Download ADMIT BioSuccInnovate

A Bio Refining Centre of Excellence for Wales
ADMIT BioSuccInnovate
Adaptation and Mitigation through Bio-Succinate Innovation
12 partners; 4 Industrial & 7 academic,
UK led with FR, NL, CHF & HU
Dr David Bryant [email protected]
What is Climate KIC?
Bioeconomy Platform Overview
Illustration by David Parkins
KIC Value Proposition
“Investment in public/private partnership projects to
reduce carbon emissions & promote economic growth”
The Ecosystem
LCA & carbon stock management
Xylitol
C5
sugars
C6
sugars
Biomass
lignin
Biosuccinium
New biotech
process & product
launched
Improved climate
change mitigation,
greater market
penetration &
bioeconomic
growth
New biotech
Polyurethane process & product
precursors
launched
BioSuccInnovate Goals
To demonstrate the production of biosuccinic acid from lignocellulosic sugars
To determine the reduction of GHG
emissions compared to Reverdias
current process.
To determine the techno-economic
feasibility.
Demonstrate the applicability of the
CIMV biorefining process and provide
commercial uplift.
The biorefinery concept
Feedstocks, logistics and pre-treatment processes for sustainable lignocellulosic biorefineries: A
comprehensive review.
Kurian et al., Renewable and sustainable energy reviews 25 (2013) 2015-219
Reverdia’s Cassano Facility
for Biosuccinium Production
Bio-Succinate market size
Bio-succinate Market Growth
& Potential
What are the market sectors
for Bio-SuccinniumTM?
What are the market sectors
for Bio-SuccinniumTM?
Feedstock for BioSuccInnovate
Can Bio-Succinate Mitigate
Climate Change?
New processing techniques
Enterprise led PhD Innovation Team
Life cycle and
techno-economic
assessment
(with Uni of
Geneva)
Anna Suchy
Lignin
valorisation
Greenhouse
(with
IBERS)
funding
CoPhenol
C5 sugar
David
Walker
valorisation,
IB
Greenhouse
scale-up
xylitol
funding
H2Oasis
High Performance
Computational
protein modelling
(with IBERS)
Pretreatment and fermentation of xylose to
xylitol
David Walker
Steam explosion rig by Cambi
30 L reaction
vessel
Flash tank
Collection
point
High pressure
boiler (to 35 bar)
Pre-treated biomass
from the flash tank
SE is common scalable
pretreatment for
lignocellulosic biomass.
Above material will liquefy
in under 1 hour with
standard cellulosic
enzymes.
Saccharification / Fermentation
• Replace platform
chemicals and biofuels
traditionally produced
from petrochemicals
• Novel products
Oral hygiene and obesity
Roadmap for Xylitol Innovation
•
•
Xylitol – a natural sweetener encompassing a $537
M dollar market
Adding value to C5 sugar stream for enhanced
commercial uptake of 2G lignocellulosic sugar
platform
Xylose reductase
Substrate binding combinatorial
design
5 aa full site saturation = 5^(20)
combinations
Need “smart” sensing genetic
circuits and logic gates to select
ara-ve.
Need 2 of these strategies in
place.
Will use HPC modelling and redesign sensing components or
“parts”.
Identify xyl+ve.
Enzyme Innovation
Elenni Ioannou
The market need :
CIMV hemicellulose detoxification
Improved biomass processing enzymes
Enzymes
EnZymovate
High
Performance
Computing
Functionally
improved
Chimeras
US Market = $1.7 Bn by 2018
Economic or Environmental
sustainability?
Acknowledgements and thanks