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HLA Disease Associations HISTO TYPE SSP HISTO SPOT SSO HISTO TRAY Serology BAG Health Care GmbH Amtsgerichtsstraße 1-5 Tel.: +49 (0) 6404/ 925- 0 35423 Lich/Germany Fax: +49 (0) 6404/ 925- 250 www.bag-healthcare.com [email protected] Auftragsannahme/Ordering: Tel.: +49 (0) 6404/ 925- 450 Fax: +49 (0) 6404/ 925- 460 [email protected] Customer Service: Tel.: +49 (0) 6404/ 925- 125 Fax: +49 (0) 6404/ 925- 421 [email protected] Celiac Disease Celiac disease is an autoimmune reaction against gluten which is an ingredient of different cereals. If not diagnosed early this leads to chronic inflammation and destruction of the small intestine. Celiac disease is strongly associated with the DQA1*0501-DQB1*0201 and DQA1*03-DQB1*0302 haplotype. Additionally, DR3, DR7 and DR11 alleles ca be used as genetic markers. REF 70941 REF 726071 HISTO TYPE Celiac Disease HISTO SPOT Coeliac Disease 20 Tests / Kit 48 Tests / Kit Abacavir A treatment with antiretroviral drugs (e.g. for HIV therapy) containing the active substance Abacavir is permitted only, if the allele HLA B*5701 is excluded in the patient. This is due to a potential hypersensitivity reaction that is associated with this this allele. REF 70715 HISTO TYPE B57 l 20 Tests / Kit Morbus Bechterew et al. There is a strong association between HLA-B27 and a group of seronegative arthritic diseases like Morbus Bechterew, Morbus Reiter of post infectious reactive arthritis. HLAB27 determination is a valuable tool in the diagnosis of these diseases. The HISTO TYPE B27 kit detects most of the B27 alleles (*2701-17, 19-21, 24-28, 30-32, 34-45) with only one PCR mix: REF 7070 / 7071 REF 7006 / 7008 / 7009 REF 7004 HISTO TYPE B27 HISTO TRAY B27 HISTO TRAY B27 forte 48/96 Tests/Kit 10/20/50 Tests/Kit 10 Tests/Kit Narcolepsy Narcolepsy is a sleep disorder with symptoms like excessive daytime somnolence, sleep paralysis or hallucinations. 98 % of the Caucasian narcolepsy patient has the DRB1*1501 – DQA1*0102 – DQB1*0602 haplotype. Therefore, HLA Typing is helpful to confirm or exclude a diagnosis. The HISTO TYPE Narcolepsy kit enables a direct unambiguous determination of the haplotype associated with narcolepsy. REF 70716 HISTO TYPE Narcolepsy BAG Health Care GmbH Amtsgerichtsstraße 1-5 Tel.: +49 (0) 6404/ 925- 0 35423 Lich/Germany Fax: +49 (0) 6404/ 925- 250 www.bag-healthcare.com [email protected] 20 Tests / Kit Auftragsannahme/Ordering: Tel.: +49 (0) 6404/ 925- 450 Fax: +49 (0) 6404/ 925- 460 [email protected] Customer Service: Tel.: +49 (0) 6404/ 925- 125 Fax: +49 (0) 6404/ 925- 421 [email protected]
