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Practical information: Registration includes morning and afternoon coffee breaks but does not include lunch which can, however, be taken at our local cafeteria (8 to 15 euros depending on your selection of dishes) Access: The INRA centre of Nouzilly is located at 11.4 miles Northwest of the city of Tours (capital of the famous Loire valley castles), which is at 1hr TGV train from Paris Montparnasse or 1hr 40 min TGV train from Roissy Charles de Gaulle airport. Please also note that a very convenient air connection between London Stansted and Tours Airport exists (extremely advantageous prices by Ryanair). Transportation from Tours to the INRA centre of Nouzilly will have to be made by Taxi (about 50 euros one way). Useful links: Map Tours tourism office: Tours Taxi services: Tours Airport: London-Tours by Ryanair: gb&lc=en-gb Tours Railway station: INRA centre of Tours http://www.mapquest.com/?q=47.55,0.75&zoom=3 http://www.tours-tourisme.fr/index_en.php http://www.taxis-tours.fr/en/index.html http://www.tours.aeroport.fr/ https://www.bookryanair.com/SkySales/booking.aspx?culture=enhttp://www.sncf.com/en_EN/flash/ http://www.tours.inra.fr/le_centre/english Travel information: By car: Tours is located 129 miles southwest of Paris. The city is connected by motorways with Le Havre (150 miles) or Caen (133 miles) Airport: Tours airport. Flights London-Tours operated by Ryanair. Paris airport (Roissy-CDG and Orly) are connected to Tours by the fast train TGV Train station: Tours TGV station at "Saint-Pierre-des-Corps". 55 minutes by TGV from Paris (Montparnasse train station) and 1h40 from ROISSY Charles de Gaulle airport (CDG 2) Hotels in the neighbourhood of Tours central station (train shuttle service between St Pierre des corps TGV station and Tours central station takes about 7 min) - Three-star Grand Hôtel, 9 place du Général Leclerc - TOURS - 33 (0)2 47 05 35 31 - Alliance Hotel, 15 rue Edouard Vaillant -TOURS - 33 (0)2 47 31 12 12 - Best Western Central Hotel***, 21 rue Berthelot - TOURS - 33 (0)2 47 05 46 44 - Quality Hotel Harmonie***, 13 rue F.Joliot Curie - TOURS - 33 (0)2 47 66 01 48 - Hôtel des Châteaux de la Loire**, 12 r Gambetta - TOURS - 33 (0)2 47 05 10 05 - Hôtel des Arts**,40 rue de la Préfecture - TOURS - 33 (0)2 47 05 05 00 - Hôtel du manoir**,2 rue Traversière - TOURS - 33 (0)2 47 05 37 37 - Hôtel Asteries**, 8 r Blaise Pascal - TOURS - 33 (0)2 47 05 41 43 - Hôtel du Théatre**,57 r Scellerie - TOURS - 33 (0)2 47 05 31 29 Scientific program Recent advances in the central control of reproduction April 11th 2013, Centre INRA Val de Loire, Nouzilly, Conference hall. 9h00 Welcoming 9h15 Opening presentation by Florian Guillou MORNING SESSION. Chaired by Neil Evans (University of Glasgow, UK) 9h30 Donal C Skinner (University of Wyoming, Laramie, USA) GnRH Agonists and unexpected actions 10h00 Valérie Simonneaux (CNRS, Strasbourg, France) Kisspeptins and RFRP-3 act in concert to synchronize reproduction with seasons 10h30 Sue M Moenter (University of Michigan, Ann Arbor, USA) Regulation of gonadotropin-releasing hormone (GnRH) release 11h00 Coffee Break 11h15 Vincent Prévot (INSERM, Lille, France) Preoptic Nitric Oxide synthesizing neurons: an interface between energy homeostasis and reproduction 11h45 Jérôme Leprince (INSERM, Rouen, France) Agonist docking in a GPR103 homology model: site-directed mutagenesis and structure-activity relationship studies 12h15 Isabelle Franceschini (INRA, Nouzilly, France) Development of kisspeptin neurons 12h45 Lunch AFTERNOON SESSION. Chaired by Philippe Bouchard (Hôpital Saint Antoine, Paris) 14h00 Massimiliano Beltramo (INRA, Nouzilly, France) New pharmacological tools to investigate kisspeptin action 14h30 Allan E Herbison (University of Otago, Dunedin, New Zealand) The road to electrical recordings of GnRH neurons in vivo 15h00 Nicolas de Roux (INSERM, Paris, France) Evidence that loss of function mutations of synaptic proteins cause complex syndromic hypogonadotropic hypogonadism 15h30 Kei-ichiro Maeda (University of Tokyo, Tokyo, Japan) Energetic regulation of reproduction: an energy sensor in the brain 16h00 Coffee Break 16h15 Marcel Amstalden (Texas A&M University, College Station, USA) Neuroendocrine programing of accelerated puberty 16h45 Hiroko Tsukamura (University of Nagoya, Nagoya, Japon) Kisspeptin control of gonadotropin release 17h15-17h45 Perspectives by Alain Caraty (INRA, Nouzilly, France)