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Integrated Health Clinic Cancer Care Centre Treatment - Oncothermia H... http://www.integratedhealthclinic.com/_cancercare/cancerHyperthermia.htm
For access to clinical trial and reference material, Click Here.
Dr. Parmar's Hyperthermia Lecture
Dr. Gurdev Parmar ND FABNO was recently invited as a keynote speaker for the Oncology Association
of Naturopathic Physicians (OncANP) inaugural Naturopathic Oncology Conference. Please click on the OncANP logo to
view Dr. Parmar's presentation on Hyperthermia in Oncology.
What is Hyperthermia treatment?
Hyperthermia is a therapy where heat is induced to damage or kill cancer cells, or to make cancer cells more susceptible to
the effects of radiation and chemotherapy. According to the National Cancer Institute (NCI), scientists believe that this
noninvasive heat therapy can help shrink tumours with minimal impact on normal healthy tissue.
Hyperthermia works in four principle ways to address a malignant tumor:
Heat damages or weakens the protiens and structures of malignant cells.
Heat increases blood flow through the weakened tumor, which can allow chemo and radiation therapies to more
thoroughly permeate the tumor.
Increased blood flow raises oxygen levels in tumors so the cancer can be more effectively treated by radiation
therapy.
The body senses fever and can stimulate the immune system.
For more information regarding hyperthermia and its mechanisms of action, please visit our Education Centre and select
the Cancer Centre tab on the left side of the page.
What is LRHT?
In LRHT, focused and controlled radio-frequency (RF) waves are directed straight to the tissue or organ affected by the
tumour. The LRHT treatment device employs a capacitive coupled electrode pair to transmit RF as a carrier for energy. The
energy is absorbed by the extra-cellular matrix (ECM) of the malignant cells and subsequently heats the cells to
temperatures that drive synergistic benefit.
LRHT is based on the classical method of Hyperthermia (high-heat) but does more than just randomly heat layers of tissue.
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LRHT employs a modulated electric field to selectively deliver a controlled energy dose to a localized treatment area. A
mobile electrode is positioned on the treatment area, while a second stationary electrode remains in a fixed position below
the patient, integrated within the therapy bed. Operating at a carrier frequency of 13.56 MHz, this capacitive coupled circuit
delivers energy directly to the malignant cells.
Microbiological tests have demonstrated that higher ionic concentrations exist in the more active malignant cellular
environment. Consequently, the extracellular matrix of malignant tissue inherently has greater conductivity and permittivity
than healthy tissue. This difference facilitates selective focus on malignant cells even in highly mixed tissue containing
large numbers of healthy and malignant cells. The derived advantage is the electric field tends to flow predominantly
through the tumor tissue where the concentration of focused electric energy selectively heats the malignant cells to
clinically relevant temperatures. This process of natural selection is further enhanced by the electric-field modulation,
which addresses the autonomous, non-collective behavior of individual malignant cells by reengaging the body's inherent
immune response. Malignant tumour cells are then driven to a process known as "apoptosis".
This effect of modulated electric field is unique and exclusive to LRHT therapy administered with the EHY-2000 Plus
device.
The demonstrated benefits of LRHT can include:
Chemo-sensitization. LRHT sensitizes the tumor to complementarily applied chemotherapy because constrained
thermodynamic flow effects destabilize the cell membrane, increasing its permeability and structural dysfunction,
thereby increasing the absorption rate of the administered chemotherapy agent. LRHT compromises the tumor cell
membrane allowing higher intracellular drug concentrations. The positive results of phase II/III trails have established
that LRHT with chemotherapy is a novel clinical modality that allows the chemotherapy to be better targeted within
the heated tumor.
Radio-sensitization. LRHT sensitizes the tumor to complementarily applied radiotherapy by oxygenation (increased
oxygen delivery to the cells via blood perfusion). The addition of LRHT during a series of radiotherapy treatments
improves relevant clinical endpoints such as response rate, local control and overall survival. LRHT increases
oxygenation, thus reducing hypoxia and amplifying the radiation cytotoxic effect. LRHT also inhibits the repair of
radiation damaged tumor cells.
Immune System Responsee. LRHT triggers antigen expression through the compromised malignant cellular
membrane. Of particular significance is the release of heat shock proteins (HSP) that promotes a natural immune
response destructive to the tumor. Danger signals such as mobility group B1 protein, ATP and HSP, which are
released from treated necrotic tumor cells, stimulate the natural immune system and therefore assist the anti-tumor
response. LRHT also stimulates the re-establishment of adherent connections (β-catenins, E-cadherins) that play a
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key role in triggering apoptosis and suppressing malignant cell dissemination.
Gene Activation. LRHT activates the p53 tumor suppressor gene.
Surgical Procedures. LRHT has application in the post-surgical setting to treat potential rogue cells liberated via
biopsy or surgery.
Can LRHT be combined with other forms of treatment?
LRHT is intended for use as an adjunct to chemotherapy and radiotherapy, and is devoted to the non-invasive hyperthermia
based treatment of indicated solid tumour cancers. LRHT has proven to be complementary to these treatments by enhancing
the beneficial effects of chemotherapy and radiation while helping to mitigate side effects. Even a tumour which has
developed a resistance to chemotherapy and radiation, may respond again to these therapies following LRHT treatment.
How is LRHT treatment applied?
LRHT is a treatment for solid tumour cancers with indications for both primary and metastatic malignancies, as
demonstrated through phase II & III clinical trials.
LRHT can deliver increased survival times and improved quality of life for indicated cancer types. Furthermore, LRHT has
potential palliative application when available conventional therapies are no longer indicated.
Are there any adverse side-effects to LRHT?
This complementary therapy presents minimal risk and limited adverse side effects. Heating the tumour has minimal effect
on adjacent healthy tissue; however, some slight surface skin reddening can occur. This effect is mitigated through regular
patient communication during treatment. Also, the body's natural circulation is extremely efficient and soon dissipates the
heat - something the tumour is not capable of because of its more primitive blood supply.
Cancer patients can now benefit from the historical successes recorded by this treatment here at home, in Fort
Langley, British Columbia... the only location in North America.
For additional information and details on this exciting new technology available at Integrated Health ClinicTM Cancer Care
Centre please feel free to contact us at:
Email: [email protected]
Or call us today to schedule an appointment with our Doctors to learn more about how LRHT can help you: 604.888.8325.
Integrative Cancer Care - Patient Resource Centre
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