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Institut Paoli-Calmettes
Centre régional de lutte contre le cancer Provence-Alpes-Côte d’Azur
Keynote seminar “Biologie & Clinique”
Prof Francisco Sanchez-Madrid
Professor of Immunology, Autonomous University of Madrid, Spain
Le Prof Sanchez-Madrid s’intéresse aux mécanismes de communication intercellulaires dans le système immunitaire : les interactions entre leucocytes et cellules présentatrices d’antigène, d’une part, et les leucocytes et
les cellules endothéliales d’autre part. Il étudie en particulier le rôle des exosomes dans le transfert de miRNA
et la communication entre les cellules T et les cellules présentatrices d’antigène
Immune Cell-to-Cell
communication and ExosomalmicroRNA Transfer
Mardi 23 Juin 2015 à 13h - Accès libre
Salle de Conférence du Centre d’Information, de Prévention et de Consultation en Cancérologie
de l’Institut Paoli-Calmettes, entrée et parking 15 Bd Leï Roure - 13009 Marseille
Renseignem ents
Secrétariat du Centre de Recherche en Cancérologie de Marseille UMR 1068
Laurence Duvivier - Tél. : 04 86 97 72 04 - [email protected]
Centre de Recherche en Cancérologie de Marseille
Unité Mixte de Recherche
Instituts
thématiques
Service communication - Institut Paoli-Calmettes 05/2015
Invitation : Pascale Zimmermann - Centre de Recherche en Cancérologie de Marseille
Keynote seminar “Biologie & Clinique”
Exploring the interface between
immunology and metabolism
Prof Francisco Sanchez-Madrid
Professor of Immunology, Autonomous University of Madrid, Spain
Prof Sanchez-Madrid is interested in the molecular basis of key communication processes involving immune cells, such as the
formation of the immune synapse between antigen presenting cells (APC) and T cells, and the migration of leukocytes across
the endothelium. His team is currently investigating the possibility that the immune synapse (IS), the contact site between
the T cell and APC, allows the directional transfer of miRNA-loaded exosomes from T cell to APC, providing a specific means
of cell-cell communication with important functional consequences for APC biology.
They are also studying the supra-molecular organization of the receptors involved in leukocytes interaction with the vascular
endothelium, which allows the selective recruitment of inflammatory leukocyte subsets to inflammatory foci, with the ultimate aim of identifying
new molecular targets for therapy.
Selected publications:
Martín-Cófreces NB, Baixauli F, Sánchez-Madrid F
Immune synapse: conductor of orchestrated organelle movement.
Retour
Cliquez Ici
Trends Cell Biol (2014) 24:61-72
Villarroya-Beltri C, Gutiérrez-Vázquez C, Sánchez-Madrid F Pérez-Hernández D,
Vázquez J, Martin-Cofreces N, Martinez-Herrera DJ, Pascual-Montano A,
Mittelbrunn M*, Sánchez-Madrid F* (MM and FSM contributed equally).
Sumoylated hnRNPA2B1 controls the sorting of miRNAs
into exosomes through binding to specific motifs.
Nat Commun (2013) 4:2980
Gutiérrez-Vázquez C, Villarroya-Beltri C, Mittelbrunn M,
Sánchez-Madrid F (CGV and CVB contributed equally).
Transfer of extracellular vesicles during immune cell-cell interactions.
Immunol Rev (2013) 251:125-42
Mittelbrunn M, Sánchez-Madrid F.
Intercellular communication: diverse structures
for exchange of genetic information.
Nat Rev Mol Cell Biol (2012) 13:328-35
Mittelbrunn M, Gutiérrez-Vázquez C, Villarroya-Beltri C, González S,
Sánchez-Cabo F, González MÁ, Bernad A, Sánchez-Madrid F.
Unidirectional transfer of microRNA-loaded exosomes from T
cells to antigen-presenting cells.
Nat Commun (2011) 2:282
Baixauli F, Martín-Cófreces NB, Morlino G, Carrasco YR,
Calabia-Linares C, Veiga E, Serrador JM, Sánchez-Madrid F.
The mitochondrial fission factor dynamin-related
protein 1 modulates T-cell receptor signalling at the immune synapse.
Embo J (2011) 30:1238-50
Centre de Recherche en Cancérologie de Marseille
Unité Mixte de Recherche