. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. No Care of the Tunneled External CVC Learning Module CC 50-050 Page 33 of 33 Critical Behaviours Performed Yes 7. Cleans CVC lumen TEGO connector with 2% chlorhexidine gluconate/70% Isopropyl alcohol swab(s). Allows to air dry completely. 8. Attaches the normal saline syringe, opens the clamp, verifies blood return and flushes with 10 mL of saline. Disconnects syringe from TEGO. Closes clamp. 9. Attaches syringe containing locking solution, opens the clamp and instils the prescribed locking solution (as outlined in the Maintaining Catheter Patency Procedure). Removes the syringe. Closes clamp. Alteplase or antibiotic locking solution instillation is performed by RN only. 10. Wraps the catheter lumens with sterile gauze and tape. Documents accordingly. (Return to Table of Contents) This is a CONTROLLED document for internal use only. Any documents appearing in paper form are not controlled and should be checked against the electronic file version prior to use. No