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PPx Media Kit
PPx Technology Fact Sheet
Photopneumatic (PPx) Therapy
PPx Therapy is a breakthrough PAINLESS aesthetic treatment that uses a combination of pneumatic energy and
broadband light hence, photopneumatic (PPx). Photo meaning light and pneumatic meaning vacuum. PPx therapy is
the first clinically proven, no pain treatment that is up to 5 times safer and faster for permanently reducing unwanted
hair, unwanted brown or red spots and unsightly veins.
Most conventional laser and light based systems emit large amounts of energy in an effort to drive energy deeper into
the skin. This results in more pain for the patient along with high powered laser energy hitting not only the target but
a lot of surrounding healthy tissue.
The PPx system’s unique mechanism lifts targets, bringing them closer to the skin’s surface. Vacuum activation puts
pressure on the sebaceous gland causing it to empty out sebum resulting in cleaner pores and healthier skin. Skin is
momentarily stretched 25 – 35%. Blood vessels are blanched for a fraction of a second. Competing targets are
removed allowing the light to be efficiently and painlessly deposited to the area being treated while protecting normal
surrounding skin.
PPx™ Treatment Overview
The handpiece is placed
on the area of the body to
be treated.
In a fraction of a second,
a vacuum gently draws
the skin into the
treatment tip. Vacuum
activation pressures the
sebaceous gland
causing it to empty out
sebum resulting in
cleaner pores and
healthier skin. Targets,
such as hair follicles, are
elevated closer to the
skin’s surface. Blood
vessels are immediately
compressed and
blanched.
A painless light emits
highly efficient photons
to the target at 4-5 times
the standard rate.
Because targets such as
hair follicles are closer to
the skin’s surface, small
amounts of energy are
used effectively,
providing an overall
safer, painless
procedure that’s
extremely fast.
The vacuum gently
releases the skin
bringing it back to
normal position.
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PPx Technology Fact Sheet
Photopneumatic (PPx) Therapy Review
No Pain treatments
PPx therapy is a relaxing, no-pain treatment. In a recent
clinical trial by Dr. Vic A. Narurkar, a majority of patients
in the study reported no pain or burning sensation when
treated.
Fast - Treat Whole Legs and Backs in
Less Than 20 Minutes
PPx therapy is up to 5 times faster than traditional lightbased treatments, making it ideal for busy patients and
physicians. A very large treatment tip allows physicians
to perform full leg and whole back treatments in less
than 20 minutes, providing an additional source of new
treatment revenue.
Helps Protect Surrounding Tissue
PPx is the first therapy to change the optics of the skin
to deliver small amounts of highly efficient energy to the
target. This effective and efficient use of lower
energies allows the painless destruction of
targets (unwanted hair, brown or red spots and unsightly
veins).
Less Hassles - Requires No PreTreatments with Topical Anesthetics
PPx System
PPx therapy eliminates the need for 30-45 minute
numbing pre-treatments with topical anesthetics.
PPx IntelliTip+
Used with the PPx System - Available in Hair Reduction (small, medium,
large and XL) & Skin Rejuvenation (small and medium)
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Market Opportunity –
Aesthetic Light Based Treatments
What procedures will patients most demand in the long term?*
Year
Hair Removal
Skin Rejuvenation
Acne
Vascular Lesions
Tattoo/PL Removal
2004
14,013,401
8,550,000
450,000
2,275,000
1,540,000
2005
18,107,708
11,251,327
743,750
2,628,400
1,675,721
2006
22,658,966
14,487,516
1,175,000
3,018,517
1,813,866
2007
28,465,442
18,336,558
1,771,875
3,433,858
1,954,497
2008
35,867,613
22,889,667
2,562,500
3,556,496
2,097,678
2009
45,445,884
28,254,304
3,575,000
4,011,715
2,243,485
% Share of Procedure Volumes, 2004 - 2009
100%
90%
80%
70%
Vascular Lesions
60%
Acne
50%
Tattoo / PL Removal
40%
Skin Rejuvenation
30%
Hair Removal
20%
10%
0%
2004
2005
2006
2007
2008
2009
85% of LASER & LIGHT BASED TREATMENTS BETWEEN 2004 & 2009
o
SKIN REJUVENATION: Procedures will grow 232% from 8.5 million to 28.2 million between 2004 and 2009.
o
HAIR REMOVAL: Volume of procedures offered will grow 217% from 14 million to 45.4 million between 2004
and 2009.
* Source: Global Aesthetic Market Report, Medical Insight Inc, CA, 2005.
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Market Opportunity –
Aesthetic Light Based Treatments
What procedures will drive highest revenues for physicians?*
Treatment Fees by Aesthetic Procedure
8,000
7,000
GROWTH OPPORTUNITY
IS HERE
Fees in $MM
6,000
5,000
4,000
3,000
2,000
1,000
0
2004
2005
Cosmetic PDT
Botox
Hair Removal
Emerging Skin Rejuvenation
Acne Reduction
Body Shaping
2006
2007
2008
2009
Dermal Fillers
Chemical Peels
Light-Based Skin Rejuvenation
Tattoo & Pigmented Lesion Removal
Vascular Lesions
Microdermabrasion
TOTAL PHYSICIAN REVENUES GENERATED FROM PERFORMING:
o
SKIN REJUVENATION treatments will grow 75% from $3.6B to $6.3B
o
HAIR REDUCTION treatments will grow 60% from $3.5B to over $5.6B
* Source: Global Aesthetic Market Report, Medical Insight Inc, CA, 2005.
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Glossary of Terms
Absorption
Transformation of radiant energy to a different form of energy by the interaction of
matter.
Café au Lait
Spots of patchy pigmentation of the skin, usually light brown in color that are
characteristic of neurofibromatosis (tumors of the peripheral nerves), but also
found in normal individuals.
Chromophore
A chemical group that absorbs light at a specific frequency and so imparts color to
a molecule.
Collagen
The major structural protein of the dermis. Manufactured by fibroblasts, the
arrangement of collagen fibrils into small groups of fibers which then come
together in thin, wavy, fiber bundles. These bundles are then arranged into a
mat-like pattern resulting in great tensil strength.
Comedones
Blackhead, the basic lesion of acne vulgaris, caused by an accumulation of
keratin and sebum within the opening of the hair follicle.
Dermis
The layer of skin lying immediately under the epidermis, the true skin; consisting
of two layers composed of loose connective tissue in which are numerous
capillaries, lymphatics and nerve endings. In it are hair follicles, sebaceous
glands, sweat glands and smooth muscle fibers.
Dyschromia
A discoloration of the skin.
Edema
The abnormal accumulation of fluid in interstitial spaces of tissue. An abnormal
infiltration and excess accumulation of serous fluid in connective tissue.
Electromagnetic Spectrum
Frequencies and wavelengths emitted by atomic systems. Ranges from visible
light to the invisible, ionizing radiation to no-ionizing, cosmic and ultraviolet rays of
microwaves and radio waves.
Energy
The product of power (watts) and duration (seconds); one watt second = one
joule.
Epidermis
The superficial avascular layers of the skin made up of an outer, hardened dead
part and a deeper, cellular living part. Epidermal cells gradually move outward to
the skin surface, undergoing change as they migrate, until they flake off. Cells in
various transitional stages make up the stratum basale, stratum spinosum,
stratum gramulosum, stratum licidum, and stratum corneum. Cells become
hardened as they fill with waterproofing protein called keratin, which hardens over
several days. Altogether these layers are between 0.5 and 1.1 mm in thickness.
Epidermis
The superficial avascular layers of the skin made up of an outer, hardened dead
part and a deeper, cellular living part. Epidermal cells gradually move outward to
the skin surface, undergoing change as they migrate, until they flake off. Cells in
various transitional stages make up the stratum basale, stratum spinosum,
stratum gramulosum, stratum licidum, and stratum corneum. Cells become
hardened as they fill with waterproofing protein called keratin, which hardens over
several days. Altogether these layers are between 0.5 and 1.1 mm in thickness.
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Glossary of Terms
Erythema
Redness or inflammation of the skin or mucous membranes that is the result
of dilation and congestion of superficial capillaries.
Fibers
Thin flexible devices used to carry optical energy.
Fibroblasts
Cells that make structural fibers and ground substance of connective tissue.
Fibroblasts make collagen and elastin found in the extra cellular matrix.
Fitzpatrick Skin Type
Classification
The Fitzpatrick Skin Type Classification was originally developed by
Thomas Fitzpatrick in 1975. It is currently the most widely known tool for
skin typing which helps with proper patient selection.
Fluence
The sum of the energies of the particles of fluence, measured in joules/cm
squared.
Flushing
The swelling of blood vessels under the skin. Transient reddening of the
skin.
Hirsuitism
Excessive facial hair growth in women. Ordinarily results from too much
testosterone in the body, causing an over stimulation of the follicle.
Hyperpigmentation
Darkening of the skin.
Inflammatory
Protective response of body tissues to irritation or injury. May be acute or
chronic. Its cardinal signs are redness, heat, swelling, and pain.
Joules
The unit of energy.
Keratosis
Any skin lesion in which there is overgrowth and thickening of the cornified
epithelium.
Lentigines
Tan or brown macule on the skin brought on by sun exposure. It is benign.
Macropores
A pore of comparatively large size.
Melanin
The pigment present in skin that reduces the amount of ultraviolet light
that penetrates the skin. Increased amounts are formed during tanning.
Melanin determines skin color of racial groups.
Melasma
Tan or brown pigment, particularly of the forehead, cheeks, and nose,
commonly associated with pregnancy or oral contraceptives.
Melanocytes
A body cell capable of producing melanin. Melanocytes are distributed
throughout the basal cell layer of the epidermis and form melanin pigment
from tyrosine, and amino acid. Melanin granules are then transferred to
adjacent basal cells and to hair.
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Glossary of Terms
Multichromatic
Multi colored.
Nm
Nanometer (1 billionth of a meter).
Noncoherent
Noncoherent light travels in all directions such as the light from a light bulb
as opposed to coherent light waves which travel in the same direction in a
straight line, i.e., laser light is coherent.
Papillary Dermis
The part of the dermis that lies immediately below the epidermis. It has vertically
oriented connective tissue fibers and a rich supply of blood vessels.
Photoaging
The cumulative detrimental effects of skin that result from long-term exposure to
sunlight and especially ultraviolet light (wrinkles or dark spots).
Photopneumatic™ Therapy
(PPx™)
Photopneumatic™ technology (PPx™) is proprietary technology that
innovatively combines the unique properties of broadband light with pneumatic
energy for light based aesthetic treatments such as permanent hair removal, the
treatment of vascular and pigmented lesions and more.
Photorejuvenation
Noninvasive process, using light sources to reverse signs of photo-aging skin.
Post Inflammatory
Hyperpigmentation
Hyperpigmentation or skin darkening that occurs with an inflammation-including
event such as a peel or laser resurfacing procedure.
PPx™
See Photopneumatic™. Clinically proven painless treatment for hair removal
and skin rejuvenation only offered by Aesthera™ Corporation.
www.AESTHERA.com
Pulse Duration
Duration of time that target is exposed to the photon energy measured in
milliseconds.
Purpura
Bruising.
Rejuvenation
A return to a more youthful appearance of the skin or to what would be normal
for a specific age.
Retin-A
Retin-A gel, cream and liquid, containing tretinoin (vitamin A based acid) is used
for the topical treatment of acne vulgaris, Retin-A is used as part of an
exfoliation skin care regimen.
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Glossary of Terms
Rhytides
Prefix means “wrinkled”.
Rosacea
Begins with flushing, especially the nose and cheeks. In many cases the
vessels stay dilated and sunburn redness becomes a permanent feature on
the central areas of the face. May have small blood vessels that have
become enlarged, called telangiectasia.
Sebaceous Glands
Small oil-producing gland present in the skin of mammals. Sebaceous glands
are usually attached to hair follicles and release a fatty substance, sebum, into
the follicular duct and thence to the surface of the skin. The glands are
distributed over the entire body with the exception of the palms of the hands
and the soles of the feet; they are most abundant on the scalp.
Sebaceous
Relating to, secreting, or composed of fatty matter.
Sebum
The oily product of a sebaceous gland.
Selective Injury
Damage or injury to a selective target without harming the surrounding
tissues.
Spot Size
Diameter or size of the laser or light beam spot as it impacts on a surface.
Telangiectasia
Permanent dilation of groups of the superficial capillaries and venules.
Test Patch
A process of testing skin reaction in a particular area or segment of the skin.
Thermal Damage
Harm or injury caused by heat.
Tx
Treatment
Venules
Small vein; any of the minute veins connecting the capillaries with the larger
systemic veins.
Visible Light Radiation
Electromagnetic energy which may be detected by the human eye (0.38-.07
nm).
Watt
A unit of power equivalent to one joule per second used to express laser
power.
Wavelength
The distance in the line of advance of a wave from any one point to the next
point at which at the same instant there is the same phase.
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Hair Reduction Q&A
Who is a candidate for hair reduction?
Any person who has unwanted hair on his/her body and chooses to have it permanently reduced is a
candidate for hair reduction.
What options are available for people who are considering hair reduction?
There are multiple treatment options for people who are considering hair reduction. The majority of currently
available treatment options for hair reduction are not permanent. Below are some of the most commonly
accepted treatment options for hair reduction.
1. Shaving – Perhaps the most common of hair reduction methods, shaving is quick and painless. Hair is
removed above skin level without impacting the follicle. Shaving is not permanent, is often associated
with cuts and grazes and is inconvenient on difficult to reach areas such as the back.
2. Waxing – Also popular, waxing is a process where warm wax is applied to the skin using a fabric or
fabric-like applicator. The applicator is placed on the area to be treated and then quickly pulled off. The
treatment typically performed at salons, spas or at home needs to be repeated at very regular intervals
and does not retard hair growth. Waxing is painful and can cause temporary redness, bumps and skin
irritation.
3. Electrolysis – In this method, a tiny needle targets the hair follicle at its root and eventually results in
its destruction. The procedure, typically performed by a licensed electrologist, will need to be repeated
very regularly every other week. Extremely time-consuming, electrolysis is best performed on small
parts of the body such as the eyebrows.
4. Lasers– Light at a specified wavelength or a range of light is delivered from the laser handpiece into
the skin. This light targets the hair follicle to be destroyed, while theoretically sparing the surrounding
tissue. Although light-skin patients with dark hair are typically the best responders, laser hair reduction
can be used on a variety of skin types. While the most permanent of all hair reduction options, laser hair
reduction is also the most painful and expensive of hair reduction options. Most commonly performed
on smaller body areas such as the underarms, bikini and upper lip, laser hair reduction can be
performed on larger areas such as the back and legs at a high cost.
What is Photopneumatic Therapy (PPx)?
PPx therapy is the first clinically proven painless treatment for permanent hair reduction. The PPx treatment
is a quick, non-invasive, no-downtime in-office procedure that requires no pre-treatment anesthetics or gels.
This therapy uses a proprietary combination of broadband light and pneumatic energy (vacuum) that is
delivered through a handpiece. The treatment is unique in that a vacuum momentarily draws the skin into
the treatment handpiece. Treatment targets such as hair follicles are drawn closer to the skin’s surface. A
therapeutic light is gently pulsed onto the skin, destroying the unwanted hair, quickly and painlessly.
Additional benefits include:
•
Clinically proven effective
•
100% of patients preferred PPx over previously experienced laser or light based treatments
•
Treats large areas such as the back or whole legs in under 20 minutes
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Hair Reduction Q&A
How does the PPx System work?
The PPx treatment tip gently draws the area to be treated into the hand piece of the system. This "pulling up”
motion gently brings all the unwanted hair closer to the surface of the skin. Light energy, when gently applied to
the hair, is converted to heat energy and absorbed by the hair, quickly, painlessly and effectively destroying it.
How is PPx different from other laser and light based hair reduction treatments?
There are several key differences between PPx and other laser and light based hair reduction treatments.
1. PPx therapy is the first and only clinically proven painless treatment for light based hair reduction.
The PPx treatment tip gently draws the area to be treated into the handpiece of the system. This
"pulling up” motion gently brings all the unwanted hair closer to the surface of the skin and changes
the optics of the skin. A fraction of the energy required by lasers is used, resulting in a gentle,
painless and safe treatment.
2. PPx therapy does not require any pre-treatment with anesthesia or numbing gels.
3. Hair Removal on large areas such as the back or whole legs can be completed in under 20 minutes
as opposed to up to 2 hours with other laser and light based hair reduction treatments.
Have patients been happy with their results?
Patients have been extremely happy with their clinical outcomes from PPx therapy. According to a recent
clinical study, the majority of patients surveyed noted that they would choose PPx over previously
experienced laser and light based treatments for hair removal and skin rejuvenation. In the same study
100% of patients described PPx as a painless procedure.*
* Novel Photopneumatic Therapy Delivers High-Efficiency Photons to Dermal Targets, Vic Narurkar, MD. Vol 18, No. 2,
February 2005, Cosmetic Dermatology
Is there downtime associated with the treatment?
PPx treatments are relaxing and do not include any side effects such as redness, crusting or other common
post-treatment discomforts. With PPx Therapy, you can go right back to your normal activities immediately
post-treatment.
How does PPx Hair Reduction feel?
PPx Treatments are the only pain-free treatments for permanent hair reduction. You will feel a gentle and
warm sensation as your skin is drawn into the treatment tip. A very gentle light energy will be applied to the
treatment area, immediately after which you will feel your skin being gently released back into normal
position.
How long does a treatment take?
Treatment times depend on the area being treated. Upper lip hair reduction may take 1 minute, treating
underarms might take up to 3 minutes, while treating larger areas such as the back or whole leg could take
up to 20 minutes. PPx therapy does not require topical anesthesia or pre-treatment with numbing creams
which saves an additional 35-45 minutes.
How many treatments are need?
Typically, 7 – 11 treatments are needed to get excellent long term results. However, the exact number of
treatments varies from patient to patient and often varies between body parts being treated.
Where can I go to receive a PPx hair reduction treatment?
(Insert center name, contact information, website)
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Skin Rejuvenation Q&A
Who is a candidate for skin rejuvenation?
Any person who has uneven skin tone, mottled pigment, red and brown spots, sun damaged skin and unsightly
veins on their body is a candidate for skin rejuvenation.
What options are available for people who are considering skin rejuvenation?
There are two main treatment options for people who are considering skin rejuvenation.
1. Creams – Perhaps the most common method of skin rejuvenation is the use of creams. Skin creams
available in a variety of formulations require continuous use. While prescription creams are available through
a doctor’s office, the majority of creams are available over-the-counter. While a wide range of claims
regarding efficacy are made, results are typically very subtle and visible only after sustained use.
2.
Lasers – Skin rejuvenation using Lasers may be ablative or non-ablative*
a.
b.
Non Ablative Rejuvenation: Non ablative lasers or light sources work by bypassing the surface
of the skin to target the layers below. Surface layers of the skin are generally not removed.
Non ablative laser or light based treatments typically require 5 or more treatment sessions at
regular intervals. Results are typically visible after the first 2 treatments. While being noninvasive office-based procedures, these treatments are often painful and require the use of
topical anesthetics.
Ablative Lasers – Ablative laser treatments remove the top layers of the skin (referred to as
the epidermis) and heat the layer under the epidermis (the papillary dermis). As the wound
caused by the laser heals, smoother and more even skin is seen. Heat also causes collagen to
regenerate. Ablative laser treatments are performed under anesthesia and have several weeks
of recovery time.
* American Academy of Dermatology (AAD), Online Public Resource Center.
http://www.aad.org/public/Publications/pamphlets/LaserResurfacingRejuv.htm
What is Photopneumatic™ Therapy (PPx™)?
PPx therapy is the first clinically proven painless treatment for the treatment of sun damaged and aging skin,
including brown spots, redness and broken capillaries, as well as unsightly veins. The PPx treatment is a quick, noninvasive, no-downtime in-office procedure that requires no pre-treatment anesthetics or gels. This unique therapy
uses a proprietary combination of broadband light and pneumatic energy (vacuum) that is delivered through a
handpiece. The treatment is unique in that a vacuum momentarily draws the skin into the treatment handpiece.
Treatment targets such as pigment and broken capillaries are drawn closer to the skin’s surface. A therapeutic light is
gently pulsed onto the skin, destroying the unwanted pigment or unsightly veins, leaving the skin with a smoother and
more youthful look.
Additional benefits include:
•
•
•
Clinically proven effective
100% of patients preferred PPx over previously experienced laser or light based treatments
Treats large areas such as the back or whole legs in under 20 minutes
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Skin Rejuvenation Q&A
How does the PPx System work?
The PPx treatment tip gently draws the area to be treated into the handpiece of the system. This "pulling up” motion
gently brings all the unwanted targets such as pigment and unsightly veins closer to the surface of the skin. Light
energy is gently applied to the target. This light energy is converted to heat energy, absorbed by the treatment
targets, quickly, painlessly and effectively destroying them.
How is PPx different from other laser and light-based skin rejuvenation
treatments?
There are several key differences between PPx and other laser and light-based skin rejuvenation treatments.
1. PPx Therapy is the first and only clinically proven painless treatment of unwanted pigment, red and brown
spots and unsightly veins. The PPx treatment tip gently draws the area to be treated into the handpiece of
the system. This "pulling up” motion gently brings all the unwanted targets closer to the surface of the skin
and changes the optics of the skin. A fraction of the energy required by lasers is used, resulting in a gentle,
painless and safe treatment.
2. PPx therapy does not require any pre-treatment with anesthesia or numbing gels.
Have patients been happy with their results?
Patients have been extremely happy with their clinical outcomes from PPx therapy. According to a recent clinical
study, 100% of patients surveyed noted that they would choose PPx over previously experienced laser and lightbased treatments for hair removal and skin rejuvenation. In the same study, the majority of patients described PPx as
a painless procedure.* Novel Photopneumatic Therapy Delivers High-Efficiency Photons to Dermal Targets, Vic Narurkar, MD.
Vol 18, No. 2, February 2005, Cosmetic Dermatology
Is there downtime associated with the treatment?
PPx treatments are relaxing and do not include any side effects such as redness, crusting or other common posttreatment discomforts. With PPx Therapy, you can go right back to your normal activities immediately post-treatment.
How does PPx Skin Rejuvenation feel?
PPx Treatments are the only painless treatments for skin rejuvenation. You will feel a gentle and warm sensation as
your skin is drawn into the treatment tip. A very gentle light energy will be applied to the treatment area, immediately
after which you will feel your skin being gently released back into normal position.
How long does a treatment take?
Generally, rejuvenation treatments on the face, neck and chest take between 3 and 5 minutes. Full arm treatments
could take 10 minutes. Treatment times depend on the area being treated.
How many treatments will I need?
Typically, 5 treatments are needed to get excellent results. However, the exact number of treatments varies
from patient to patient and often varies between body parts being treated.
Where can I go to receive a PPx skin rejuvenation treatment?
The PPx treatment is available now at selected medical and cosmetic centers throughout the United States.
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Talking Points
PPx is the first and only clinically proven painless treatment for hair reduction
and skin rejuvenation
•
The majority of patients surveyed in a peer reviewed study rated PPx as a no-pain
treatment
100% of patients who had experienced other laser / light based treatments would
never go back to other treatments after having experienced PPx
100% of patients surveyed would recommend PPx over other laser/light based
treatments to their friends
•
•
No pre-treatment anesthetics necessary
•
•
No need to use lidocaine (Recall the recent lidocaine deaths from people using
lidocaine for long periods on large areas)
No need for pre-treatments with anesthetics also eliminates numbing time (typically
between 30 – 45 minutes depending on treatment area)
Fastest Treatments –
Only method to treat legs and backs for hair removal in under 20 minutes
•
•
Prior to PPx, back and leg treatments that took upwards of 2 hours were not an
economically viable option for consumers or physicians. PPx’s very large treatment
tip can cover a back/leg in under 20 minutes making it economical for practitioners to
offer treatments
No need to use anesthetics reduces overall treatment time by 35 – 45 minutes
Safe Photopneumatic Therapy
PPx treatments are 4x – 5x safer than other laser/light based treatments. Unique
technology that combines vacuum with light uses energy very efficiently for great
treatment safety.
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Before and After Photos
Here are a few of the fabulous results one can achieve with the PPx system.
Hair Removal
Sun Damaged Skin
Rosacea
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