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Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02346746 Extracorporeal Shock Waves (ESW) as a tool in stem cell‐based procedures for cartilage and tendon regeneration Piemonte Frairia Roberto Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02346750 The extracellular matrix protein EMILIN1 as a novel structural and functional determinant of lymphangiogenesis and lymphedema C.R.O. AVIANO Spessotto Paola Biomedical Vascular and Hematology Oncology RF‐2011‐02346751 The subcutaneous immunoglobulins as first‐ line therapy of chronic inflammatory neuropathies. A pilot study. Piemonte Cocito Dario Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02346752 Genetic and immunological factors involved in natural resistance to lentiviral infection Istituto Superiore di Sanita' borsetti alessandra Biomedical Immunology Infection and immunity RF‐2011‐02346754 Tie2 monocyte‐mediated delivery of IFN‐ alpha into the liver as a novel treatment for colorectal carcinoma (CRC) liver metastases. SAN RAFFAELE MILANO Sitia Giovanni Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02346756 Surveillance, control and prevention of Sicilia infections by multidrug resistant organisms in alternative healthcare settings: nursing and residential homes Mammina Caterina Clinical Healthcare Delivery and Methodologies Infection and immunity RF‐2011‐02346762 Evaluation of patient preferences around the different cancer services dimensions: new evidences for improving service organisation. Pagano Eva Clinical Healthcare Delivery and Methodologies Oncology Piemonte Pagina 1 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02346763 Positive selection, expansion and transplantation of regulatory T cells (Tregs) to prevent cellular rejection and to induce tolerance in solid organ transplantation. Emilia‐Romagna Lemoli Roberto Massimo Clinical Immunology The new biotechnologies RF‐2011‐02346764 TRIMming away HIV‐1. infection Role of TRIM proteins in establishement and maintenance of HIV‐1 latency SAN RAFFAELE MILANO Vicenzi Elisa Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02346768 Population‐based active surveillance of acute HIV infection. SAN MATTEO SCUDELLER LUIGIA Clinical AIDS and Related Research Infection and immunity RF‐2011‐02346770 Toscana Clinical and healthcare strategies for improving quality of life in persons affected by spinal cord injuries: Tuscany regional network and use of innovative technological devices Stampacchia Giulia Clinical Healthcare Delivery and Methodologies Neurological diseases RF‐2011‐02346771 SANTA LUCIA Does gut flora influence autoimmune responses in Multiple Sclerosis? The MAIT cell story. Battistini Luca Biomedical Immunology Infection and immunity RF‐2011‐02346772 Novel therapeutic strategies for Amyotrophic Lateral Sclerosis: testing the efficacy of cell‐ permeable peptides in preclinical models. MAUGERI Rossi Daniela Maria Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02346773 Development of a therapeutic approach against HIV/AIDS combining the delivery of single‐chain Fv antibodies and transcription activator like effector protein. Istituto Superiore di Sanita' Titti Fausto Biomedical AIDS and Related Research The new biotechnologies RF‐2011‐02346774 HLA‐G expression and DC‐10 as new risk SAN RAFFAELE MILANO factors for HHV6 reactivation after allo‐HSCT. Gregori Silvia Biomedical Immunology Infection and immunity Pagina 2 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02346790 MOLECULAR EVENTS RESPONSIBLE FOR MIGRATORY PLASTICITY AND INVADOPODIA FORMATION IN BONE METASTASIS FROM BREAST CARCINOMA GALEAZZI Maroni Paola Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02346792 Governance of diabetes management in non‐ specialistic hospital settings Emilia‐Romagna ZAVARONI IVANA Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02346793 Eukaryotic translation Initiation Factor 4H /Wbscr1: its role in gametogenesis, fertility and gonadal carcinogenesis SAN RAFFAELE MILANO Pannese Maria Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies RF‐2011‐02346800 A new predictive assay to assess the efficacy of PASCALE combinatorial treatments against stem cells enriched cultures from metastatic melanoma patients Ciliberto Gennaro Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02346802 A translational integrated study on prostate diseases and environmental risk factors in Sicily for primary and secondary prevention (acronym: PROSTENV) Lorenzetti Stefano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diseases of environmental origin, with reference also to the workplace RF‐2011‐02346810 Study of the mechanisms responsible for the Emilia‐Romagna increased cancer risk and reduced tumour sensitivity in obese and diabetic type 2 people: role of the interleukin 6 Derenzini Massimo Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02346811 Towards a functional classification of human ISTITUTO TUMORI melanoma: dissecting the altered intracellular MILANO signaling profile by phosphoproteomics approaches Anichini Andrea Biomedical Oncology 1 ‐ Basic Translational Oncology Istituto Superiore di Sanita' Pagina 3 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02346822 One or more beta‐amyloids? Links between amyloid composition and phenotypic heterogeneity in Alzheimer's disease: implications for diagnosis and therapy CARLO BESTA Di Fede Giuseppe Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02346823 Evaluation of the clinical relevance of the aggressive trastuzumab‐resistant HER2 p95/611‐CTF isoform and development of recombinant nanobodies for its imaging and therapeutic control BURLO GAROFALO de Marco Ario Biomedical Bioengineering Sciences and Technologies Oncology RF‐2011‐02346830 Cyclodextrin cross‐linking ‐ nanosponges (CD‐ Piemonte NS) for melanoma‐targeted drug delivery BERNENGO MARIA GRAZIA Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02346842 Development of theranostic agents targeting PASCALE molecular pathways involved in cell migration and metastases Aloj Luigi Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02346851 Antimicrobial Microbubbles (MBs) for treatment of biofilm‐associated infections Istituto Superiore di Sanita' Baldassarri Lucilla Biomedical Bioengineering Sciences and Technologies Infection and immunity RF‐2011‐02346852 The extracellular matrix EMILIN2 as a key molecule regulating colon carcinogenesis and as a potential prognostic marker. C.R.O. AVIANO Mongiat Maurizio Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02346855 Branched peptides as cancer theranostics Toscana Bracci Luisa Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02346859 Memory training with transcranial direct current stimulation (tDCS) and cognitive reserve in Multiple Sclerosis and Alzheimer disease. A longitudinal clinical and MRI study Lombardia Mattioli Flavia Clinical Brain Disorders and Clinical Neuroscience Neurological diseases Pagina 4 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02346867 The role of mechanobiology in establishment and progression of intima hyperplasia associated to vein coronary bypass grafts disease MONZINO Pesce Maurizio Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02346871 Exploiting neural stem cell‐targeted mouse models for improving the understanding of the pathogenetic mechanisms underlying Tuberous Sclerosis Complex and developing novel therapeutic approaches. SAN RAFFAELE MILANO Galli Rossella Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02346876 Stimulating the left Broca's area to rehabilitate SANTA LUCIA verbal communicative abilities in severe post‐ stroke aphasia Marangolo Paola Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02346880 Targeted next generation sequencing as tool for molecular diagnosis of rare anemias Campania Iolascon Achille Biomedical Genes, Genomes and Genetics The new biotechnologies RF‐2011‐02346883 Expression of indoleamine 2,3‐dioxygenase 1 (IDO1) in childhood acute leukemia: mechanisms of induction/regulation and clinical implications for leukemia control and patient survival. OSPEDALE BAMBINO GESU' Rutella Sergio Biomedical Immunology Oncology RF‐2011‐02346886 Novel formula milks and neonatal gut microbiota: a dynamic interplay approached by systems biology OSPEDALE BAMBINO GESU' Putignani Lorenza Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Food safety and animal welfare RF‐2011‐02346887 Bowel microbiota and chronic inflammatory bowel diseases: a metabolomic approach Sardegna MANZIN ALDO Biomedical Infectious Diseases and Microbiology Infection and immunity Pagina 5 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione Area Strategica. Favale Stefano Biomedical Cardiovascular and Respiratory Sciences The new biotechnologies The low density lipoprotein‐associated protein MONZINO prenylcysteine lyase: a novel player in atherosclerosis? Banfi Cristina Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02346898 Burden of alcohol‐related diseases and priorities for health policy control. Istituto Superiore di Sanita' Pichini Simona Biomedical Population Sciences and Epidemiology Oncology RF‐2011‐02346914 Phase 1/2 study of valproic acid and short‐ course radiotherapy plus capecitabine as preoperative treatment in low‐moderate risk rectal cancer PASCALE Budillon Alfredo Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02346915 Multifunctional "hybrid" drugs for targeting skeletal metastases RIZZOLI Granchi Donatella Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02346917 Transcriptomic profiling in circulating mesenchymal stem cells of patients with degenerative diseases. Veneto DALLE LUCA CARBONARE GIUSEPPE Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02346918 Influence of Zinc transporters on glycemic control and cardiovascular risk prevention I.N.R.C.A. Giacconi Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02346923 Exploiting the p53‐p66Shc signaling pathway to identify new molecular markers for the prevention of cancerand age‐related diseases I.E.O. MIGLIACCIO ENRICA Biomedical Biology of Development and Aging Oncology RF‐2011‐02346888 Analysis of cardiomyopathies and arrhythmogenic syndromes associated with high risk of sudden death: an integrated approach of functional genomics and clinical‐ instrumental parameters. RF‐2011‐02346892 Puglia AREA P.I. Roberta Pagina 6 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Lucia Maria Biomedical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace Morsica Giulia Clinical Infectious Diseases and Microbiology Infection and immunity SAN RAFFAELE MILANO Muzio Luca Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases MONZINO Sironi Luigi Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Melone Mariarosa Anna Beatrice Biomedical Brain Disorders and Clinical Neuroscience Diseases of environmental origin, with reference also to the workplace RF‐2011‐02346929 Genetic and environmental factors underlying Istituto Superiore di Sanita' metabolic inflexibility and their impact for the prevention and treatment of obesity: basic and clinical studies Cirulli Francesca RF‐2011‐02346933 Identification and use of markers of exposure RIZZOLI and effect on decision‐making in patients with metal‐on‐metal joint implants Savarino RF‐2011‐02346935 Analysis of hepatitis C virus heterogeneity in SAN RAFFAELE MILANO direct‐acting antivirals (DAAs) targeted region (non‐structural region 3) during anti‐HCV treatment: new implications for treatment strategy. RF‐2011‐02346938 ASIC1: a Therapeutic Target for new neuroprotective pharmacological approaches for multiple sclerosis RF‐2011‐02346940 An in vitro ad in vivo imaging approach to myelin dysfunction and reconstruction after stroke: role of GPR17, a new player in oligodendrocyte specification RF‐2011‐02346956 Association between environmental exposure Campania to chemical pollutants and the development of neurodegenerative diseases: a clinical epidemiological study combinated with environmental and biomolecular observations in contaminated Terzigno area Biomedical Pagina 7 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02346959 Evaluation of the efficacy of Rapamycin and a DPP‐4 inhibitor (Vildagliptin) in improving beta cell function in type 1 diabetes of long duration, a perspective randomized study SAN RAFFAELE MILANO Piemonti Lorenzo Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02346963 Role of GALNT2 on glucose homeostasis. A multidisciplinary approach including cell biology, animal and human studies. CASA SOLLIEVO SOFFERENZA Rosa Di Paola Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02346965 Metastasis at the onset: to inhibit cell cannibalism in order to hinder tumor spreading Istituto Superiore di Sanita' Malorni Walter Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02346966 Epigenetic signatures in human glioblastoma cells: implications for tumor biology and treatment IRCCS AOU San Martino‐ IST (Genova) Romani Massimo Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02346973 Modulating TACE secretase activity and Neuregulin 1 type III signaling to treat inherited hypermyelinating neuropathies SAN RAFFAELE MILANO Bolino Alessandra Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02346976 Identification of critical p53 co‐regulators and I.E.O. effectors during tumor suppression AMATI BRUNO Biomedical Genes, Genomes and Genetics Oncology RF‐2011‐02346977 Slow potentials due to glial dysfunction as biomarkers of the seizure‐onset zone in surgically‐remediable focal epilepsies Garbelli Rita Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02346978 Improving radiotherapy of high grade gliomas IRCCS AOU San Martino‐ by Ataxia Telangiectasia Mutated protein IST (Genova) inhibition Frosina Guido Biomedical Brain Disorders and Clinical Neuroscience Oncology CARLO BESTA Pagina 8 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02346980 Novel biocomposite for cranial bone regeneration in pediatric patients Lazio Di Rocco Concezio Biomedical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02346983 Investigation on the role of iron and mitochondria in neurodegenerative disorders through the development of new human neuronal cellular systems CARLO BESTA Tiranti Valeria Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02346984 Identification of new therapeutical targets of I.E.O. cancer stem cells: study of the mechanistics of mitotic spindle alignment to cortical polarity in mammary stem cell asymmetric divisions MAPELLI MARINA Biomedical Biological Chemistry and Macromolecular Biophysics Oncology RF‐2011‐02346986 TRAIL receptor embedding in membrane rafts Istituto Superiore di Sanita' could predict cancer cell susceptibility to TRAIL‐based molecularly targeted therapy matarrese paola Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02346987 Development of a second generation PCR‐ Based Replicon Typing system to trace and control the antimicrobial resistance spread in Enterobacteriaceae Carattoli Alessandra Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02346990 Development of a service interface method ( Toscana WebService) beetween family care physicians operating in a primary care setting and nephrologists , for the prevention, diagnosis and treatment of kidney damage in patients with type II diabetes mellitus . Bianchi Stefano Clinical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease RF‐2011‐02346993 Interference evaluation of cancer microenvironment in the tumor‐specific immune response of pancreatic cancer patients Amedei Amedeo Biomedical Oncology 1 ‐ Basic Translational Oncology Istituto Superiore di Sanita' Toscana Pagina 9 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02346995 Radiation exposure optimization by wireless technology for professionals involved in the management and care of patients undergoing therapy with radionuclides. Implementation of environmental monitoring. CROB Storto Giovanni Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02347019 Telemonitoring in long‐term ventilator‐ dependent patients: a multicenter randomized controlled study Toscana Ambrosino Nicolino Clinical Cardiovascular and Respiratory Sciences Neurological diseases RF‐2011‐02347025 Amniotic stem cells to improve congenital kidney damage: a fetal lamb model SAN MATTEO Avolio Luigi Biomedical Digestive, Kidney and Urological Systems The new biotechnologies RF‐2011‐02347027 THE ROLE OF CALCIUM HOMEOSTASIS IN OSPEDALE BAMBINO CONGENITAL CEREBELLAR ATAXIAS : GESU' genetic dissection and functional characterization of a neuronal specific plasma membrane Ca2+ATPase Zanni Ginevra Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02347029 Treatment of Subsyndromal Delirum (SSD) Emilia‐Romagna and long term Cognitive Dysfunction after Cardiac Surgery. Evaluation of possible neural mechanism underlyning Delirium vezzani antonella Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02347031 Development of a wearable system for the integrated assessment of seismocardiogram and other vital signs out of the laboratory setting. DON GNOCCHI Di Rienzo Marco Biomedical Bioengineering Sciences and Technologies Metabolism disorders and cardiovascular disease RF‐2011‐02347032 Molecular factors predictive of heart and brain involvement in myotonic dystrophy S.CAMILLO Angelini Corrado Clinical Musculoskeletal, Oral and Skin Sciences Neurological diseases RF‐2011‐02347051 Tregs/Th17 Imbalance, Intrahepatic Cytokine Milieu and Immune Dysregulation in Autoimmune Hepatitis Emilia‐Romagna Muratori Luigi Biomedical Immunology Infection and immunity Pagina 10 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Zaffagnini Stefano Clinical Musculoskeletal, Oral and Skin Sciences The new biotechnologies SAN RAFFAELE MILANO Study of orphan muscle diseases with an inflammatory component and identification of novel therapeutic molecules. Silvia Brunelli Biomedical Musculoskeletal, Oral and Skin Sciences Infection and immunity RF‐2011‐02347060 Surveillance of the circulation of rotaviruses in Sicilia the infantile population of Sicily following the introduction of rotavirus vaccination Giammanco Giovanni Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02347071 Exploiting Immunoglobulin Stereotypy as a marker of prognosis and a target for therapy in Chronic Lymphocytic Leukemia Ghia Paolo Prospero Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347074 Role of Toll‐like receptors in chemoresistance SAN RAFFAELE MILANO of chronic lymphocytic leukemia Muzio Marta Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347084 Inflammation and oxidative stress in preeclampsia: role of the maternal endothelium and of the placenta, potential role in early markers development Lombardia cetin irene Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies RF‐2011‐02347086 Characterization of HIV‐related mechanisms involved in the development of Burkitt's lymphoma Emilia‐Romagna Gibellini Davide Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02347087 HIV‐TLR4 interaction as a novel target for intervention strategies against HIV disease Istituto Superiore di Sanita' Gessani Sandra Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02347096 Prostate cancer: a study on the mechanisms underlying the development of androgen‐ independence to identify early biomarkers and new therapeutic targets IRCCS AOU San Martino‐ IST (Genova) Balbi Cecilia Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347052 Biomechanical Modeling for Customized Surgical Planning in the Cartilage Treatment of the Patello‐Femoral Joint. RF‐2011‐02347055 RIZZOLI SAN RAFFAELE MILANO Pagina 11 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347099 Emilia‐Romagna The MINA PROJECT. Mirror Neurons In Alcoholics: can Mirror Neuron System help us to understand and treat Alcohol Addiction? Di Gennaro Cristiana Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347100 SANTA LUCIA EFFECTS OF PERIPHERALLY ADMINISTERED BDNF IN THE R6/2 MOUSE MODEL OF HUNTINGTON¿S DISEASE Fusco Francesca Romana Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02347102 Liver targeted cell therapy: applications to GASLINI experimental Glycogen Storage Disease type 1a Eva Alessandra Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02347105 Novel Plasmodium falciparum cell‐based assays for new antimalarial drugs Istituto Superiore di Sanita' Alano Pietro Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02347106 Development of high throughput, integrated and cost‐effective molecular diagnostic tests for the detection of genetic and epigenetic defects involved in human disease MAGGIORE Miozzo Monica Rosa Clinical Genes, Genomes and Genetics The new biotechnologies RF‐2011‐02347107 Upper limb impairment in Charcot‐Marie‐ Tooth patients: motor strategies, impact on quality of life and cortical functional reorganization DON GNOCCHI Padua Luca Clinical Musculoskeletal, Oral and Skin Sciences Neurological diseases RF‐2011‐02347109 Role of growth hormone‐releasing hormone (GHRH) in cardiac hypertrophy Piemonte Granata Riccarda Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347120 Istituto Superiore di Sanita' Cell‐on‐chip technology as a novel tool to investigate the crosstalk between cancer and immune cells: role of the transcription factors Interferon Regulatory Factor 1 and 8 (IRF1, IRF8) in melanoma as a model system. Mattei Fabrizio Biomedical Oncology 1 ‐ Basic Translational The new biotechnologies Pagina 12 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Neurological diseases Elio Angelo Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Ricci Antonia Veterinary Food safety and animal welfare D'Errico Mariarosari Biomedical a Molecular, Cellular, and Developmental Neuroscience Neurological diseases Pietraforte Donatella Biomedical Oncology 1 ‐ Basic Translational Oncology Cifarelli RosaAnna Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace Pitteri Marco Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Ferri Raffaele Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Genomic approach for motor neuron diseases SAN RAFFAELE MILANO Previtali Stefano RF‐2011‐02347140 Pathogenesis, diagnosis and course of familial and sporadic Alzheimer¿s disease and Frontotemporal Lobar degeneration: epigenetics and proteomics as new tools for disease mechanisms and biomarker discovery MAGGIORE Scarpini RF‐2011‐02347141 Effect of Ag nanoparticles in controlling Salmonella and Campylobacter in laying hens and clinical and food safety insights IZSVE RF‐2011‐02347143 Cockayne syndrome: the role of bioenergetics dysfunction in neurodegeneration and design of new therapeutic approaches Istituto Superiore di Sanita' RF‐2011‐02347153 Nitrosation of drugs of abuse in human saliva Istituto Superiore di Sanita' at the acidic pH of the stomach: mechanism of transformation and evaluation of the associated carcinogenic risk. RF‐2011‐02347154 Potential health and environmental risks associated to air pollutants in the petrochemical site of Basilicata RF‐2011‐02347163 The anatomical substrate of unilateral neglect S.CAMILLO subtypes: behavioral and neuroimaging investigation RF‐2011‐02347164 The clinical significance of the association between REM Sleep Behavior Disorder and Parkinson's Disease Associazione Oasi Maria SS Area Strategica. Brain Disorders and Clinical Neuroscience RF‐2011‐02347127 Basilicata Classificazione Clinical Biomedical Pagina 13 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347166 PREVENTION OF MOTHER‐TO‐CHILD TRANSMISSION OF HIV: SAFETY, EFFICACY AND ACCEPTABILITY OF THE ADMINISTRATION OF TENOFOVIR, LAMIVUDINE AND EFAVIRENZ WITHIN A LIFELONG TREATMENT STRATEGY FOR ALL PREGNANT WOMEN WITH HIV Istituto Superiore di Sanita' Giuliano Marina Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02347168 NSD1 PHD fingers as potential targets for Acute Myeloid Leukemia SAN RAFFAELE MILANO Musco Giovanna Biomedical Biological Chemistry and Macromolecular Biophysics Oncology RF‐2011‐02347169 GASLINI MECHANISMS REGULATING DENDRITIC CELL PROTUMORAL ACTIVITY WITHIN THE HYPOXIC MICROENVIRONMENT: POTENTIAL THERAPEUTIC APPLICATIONS IN NEUROBLASTOMA Bosco Maria Carla Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347171 Assessment of cancer risk behaviours of immigrant population in Italy and the impact in the socio‐sanitary context. Strategies for a conscious prevention. PASCALE De Falco Francesco Clinical Risk, Prevention and Health Behavior Oncology RF‐2011‐02347172 Risk maps of MAP (Mycobacterium avium subsp. paratuberculosis) using advances technologies IZSLT de grossi luigi Biomedical Veterinary Infection and immunity RF‐2011‐02347187 Structural genomics/proteomics and solution IRCCS AOU San Martino‐ IST (Genova) characterization of proteins of biomedical interest: development of a comprehensive facility, application to therapeutic monoclonal antibodies, and to the fibrin(ogen)‐integrins cell‐matrix interactions model sy Rocco Mattia Biomedical Biological Chemistry and Macromolecular Biophysics Oncology RF‐2011‐02347188 Cellular and molecular mechanisms underlying the dyskinetic effects of L‐DOPA versus Dopamine D2‐D3 agonists Picconi Barbara Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases SANTA LUCIA Pagina 14 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347189 BEVO SIRCOPANOS (endocrine Benefits from Sicilian Extra Virgin Olive Oil, Sicilian Red wine and Consumption of Pesce Azzurro but No Smoking): a project by the Program of Molecular & Clincical Endocrinology and Women's Endocrine Health. Sicilia Benvenga Salvatore Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diseases of environmental origin, with reference also to the workplace RF‐2011‐02347193 Characterization of human amniotic mesenchymal stem cells (hA‐MSCs) isolated from obese women at delivery to identify gene or protein alterations predisposing the newborn to obesity. SDN Sacchetti Lucia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347194 INNOVATIVE TRANSLATIONAL APPROACHES TO IDENTIFY IMMUNE CORRELATES OF PROTECTION IN AIDS VACCINE TRIALS Istituto Superiore di Sanita' FERRANTELLI FLAVIA Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02347197 Epidrugs and cardiac differentiation: relevance for the 22q11.2 deletion syndrome NEUROMED Baldini Antonio Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347199 Molecular understanding of E3 ligases involved in signaling and cancer I.E.O. Pasqualato Sebastiano Biomedical Biological Chemistry and Macromolecular Biophysics Oncology RF‐2011‐02347204 GENETIC PREVENTION OF LYMPHOMA DEVELOPMENT IN p53 KNOCKOUT MICE REVEALS A NOVEL MOUSE MODEL OF OSTEOSARCOMA AND HEMANGIOSARCOMA. EARLY MOLECULAR AND IMMUNOLOGICAL MECHANISMS INVOLVED IN TUMOR ONSET AND MALIGNANCY AS TARGET OF INNOVATIVES THERAPIES. RIZZOLI Landuzzi Lorena Oncology 1 ‐ Basic Translational Oncology Biomedical Pagina 15 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02347211 Istituto Superiore di Sanita' NOVEL TOOLS TO STUDY AND INHIBIT MALARIA GAMETOCYTE SEQUESTRATION IN HUMAN BONE MARROW RF‐2011‐02347219 Heart remodelling in Chronic Obstructive Pulmonary Disease: diagnostic and therapeutic implications. RF‐2011‐02347224 AREA P.I. Classificazione Area Strategica. Silvestrini Francesco Biomedical Infectious Diseases and Microbiology Infection and immunity Pelà Giovanna Maria Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease CCL2/CCR2 blocking:molecular insights into a Istituto Superiore di Sanita' potential therapeutic strategy against HIV replication Fantuzzi Laura Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02347227 IZSUM BIOLOGICAL APPROACH TO DECONTAMINATION OF BIVALVE MOLLUSCS FROM V.PARAHAEMOLYTICUS AND SALMONELLA BY MARINE BDELLOVIBRIO‐AND‐LIKE ORGANISMS (BALOs). Ottaviani Donatella Biomedical Veterinary Food safety and animal welfare RF‐2011‐02347228 Altered host‐virus interaction as cause of multiple sclerosis: focus on Epstein‐Barr virus and antiviral immune response Aloisi Francesca Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347229 Functional Immune Reconstitution Evaluation SPALLANZANI of Immune Senescence Process in HIV Mono‐ infected and Co‐infected Patients Undergoing cART (FIRE Study) Martini Federico Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02347230 The role of Iron in White Matter changes in Neurodegenerative Diseases (Alzheimer, Parkinson and Huntington's Diseases). Does the white matter share with the gray matter the same physiopathology (iron accumulation)? Di Paola Margherita Clinical Brain Disorders and Clinical Neuroscience Neurological diseases Emilia‐Romagna Istituto Superiore di Sanita' SANTA LUCIA Pagina 16 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02347242 Enhancement of NKG2D ligands‐induced anti‐ SAN RAFFAELE MILANO tumor response in Hodgkin and non Hodgkin lymphomas: ERp5 thiol isomerase and ADAM10 disintegrin‐metalloproteinase as possible therapeutic targets. RF‐2011‐02347243 Genomic architecture and clonal evolution of myelodysplastic syndromes and myeloproliferative neoplasms RF‐2011‐02347244 AREA P.I. Classificazione Area Strategica. Zocchi Maria Raffaella Biomedical Immunology Oncology SAN MATTEO CAZZOLA MARIO Biomedical Oncology 1 ‐ Basic Translational Oncology Dissecting the genetic etiology of epileptic encephalopathies by high‐throughput sequencing GASLINI Zara Federico Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347245 Development of an immunotherapeutic strategy for an effective therapeutic HPV vaccine Istituto Superiore di Sanita' NEGRI DONATELL Biomedical A Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347249 Evaluation of the prognostic role of Toscana phosphatidylinositol 3‐kinase pathway mutations through analysis of peripheral blood and circulating tumor cells in metastatic breast cancer patients treated with endocrine therapy Di Leo Angelo Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347250 Vitamin D as a disease modulator in multiple sclerosis: immunomodulatory activity on antigen presenting cell and gamma/delta T lymphocytes and regulation of their cross‐talk Gauzzi Maria Cristina Biomedical Immunology Neurological diseases RF‐2011‐02347252 Targeting endothelin‐1/ß‐arrestin signaling to REGINA ELENA circumvent chemoresistance in epithelial ovarian cancer Bagnato Anna Teresa Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347253 Identification and validation of new therapeutic targets in Acute Myeloid Leukaemia Colombo Emanuela Biomedical Oncology 1 ‐ Basic Translational Oncology Istituto Superiore di Sanita' I.E.O. Pagina 17 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347254 Targeting leukemia cells by CD1c‐restricted autoreactive T cell response SAN RAFFAELE MILANO Casorati Giulia Biomedical Immunology Oncology RF‐2011‐02347258 Assessment of transplant benefit of downstaging strategies in patients with hepatocellular carcinoma exceeding Milan Criteria: a randomized study ISTITUTO TUMORI MILANO Mazzaferro Vincenzo Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347259 STUDY ON THE POTENTIAL USE OF COMBRETUM MICRANTHUM AS AN ANTITUMOR AND CHEMOPREVENTIVE AGENT. IRCCS AOU San Martino‐ IST (Genova) Astigiano Simonetta Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347260 In vivo toxi‐omic signatures for brain and thyroid function: combined exposure to mixtures of endocrine disrupting chemicals and iodine deficiency in animal models and translation to epidemiological/clinical studies Istituto Superiore di Sanita' Calamandrei Gemma Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diseases of environmental origin, with reference also to the workplace RF‐2011‐02347262 RESPONSE ORIENTED MAINTENANCE IMMUNOTHERAPY IN PATIENTS WITH FOLLICULAR LYMPHOMA. Emilia‐Romagna Federico Massimo Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347264 Molecular techniques as epidemiological tools IZSVE to answer some of the queries about Q fever Natale Alda Biomedical Veterinary Food safety and animal welfare RF‐2011‐02347271 Role of basophils derived interleukin‐4 in driving thymic stromal lymphopoietin dependent pro‐tumor Th2 inflammation in pancreatic cancer SAN RAFFAELE MILANO Protti Maria Pia Biomedical Immunology Oncology RF‐2011‐02347273 New molecular markers of pathogenetic and translational significance in tumoral and peritumoral tissue of primary liver cancer HUMANITAS RONCALLI MASSIMO Biomedical Oncology 1 ‐ Basic Translational Oncology Pagina 18 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347275 Targeting Tenascin‐C to inhibit early lymph node colonization by prostate cancer stem/initiating cells and immune evasion SAN RAFFAELE MILANO Bellone Matteo Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347276 Investigating the molecular mechanisms leading to genome instability in tumours: analysis of role of the replicationstress response and its potential for early diagnosis and target therapy of cancer Istituto Superiore di Sanita' Pichierri Pietro Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347280 Morphofunctional visual pathways evaluation BIETTI in multiple sclerosis: possible identification of neurodegenerative bio‐markers Parisi Vincenzo Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02347283 Breast cancer with low risk of local Emilia‐Romagna recurrence: 3D Conformal Accelerated and Hypofractionated Partial Breast Irradiation vs. standard whole breast radiotherapy after conservative surgery Frezza Giovanni Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347284 unraveling the pathogenesis of autoinflammatory syndromes: from improved molecular diagnosis to the identification of novel therapeutic targets BURLO GAROFALO Tommasini Alberto Clinical Immunology Infection and immunity RF‐2011‐02347285 SISTEMATIC APPLICATION OF A STANDARDIZED COMPREHENSIVE GERIATRIC ASSESSMENT TO PREDICT OUTCOME AND POSSIBILITY OF TREATMENT ON ELDERLY CANCER PATIENTS Emilia‐Romagna Gallerani Massimo Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347297 TARGETING CD99 TO TREAT EWING SARCOMA RIZZOLI Scotlandi Katia Biomedical Oncology 2 ‐ Translational Clinical Oncology Pagina 19 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Cardillo Carmine Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Istituto Superiore di Sanita' Specialized‐functionally connected membranes as caveolae and exosomes include molecular signature to decode melanoma progression mechanisms exploitable in clinical therapy Sargiacomo Massimo Biomedical Cell Biology Oncology RF‐2011‐02347308 Biochemical, electrophysiological and genetic Sicilia determinants of disease progression and survival in Amyotrophic Lateral Sclerosis (ALS) La Bella Vincenzo Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347309 Ranking patient‐oriented outcome measures with evidence‐based criteria in brain tumor patients Veneto Talacchi Andrea Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347320 PROTEASE VARIABILITY IN PATIENTS INFECTED WITH HEPATITIS C VIRUS GENOTYPE 1: IMPLICATION FOR ANTIVIRAL TREATMENT USING DIRECTLY ACTING ANTIVIRALS (DAA) Sicilia Ferraro Donatella Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02347335 Innovative analytical methods for determination of veterinary drug residues in foodstuffs IZSUM Galarini Roberta Biomedical Veterinary Food safety and animal welfare RF‐2011‐02347336 Multi‐disciplinary approach to predict adverse Lombardia ventricular remodeling in post‐MI patients: combined evaluation of cardiac dysfunction and immune‐related biomarkers after revascularization procedure Mafrici Antonio Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347299 Pathophysiology of obesity‐related vascular dysfunction: comparison between "metabolically healthy obesity" and the metabolic syndrome RF‐2011‐02347300 Lazio Pagina 20 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. belardelli filippo Biomedical Oncology 2 ‐ Translational Clinical Oncology Pre‐clinical evaluation of safety and efficacy of MONDINO intra‐arterial infusion of mesenchymal stems cells in experimental models ofneurodegenerative parkinsonisms and analysis of potential therapeutic mechanisms: en route for a clinical trial Blandini Fabio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347343 COCAINE AND CHEST PAIN pavarin raimondo Clinical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease RF‐2011‐02347345 Sicilia Identification of early neurophysiological markers of cognitive‐behavioural disturbances in patients with cerebrovascular disease. Pennisi Giovanni Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347348 Validation of Augmented Reality Navigation for HIFU Treatments Di Candio Giulio Clinical Oncology Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02347356 SAN RAFFAELE MILANO PHARMACOGENOMICS OF HYPERTENSION: A NEW APPROACH FOR A PERSONALIZED MEDICINE Manunta Paolo Clinical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease RF‐2011‐02347359 Comparative analysis of genomic and epigenomic alterations induced by leukemogenic AML1‐fusion proteins I.E.O. ALCALAY MYRIAM Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347360 Identification and characterization of genes involved in progenitor cells reprogramming into stem cells and cancer stem cells, as novel cancer therapeutic targets. I.E.O. Moroni Maria Cristina Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347337 Dendritic cell‐based vaccine therapy in indolent non‐Hodgkin lymphoma patients: a phase I clinical study RF‐2011‐02347340 Istituto Superiore di Sanita' Emilia‐Romagna Toscana Pagina 21 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347362 Induced pluripotent stem cells (iPSCs) as a tool to develop neuroprotective (autologous) neural stem cell‐based therapy in multiple sclerosis SAN RAFFAELE MILANO Martino Gianvito Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347363 Potential relevance of non classical human leukocyte antigens (HLA)‐G and ‐E and gelatinases as markers of tumor invasion and progression and their association with Computed Tomography and Magnetic Resonance Imaging perfusion findings in patients with hig Emilia‐Romagna Fainardi Enrico Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347365 From breast to brain: study of the molecular mechanisms mediating the development of brain metastasis I.E.O. PELICCI GIULIANA Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347369 Neurorehabilitation of post‐stroke disorders using integrated behavioral and brain stimulation tools SANTA LUCIA Oliveri Massimilian Clinical o Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347399 Senescence‐Associated microRNAs (SAmiRs) in cellular senescence and organismal aging SDN Cimino Filiberto Biomedical Biology of Development and Aging Neurological diseases RF‐2011‐02347400 A role for the modulation of Rho GTPase Istituto Superiore di Sanita' signalling in the therapy of Fragile X syndrome Diana Giovanni Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347402 Non‐invasive assessment of liver steatosis and SAN MATTEO fibrosis in pediatric patients FILICE CARLO Clinical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease RF‐2011‐02347403 The tumor cell spheroid as a key factor in the drug resistance and dissemination of high grade ovarian serous carcinoma (sEOC) Colombatti Alfonso Biomedical Oncology 1 ‐ Basic Translational Oncology C.R.O. AVIANO Pagina 22 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347404 GENE EXPRESSION PROFILING IN HUMAN ACTH‐SECRETING PITUITARY TUMORS IN ASSOCIATION WITH CLINICAL AND BIOCHEMICAL FEATURES AUXOLOGICO Pecori‐giraldi Francesca Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347420 Monitoring disease progression and phenotypic heterogeneity in hereditary ataxias: clinical, cognitive, neuroimaging, and neurophysiological study to identify early markers of cerebellar dysfunction in patients and presymptomatic carriers CARLO BESTA Mariotti Caterina Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347422 Naturally occurring and re‐programed cancer stem cells in ovarian carcinoma: functional role and clinical implications. I.E.O. Cavallaro Ugo Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347423 Dendritic cell engineering with IRF‐1 and IRF‐ 8 for new immunotherapy interventions Istituto Superiore di Sanita' Fragale Alessandra Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347424 The integrated and multi‐disciplinary management of patients with peripheral arterial disease and lower limbs trophic lesions: improving adherence and quality of life Sicilia Di Salvo Michelangel Clinical o Maria Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease RF‐2011‐02347425 A pharmacological chaperone approach to rescue nucleophosmin mutants in acute myeloid leukemia Abruzzo Federici Luca Biomedical Biological Chemistry and Macromolecular Biophysics Oncology RF‐2011‐02347432 Safety and technology assessment of Ultra High Field Magnetic Resonance 7 Tesla System for children applications STELLA MARIS Tosetti Michela Biomedical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering Pagina 23 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347436 Effects of Neuropeptide Y on the central nervous system neurons of rat models of Alzheimer Disease SANTA LUCIA Angelucci Francesco Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347437 Role of HDL and endothelial dysfunctions in modulating the impact of risk factors on sub clinical atherosclerosis in diabetes Toscana Natali Andrea Clinical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02347440 ROLE OF MITOCHONDRIAL OXIDATIVE METABOLISM AND REDOX SIGNALING IN ADULT STEM CELL PROLIFERATION AND DIFFERENTIATION: DEVELOPMENT OF INNOVATIVE STRATEGIES FOR EX VIVO HEMATOPOIETIC STEM CELL EXPANSION TO BE USED IN ONCO‐HEMATOLOGICAL THERAPIES CROB Piccoli Claudia Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347444 Mechanisms underlying cognitive dysfunction DON GNOCCHI and decline in Parkinson's disease and related disorders: brain damage, functional reorganization, and effects of BDNF polymorphisms. Nemni Raffaello Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347455 Modulation of somatosensory, vestibular and interoceptive signals as a proxy for improving quality of life in patients with Spinal cord injury Aglioti Salvatore Maria Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347456 ROLE OF THE NEUROTROPHIN BDNF AND MONZINO ITS INTERACTION WITH ENVIRONMENTAL FACTORS IN THE REGULATION OF THROMBOSIS Barbieri Silvia Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02347457 Post‐transplant hematopoiesis: a model to understand self‐renewal mechanisms of hematopoietic stem cells Frassoni Francesco Biomedical Vascular and Hematology Oncology SANTA LUCIA GASLINI Pagina 24 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347458 Cardiopulmonary risk and Transplantation Campania Tufano Rosalba Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347467 The Rac1‐activator CNF1 as a therapeutic approach for amyotrophic lateral sclerosis Istituto Superiore di Sanita' Fiorentini Carla Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02347470 Regulation of mitotic transitions I.E.O. Visintin Rosella Biomedical Cell Biology Oncology RF‐2011‐02347471 New frontiers in breast imaging: contrast enhanced digital mammography. ‐ Clinical performance of contrast‐enhanced spectral mammography (CESM ‐ SenoBright) in pre‐ surgical evaluation of extent of malignancy in a population of women with breast cancer I.E.O. CASSANO ENRICO Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347473 Nanotechnology for the delivery of Zoledronic REGINA ELENA Acid: a new opportunity against cancer Leonetti Carlo Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347475 DNA vaccines coding for chimeric human/rat Piemonte HER‐2 as innovative immunotherapeutic tools for the treatment of HER‐2+ cancer patients Giovarelli Mirella Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347476 ROLE OF ALTERED PRESYNAPTIC PROTEINS‐MEDIATED SYNAPTIC PLASTICITY IN COGNITIVE DECLINE IN THE ELDERLY I.N.R.C.A. Conti Fiorenzo Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02347480 ANTI‐INFLAMMATORY ACTIVITY OF POLYPHENOLS IN CANCER CHEMOPREVENTION: IN VITRO AND IN VIVO STUDIES Istituto Superiore di Sanita' MASELLA ROBERTA Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Pagina 25 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347481 Epigenetic therapy for the treatment of Parkinson's disease and improvement of exercise‐based rehabilitation S.CAMILLO Pizzi Marina Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347483 Standardization of cord blood CD34+ cell count in a European multicenter trial. Impact on haematopoetic stem cell transplantation for haematological malignancies. Lombardia Lanza Francesco Biomedical Vascular and Hematology Oncology RF‐2011‐02347487 ROLE OF GROUP I METABOTROPIC GLUTAMATE RECEPTORS IN THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS AND IN ITS PHARMACOLOGICAL CONTROL I.N.R.C.A. Melone Marcello Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347490 Uncovering the molecular bases of the SAN RAFFAELE MILANO association of uromodulin common variants with hypertension and chronic kidney disease for the identification of novel therapeutic strategies Rampoldi Luca Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease RF‐2011‐02347497 Cortical TRPV1 in neuroglial network: a new tool for studying neuropathic pain Marinelli Silvia Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02347506 GENE‐ENVIRONMENT INTERACTIONS, Sicilia VITAMIN D STATUS AND SUSCEPTIBILITY: IMMUNE RESPONSE AND PULMONARY TUBERCULOSIS RISK IN SICILY CINA' DIANA Biomedical Population Sciences and Epidemiology Infection and immunity RF‐2011‐02347507 PTPRG as a new candidate biomarker for Chronic Myeloid Leukemia Sardegna PIRAS GIOVANNA Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347508 Therapy de‐escalation in Inflammatory Bowel Disease ‐ Identification of biomarkers to assess prognostic factors in patients with mucosal healing Sicilia Fries Walter Digestive, Kidney and Urological Systems Infection and immunity SANTA LUCIA Clinical Pagina 26 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347511 Emilia‐Romagna GENETIC REGULATION OF PLASMA LOW DENSITY LIPOPROTEIN LEVELS. EFFECT OF MUTATIONS OF APOB AND ANGPTL3/8 GENES ON HEPATIC SECRETION OF APOB‐ CONTAINING LIPOPROTEINS. TARUGI PATRIZIA Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347517 PARP‐1 and PARP‐2 may have a differential role in supporting tumor cell growth: studies on the effects of selective subtype inhibitors Toscana Moroni Flavio Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347521 DEVELOPMENT AND VALIDATION OF A COMORBIDITY INDEX SPECIFIC FOR STROKE PATIENTS Emilia‐Romagna Denti Licia Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347522 Genetic markers in elderly to estimate the risk Sicilia for vascular diseases by using the peripheral arterial disease model. Signorelli Salvatore Santo Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02347524 Novel tools for immune monitoring and immune reconstitution in children with severely compromised T‐lymphocyte responses associated with hemato‐ oncological diseases. OSPEDALE BAMBINO GESU' Li Pira Giuseppina Clinical Immunology Infection and immunity RF‐2011‐02347532 A multi‐site international RCT comparing regional and general anesthesia in infants for effects on neurodevelopmental outcome at five year of age: The GAS Trial. GASLINI Disma Nicola Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347544 Studies on the molecular characteristics of the Istituto Superiore di Sanita' Env protein from HIV‐1 subtypes and recombinant forms circulating in Cameroon and their correlation with disease stage, virus infectivity and resistance to neutralization Butto Stefano Biomedical AIDS and Related Research Infection and immunity Pagina 27 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347545 Circulating microRNAs as novel biomarkers for Amyotrophic Lateral Sclerosis Toscana Battistini Stefania Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347552 Familial Hyperaldosteronism: Studies in Humans and in Animal Models Piemonte MULATERO PAOLO Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02347553 A phase II, randomised, placebo‐ controlled trial of neuroprotection with Raltegravir in Secondary Progressive Multiple Sclerosis Istituto Superiore di Sanita' palmisano Lucia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347554 Cardiovascular risk and genetic hypercholesterolemias: improving risk assessment to optimize treatment. Sicilia Averna Maurizio Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02347557 Role of chronic inflammation in the pathogenesis of Philadelphia‐negative myeloproliferative neoplasms (MPNs): an in vitro and in vivo biomolecular and functional analysis of the stem/progenitor and megakaryocytic cell compartments Emilia‐Romagna Catani Lucia Biomedical Cell Biology Oncology RF‐2011‐02347559 Preclinical evaluation of isoform‐specific PI3K Sicilia inhibitors' effects in IPF for novel potentialtherapies of malignat mesenchymal tumors Vancheri Carlo Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347560 Discovering metabolomic signatures associated with specific gene mutations in melanoma and their role in tumor radiosensitivity and immunogenicity Istituto Superiore di Sanita' Rainaldi Gabriella Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347561 BRAIN MACHINE INTERFACE (BMI) IN PARALYSIS S.CAMILLO Birbaumer Niels Clinical Biobehavioral and Behavioral Processes Neurological diseases Pagina 28 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347562 CLINICAL RELEVANCE OF IMMUNE RESPONSES TO PROPHYLACTIC HPV VACCINE IN ITALY: A NATIONAL IMMUNOMONITORING NETWORK Istituto Superiore di Sanita' Di Bonito Paola Biomedical Immunology Infection and immunity RF‐2011‐02347563 ENGINEERED EXOSOMES FOR A NEW GENERATION OF ANTI‐HCV VACCINES Istituto Superiore di Sanita' Federico Maurizio Biomedical Immunology Infection and immunity RF‐2011‐02347571 Cell senescence and age‐dependent decrease in heart function: role of HMGB1 protein ISTITUTO DERMOPATICO Capogrossi DELL'IMMACOLATA Maurizio Biomedical Biology of Development and Aging Metabolism disorders and cardiovascular disease RF‐2011‐02347574 Istituto Superiore di Sanita' HCV Direct Acting Antivirals (DAA) and antiretroviral drugs in pregnant women: a comprehensive surveillance/research program on maternal and neonatal safety, treatment policies, immunovirology and pharmacokinetics. Floridia marco Biomedical Population Sciences and Epidemiology Infection and immunity RF‐2011‐02347575 Update, integration and implementation of the Italian Respiratory Risk Charts Carrozzi Laura Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02347576 Striatal cholinergic transmission as a target for SANTA LUCIA therapeutic intervention in Tourette Syndrome Bonsi Paola Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347577 Otoacoustic emissions as biomarkers of possible synergistic interaction in inducing hearing damage: an experimental study INAIL Sisto Renata Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02347578 Novel high‐troughoutput approaches for minimal residual disease (MRD) detection in mantle cell lymphoma (MCL) Provincia autonoma Bolzano Cortelazzo Sergio Clinical Oncology 2 ‐ Translational Clinical Oncology Toscana Pagina 29 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347580 A new therapeutic approach against HPV cancer based on anti‐E6 and ‐E7 scFv antibodies: validation in preclinical models and studies on the molecular mechanisms Istituto Superiore di Sanita' Accardi Luisa Biomedical Oncology 2 ‐ Translational Clinical The new biotechnologies RF‐2011‐02347582 Understanding high‐risk HPV‐induced derangements in cervical cancer to address patients' prognosis and therapy and to defeat the viral oncogenic machinery REGINA ELENA Paggi Marco Giorgio Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347584 Metal on metal hip prosthesis: Cobalt‐induced RIZZOLI neurotoxicity Toni Aldo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347589 Lazio Apoptotic and DNA damage/repair mechanisms induced by anti‐neoplastic agents in mammalian oocytes of the ovarian reserve and strategies for fertility preservation in female patients. Piccione Emilio Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Oncology RF‐2011‐02347596 LEKTI, a multifunctional protein involved in skin desquamation and immunity: towards novel therapeutic approaches for rare and common skin diseases ISTITUTO DERMOPATICO Zambruno DELL'IMMACOLATA Giovanna Biomedical Musculoskeletal, Oral and Skin Sciences Infection and immunity RF‐2011‐02347597 Exploiting the diagnostic, prognostic and therapeutic potential of microRNAs in melanoma ISTITUTO DERMOPATICO D'atri DELL'IMMACOLATA Stefania Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347598 Impact of HIV on the pathogenesis of Mycobacterium tuberculosis: autophagy involvement and new pharmacological target SPALLANZANI Falasca Laura Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02347601 HIV‐ infected mesenchimal stem cell differentiation: miRNA expression profile and role of antiretroviral therapy Lombardia SQUILLACE NICOLA Biomedical AIDS and Related Research Infection and immunity Pagina 30 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347603 Nationwide study on trends in hospital admissions for major cardiovascular events and procedures among people with and without diabetes in Italy, 2001‐2010 Piemonte BRUNO GRAZIELLA Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02347604 Type 3 ryanodine receptor in post‐stroke recovery: genetic, cellular and functional study. CARLO BESTA Parati Eugenio Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02347608 Clostridium difficile infection in Italy: do we know the true magnitude of the problem? SPALLANZANI Petrosillo Nicola Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02347616 The role of CRPs and SIRTs in modulating cellular stress response after myocardial infarction. SAN RAFFAELE PISANA PUCCI BRUNA Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347626 Selective targeting of Lyn kinase and potassium channels by nocodazole and psoralen analogs in malignant cells to define innovative strategies for therapy in B‐cell chronic lymphocytic leukemia Veneto SEMENZATO GIANPIETR Biomedical O Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347636 Development and standardization of biosensor‐based assays for the fast and sensitive detection of food‐borne bacteria in food IZSME capuano federico Bioengineering Sciences and Technologies Food safety and animal welfare RF‐2011‐02347639 Integrated analysis of somatic mutations and PASCALE related altered pathways for the identification of new biomarkers and molecular targets in tumors of the lower female genital tract. Tornesello Maria Lina Clinical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347640 Nef protein of HIV‐1 contributes in increasing susceptibility to malaria and opportunistic infections through downregulation of class B scavenger receptor CD36 expression Sanchez Massimo AIDS and Related Research Infection and immunity Istituto Superiore di Sanita' Biomedical Biomedical Pagina 31 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347668 Oxidative stress in animal cancer stem cells: biological mechanisms involved in the pathogenesis of mammary spontaneous tumors IZSPLV Ferrari Angelo Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347669 Characterization of cystic fibrosis airway microbiome in patients showing a severe decline in lung function and not responding to antimicrobial therapy: a multicentre study OSPEDALE BAMBINO GESU' Fiscarelli Ersilia Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02347670 Active music therapy approach in the rehabilitation of stroke: a randomized controlled trial. MAUGERI Raglio Alfredo Clinical Healthcare Delivery and Methodologies Neurological diseases RF‐2011‐02347673 Characterization of micro‐vesicles in plasma of Alzheimer's disease patients: possible new biomarkers of neurodegeneration S.CAMILLO Agnati Luigi Francesco Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347675 Radiation biodosimetry in emergency: validation of automated scoring and accuracy of dose prediction IRCCS AOU San Martino‐ IST (Genova) Bolognesi Claudia Biomedical Oncology 1 ‐ Basic Translational Diseases of environmental origin, with reference also to the workplace RF‐2011‐02347676 Novel PHOX2B defects and additional genes involved in the onset of Respiratory and Autonomic Disorders in Infancy, Childhood and Adulthood (RADICA): definition of pathogenic mechanisms and search for ameliorative drugs GASLINI Ceccherini Isabella Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02347679 Azacitidine, Depsipeptide and IFN‐alpha (ADI)‐combined treatment of colorectal cancer (CRC): depicting the therapeutic cross‐ talk between epigenetic and IFN signatures Istituto Superiore di Sanita' Gabriele Lucia Biomedical Oncology 2 ‐ Translational Clinical Oncology Pagina 32 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02347686 Food safety of bivalve molluscs: Development IZSUM and application of molecular tools for identification, quantification and evaluation of antibiotic resistance and virulence potential of food‐associated enteric and autochthonous bacterial pathogens RF‐2011‐02347687 ASSESSMENT OF NEOPLASTIC CONTAMINATION IN CRYOPRESERVED OVARIAN TISSUE OF PATIENTS AFFECTED BY SARCOMAS AND HEMATOLOGICAL MALIGNANT DISEASES: SAFETY OF TISSUE AUTOTRANSPLANTATION RF‐2011‐02347689 Role of Type I Interferon in the Cross‐talk between Neutrophils and Dendritic Cells in the induction of adaptive immunity during Mycobacterium tuberculosis and BCG infections. RF‐2011‐02347690 AREA P.I. Classificazione Area Strategica. Leoni Francesca Biomedical Veterinary Food safety and animal welfare Emilia‐Romagna Fabbri Raffaella Clinical Oncology 2 ‐ Translational Clinical Oncology Istituto Superiore di Sanita' Parlato Stefania Biomedical Immunology Infection and immunity Pyrimethamine derivatives: a new generation Istituto Superiore di Sanita' of antifolate drugs for treatment of metastatic melanoma. A prepreclinicalstudy. Giammarioli Anna Maria Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347691 Generation and functional characterization of SAN RAFFAELE MILANO artificial lymphoid organs with mutipotent stromal progenitors Brendolan Andrea Biomedical Biology of Development and Aging Oncology RF‐2011‐02347694 Therapeutic correction of mis‐spliced RNA transcripts and of protein conformational defects in Lysosomal Storage Disorders Toscana MORRONE AMELIA Clinical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02347696 HUMAN ADIPOSE STEM CELLS AS A NOVEL TARGET FOR THERAPEUTIC INTERVENTION IN OBESITY Toscana LUCONI MICHAELA Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Pagina 33 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347698 New molecular mechanisms responsible for drug resistance and novel biomarkers predictive of the individual response to therapy in human breast and ovarian carcinomas CROB Landriscina Matteo Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347700 Reduction in medication expenses for comorbid conditions in obese patients after bariatric surgery Campania Musella Mario Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02347702 The effects of intensive arm training on upper Emilia‐Romagna extremity motor recovery in chronic stroke survivors. Identification of biomarkers related to clinical outcome. BASAGLIA NINO Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347708 Host genetic factors and response to dendritic BURLO GAROFALO cells based immune treatment in HIV‐1 infected patients CROVELLA SERGIO Clinical AIDS and Related Research Infection and immunity RF‐2011‐02347709 Identification of Biomarkers for Non Melanoma Skin Cancers in a Multicenter Cohort of Kidney Transplant Recipients: Evaluation of Ethiopatogenetic Role and Clinical Implications. Piemonte Savoia Paola Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347730 Modulating the inflammation of cerebral death to improve the survival of graft Campania Piazza Ornella Biomedical Surgical Sciences, Infection and immunity Biomedical Imaging, and Bioengineering RF‐2011‐02347736 CLINICAL AND MOLECULAR STUDIES OF NEXT‐GENERATION IN HEREDITARY SPASTIC PARAPLEGIAS STELLA MARIS Santorelli Filippo Maria Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Pagina 34 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. BERGHELLA LIBERA Biomedical Musculoskeletal, Oral and Skin Sciences Neurological diseases Genetic manipulation of embryonic stem cells NEUROMED and induced pluripotent stem cells (ES and iPS) for endorsing cardiac fate toward beating cardiomyocytes: novel strategies for cardiac regeneration in myocardial infarction. Lembo Giuseppe Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347756 Piemonte Retinal vascular imaging and risk of target organ damage among patients with suspected hypertension in primary care VEGLIO FRANCO Clinical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease RF‐2011‐02347757 Risk assessment of occupational and Campania environmental exposure to benzene and other chemicals at low doses: from molecular mechanisms to biological monitoring Manno Maurizio Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace RF‐2011‐02347758 Reverse transcriptase inhibitors in an innovative anticancer therapy Istituto Superiore di Sanita' Spadafora Corrado Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347760 Urine proteome analysis: A possible method that may allow noninvasive differential diagnosis of diabetic nephropathy andgive new insight into monogenic type 2 diabetes OSPEDALE BAMBINO GESU' Massa Ornella Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease RF‐2011‐02347764 Interferome: renaissance of the innate immune system in understanding dysregulated genes and networks in multiple sclerosis. Istituto Superiore di Sanita' Coccia Eliana Marina Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347738 Transcritpional regulation of skeletal muscle muscle maturation and degeneration: new potential targets for therapies against muscle wasting caused by neurogenic disorders and aging. RF‐2011‐02347753 SANTA LUCIA Pagina 35 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Istituto Scienze Neurologiche AREA P.I. Classificazione Area Strategica. Cevoli Sabina Clinical Emerging Technologies and Training in Neurosciences Neurological diseases Dallapiccola Bruno Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Food safety and animal welfare SAN RAFFAELE MILANO Orsenigo Elena Clinical Oncology 2 ‐ Translational Clinical Oncology Molecular portrait of heterogeneous lesions throughout the course of bovine tuberculosis Sardegna uzzau sergio Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02347782 Randomized pilot phase II study of Lenalidomide as adjuvant therapy for prevention in Hepatocellular carcinoma (HCC) recurrence after radiofrequency thermal ablation (RFA): molecular and immunological prognostic biomarkers Emilia‐Romagna Missale Gabriele Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347785 Detection of thyroid cancer biomarkers by SEREX: development of a new diagnostic assay and identification of targets for immunotherapy. Campania Vitale Mario Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347786 A network of external quality controls for the molecular diagnosis of sporadic and hereditary cancers Emilia‐Romagna FIORENTINO MICHELAN Clinical GELO Healthcare Delivery and Methodologies Oncology RF‐2011‐02347774 Therapeutic strategies in refractory chronic daily headache: A multicenter, randomized, controlled trial. RF‐2011‐02347775 OSPEDALE BAMBINO Mediterranean diet and gut microbiota: an operational agorithm to unveil food effects on GESU' healthy growth and disease control RF‐2011‐02347776 Inflammatory environment in patients with peritoneal carcinomatosis from gastrointestinal malignancies undergoing cytoreductive surgery and HIPEC: research of systemic and peritoneal involved factors and development of a murine model RF‐2011‐02347777 Pagina 36 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347791 Development and implementation of a protocol for communication of genetic information and multidisciplinary genetic counseling in ALS, in parallel with identification of early alterations in pre‐ symptomatic ALS. Piemonte Chio Adriano Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347800 Novel molecular and cellular pathophysiological mechanisms of diabetic vascular disease Abruzzo De Caterina Raffaele Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347801 PREVALENCE OF SYSTEMIC AMYLOIDOSES Lazio IN PATIENTS WITH MONOCLONAL GAMMOPATHY OF UNCERTAIN SIGNIFICANCE (MGUS) AND ORGAN DAMAGE. ROLE OF PROTEOMIC TYPING IN ASSESSING PROGNOSYS AND TARGETED THERAPY Moscetti Alessandro Clinical Population Sciences and Epidemiology Oncology RF‐2011‐02347802 C.R.O. AVIANO Genetic characterization of Non‐Small‐Cell Lung Cancer (NSCLC) to evaluate intratumor heterogeneity and modification after Tyrosine Kinase Inhibitors' (TKI) failure Bearz Alessandra Clinical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347806 The epigenetic basis of glioblastoma multiforme invasiveness and recurrence I.E.O. TESTA GIUSEPPE Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347808 Ex vivo studies on hyperhomocysteinemia‐ induced epigenetic modifications as potential biomarkers for early diagnosis of cerebrovascular disorders. Sardegna Carru Ciriaco Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02347810 Advanced diagnosis and therapies for migraine caused by K+ channel dysfunction MONDINO Sandrini Giorgio Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases Pagina 37 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347811 Abnormalities in T lymphocyte subsets and phagocytes in Cutaneous T‐cell Lymphomas (CTCL): potential mechanisms driving immunodeficiency and increased susceptibility to infections. Piemonte FIERRO MARIA TERESA Biomedical Immunology Infection and immunity RF‐2011‐02347821 Arterial and Venous thrombotic risk in women approaching ART procedures: evaluation of thrombophilia screening. ‐ A prospective cohort study. CASA SOLLIEVO SOFFERENZA Grandone Elvira Biomedical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02347827 CASA SOLLIEVO Unravelling the genetic basis of variable clinical expression in NF1: use of an integrated SOFFERENZA next generation sequencing platform to identify novel disease‐causing and modifier genes. De Luca Alessandro Biomedical Genes, Genomes and Genetics Oncology RF‐2011‐02347830 AN EXTENSIVE STUDY ON EVOLUTION AND PROGNOSIS IN MONOCLONAL GAMMOPATHIES: THE ROLE OF IMMUNOPHENOTYPE, CYTOGENETICS AND HLC RATIO IN PC AND Pre‐PC SUBCLONAL COMPARTMENTS Piemonte Omede' Paola maria Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347832 Effectiveness of repeated immunizations with DNA plasmids encoding HER‐2/neu in the long‐term prevention of mammary cancer in HER‐2/neu transgenic mice I.N.R.C.A. Provinciali Mauro Biomedical Biology of Development and Aging Oncology RF‐2011‐02347852 Angelman Syndrome: a clinical and functional MEDEA imaging, molecular and biochemical investigation to uncover new therapeutic strategies Bonanni Paolo Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347855 The role of the EGFR in the interaction between mesenchymal stem cells and breast cancer cells: implications for novel therapeutic approaches De Luca Antonella Biomedical Oncology 1 ‐ Basic Translational Oncology PASCALE Pagina 38 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione Area Strategica. Amadori Alberto Biomedical Oncology 1 ‐ Basic Translational Oncology AUXOLOGICO Isolated Hemihyperplasia (IH), a pediatric cancer risk disease: search for novel genes and mechanisms Larizza Lidia Biomedical Genes, Genomes and Genetics The new biotechnologies RF‐2011‐02347860 IMMUNOCARRIER DEVELOPMENT AND VALIDATION STUDY FOR TARGETED IMAGING/DRUGDELIVERY IN CANCER THERAPY TACCHETTI CARLO Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347864 Toscana Molecular diagnosis of thyroid nodules: evaluation of candidate microRNA in fine‐ needle aspiration biopsy samples and use of circulating microRNA as potential biomarkers to differentiate malignant from benign undetermined nodules. agretti patrizia Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347865 New insights for Attention Deficit and Istituto Superiore di Sanita' Hyperactivity Disorder (ADHD): novel serotonin 7 receptor agonist drugs for putative therapy, and clinical validation of the circulating auto‐Antibodies against DAT as a bio‐marker for diagnosis. Adriani Walter Biomedical Biobehavioral and Behavioral Processes Neurological diseases Nicastri Emanuele Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02347858 OVARIAN CANCER STEM CELLS: PHENOTYPIC, GENOTYPIC AND METABOLIC CHARACTERIZATION OF A SUITABLE TARGET FOR LOCO‐REGIONAL THERAPIES RF‐2011‐02347859 RF‐2011‐02347866 I. O. V. AREA P.I. SAN RAFFAELE MILANO SPALLANZANI A registry of intravenous artesunate for severe malaria in returning travelers from endemic countries: pharmacokinetic data, adverse events, and clinical outcome. NetwOrk for severe MALaria treatment ‐ NOMAL study Pagina 39 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347867 Treatment of therapy‐refractory cancer in patients affected by Swachman Diamond syndrome or related inherited diseases due to alterations of the ribosomal apparatus. SAN RAFFAELE MILANO Biffo Stefano Biomedical Genes, Genomes and Genetics Oncology RF‐2011‐02347868 Novel clinical applications of autologous adipose‐derived stem cells. Emilia‐Romagna Raposio Edoardo Clinical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02347869 CHANGES IN STRUCTURE AND RECRUITMENT OF MUSCLE SYNERGIES AFTER CORTICAL AND CEREBELLAR LESIONS SANTA LUCIA d'Avella Andrea Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02347870 miRNA in the blood as biomarkers and therapeutic indicators of progressive tissue degeneration in Glycogen Storage Disease type 1a patients GASLINI Di Rocco Maja Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02347871 Identification of novel molecular mechanisms Istituto Superiore di Sanita' promoting oncogenic RAS signaling Martinelli Simone Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347873 Cord blood expanded endothelial progenitors Lazio in patients with no‐option critical limb ischemia. Teofili Luciana Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02347881 Development of a novel immunotherapeutic approach to contrast prion‐mediated Abeta oligomer neurotoxicity by intracellular antibody technology SAN RAFFAELE PISANA CARDINALE ALESSIO Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347883 Regulation of kinetochore activity by the conserved cell cycle kinase Rio1 I.E.O. DE WULF PETER ARTHUR Biomedical Cell Biology Oncology RF‐2011‐02347894 A new vaccine design to eliminate CCR5 expression and prevent HIV infection SAN RAFFAELE MILANO Lopalco Lucia Biomedical AIDS and Related Research Infection and immunity Pagina 40 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347898 Cystic Lesions of the Pancreas: Creation of a Database and a New Evidence‐Based, CostEffective Algorithm Sicilia Barresi Luca Clinical Sebastiano Digestive, Kidney and Urological Systems Oncology RF‐2011‐02347901 DNA fingerprinting of Mycobacterium tuberculosis as a major tool in Tuberculosis prevention and control : implementation of new protocols for prospective molecular typing of M.tuberculosis isolates in Piemonte and development of a Tuberculosis Genotypin Piemonte GHISETTI VALERIA Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02347907 Enhanced cell therapy: novel strategies to improve transplanted cell survival and engraftment by protection from oxidative stress REGINA ELENA Toietta Gabriele Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02347908 Prospective validation of predictive PASCALE biomarkers in elderly patients with non‐small‐ cell lung cancer Morabito Alessandro Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02347913 Circulating microRNAs associated to cardiac‐ derived microparticles and their role in endothelial dysfunction: age‐dependence of their expression in stable angina patients and following acute myocardial infarction I.N.R.C.A. Antonicelli Roberto Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347915 ASSESSMENT OF PSYCHO‐PHYSICAL RESPONSE TO STRESSORS IN WORK ENVIRONMENT. RESEARCH OF CHANGES IN HEALTH PROFESSIONALS AS A RESULT OF PARTICIPATION IN A GROUP EXPERIENCE ON STRESS MANAGEMENT AND INTERPERSONAL COMMUNICATION. I.N.R.C.A. Santarelli Lory Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace RF‐2011‐02347926 Proposal of a methodological procedure for animal biomonitoring in contaminated areas IZSLT scaramozzino paola Biomedical Veterinary Food safety and animal welfare Pagina 41 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347935 PRECLINICAL DEVELOPMENT OF THERAPEUTIC, ANTI‐BETA‐GLUCAN ANTIBODIES FOR UNIVERSAL PROTECTION AGAINST FUNGAL PATHOGENS Istituto Superiore di Sanita' Torosantucci Antonella Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02347941 SOCIAL INTERACTION AND RIGHT BRAIN DAMAGE IN STROKE PATIENTS AUXOLOGICO Vallar Giuseppe Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02347944 From microGIST to overt GIST: dissection of the molecular alterations underlying GIST malignant evolution C.R.O. AVIANO Gasparotto Daniela Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347945 Caffeine as a potential therapeutic option for Alzheimer's disease Istituto Superiore di Sanita' Popoli Patrizia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347946 An image‐analysis platform for automated in‐ situ high‐content and resolution analysis of tumor heterogeneity: targeting genomic, epigenetic, and functional diversity in tissues by fluorescence microscopy I.E.O. FARETTA MARIO ROMOLO Biomedical Bioengineering Sciences and Technologies Oncology RF‐2011‐02347947 Impact of early high‐dose atorvastatin versus rosuvastatin on Contrast Induced Acute Kidney Injury in unselected patients with non‐ ST elevation acute coronary syndromes scheduled for early invasive strategy Toscana Toso Anna Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347950 Role of adipose derived stem cells in chondrocyte functional impairment in metabolic osteoarthritis RIZZOLI Borzi' Rosa Maria Biomedical Musculoskeletal, Oral and Skin Sciences Metabolism disorders and cardiovascular disease Pagina 42 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02347954 Identification of downstream targets of BAG3/BRAF‐mediated regulation as potential candidate markers and therapy targets in Anaplastic Thyroid Carcinoma PASCALE Chiappetta Gennaro Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347955 A multicenter prospective study on inflammatory/infectious CNS diseases in different immunological settings: a multidisciplinary approach using an online data base MONDINO Marchioni Enrico Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347956 Role of ATM kinase in cerebellum development, homeostasis and function: implications for Ataxia Telangiectasia and other cerebellar disorders SANTA LUCIA Barilà Daniela Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02347968 Project title: CEACAM1 is a priviliged cell surface target antigen to design human mAbs in scFv format for multimodal immunotherapeutic intervention of melanoma and lung carcinoma. Istituto Superiore di Sanita' cianfriglia maurizio Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02347970 FATEBENEFRATELLI Optimization of plasma progranulin dosage for predicting null progranulin mutations in neurodegenerative diseases: A pilot Multicentre Italian Study for harmonization of procedures to be translated into clinical practice. Ghidoni Roberta Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02347971 Molecular regulation of the redox switch in inflamed skeletal muscle as a novel target to implement muscle regeneration and limit fibrosis in immune‐mediated myositis SAN RAFFAELE MILANO Rovere‐ Querini Patrizia Biomedical Musculoskeletal, Oral and Skin Sciences Infection and immunity RF‐2011‐02347980 An integrated genomic and immunomic analysis of colon cancer to identify unique tumor antigens and parameters of underlying immune response related to disease outcome SAN RAFFAELE MILANO Dellabona Paolo Biomedical Immunology Oncology Pagina 43 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione Area Strategica. Ranavolo Alberto Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases Biomolecular networks contributing to cancer SAN RAFFAELE PISANA risk in dysmetabolic disorders: implications for type 2 diabetes and obesity FERRONI PATRIZIA Biomedical Oncology 2 ‐ Translational Clinical Metabolism disorders and cardiovascular disease RF‐2011‐02347986 A NEW STRATEGY FOR THE CONTROL OF HUMANITAS RHEUMATOID ARTHRITIS: DUAL ROLE OF THE ATYPICAL CHEMOTACTIC RECEPTOR CCRL2 AS A BIOMARKER AND THERAPEUTIC TARGET SOZZANI SILVANO Biomedical Immunology Infection and immunity RF‐2011‐02347987 Oxidative stress and microRNA‐125b: from molecular mechanisms to therapeutic implications in Hailey‐Haileydisease Istituto Superiore di Sanita' Magrelli Armando Biomedical Musculoskeletal, Oral and Skin Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02347989 Towards an optimization of epigenetic therapy of cancer I.E.O. MINUCCI SAVERIO Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02347999 A Web Intelligence approach to the patient empowerment: exploring knowledge on internet conversations C.R.O. AVIANO Truccolo Ivana Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02348001 Role of innate immunity and inflammasome activation in the progression of severity of stable COPD MAUGERI Di Stefano Antonino Biomedical Cardiovascular and Respiratory Sciences Infection and immunity RF‐2011‐02347982 Spinal cord modular organization in recovery and back to work management of ataxic subjects RF‐2011‐02347984 INAIL AREA P.I. Pagina 44 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02348013 AREA P.I. Classificazione Area Strategica. MEDEA Turconi Anna Carla Clinical Emerging Technologies and Training in Neurosciences Neurological diseases Giovanni Healthcare Delivery and Methodologies Oncology NEW TECHNOLOGIES FOR INNOVATIVE MODELS IN REHABILITATION OF CHILDREN WITH CEREBRAL PALSY: VIRTUAL REALITY (VR), VIDEO GAMES AND ON‐LINE TUTORING FOR COORDINATIVE TRAINING AND HOME CARE ASSISTANCE. EFFICACY AND COST AFFORDANCE RF‐2011‐02348015 Ethics in Cancer Care: a new service I.E.O. Boniolo Clinical RF‐2011‐02348017 PRE‐TRANSPLANT GRAFT RECONDITIONING WITH MESENCHYMAL STROMAL CELLS IN EXPERIMENTAL KIDNEY TRANSPLANTATION SAN MATTEO DAL CANTON ANTONIO Biomedical Digestive, Kidney and Urological Systems Infection and immunity RF‐2011‐02348034 A Nationwide Clinical Study on the Role of Functional HLA‐DPB1 Matching in Unrelated Hematopoietic Stem Cell Transplantation SAN RAFFAELE MILANO Fleischhauer RF‐2011‐02348036 Identification of genetic variants associated with appropriate ICD therapy RF‐2011‐02348052 RF‐2011‐02348071 Katharina Clinical Oncology 2 ‐ Translational Clinical Oncology Provincia autonoma Bolzano Cemin Roberto Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Brain proteoglycans as disease prediction genes and therapeutic targets in Multiple Sclerosis. Puglia Tortorella Carla Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases INNOVATIVE EPINEPHRINE (ADRENALINE) FORMULATIONS WITH IMPROVED STABILITY FOR USE IN EMERGENCY SITUATIONS SAN MATTEO Vigna Vincenzo Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Pagina 45 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Sette Claudio Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases Ostreopsis cf. ovata in Mediterranean fish and IZSUM shellfish products: new methods for the early identification of algal toxins, mechanism of action and human risk assessment. Orletti Roberta Biomedical Veterinary Food safety and animal welfare RF‐2011‐02348081 Genetic and pharmacological inhibitors of the REGINA ELENA Epithelial‐Mesenchymal Transition Rizzo Maria Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02348098 Phenotypic, functional and genomic characterization of bone fragility in children and adolescents and their relatives: exploring the susceptibility to fractures in youth for its prevention in adulthood SAN RAFFAELE MILANO Mora Stefano Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02348100 Impact of defective DNA repair of oxidative damage on the immune response and relevance for colorectal cancer Istituto Superiore di Sanita' bignami margherita Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02348102 BLeeding Events and Maintenance DoSe of PraSugrel. Toscana Parodi Guido Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348103 Genetic and antigenic diversity and pathogenicity of viruses associated with enteritis Emilia‐Romagna Medici Maria Cristina Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02348106 Alternative strategies for cognitive rehabilitation after stroke: which role for not invasive brain stimulation? Effects of transcranial magnetic stimulation in recovery of hemispatial attention and language in subacute and chronic patients. Sicilia Brighina Filippo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348075 Regulation of SMN2 splicing: implications for novel therapeutic approaches to Spinal Muscular Atrophy RF‐2011‐02348079 SANTA LUCIA Pagina 46 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Brain Disorders and Clinical Neuroscience Neurological diseases PALMIROTTA RAFFAELE Biomedical Veterinary Oncology Abruzzo Di Carlo Emma Biomedical Oncology 1 ‐ Basic Translational Oncology Levosimendan in high risk patients undergoing non cardiac surgery. A randomized study. SAN RAFFAELE MILANO Zangrillo Alberto Clinical Metabolism disorders Surgical Sciences, Biomedical Imaging, and cardiovascular disease and Bioengineering RF‐2011‐02348141 Cortical myoclonus: implementation of innovative quantitative diagnostic tests and a new therapeutic strategy based on repetitive transcranial magnetic stimulation. CARLO BESTA Franceschetti Silvana Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348151 Identification and manipulation of immunosuppressive networks in tumor microenvironment of patients undergoing immunobiological therapies. SAN RAFFAELE MILANO Russo Vincenzo Biomedical Immunology Oncology RF‐2011‐02348154 DEVELOPMENT AND CLINICAL CARLO BESTA APPLICATION OF A NEW BETA PROBE FOR RADIOGUIDED SURGERY IN MENINGIOMA TUMOR Ferroli Paolo Biomedical Neurological diseases Surgical Sciences, Biomedical Imaging, and Bioengineering SANTA LUCIA RF‐2011‐02348109 Developing an event‐based computational model of Alzheimer's disease progression incorporating quantitative MRI and TMS information to assist clinicians in the early diagnosis, correct prognosis, and treatment monitoring. RF‐2011‐02348110 Identification of novel biomolecular targets of SAN RAFFAELE PISANA pets spontaneous carcinomas for the development of new diagnostic and therapeutics approaches: use of the human knowledge to accelerate the management of pets tumors. RF‐2011‐02348128 Molecular profiling of laser‐microdissected prostate tissue from prostate cancer patients and not‐yet patients RF‐2011‐02348140 Bozzali Marco Clinical Pagina 47 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Tabocchini Maria Antonella Biomedical Oncology 2 ‐ Translational Clinical Oncology ISTITUTO TUMORI Role of tumor microenvironment in thyroid carcinogenesis onset and progression: thyroid MILANO cells cross‐talk with macrophages Greco Maria Angela Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02348164 CARDIOriGEN ‐ MicroRNAs inducing cardiac Friuli‐Venezia Giulia regeneration ‐ From discovery towards clinical application Sinagra Gianfranco Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348165 Development of a multi‐stage vaccine against tuberculosis Veneto Manganelli Riccardo Immunology Infection and immunity RF‐2011‐02348166 Constitutive Axl signaling in human melanoma: role in tumor biology and in resistance to BRAFV600E inhibitors ISTITUTO TUMORI MILANO Sensi Maria Luisa Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02348167 NAFLD (Non‐Alcoholic Fatty Liver Disease) : which relationship of liver steatosis and concurrent fibrosis with heart function. Sicilia Trovato Guglielmo Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease RF‐2011‐02348168 OBESITY AND DIABETES/HYPERTENSION RISK IN CHILDREN: PREVENTION AND TREATMENT THROUGH MONITORED PHYSICAL ACTIVITY and NUTRITION PROGRAMS SAN RAFFAELE PISANA IELLAMO FERDINAN Clinical DO Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348169 Lazio CONTROLLED PHYSICAL ACTIVITY, WELLNESS EDUCATION AND ACTIVE AGING. A cohort study on cardiovascular and hemodynamic responses to physical activity in the elderly. legramante jacopo maria Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348156 Radiation effects of low and/or protracted doses: from the mechanisms underlying the biological effects to the impact on public health RF‐2011‐02348159 Istituto Superiore di Sanita' Biomedical Clinical Clinical Pagina 48 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348171 Characterization of the microbiome of natural IZSVE and invasive vector mosquito populations through next‐generation sequencing Capelli Gioia Biomedical Infectious Diseases and Microbiology The new biotechnologies RF‐2011‐02348175 Abruzzo Molecular mechanisms of cystic fibrosis inflammation: Identification of novel potential biomarkers and therapeutic targets. Romano Mario Biomedical Cardiovascular and Respiratory Sciences Infection and immunity RF‐2011‐02348181 UNRAVELING THE PROTEOSTASIS NETWORK TO ADDRESS CONFORMATIONAL DISORDERS GASLINI Pedemonte Nicoletta Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02348182 Identification of metabolic and immunological parameters with a predictive value for disease or fertility problems in periparturient dairy cows IZSLER Amadori Massimo Biomedical Veterinary Food safety and animal welfare RF‐2011‐02348185 Human and swine influenza viruses: reassortment and zoonotic risks IZSLER Moreno Martin Ana Maria Biomedical Veterinary Food safety and animal welfare RF‐2011‐02348187 GENETIC INVOLVEMENT OF DESMOPLAKIN AND OTHER DESMOSOMAL PROTEINS IN DILATED CARDIOMYOPATHY SAN MATTEO GHIO STEFANO Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348194 Innovative diagnostic approach for hereditary cardiomyopathies MULTIMEDICA Roncarati Roberta Clinical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02348206 Depression and Ischemic Heart Disease: Investigation of the Role of the Endogenous Stress Response System Campania Monteleone Palmiero Clinical Biobehavioral and Behavioral Processes Metabolism disorders and cardiovascular disease RF‐2011‐02348208 Do anti‐LRP4 antibodies play a pathological significance in amyotrophic lateral sclerosis? CARLO BESTA Mantegazza Renato Biomedical Immunology Neurological diseases Pagina 49 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348210 Cognitive dysfunction after general anesthesia CARLO BESTA in the elderly: a transient, reversible phenomenon or the harbinger of Alzheimer disease? Giaccone Giorgio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348212 Developmental and genetic bases of Opitz G/BBB Syndrome towards better diagnosis and management of syndromic forms of intellectual disability BURLO GAROFALO Meroni Germana Clinical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02348213 Neurophysiological approach to evaluate cerebro‐cerebellar interactions. Characterization of a cerebellar connectivity EEG index. SANTA LUCIA Molinari Marco Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348214 HUMANS AND WILDLIFE: ZOOS IN BETWEEN. ARE ZOOS A THREAT OR BIOSENTINELS FOR INFECTIOUS DISEASES? IZSPLV Acutis Pier Luigi Biomedical Veterinary Food safety and animal welfare RF‐2011‐02348216 A translational approach to restrain local recurrence in early breast cancer patients C.R.O. AVIANO Belletti Barbara Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02348217 Health and Economic Impact of Tobacco Control Policies in Italy Toscana GORINI GIUSEPPE Biomedical Risk, Prevention and Health Behavior Oncology RF‐2011‐02348219 Soluble urokinase plasminogen activator receptor sustains immune activation in HIV+ individuals. SAN RAFFAELE MILANO Alfano Massimo Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02348221 STRUCTURED PATHOLOGICAL REPORT IN Emilia‐Romagna ONCOLOGY. A DIGITAL NETWORK AMONG PATHOLOGY UNITS, TUMOR REGISTRIES AND REGIONAL HEALTH CARE SYSTEM. SILINI ENRICO MARIA Clinical Healthcare Delivery and Methodologies Oncology Pagina 50 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione Area Strategica. Bianchi Simonetta Biomedical Oncology 1 ‐ Basic Translational Oncology Standard Operating Procedures for MR‐based FATEBENEFRATELLI Cortical Thickness Estimation Boccardi Marina Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348225 Role of HIV‐1 infection on colorectal carcinoma onset and progression: development of novel therapeutic strategies Istituto Superiore di Sanita' Toschi Elena Biomedical AIDS and Related Research Oncology RF‐2011‐02348228 Molecular analysis of Streptococcus pneumoniae and Neisseria meningitidis serotypes/serogroups and potential coverage of available vaccines. Toscana moriondo maria Biomedical Immunology Infection and immunity RF‐2011‐02348231 Respiratory Syncytial Virus (RSV) infection in infants: the IFNs/ Ectonet axis as possible therapeutic target. Istituto Superiore di Sanita' Fedele Giorgio Biomedical Immunology Infection and immunity RF‐2011‐02348235 Molecular pathologies and functional interactions of the CDKL5 and MECP2 genes involved in a large spectrum of neuro‐ psichiatric diseases SAN RAFFAELE MILANO Landsberger Nicoletta Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348236 CARPEDIEM ‐ Comorbidity And Risk Profiles Evaluation in Diabetes and hEart Morbidities Toscana Passino Claudio Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02348239 A novel anti‐CXCR4 drug RFF‐1: a Phase I/II Clinical Trial PASCALE Scala Stefania Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348240 Reperfusion injury after cerebral ischemia: an "in vivo" study using neuro‐imaging markers Toscana Inzitari Domenico Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348223 Combinatorial treatments to target cancer stem cells and elicit DNA damage in triple negative breast cancer RF‐2011‐02348224 Toscana AREA P.I. Pagina 51 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Oncology RF‐2011‐02348247 Epigenetic modulation by asbestos exposure in asbestos‐related cancers:identification of epigenetic biomarkers to predict asbestos‐ related malignancies. Marche BRUNELLI ALESSAND Biomedical RO Oncology 2 ‐ Translational Clinical RF‐2011‐02348249 New minimally invasive arthroscopical approach for the treatment and prevention of hip osteoarthritis RIZZOLI Marcacci Maurilio Clinical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02348251 MICROENVIRONMENT INFLUENCE ON CANCER STEM CELL DEVELOPMENT Veneto Patrizia Pontisso Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02348256 Molecular characterization of the T cell Emilia‐Romagna dysfunctions during HIV infection to evaluate immune restoration after HAART and plan new immunotherapeutic strategies SIGHINOLFI LAURA Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02348258 Toward a mitochondrial‐imbalance readjustment therapeutic approach to counteract remote degeneration after focal acute brain damage SANTA LUCIA Viscomi Maria Teresa Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348265 Novel approaches to understand HIV‐1 nucleotide diversity affecting viral evolution, drug‐resistance development, and related clinical implications SPALLANZANI Perno Carlo Federico Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02348267 Unraveling the molecular basis of neurodegeneration in frontotemporal lobar degeneration: role of genome instability associated with tau mutations CARLO BESTA Rossi Giacomina Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348269 Use of phages as decontamination agents in the production of traditional Italian food: evaluation of effectiveness and possible risk for the consumer IZSLER Finazzi Guido Veterinary Food safety and animal welfare Biomedical Pagina 52 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348270 Exploiting cellular transcription factors of the Istituto Superiore di Sanita' Interferon Regulatory Factors family in novel therapeutic approaches to HIV‐1 infection and reactivation from latency Battistini Angela Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02348273 Toscana Evaluation of the effect of testosterone replacement therapy (TRT) on prostatic gland in hypogonadal patients affected by benign prostatic hyperplasia (BPH) and metabolic syndrome (MetS) Vignozzi Linda Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348274 Research of new neuroimaging biomarkers to OSPEDALE BAMBINO early identify different epilepsy phenotypes in GESU' patients with Tuberous Sclerosis Complex (TSC). Bernardi Bruno Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348277 A randomized‐controlled trial for assessing the role of transcranial magnetic stimulation in reducing suicide risk among drug‐resistant mood disorders patients and evaluating how transcranial magnetic stimulation influences blood BDNF levels. Comparing Lazio Pompili Maurizio Clinical Risk, Prevention and Health Behavior The new biotechnologies RF‐2011‐02348281 Synthesis and characterization of peptide‐ peptidomimetics with antagonistic activity against thrombopoietin (TPO) for the treatment of severe sepsis and septic shock: pre‐clinical studies. Piemonte MONTRUCCH GIUSEPPE IO Biomedical Infectious Diseases and Microbiology The new biotechnologies RF‐2011‐02348282 Studying the tumor microenvironment to find C.R.O. AVIANO new therapeutic targets and strategies in Hodgkin lymphoma:the role of Mesenchymal stem cells Aldinucci Donatella Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02348296 Tuberculosis in HIV/AIDS patients: genetic diversity and drug‐resistance of clinical isolates of Mycobacterium tuberculosis Rindi Laura Biomedical AIDS and Related Research Infection and immunity Toscana Pagina 53 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348298 Functional Imaging and Transcriptomics for Prediction of Ovarian cancer response to Trabectedin Istituto Superiore di Sanita' Canese Rossella Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348299 NEW ANTIFUNGAL THERAPEUTIC STRATEGIES IN NANOMEDICINE Istituto Superiore di Sanita' Stringaro Annarita Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02348300 Cross‐talk between innate and adaptive immunity as a target for therapeutic immune intervention in the early phases of psoriasis pathogenesis Istituto Superiore di Sanita' lande roberto Biomedical Immunology Infection and immunity RF‐2011‐02348303 SAN RAFFAELE MILANO Hypermethylation and downregulation of IRX1 gene induced by Helicobacter pylori infection: etiopathogenetic role in gastric cancer development, prognostic impact after surgical resection and diagnostic employment as screening test TAMBURINI ANDREA MARCO Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348308 Mild cognitive impairment and progression to Emilia‐Romagna Alzheimer's disease: association with herpes viruses infections. Gabrielli Liliana Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348309 EXtending Computational Analysis of functionaL Images to define the total asset of Bone marrow and hematopoietic fUnction in blood disoRdes (EXCALIBUR) Sambuceti Gianmario Biomedical Bioengineering Sciences and Technologies Oncology RF‐2011‐02348311 Emilia‐Romagna IMPACT OF COMPUTERIZED PRESCRIPTION ON COMPLIANCE WITH GUIDELINES‐RECOMMENDED PROCESS IN PNEUMONIA. A STUDY TO ANALYZE A BETTER CONTROL OF ANTIBIOTIC THERAPY. Cultrera Rosario Clinical Healthcare Delivery and Methodologies Infection and immunity IRCCS AOU San Martino‐ IST (Genova) Pagina 54 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348312 I.N.R.C.A. Fractal Lacunarity of Trabecular Bone in Magnetic Resonance Images of Lumbar Vertebras: Clinical Validation of a New Diagnostic Tool for Osteoporosis and Fracture Risk Zaia Anna Maria Clinical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02348314 Study on the interaction of polyomavirus JC (JCPyV) with stem cells‐derived lineages Maggi Fabrizio Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02348315 I.E.O. Defining the cis‐regulatory bases for variability in inflammatory gene expression in humans: a 3‐D analysis in the nuclear space NATOLI GIOACCHI Biomedical NO Genes, Genomes and Genetics Infection and immunity RF‐2011‐02348318 Analysis of KIR genotype/phenotype and HLA GASLINI supratype on NK and CD8+ T cell subpopulations in elite controller, long term non‐progressor and HIV‐1‐cronically infected subjects Biassoni Roberto Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02348323 Novel clinical and pathogenic insight in the interplay between genotype 1 HCV infection and type 2 diabetes. Sicilia Purrello Francesco Clinical Digestive, Kidney and Urological Systems Infection and immunity RF‐2011‐02348324 Cellular autoimmunity and causative autoantigens in acquired thrombotic thrombocytopenic purpura (TTP) MAGGIORE Peyvandi Flora Biomedical Immunology Infection and immunity RF‐2011‐02348328 MICRORNA IN THYROID CARCINOMA: PATHWAYS INVOLVED AND POSSIBLE PROGNOSTIC AND THERAPEUTIC IMPACT ISTITUTO TUMORI MILANO Borrello Maria Grazia Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02348330 Normal and pathological development of locomotion in the first year of life SANTA LUCIA Ivanenko Yury Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases Toscana Biomedical Pagina 55 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02348334 Role of exosomes in pericardial fluid‐mediated SAN RAFFAELE PISANA cardiac regeneration. RF‐2011‐02348343 CHILDHOOD HISTIOCYTOSES: FROM PATHOGENESIS TO TARGET THERAPY ‐ "HISTIOCARE" RF‐2011‐02348346 A long ncRNA point‐of‐view to FSHD muscular dystrophy pathophysiology and therapeutics. RF‐2011‐02348348 From lifestyle to mitochondrial benefits: study Istituto Superiore di Sanita' on a combined therapeutic approach to Huntington's disease RF‐2011‐02348350 Treatment of advanced or recurrent endometrial cancer: identification of molecular predictors of response in a randomized phase II study with Bevacizumab in combination to Carboplatin‐Paclitaxel RF‐2011‐02348351 Modulation by IL‐1beta of GABAA and Glutamate Receptors function in human and experimental epilepsy: a novel therapeutic approach for intractable epilepsies. RF‐2011‐02348357 RF‐2011‐02348358 AREA P.I. Classificazione Area Strategica. LIMANA FEDERICA Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Toscana ARICO' MAURIZIO Biomedical Immunology Infection and immunity SAN RAFFAELE MILANO Gabellini Davide Biomedical Genes, Genomes and Genetics Neurological diseases Visentin Sergio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases ISTITUTO TUMORI MILANO Lorusso Domenica Clinical Oncology 2 ‐ Translational Clinical Oncology SAN RAFFAELE PISANA PALMA ELEONOR Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Natural history of circulating Endothelial Toscana Progenitor Cells in aging of healthy subjects and during vascular injury progression in patients with type 1 diabetes. Validation of the role of circulating Endothelial Progenitor Cells as a novel paradigm of Ca Toni Sonia Clinical Vascular and Hematology Metabolism disorders and cardiovascular disease Immune, procoagulant and inflammatory responses in severe sepsis and septic shock Gattinoni Luciano Biomedical Immunology Infection and immunity MAGGIORE Pagina 56 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348360 Identification of host prion proteins resistant to template‐conversion into PrPSc IZSUM Biagetti Massimo Biomedical Veterinary Food safety and animal welfare RF‐2011‐02348362 Study of the involvement of KDEL receptors in inflammatory bowel disease Abruzzo Neri Matteo Biomedical Cell Biology Infection and immunity RF‐2011‐02348364 New biomarkers for early SIRS/sepsis diagnosis in pediatric and adult patiens. Friuli‐Venezia Giulia Biolo Gianni Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02348365 Genetic and functional analysis for identification of driver pathways of resistance in breast cancer metastases and xenograft obtained from patients with triple negative, HER2 positive and Luminal B subtypes I.E.O. CURIGLIANO GIUSEPPE Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348367 IDENTIFICATION AND ANALYSIS OF NEUROLESI MOLECULAR ALTERATIONS IN ENDOTHELIAL CELLS DERIVED FROM CEREBRAL CAVERNOUS MALFORMATIONS Sidoti Antonina Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348370 Postural sway and facial mimicry as behavioral SANTA LUCIA markers of covert motor symptoms in Parkinson's disease in a new differential early diagnostic protocol. Pavone Enea Francesco Biomedical Biobehavioral and Behavioral Processes Neurological diseases RF‐2011‐02348387 NF‐kB signaling pathway, innate immunity and neurodegeneration in Alzheimer's disease NEUROLESI Mastino Antonio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348388 Mechanism of action and in vivo efficacy of anti‐inflammatory treatments in Treg induction, regulation of neuroinflammation and arrest of dementia progression. NEUROLESI Mazzon Emanuela Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348397 Astrocyte TRK on demyelination SAN RAFFAELE MILANO Farina Cinthia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Pagina 57 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348398 Observational population‐based study on ovarian cancer management within the Piedmont Region Cancer Network Piemonte Zola Paolo Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02348406 Decision making and learning impairments associated with focal cerebral lesions Lazio Orzi Francesco Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02348410 Using structural and functional MRI to assess DON GNOCCHI the effects of motor rehabilitation on brain plasticity in multiple sclerosis: a double‐blind, randomized, controlled study Tavazzi Eleonora Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348429 Ageing at work: promoting health and safety of ageing workers according to changes of demography, labourmarket and social policies. MAGGIORE Costa Giovanni Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace RF‐2011‐02348435 Investigation of the role of extracellular ATP and the P2X7 receptor in the modulation of immunosuppression within tumour microenvironment Emilia‐Romagna Di Virgilio Francesco Biomedical Immunology Oncology RF‐2011‐02348436 The role of breath fingerprints in differential diagnosis and treatment response of lower respiratory tract infections of bacterial origin Sicilia Battaglia Salvatore Clinical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02348437 alpha7‐nAChR status and response to donepezil in Alzheimer's disease patients SAN RAFFAELE PISANA RUSSO PATRIZIA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348438 Assessment of chemotherapy induced liver morbidity through non invasive tools to predict and avoid post‐hepatectomy liver failure REGINA ELENA Grazi Gian Luca Clinical Digestive, Kidney and Urological Systems Oncology Pagina 58 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348439 PREVENTION AND DIAGNOSIS OF FETAL ALCOHOL SYNDROME (FAS) AND FETAL ALCOHOL SPECTRUM DISORDER(FASD) Lazio CECCANTI MAURO Clinical Brain Disorders and Clinical Neuroscience The new biotechnologies RF‐2011‐02348441 Lung water assessment by quantitative chest ultrasonography in cardiac surgery patients Emilia‐Romagna Corradi Francesco Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348444 Inherited arrhythmias: clinical characterization, genetic geography and experimental studies in the Calabria Region isolate. MAUGERI Priori Silvia Giuliana Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02348446 Long term mechanisms of diabetes prevention Toscana and remission after bariatric surgery: study of glucose metabolism, insulin secretion and cardiovascular risk 7 years after Roux‐en Y Gastric bypass. camastra stefania Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348452 Study of the role played by the Na+‐Ca2+ Marche exchanger 1 (NCX1) for the development of the cardiac damage to bacterial infections causing hypertrophic heart response Amoroso Salvatore Biomedical Cardiovascular and Respiratory Sciences Infection and immunity RF‐2011‐02348453 Primary Central Nervous System Vasculitis in the Young. A diagnostic and follow‐up study using 7‐Tesla MRA. Toscana Cimaz Rolando\ Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348454 Fosl2 as a p53 antagonist in cancer development and progression C.R.O. AVIANO Piccinin Sara Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02348457 Regulatory mechanisms and therapeutic targeting of melanoma‐initiating cells Toscana Borgognoni Lorenzo Biomedical Oncology 1 ‐ Basic Translational Oncology Pagina 59 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348459 Emilia‐Romagna A needs‐based approach to forecast future medical specialists' requirement for the Emilia‐ Romagna Regional (ERR) NHS Senese Francesca Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02348461 Development of novel chemo‐immunotherapy PASCALE strategy for hepatocellular carcinoma Buonaguro Luigi Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348462 Puzzle: a multiparametric approach to clinical OSPEDALE BAMBINO GESU' decision making and monitoring of children admitted to pediatric cardiac intensive care for congenital heart diseases Pongiglione Giacomo Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348463 Can epilepsy affect the structure of the brain? Role of neurons and glia and effect of therapy in a model of epileptogenicbrain malformation CARLO BESTA Battaglia Giorgio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348466 GENome‐wide association study to Evaluate genetic risk factors for cerebral sinus‐venous thromboSIS (GENESIS Study) MAGGIORE Martinelli Ida Marianna Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02348469 Phenotyping Cheyne‐Stokes respiration in heart‐failure patients: a first step towards effective individualized treatment MAUGERI Pinna Giandomeni Biomedical co Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348472 Circulating nucleic acids in colorectal cancer: new non‐invasive tools for patient risk assessment and early diagnosis in high risk individuals ISTITUTO TUMORI MILANO Gariboldi Manuela Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348475 IMAGE‐BASED PREDICTIVE MODELLING OF TUMOUR RESPONSE AND NOMAL TISSUE COMPLICATONS IN THE RADIOTHERAPY OF PELVIC MALIGNACIES I.E.O. ORECCHIA ROBERTO Clinical Oncology 2 ‐ Translational Clinical Oncology Biomedical Pagina 60 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Neurological diseases RF‐2011‐02348476 SAN RAFFAELE MILANO ROLE OF THE NOVEL PRESYNAPTIC PROTEIN PRRT2 IN NEURONAL PHYSIOLOGY AND IN THE PATHOGENESIS OF PAROXYSMAL NEUROLOGICAL DISORDERS Valtorta Flavia Biomedical Molecular, Cellular, and Developmental Neuroscience RF‐2011‐02348483 Predicting post‐surgery complications in patients undergoing coronary artery bypass graft or major spine surgery through the assessment of perioperative cardiovascular control indexes GALEAZZI Porta Alberto Clinical Metabolism disorders Surgical Sciences, Biomedical Imaging, and cardiovascular disease and Bioengineering RF‐2011‐02348486 Prostaglandin D2 synthase a novel pathway modulating PNS myelination SAN RAFFAELE MILANO Taveggia Carla Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02348487 DNA damage response and metabolic alterations of obesity Istituto Superiore di Sanita' Dogliotti Eugenia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348491 HUMANITAS Effects of peripheral sensory pressure stimulation on the cardiovascular autonomic profile, inflammatory state and movement disorders in patients with Parkinson's disease: evaluation of the time course and underlying neurophysiological mechanisms. A new c Furlan Raffaello Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348502 Influence of diet on composition of faecal DE BELLIS microbiota and metabolites, metabolomics, in two informative cohorts: African children eating a Western diet. Implications on obesity onset and its control (MICROBESITY) Riezzo Giuseppe Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Pagina 61 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348514 Hypoxia and MicroRNAs in the Regulation of the Dystrophin‐associated Protein Complex: Implications for Cognitive Deficits in Duchenne Muscular Dystrophy Istituto Superiore di Sanita' Macioce Pompeo Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02348521 Determinants of the risk of adverse materno‐ fetal outcomes and future diabetes in women with GDM Abruzzo Davì Giovanni Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348524 Effect of stress ( and psychological factors) on immune and endocrine systems in patients affected by breast carcinoma and hormone‐ correlated tumours. I.N.R.C.A. Vespa Anna Clinical Biobehavioral and Behavioral Processes Oncology RF‐2011‐02348525 Involvement of mutant p53 gain of function in REGINA ELENA tumor microenvironment Bossi Gianluca Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02348527 MIND THE GAP: END‐OF‐LIFE IN ADVANCED HEART FAILURE. IMPROVING QUALITY AND CARE OPTIONS. Toscana EMDIN MICHELE Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02348532 Dipeptidyl peptidase IV inhibitors and the complex P2X7 receptor‐inflammasome: in vitro and in vivo studies. Toscana Solini Anna Biomedical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease RF‐2011‐02348533 Calcium‐sensing receptor as a predictive marker in hypertensive patients SAN RAFFAELE MILANO Vezzoli Giuseppe Clinical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02348536 Role of Prostanoid Metabolism in Aortic Valve Veneto Calcification Pauletto Paolo Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease Pagina 62 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348547 Investigation on the effect of early monolateral versus bilateral cochlear implantation on brain development of congenitally deaf children OSPEDALE BAMBINO GESU' Marsella Pasquale Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02348548 High‐coverage next generation sequencing to detect the presence and intra‐tumor frequency of mutations in the EGFR pathway activating genes: predictive value on the response to anti‐EGFR therapy in metastatic colorectal cancer. IRCCS AOU San Martino‐ IST (Genova) Ballestrero Alberto Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348553 IS THERE A "SMELLING SIDE" IN THE HUMAN MOTOR SYSTEM? Towards a clinical relevance of olfacto‐motor cross‐ modal intercations Toscana Rossi Simone Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348554 Molecular and Clinical study of next generation in Autism‐Epilepsy Phenotype: Focus on Astrocyte‐Neuron interaction. STELLA MARIS Sicca Federico Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348556 A novel approach to diagnosis, allocation and treatment of HCC SAN MATTEO MAESTRI MARCELLO Clinical Oncology Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02348558 Combined intravenous and intra‐arterial thrombolysis for ischemic stroke due to large vessel occlusion: feasibility, safety and effectiveness. IRCCS AOU San Martino‐ IST (Genova) Balestrino Maurizio Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348570 Role of CREB protein family members in human lymphoid malignancies Abruzzo Di Pietro Roberta Biomedical Cell Biology Oncology Pagina 63 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348580 A translational medicine research collaboration to fight preeclampsia: from molecular pathogenesis to biomarkers of the disease and novel treatments Veneto Minuz Pietro Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348581 T cells redirected with a Chimeric Antigen Receptor (CAR) targeting the CD30 molecule for therapy of CD30+ malignancies OSPEDALE BAMBINO GESU' Savoldo Barbara Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348584 Unraveling the role of sodium channels in the CARLO BESTA susceptibility to neuropathic pain Lauria Giuseppe Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02348593 Biomolecular serological and epidemiological investigations on Encefalomyocarditis virus and his zoonotic roles in Italy. IZSLER Bonilauri Paolo Biomedical Veterinary Food safety and animal welfare RF‐2011‐02348599 Traditional and innovative monitoring of dioxins and dioxin like‐compounds in exposed sheep: chemical and biomolecular approaches in a sentinel species. IZSPLV Abete Maria Cesarina Biomedical Veterinary Food safety and animal welfare RF‐2011‐02348600 Role of Neutrophil activation and NET formation in venous thromboembolic disease Veneto Villalta Sabina Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02348608 Safe production of 99mTc with a biomedical cyclotron Emilia‐Romagna CICORIA GIANFRAN Biomedical CO Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02348610 Personalized multidisciplinary therapy in head and neck cancer based on clinical and molecular markers C.R.O. AVIANO Franchin Giovanni Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348613 MELATONIN LOADED NANOPARTICLES FOR POSTNATAL TREATMENT OF CEREBRAL PALSY IN A RAT MODEL Toscana Dani Carlo Biomedical Brain Disorders and Clinical Neuroscience The new biotechnologies Pagina 64 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Katsaros Dionyssios Biomedical Oncology 2 ‐ Translational Clinical Oncology Maternal exposure to ENMs: a comprehensive Lazio study of feto‐placental effects as a function of developmental stage. Pietroiusti Antonio Biomedical Bioengineering Sciences and Technologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02348619 The impact of the Directive 2010/63/EU on Italian research activities and welfare of animals Istituto Superiore di Sanita' Vitale Augusto Biomedical Veterinary Food safety and animal welfare RF‐2011‐02348623 Implementation of the Montreal Cognitive Assessment as a standard neuropsychological screening tool in Italian stroke units Toscana Pantoni Leonardo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348632 Environmental, food related (mycotoxins) and MEDEA genetic basis of Neural Tube Defects susceptibility n Italian and Sudanese populations. Bresolin Nereo Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Neurological diseases RF‐2011‐02348635 Charcot Foot: whole genome analysis and inflammatory evaluation for the development of potential treatment strategies I.N.R.C.A. Marchegiani Francesca Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348646 EFFECTS OF BLUNTING DAILY GLUCOSE FLUCTUATIONS ON COGNITIVE PERFORMANCE IN AGED TYPE 2 DIABETIC PATIENTS I.N.R.C.A. Abbatecola Angela Marie Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348649 Peptides from lactoferrin as new therapeutic agents against Influenza virus infection Istituto Superiore di Sanita' Superti Fabiana Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02348614 Innovative preclinical platforms for the personalized treatment in ovarian cancer RF‐2011‐02348616 Piemonte Pagina 65 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348650 Genetic response of colorectal carcinoma to chemotherapy to predict tumor response and circumvent chemoresitance Veneto MOCELLIN SIMONE Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348657 Development and validation of predictive models of toxicity after radiotherapy for prostate cancer based on large data‐bases from clinical trials SAN RAFFAELE MILANO FIORINO CLAUDIO Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348661 Cotransplantation of pancreatic islets and engineered, third‐party, human umbilical cord mesenchymal stem cells as a novel approach to improve graft survival and immune‐tolerance in type 1 diabetes patients Toscana Pistello Mauro Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348665 Identification of novel therapeutic targets to halt HCV infection: a proteomic approach. SPALLANZANI Piacentini Mauro Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02348667 Intraoperative Calcitonin Monitoring as marker of disease cure after surgery and indicator of type of surgery in patients withMedullary Thyroid Cancer PASCALE Pezzullo Luciano Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348668 Innovative approaches for the treatment of Pompe disease: identification of potential therapeutic targets in patients with the common splicing mutation c.‐32‐13T>G and pharmacological chaperoning of alpha glucosidase. Friuli‐Venezia Giulia BEMBI BRUNO Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02348670 Macrophage Senescence in Alzheimer Disease: I.N.R.C.A. possible link with onset and progression of the disease. Costarelli Laura Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Pagina 66 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348672 MOLECULAR CHARACTERIZATION OF PLEURO‐PULMONARY NEOPLASMS IN PATIENTS AGED <=40 YEARS AT DIAGNOSIS FOR A CUSTOMIZED THERAPEUTIC APPROACH Piemonte SCAGLIOTTI GIORGIO Clinical VITTORIO Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348681 Autologous transplantation of SPIO‐labeled bone marrow stem cells in Critical Limb Ischemia (CLI): a preclinical study. Liguria Schiavetta Alessandro Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02348683 Multimodal nanotechnological approach against hepatocellular carcinoma: Sorafenib loaded magnetic nanoparticles for targeted chemotherapy and localized hyperthermia. Toscana Sacco Rodolfo Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348684 Taking a step forwards the preparedness for preventing crises: Improving the molecular detection of emerging pathogens in food. IZSPLV Decastelli Lucia Biomedical Veterinary Food safety and animal welfare RF‐2011‐02348698 Dissection of Pertussis Toxin B‐oligomer Istituto Superiore di Sanita' (PTB) in adjuvant and anti‐viral components: human and mouse preclinical platforms to the identification of dimers/monomers/minimal domains to be developed as intracellular pathogen adjuvant and anti‐viral molecul Ausiello Clara Maria Biomedical Immunology Infection and immunity RF‐2011‐02348699 A packaging RNA nanotherapeutic approach to arrest nigrostriatal dopaminergic neuronal cell death in experimental Parkinson's disease Associazione Oasi Maria SS Marchetti Bianca Maria Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348701 Epidemiological, clinical and molecular aspects of Environmental Intolerance Disorders with Difficult Diagnosis in the Italian population, with special focus on the sick worker. Implications for Disease Definition, Diagnosis and Treatment, and Workplace S ISTITUTO DERMOPATICO De Luca DELL'IMMACOLATA Chiara Biomedical Immunology Diseases of environmental origin, with reference also to the workplace Pagina 67 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348702 GENE EXPRESSION PROFILE AT THE ONSET OF SEVERE CARDIAC FAILURE: IDENTIFICATION AND VALIDATION OF NEW BIOMARKERS GASLINI Zannini Lucio Valerio Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348704 Zinc Finger Protein 423 as a candidate gene for Autism Spectrum Disorder susceptibility ‐ a comprehensive analysis in mouse mutants and autistic children. SAN RAFFAELE MILANO Consalez Giangiacom Biomedical o Biobehavioral and Behavioral Processes Neurological diseases RF‐2011‐02348712 Pregnancy complication in transplanted women: anti‐phospholipids antibodies as sensitive biomarkers of prognostic value and pathogenetic determinants. Istituto Superiore di Sanita' Ortona Elena Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Infection and immunity RF‐2011‐02348713 Genetic variability of Mycobacterium tuberculosis and its implications for transmission dynamics, pathogenesis and immune response SPALLANZANI Girardi Enrico Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02348715 In vitro and in vivo testing of novel therapeutic strategies for lysosomal leukodystrophies: aptamer‐mediated delivery of functional enzymes and gene silencing approaches GASLINI Filocamo Mirella Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02348718 Telomere‐targeting agents: Towards clinical candidates selections REGINA ELENA Biroccio Annamaria Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348719 Masked mycotoxins in cereal‐based food products. Analytical methods, evaluation of their occurrence and risk assessment: an emerging issue for food safety? IZSVE Biancotto Giancarlo Veterinary Food safety and animal welfare Biomedical Pagina 68 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348728 Sonic hedgehog signaling and cholesterol dishomeostasis at the primary cilium in Niemann Pick C disease: implications for therapy Friuli‐Venezia Giulia Dardis Andrea Elena Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348733 Tailoring engineered micro‐nanocarriers properties to finely modulate immune responses: the allergy immunotherapy proof of concept Istituto Superiore di Sanita' Di Felice Gabriella Biomedical Immunology Infection and immunity RF‐2011‐02348735 Dysglicemia in hypertensive and normotensive adult and old subjects: role of glucocorticoids and Metallothioneins. From pathophysiology to cardiovascular risk prevention. Acronym: DYGAM‐AGE I.N.R.C.A. Mocchegiani Eugenio Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348737 Comparative Effectiveness of dual antiplatelet Emilia‐Romagna therapy after acute coronary syndromes vignali luigi Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348744 A combined therapeutic approach to Spino‐ Bulbar Muscle Atrophy (SBMA): from cellular models to clinical studies CARLO BESTA Pareyson Davide Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348745 Implementation of reading/writing learning method called "Globalismo Affettivo" in children with Neuropsychiatric Disorders Puglia Margari Lucia Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348746 Nanoparticles engineered with antibody derivatives or other molecules recognizing markers overexpressed in breast cancer cells for metastatic tumor detection Lombardia CORSI FABIO Biomedical RUGGERO Oncology Surgical Sciences, Biomedical Imaging, and Bioengineering Pagina 69 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. RF‐2011‐02348748 Identification of immunologic and vascular biomarkers of disease progression or remission in autoimmune disorders for the clinical management and therapeutic monitoring SAN GALLICANO Cordiali Fei Paola RF‐2011‐02348750 Molecular characterization of human atherosclerotic plaques: role of Calcium‐ Calmodulin dependent kinases and of their activating receptors in vascular wall and infiltrating inflammatory cells. Campania Illario RF‐2011‐02348772 Gray‐zone lymphomas: A cooperative study for a standardized diagnosis and treatment in the Lazio Region Lazio RF‐2011‐02348788 Characterization of the relationship of microbiota, Vitamin D, and mucins towards new colorectal cancer prevention strategies. RF‐2011‐02348790 Clinical Classificazione Area Strategica. Immunology Infection and immunity Maddalena Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Ruco Luigi Clinical Oncology 2 ‐ Translational Clinical Oncology I.E.O. SERRANO DAVIDE Clinical Oncology 2 ‐ Translational Clinical Oncology Culture and characterization of oral mucosal and conjunctival epithelial stem cells for the reconstruction of the ocular surface in patients with bilateral limbal stem cell deficiency Veneto Ponzin Diego Biomedical Brain Disorders and Clinical Neuroscience The new biotechnologies RF‐2011‐02348791 Role of functional and morphological MRI in the study of thalamus and auditory cortex for the assessment ofthe neurocognitive and clinical outcomes of premature newborns SAN RAFFAELE MILANO Scifo Paola Vittoria Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348796 ETHYL‐EICOSAPENTAENOIC ACID ADDED TO INTERFERON ß THERAPY IN RELAPSING‐REMITTING MULTIPLE SCLEROSIS: A RANDOMIZED PHASE II CLINICAL TRIAL. Istituto Superiore di Sanita' Salvati Serafina Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Pagina 70 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348799 Stereotactic body radiotherapy as monotherapy or boost combined with externalbeam radiotherapy for localized prostate cancer ISTITUTO TUMORI MILANO Valdagni Riccardo Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348800 Unravelling the genetics of Autosomal Dominant Diabetes Mellitus of the Adulthood CASA SOLLIEVO SOFFERENZA Trischitta Vincenzo Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02348801 THE ROLE OF SOD1 IN THE NUCLEUS: NEW INSIGHTS INTO THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) MONDINO Cereda Cristina Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02348803 Pathophysiological mechanisms of fibrosis: molecular characterization in a cell based assay. CARLO BESTA Zanotti Simona Biomedical Musculoskeletal, Oral and Skin Sciences Neurological diseases RF‐2011‐02348817 Prospective multicenter study on antibiotic CARLO BESTA prophylaxis protocol (ABP) for the prevention of Neurosurgical Surgical Site Infection (N‐ SSIs), with taylored strategies for High Risk (HR) classes Valentini Laura Grazia Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02348826 Fertility preservation in gonadotoxic treatments Emilia‐Romagna Porcu Eleonora Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348839 Identification of therapeutic targets for neurological disorders: analysis of the mechanisms regulating cortical interneuronsdevelopment. SAN RAFFAELE MILANO De Curtis Ivan Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02348856 Superpolyps: superantigen‐induced T‐ and B‐ cell accumulation in nasal polyps Lombardia NICOLAI PIERO Clinical Infectious Diseases and Microbiology Infection and immunity Pagina 71 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348857 Veneto ACG4GEO: Integration between "Adjusted Clinical Group" system and Geomedicine for a new vision about the environment health and personal health Idelfo Borgo Clinical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02348858 Lombardia Effectiveness of a Communication Skills Training program for oncology clinicians on patient Health‐Related Quality of Life: a stepped‐wedge, cluster randomized controlled trial Passalacqua Rodolfo Clinical Risk, Prevention and Health Behavior Oncology RF‐2011‐02348860 The potential of the SRCIN1/p140Cap gene as GASLINI prognostic risk factor and tumor suppressor in neuroblastoma Gambini Claudio Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02348864 Outcome of Rehabilitation in an experimental Emilia‐Romagna Hospital garden: a prospective, quasi‐ experimental study on a sample of subacute stroke patients. Dazzi Fabrizio Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348870 Toscana From psycho‐social stress to immuno‐ mediated dermatoses (vitiligo and psoriasis): a molecular approach. Moretti Silvia Biomedical Immunology Infection and immunity RF‐2011‐02348872 The role coagulation/complement upregulation and neurotropic viral activation play in Multiple Sclerosis REGINA ELENA Koudriavtseva Tatiana Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348873 Overcoming Anti‐Angiogenic Therapy Resistance: Investigation of MICAL2 as a Predictive Marker and Molecular Target in Cancer Therapy Toscana PINO MARIA SIMONA Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348875 A multidisciplinary approach to Early Onset Dementia Istituto Superiore di Sanita' Confaloni Annamaria Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Pagina 72 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348876 Novel mechanisms mediated by nicotinic acetylcholine receptors, and interactions with nuclear PPARalpha, in the neuropathogenesis of epilepsy: preclinical and translational studies Sardegna MARROSU FRANCESC Biomedical O Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348878 A FoxO1 metabolomics signature to identify patients at risk for major cardiovascular events: studies in human subjects with diabetes and atherosclerosis Lazio Federici Massimo Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02348887 Role of local immune response in the development of ano‐genital HPV related invasive diseases Lombardia orlando giovanna Clinical Immunology Infection and immunity RF‐2011‐02348888 Oncolytic Properties of Influenza A Viruses in IZSVE Human Pancreatic Tumour Cells and Xenograft Models Capua Ilaria Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348890 Livestock‐associated methicillin‐resistant Istituto Superiore di Sanita' Staphylococcus aureus (LA‐MRSA) as cause of human infection and colonization in an Italian Region with high density of pig farming Pantosti Annalisa Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02348895 Comparison of therapy with Ticagrelor, Prasugrel and high Clopidogrel dose in PCI patients with high on treatment platelet reactivity and genotyoe variation. Lazio Sardella Gennaro Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348907 A novel truncated variant of eNOS as a major risk factor for type 2 diabetes SAN RAFFAELE MILANO Casari Giorgio Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Pagina 73 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348911 Microbiome assessment in the myocardial tissue of patients with dilated cardiomyopathy and myocarditis negative to the known cardiotropic viruses. SPALLANZANI Frustaci Andrea Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02348916 Neuroactive steroids in Multiple Sclerosis, correlation with immunity and neurodegeneration CARLO BESTA Confalonieri Paolo Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348920 Analysis of the role of different isoforms of thymic stromal lymphopoietin and the microbiota in T cell activation in inflammatory conditions of the gut I.E.O. RESCIGNO MARIA Clinical Immunology Infection and immunity RF‐2011‐02348921 Expression of PARP1 and LDOC1 genes in subjects with Down syndrome and identification of new markers of neurodegenerative disorders in these subjects. Associazione Oasi Maria SS Salemi Michele Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02348922 SILK BASED BASEMENT MEMBRANE SAN MATTEO MODEL: A NEW TOOL FOR THE STUDY OF PLATELET PRODUCTION, FUNCTIONALITY AND THERAPEUTIC APPROACHES BALDUINI ALESSAND Biomedical RA Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02348926 HOMEOSTASIS OF pH AND BICARBONATE GASLINI CONCENTRATION IN THE AIRWAY SURFACE FLUID AS A TARGET FOR THE TREATMENT OF RESPIRATORY INFECTIONS IN CYSTIC FIBROSIS AND OTHER CHRONIC LUNG DISEASES Galietta Luis Juan V Biomedical Cell Biology Infection and immunity RF‐2011‐02348928 Innovative strategies for preventing emergence and transmission of multi drug resistant Gram negative bacteria in hospitalized newborns, infants, and children Raponi Massimilian Clinical o Population Sciences and Epidemiology Infection and immunity OSPEDALE BAMBINO GESU' Pagina 74 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02348938 Sustainable innovation of husbandry practices IZSVE to improve animal health and welfare and to reduce the use of antimicrobials in broiler chickens RF‐2011‐02348939 The Development and progression of breast cancer: when microRNAs fail to inhibit EMT and stemness. RF‐2011‐02348944 AREA P.I. Classificazione Area Strategica. BONFANTI LEBANA Biomedical Veterinary Food safety and animal welfare C.R.O. AVIANO Santarosa Manuela Biomedical Oncology 1 ‐ Basic Translational Oncology Identification and validation of novel biomarkers for Multiple Sclerosis and Alzheimer's Disease SAN RAFFAELE MILANO Furlan Roberto Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348945 Development of innovative compounds for the treatment of renal cell carcinoma Abruzzo Tinari Nicola Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02348951 Innate immune response as a key factor aimed SPALLANZANI to optimize HCV patients therapy management Sacchi Alessandra Biomedical Immunology Infection and immunity RF‐2011‐02348952 MULTICENTRIC ITALIAN OBSERVATIONAL Liguria STUDY ON RESISTANCE AGAINST ANTI‐ PLATELET THERAPY IN RECENT ISCHEMIC NON‐CARDIOEMBOLIC STROKE PATIENTS GANDOLFO CARLO Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02348953 A Twist code of p53 inactivation in sarcomas: clinicopathological and therapeutic implications C.R.O. AVIANO Maestro Roberta Clinical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02348957 Application of optical nanoplasmonic biosensors as a complementary tool for the early detection of Legionella spp in water systems. (NANOBIOLEG) Puglia MONTAGNA MARIA TERESA Biomedical Bioengineering Sciences and Technologies Diseases of environmental origin, with reference also to the workplace Pagina 75 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348959 From the measure of guidelines adherence in oncology to the assessment of health system performance Lombardia Russo Antonio Giampiero Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02348970 Structure and biology of the Tat/Env complex and role of anti‐Tat/Env antibodies in HIV infection: implication for HIV/AIDS preventative vaccine development Istituto Superiore di Sanita' Cafaro Aurelio Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02348971 Development of a diagnostic, histopathologic Toscana and therapeutic program for the management of gastrointestinal motor disorders in Parkinson disease: proposal of a new translational collaborative approach Blandizzi Corrado Clinical Digestive, Kidney and Urological Systems Neurological diseases RF‐2011‐02348977 Proof of concept for a new organizational model of care delivery: the Personalized Medicine approach to the treatment of Idiopathic Environmental Intolerance Lazio SIMMACO MAURIZIO Biomedical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02348978 Role of the mitogen‐activated protein kinase ERK5 in the development of hepatocellular carcinoma associated with chronic liver injury Toscana Marra Fabio Digestive, Kidney and Urological Systems Oncology RF‐2011‐02348982 EARLY‐START EXERCISE TRAINING AFTER ACUTE HEMODYNAMIC DECOMPENSATION IN PATIENTS WITH CHRONIC HEART FAILURE (RE‐START). A MULTICENTER, RANDOMIZED, CONTROLLED TRIAL ON SHORT‐TERM FEASIBILITY AND IMPACT ON FUNCTIONAL CAPACITY, SYMPTOMS AND NEUROHUMORAL ACTI MAUGERI Mezzani Alessandro Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02348984 Next Generation Sequencing (NGS): from Puglia basic research to diagnostic tool for nephrotic syndrome. Gigante Maddalena Biomedical Genes, Genomes and Genetics The new biotechnologies Biomedical Pagina 76 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02348991 Age‐immunological profile of stable kidney allograft patients as a key to modulate the immunosuppressive therapy Piemonte amoroso antonio Clinical Immunology Infection and immunity RF‐2011‐02349002 Nanoparticle‐Enhanced Surface Plasmon Resonance Imaging (NE‐SPRI): PCR‐free ultrasensitive cancer prognosis and therapy prediction REGINA ELENA Giacomini Patrizio Clinical Oncology 2 ‐ Translational Clinical The new biotechnologies RF‐2011‐02349003 Gene‐environment interaction in top‐down regulation of compulsive eating: a translational study of food addiction SANTA LUCIA Ventura Rossella Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349028 SANTA LUCIA Intensive vs non‐intensive rehabilitation program in Parkinson's disease (PD) patients. Study for evaluating a non invasive approch to increase neurotrophic factors in the brain of PD patients. peppe antonella Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349040 Definition of a clinical and immunological phenotype of antibody mediated rejection in heart transplant recipients: prognostic and therapeutic implications Emilia‐Romagna Potena Luciano Clinical Immunology Infection and immunity RF‐2011‐02349043 IMPROVING THERAPEUTIC RESPONSES IN MELANOMA THROUGH THE COMBINATION OF TARGET AND IMMUNOLOGIC THERAPIES: AN IN VITRO AND IN VIVO STUDY Lombardia mandala mario Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349056 SAN RAFFAELE MILANO The effect of metabolic surgery on the immunometabolome profile in non obese type 2 diabetic patients Staudacher Carlo Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Pagina 77 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02349061 Growth factors and lipid mediators signalling: SAN GALLICANO shared intracellular pathways regulating the complex and dynamic process of wound healing RF‐2011‐02349062 Role of microRNA regulation by estrogen receptor beta in hormone‐responsive breast cancer RF‐2011‐02349063 AREA P.I. Classificazione Area Strategica. Cardinali Giorgia Biomedical Cell Biology Metabolism disorders and cardiovascular disease PASCALE Botti Gerardo Biomedical Oncology 1 ‐ Basic Translational Oncology Identification of new biomarkers of colorectal cancer I.E.O. BIFFI ROBERTO Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349065 MULTIMODAL APPROACH TO PERSONALIZED THERAPY IN ANAL CANCER: CREATION OF A BIOMARKER PREDICTIVE PROFILE ADDRESSING TOWARDS NEW THERAPUTIC STRATEGIES Piemonte CASSONI PAOLA Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349068 Development of in vitro insulin‐producing biohybrid organ for the cure of type 1 diabetes Umbria Calafiore Riccardo Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349070 Mens sana in corpore sano? The impact of multi‐year exercise on physical and mental health at different ages. Toscana Santoro Gino Biomedical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease RF‐2011‐02349076 Assessment and management of AUXOLOGICO cardiovascular risk in perimenopausal women undergoing breast cancer screening Stramba‐ badiale Marco Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02349077 IDENTIFICATION OF NEW DRUGGABLE PATHWAYS FOR PERSONALIZED TREATMENTS IN INTRAHEPATIC CHOLANGIOCARCINOMA Leone Francesco Biomedical Oncology 2 ‐ Translational Clinical Oncology Piemonte Pagina 78 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349080 Brain Mechanisms of Chronic Subjective Dizziness SANTA LUCIA Indovina Iole Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02349083 Molecular Biomarkers for Colorectal Liver Metastases Resectability after Chemotherapy with Cetuximab REGINA ELENA Garufi Carlo Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349084 Circulating microRNAs as biomarkers of cardiovascular inflammatory diseases HUMANITAS CONDORELLI GIANLUIGI Clinical Cardiovascular and Respiratory Sciences Infection and immunity RF‐2011‐02349087 Oleuropein aglycone can be effective against AD in humans. A clinical trial Toscana Bracco Laura Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349088 A translational approach to hereditary neuropathies IRCCS AOU San Martino‐ IST (Genova) Schenone Angelo Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02349089 Rescue of Transforming‐Growth‐Factor‐beta 1 Associazione Oasi Maria SS signaling as a new strategy for neuroprotection in Alzheimer's disease: role of antidepressant drugs Caraci Filippo Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349090 Bisphenol A, obesity and breast cancer: epidemiological, clinical, analytical and biological approach PASCALE Montella Maurizio Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349091 Serum myostatin and type 2 diabetes: correlation with degree of metabolic control SDN Buono Pasqualina Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Pagina 79 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. RF‐2011‐02349104 Impact of early extracorporeal photopheresis (ECP) on the management of acute Graft versus host disease (aGVHD): clinical, biological and economical implications Friuli‐Venezia Giulia fanin renato RF‐2011‐02349107 Role of miR‐155 in FLT3 ITD in mutated acute myeloid leukemia: studies of network, signalling and silencing Sicilia SANTORO RF‐2011‐02349111 CHARACTERIZATION OF HOMOCYSTEINE‐ NEUROLESI INDUCED PROTEIN STRESS IN NEURODEGENERATIVE DISEASES: ROLE OF TRANGLUTAMINASE AND POTENTIAL IMPLICATION FOR THERAPY RF‐2011‐02349114 Clinical Classificazione Area Strategica. Immunology The new biotechnologies ALESSAND Biomedical RA Oncology 1 ‐ Basic Translational Oncology Ientile Riccardo Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases Dissecting the interplay between ERK and JNK SAN RAFFAELE MILANO signalling in the brain. From basic mechanisms to new therapeutic approaches against neurodenegerative disorders. Fasano Stefania Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02349115 ISTITUTO TUMORI Biological and therapeutical significance of androgen receptor expression in salivary gland MILANO cancers (SGCs): a translation research in a randomized, international, phase II study to evaluate the efficacy of chemotherapy versus androgen deprivation therapy Licitra Lisa Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349119 Innovative biological markers in type 1 diabetes SAN RAFFAELE MILANO Bosi Emanuele Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349122 Evaluation of denosumab effects on RANKL/RANK signalling in human osteosarcoma cells. Abruzzo de martinis massimo Biomedical Oncology 1 ‐ Basic Translational Oncology Pagina 80 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349125 Follow up study of the relationship between telomere length and the onset of diabetic complications I.N.R.C.A. Testa Roberto Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349126 Hypoxia, Inflammation and redox status as determinants of malignant progression of cancer stem cells SAN RAFFAELE PISANA TAFANI MARCO Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349127 Melanocortin‐1 receptor as a regulator of proliferation pathways in melanoma SAN GALLICANO Maresca Vittoria Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349128 Istituto Superiore di Sanita' Avian reservoirs as a potential source of human extraintestinal pathogenic Escherichia coli Cerquetti Marina Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349130 Vagal nerve stimulation as a novel strategy to limit post‐ischemic injury and possibly to prevent the development of ischemic cardiomyopathy AUXOLOGICO Calvillo Laura Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349133 EMERGING NOROVIRUS MUTANT AND RECOMBINANT STRAINS: A MOLECULAR EPIDEMIOLOGICAL INVESTIGATION ON SEWER SYSTEMS AND HOSPITALIZED PATIENTS Istituto Superiore di Sanita' La Rosa Giuseppina Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349134 New biomarkers to predict prognosis and tailor systemic therapy in patients with Pseudomyxoma Peritonei ISTITUTO TUMORI MILANO Deraco Marcello Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349135 A new kinkless polyurethane‐silicone vascular Emilia‐Romagna graft implanted as femoropopliteal bypass for ischemic limb salvage: a pilot clinical study. Silingardi Roberto Biomedical Metabolism disorders Surgical Sciences, Biomedical Imaging, and cardiovascular disease and Bioengineering Pagina 81 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02349136 FROM REMOTE MONITORING TO REMOTE Emilia‐Romagna CARE: IMPACT ON CLINICAL AND MANAGEMENT ISSUES OF AN INTEGRATED APPROACH TO FOLLOW HEART FAILURE PATIENTS WITH IMPLANTABLE CARDIAC DEVICES. RF‐2011‐02349138 Rethinking neuroinflammation in sporadic AD: exploring novel pathways to boost endogenous neuroprotective mechanisms RF‐2011‐02349144 Identification and biomolecular characterization of circulating tumor cells from patients with ovarian epithelial cancer using tumor‐specific fluorescent ligands: A new in vivo non‐invasive method. RF‐2011‐02349145 A multifaceted intervention for preventing SPALLANZANI spread of carbapenem‐resistant Enterobacteriaceae in hospital critical areas: a controlled before‐after study. RF‐2011‐02349148 Age‐related evaluation of the usefulness of implantable cardiac defibrillator with or without cardiac resynchronization therapy: a real‐world analysis in patients with severe chronic heart failure RF‐2011‐02349149 RF‐2011‐02349156 AREA P.I. Classificazione Area Strategica. Boriani Giuseppe Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Istituto Superiore di Sanita' Minghetti Luisa Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases I.E.O. PEIRETTI MICHELE Clinical Oncology 2 ‐ Translational Clinical Oncology Taglietti Fabrizio Clinical Infectious Diseases and Microbiology Infection and immunity Toscana Fumagalli Stefano Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Therapeutic drug monitoring protocols for dose personalization of antibacterial agents administered to patients with severeGram‐ positive infections Toscana Di Paolo Antonello Clinical Healthcare Delivery and Methodologies Infection and immunity DEVELOPMENT OF AN EXOSOME BASED IN‐VIVO TEST TO DETECT PRIONS IN BLOOD IZSPLV casalone cristina Biomedical Veterinary Food safety and animal welfare Pagina 82 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349167 GENETIC AND NEUROBIOLOGICAL INFLUENCES ON RISK‐TAKING PROPENSITY Istituto Superiore di Sanita' Angelo Picardi Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349168 NEW HYBRID POLYMERIC SCAFFOLD FOR OSTEOCHONDRAL ENGINEERED TREATMENT RIZZOLI Torricelli Paola Biomedical Musculoskeletal, Oral and Skin Sciences The new biotechnologies RF‐2011‐02349169 The emerging role of microRNAs in autism spectrum disorders Associazione Oasi Maria SS Elia Maurizio Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02349170 EFFECTS OF ADALIMUMAB ON PATIENT SERUM CAPACITY TO LOAD AND DISCHARGE MACHROPHAGES WITH CHOLESTEROL Lombardia GEROSA MARIA Biomedical Immunology Infection and immunity RF‐2011‐02349171 Relationship between 3D BCR structure, IRCCS AOU San Martino‐ microenvironment and response to BCR IST (Genova) inhibitors/4HPR, to design novel Chronic Lymphocytic Leukemia combination therapies. Cutrona Giovanna Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349172 Genetic and epigenetic biomarkers in myasthenia gravis Migliore Lucia Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02349174 New Therapeutic Approaches for Tuberculosis Istituto Superiore di Sanita' Giannoni Federico Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349178 A Prospective Cohort Study to Evaluate the Prognostic Value of Mobile Genetic Element Insertions in Non‐Small Cell Lung Cancer (NSCLC). I.N.R.C.A. Cardelli Maurizio Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349179 Prognostic and Predictive microRNA Biomarkers in Sarcoma C.R.O. AVIANO Modena Piergiorgio Biomedical Oncology 2 ‐ Translational Clinical Oncology Toscana Pagina 83 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349186 Evaluation of potential presence of heavy metals and nanoparticles in fishes and baby foods IZSSI ferrantelli vincenzo Biomedical Risk, Prevention and Health Behavior Food safety and animal welfare RF‐2011‐02349188 Evaluation of the olfactory function in the endoscopic trans‐nasal neurosurgical cancer patients: advanced medical technology and methodology Istituto Scienze Neurologiche Mazzatenta Diego Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349194 THERAPEUTIC DEVICE OF AREA FOR ADOLESCENTS WITH SEVERE PSYCHIATRIC DISORDERS. INTENSIVE SPECIFIC OUT‐PATIENT SERVICE Lombardia bolchi gianluca Clinical Risk, Prevention and Health Behavior Neurological diseases RF‐2011‐02349199 CANCER RISK EVALUATION IN A COHORT OF FARMERS EXPOSED TO ZOONOTIC AGENTS IZSSI MARINO ANNA MARIA FAUSTA Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349202 The molecular basis of the interplay between leukotriene and purinergic systems: new therapies in vascular inflammation Lombardia Cattaneo Marco Natale Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349203 Exploring the mechanisms of the cardiovascular effects of urban air particulate matter in susceptible individuals. Veneto Lotti Marcello Clinical Cardiovascular and Respiratory Sciences Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349204 MITOCHONDRIA AND AUTOPHAGY IN DEGENERATIVE SYNAPSES SANTA LUCIA Cecconi Francesco Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02349205 Cell characterization and analysis of the proliferative/differentiative potential of human coelomic fluid cells for "in utero" haematopoietic stem cell transplantation in haemoglobinopathies Sicilia MAGGIO AURELIO Biomedical Vascular and Hematology The new biotechnologies Pagina 84 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349208 Mucosal and Systemic immunological and genetic correlates of HIV resistance in exposed HIV‐seronegative individuals Lombardia Gori Andrea Clinical AIDS and Related Research Infection and immunity RF‐2011‐02349209 Structural fat grafting for management of Chron's fistulas Lazio Cosenza Umile Michele Clinical Digestive, Kidney and Urological Systems Infection and immunity RF‐2011‐02349210 Circulating microRNAs as prognostic biomarkers of arterial remodeling/restenosis after percutaneous transluminal intervention in patients with peripheral arterial disease I.N.R.C.A. Recchioni Rina Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349213 Genomics of treatment response in acute myeloid leukemia I.E.O. BERTOLINI FRANCESC Biomedical O Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349214 Activation‐Induced Cytidine Deaminase as Oncogenic Mutator in HCV‐related B‐cell Non‐Hodgkin¿s Lymphoma and Hepatocellular Carcinoma: A Single Cell‐level Study. Puglia Sansonno Domenico Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349218 Standardization of a SNP‐typing protocol for epidemiology of Listeria monocytogenes and study of the molecular evolution of an emerging Epidemic Clone. IZSPB Parisi Antonio Biomedical Infectious Diseases and Microbiology Food safety and animal welfare RF‐2011‐02349219 Proposal of an animal platform for assessing the tumoral cell response to anti‐angiogenic or cytotoxix antineoplastic agents based on multimodality molecular imaging: multiparametric assessment by optical imaging, microMagnetic Resonance Imaging, and micr Friuli‐Venezia Giulia Emilio Quaia Biomedical Oncology 2 ‐ Translational Clinical Oncology Pagina 85 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349223 ADOPTIVE IMMUNOTHERAPY FOR METASTATIC COLORECTAL CANCER PATIENTS Lombardia Bregni Marco Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349224 Role of Vitamin D receptor in angiogenic and DNA damage repair pathways with respect to BRCA1 status ONCOLOGICO DI BARI Tommasi Stefania Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349231 DEVELOPMENT OF ADVANCED Puglia NANOTECHNOLOGIES FOR EARLY ALZHEIMER DIAGNOSIS: FROM THE SYNTHESIS TO THE CLINICAL VALIDATION Brescia Vincenzo Biomedical Bioengineering Sciences and Technologies Neurological diseases RF‐2011‐02349233 Directing the axonal outgrowth via magnetic nanoparticles and magnetic fields for nerve regeneration: a pre‐clinical study Toscana Rossi Bruno Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02349235 Dissection of the MYCN/MAX/MAD transcription factor network as a critical step to designnovel therapeutic approaches to treat pediatric neuroblastoma Emilia‐Romagna Pession Andrea Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349240 Dynamics of epigenetic landscape during phase‐specific colorectal cancer reprogramming of stem cells and tissues in a murine stress related carcinogenesis model and human tumor biopsies. CASA SOLLIEVO SOFFERENZA Fazio Vito Michele Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349247 INNOVATIVE TREATMENTS FOR OSTEOSARCOMA: VALIDATION OF PROTEIN KINASE INHIBITORS AS TARGETED DRUGS AND ABC TRANSPORTERS INTERACTING AGENTS RIZZOLI Serra Massimo Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349249 The early identification of newborns at high Toscana risk of brain injury: the role of oxidative stress. Clinical Brain Disorders and Clinical Neuroscience Neurological diseases BUONOCORE GIUSEPPE Pagina 86 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349250 DEVELOPMENT OF NEW DIAGNOSTIC TOOLS FOR THE DETECTION OF ONCOGENIC POLYOMAVIRUSES IN HUMAN TUMORS. Emilia‐Romagna Tognon Mauro Biomedical Infectious Diseases and Microbiology The new biotechnologies RF‐2011‐02349251 INFLAMMATORY AND THROMBOCCLUSIVE VASCULOPATHY: THE ROLE OF PROTEINS RELATED TO COMPLEMENT ACTIVATION. C.R.O. AVIANO De Marco Luigi Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02349254 Copayment and compliance to the diagnostic therapeutic pathways Agenzia per i Servizi Sanitari Regionali Cislaghi Cesare Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02349256 INAIL Nanomaterials and Health: a multilevel approach to study the effects of nanomaterials at workplaces Ursini Cinzia Lucia Biomedical Bioengineering Sciences and Technologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349259 Two innovative rapid screening methods of IZSPLV corticosteroids as growth‐promoters in cattles using MEAs and an enhanced histopathological approach Bozzetta Elena Maria Biomedical Veterinary Food safety and animal welfare RF‐2011‐02349264 Insights into epigenetic changes in hepatocellular carcinoma and rationales for their therapeutic targeting Emilia‐Romagna Gramantieri Laura Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349265 Ultrasound on bioeffects and safety: an integrated approach in evaluating ultrasound‐ mediated cell alterations at both cell membrane and genetic level INAIL Bedini Angelico Biomedical Cell Biology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349269 From protein‐protein interaction studies new SDN potential therapeutic targets to treat the MLL‐ related acute lymphoblastic leukemias Esposito Gabriella Biomedical Oncology 1 ‐ Basic Translational Oncology Pagina 87 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349272 IZSLER DEVELOPMENT OF 3D IN VITRO TUMOUR/MSC COCULTURE MODEL AND IN VIVO IMAGING LUMINESCENT PROTOCOL TO REFINE AND REDUCE THE USE OF ANIMAL IN ONCOLOGICAL STUDIES. (DIANA) Ferrari Maura Biomedical Veterinary Food safety and animal welfare RF‐2011‐02349276 Characterization of the mitochondrial oxidative defect in Spinal Muscular Atrophy. Investigation of the molecular pathways leading to mitochondrial dysfunction and their relation to Spinal Muscular Atrophy pathogenesis. MAGGIORE Sciacco Monica Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349283 Pathophysiology of frontal cortical impairments in phenylketonuria: a translational investigation. SANTA LUCIA Puglisi‐Allegra Stefano Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349284 Dissecting the role of chronic stress and its consequences on tumor growth and metastasis in animal models PASCALE Arra Claudio Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349295 Primate to human cross‐species transmission of simian Type D retrovirus (SRV): seroprevalence study in Italian cohorts. Istituto Superiore di Sanita' maggiorella maria teresa Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349296 Combined study of genomic CNVs and immunological profiles in a population of patients with Autistim Spectrum Disorders (ASD) AUXOLOGICO Finelli Palma Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02349297 Genetic factors influencing early plasma ribavirin cut‐off values in HCV therapy to reduce anemia toxicity and improve outcome. Piemonte Di Perri Giovanni Biomedical Infectious Diseases and Microbiology Infection and immunity Pagina 88 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349298 Early genomic and cellular markers in sporadic colorectal cancer: an integrative methodological approach combining the response of biomarkers in organ biopsies and in a healthy cell system like peripheral mononuclear cells. Toscana nardini vincenzo Biomedical Genes, Genomes and Genetics Oncology RF‐2011‐02349299 Respiratory Muscle weakness in Duchenne Muscular Dystrophy: new approaches for noninvasive functional evaluation of effectiveness of the treatment MEDEA D'Angelo Maria Grazia Clinical Musculoskeletal, Oral and Skin Sciences Neurological diseases RF‐2011‐02349303 Impact of deep Transcranic Magnetic Stimulation (TMS) on satiety and weight control SAN DONATO Luzi Livio Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349306 Clinical markers of chilhood apraxia of speech STELLA MARIS and its neurobiological and genetic correlates Chilosi Anna Maria Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349307 Study of the molecular mechanisms underlying the susceptibility to neonatal group B streptococcal disease BORGHESI ALESSAND Biomedical RO Immunology Infection and immunity RF‐2011‐02349311 IZSLER Development of different technologies and alternative in vivo assays to evaluate the safety of medical devices. Lombardi Guerino Biomedical Veterinary Food safety and animal welfare RF‐2011‐02349313 Exploring the functions of the immune system Toscana in chronic fatigue syndrome (CFS) by means of silent viral infections and cytokine pathway evaluations and proteomic approach Bazzichi Laura Clinical Integrative, Functional, and Cognitive Neuroscience Infection and immunity RF‐2011‐02349320 Identification of novel biomarkers in psoriasis: SAN GALLICANO a systems biology approach Berardesca Enzo Clinical Immunology Infection and immunity SAN MATTEO Pagina 89 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349321 Involvement of ADAR1‐ and ADAR2‐RNA‐ editing activity on myeloid leukemia and myeloid cell differentiation: novel future therapeutic implications. OSPEDALE BAMBINO GESU' Gallo Angela Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349331 Lung cancer cell cultures from mediastinal node metastasis to develop target therapies. Lazio Mariotta Salvatore Clinical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349333 LAV‐ BPIFB4 isoform, a new target to fight endothelial dysfunction MULTIMEDICA Puca Annibale Biomedical Alessandro Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349335 SEEKING MOLECULAR BIOMARKERS OF Emilia‐Romagna CERVICAL INTRAEPITHELIAL NEOPLASIA PROGRESSION BY MICROARRAY ANALYSIS OF CLONAL CIN3 KERATINOCYTES. Martini Fernanda Biomedical Oncology 2 ‐ Translational Clinical The new biotechnologies RF‐2011‐02349348 Role of plasma dysregulated microRNAs in the Emilia‐Romagna diagnosis and screening of Human Malignant Pleural Mesothelioma (MPM) Boschetto Piera Biomedical Oncology 2 ‐ Translational Clinical Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349353 Postactivation depression in hemiplegic stroke IRCCS AOU San Martino‐ IST (Genova) survivors: implications for assessment and treatment of spasticity Trompetto Carlo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349354 DNA replication licensing in Plasmodia: molecular characterisation of a potential new therapeutic target for malaria treatment. Camarda Grazia Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349367 White Blood Cells expression profiles as a tool CASA SOLLIEVO SOFFERENZA for predicting Metformin Efficacy in Patients with Type 2 Diabetes Prudente Sabrina Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02349381 MicroRNAs regulated by mutated p53 oncoproteins in colon cancer gurtner aymone Biomedical Oncology 1 ‐ Basic Translational Oncology Istituto Superiore di Sanita' REGINA ELENA Pagina 90 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349393 Human Ewing Sarcoma Family Tumor (ESFT) Revisited From Cancer Stem Cells (CSCs) to the Epigenetic Regulation: cross‐talk between ncRNA and DNA methylation Lombardia Parafioriti Antonina Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349395 Role of IP‐10 and its truncated form in the pathogenesis of tuberculosis SPALLANZANI Goletti Delia Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349396 New pathobiologic prognostic factors in colorectal cancers: the role of circulating tumor cells, mismatch repair system's competence, and tumor deposits in non metastatic rectal cancer. ISTITUTO TUMORI MILANO Leo Ermanno Clinical Digestive, Kidney and Urological Systems Oncology RF‐2011‐02349399 Antenatal human heart development Lombardia cuttin maria serena Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349403 Identification of genetic determinants for cetuximab‐induced immunogenic cell death and response to treatment I.E.O. Zampino Maria Giulia Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349412 Modulation of the metabotropic glutamate receptor 1 as a novel strategy to treat nephrotic syndrome. MAGGIORE Messa Piergiorgio Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease RF‐2011‐02349413 Development of nanostructured biomimetic nerve scaffolds Piemonte Tos Pierluigi Biomedical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02349416 Role of the menstrual cycle and of sexual hormones in HIV‐1 infection of human cervico‐vaginal tissue explants SAN RAFFAELE MILANO Poli Guido Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02349418 Gut Bacteria (microbiOta) in HepAtic EncephaLopathy and Possible Utility of its Modulation (the GOAL study) DE BELLIS Leandro Gioacchino Clinical Infectious Diseases and Microbiology Infection and immunity Pagina 91 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02349422 The prevalence of Autoimmune Polyglandular Veneto Syndromes type I and type II in Italy RF‐2011‐02349424 Transcranial Magnetic Stimulation in alcohol dependence RF‐2011‐02349426 AREA P.I. Classificazione Area Strategica. BETTERLE CORRADO Clinical Immunology Infection and immunity Addolorato Giovanni Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Preclinical study in mouse models to evaluate SANTA LUCIA the use of the chemokine Cxcl3 in the therapy of medulloblastoma Tirone Felice Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349429 I.E.O. In vivo identification of molecular determinants critical to the metastatic process in melanoma. LANFRANCO LUISA NE MARIA Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349430 Epithelial ovarian cancer: management of advanced stage disease recurrence by an (epi)genomic‐driven approach ISTITUTO TUMORI MILANO Bagnoli Marina Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349431 Hemoglobin A1c (HbA1c) levels and early markers of cardiovascular disease: Sicilia Piro Salvatore Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Lazio identification of cardiometabolic risk in pre‐ diabetic subjects. RF‐2011‐02349433 Innovative aspects in the study of acute hepatitis C, in the laboratory diagnosis and study of clinica, genetic, virological and biomolecular prognostic markers and in the optimization of therapeutic protocols Campania Sagnelli Evangelista Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349435 Fostering donation: from bench to culture MAGGIORE Valenza Franco Clinical Healthcare Delivery and Methodologies Neurological diseases RF‐2011‐02349439 Molecular imaging and genome wide analysis: REGINA ELENA an integrated approach to identify early diagnostic biomarkers. Piaggio Giulia Biomedical Oncology 2 ‐ Translational Clinical Oncology Pagina 92 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349443 Integrated diagnostic evaluation of PET/RM and molecular markers in the diagnosis of bone lesions SDN Napoli Claudio Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349447 Coronary Arteriogenesis with combined Heparin and EXercise therapy in Chronic refractory Angina (CARHEXA study) Toscana Bolognese Leonardo Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349448 Genetic risk prediction of atrial fibrillation Emilia‐Romagna recurrences: new insight from next generation sequencing Zardini Marco Clinical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02349450 Role of autophagy and its regulators in melanoma and in the differential therapeutic response to BRAF‐inhibitors Toscana Massi Daniela Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349452 Generation of human artificial striated muscle MULTIMEDICA Rizzi Roberto Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02349454 The role of Integrin alpha5/beta1 as a potential Lazio therapeutic target in breast cancer bone metastasis Tonini Giuseppe Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349456 Pulmonary Rehabilitation in Lung Cancer surgical patients. CESARIO ALFREDO Clinical Cardiovascular and Respiratory Sciences Oncology RF‐2011‐02349457 Congenital cytomegalovirus infection: SAN MATTEO prognostic factors of virus transmission to the fetus and congenital disease Lilleri Daniele Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349462 ULTRAsound in ischemic Stroke (ULTRAS) study Finocchi Cinzia Clinical Brain Disorders and Clinical Neuroscience Neurological diseases SAN RAFFAELE PISANA IRCCS AOU San Martino‐ IST (Genova) Pagina 93 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349478 A multiparametric approach based on clinical, CASA SOLLIEVO biochemical, genetic and neuroimaging data SOFFERENZA to predict cognitive impairment in Parkinson's disease Valente Enza Maria Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349479 Identification of biological and immune correlates of therapeutic responses for HPV‐ positive epithelial cancers: an ex vivo organotypic multi‐cellular model for patient‐ tailored therapies. PASCALE Buonaguro Franco Maria Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349480 Lentiviral‐mediated telomere stabilization in hematopoietic stem cell transplantation for graft improvement and GVHD reduction in thalassemia patients Sardegna LA NASA GIORGIO Clinical Vascular and Hematology The new biotechnologies RF‐2011‐02349483 Development of an antimicrobial food packaging by using essential oils and nanotechnology ‐ EssencePack IZSME Proroga Yolande Therese Rose Biomedical Veterinary Food safety and animal welfare RF‐2011‐02349484 WNV endemization in Italy: implications for the national transplant program SPALLANZANI Capobianchi Maria Rosaria Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349492 Deep molecular mechanisms of amyloid beta peptide aggregation promoting Alzheimer's Disease: characterization with Nuclear Magnetic Resonance (NMR) techniques using an "in vitro" model of anesthetic inducing oligomerization. NEUROLESI Fodale Vincenzo Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349495 Global Rare Tumor Networking and new REGINA ELENA staging/prognostic concepts in Thymic Epithelial Tumors and in Non Small Cell Lung Carcinomas metastatic to the Mediastinum: an integrated clinicopathological and molecular study Marino Mirella Clinical Oncology 2 ‐ Translational Clinical Oncology Pagina 94 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349496 Host factors and new therapeutic approaches Sardegna involved in the clearance of HBsAg in patients with chronic hepatitisB, HBeAg negative Chessa Luchino Clinical Digestive, Kidney and Urological Systems Infection and immunity RF‐2011‐02349501 FISH FARMING AND WELFARE: ASSESSMENT OF ACOUSTIC, THERMAL AND CHEMICAL STRESS FOR A MORE AQUACULTURE SUSTAINABLE IZSPLV Prearo Marino Biomedical Veterinary Food safety and animal welfare RF‐2011‐02349502 Neuronal lifespan in longer living brains SAN MATTEO MAGRASSI LORENZO Biomedical Biology of Development and Aging Neurological diseases RF‐2011‐02349503 Searching for a common pathogenetic pathway causing muscle misfunctioning in different laminopathies RIZZOLI Columbaro Marta Biomedical Cell Biology The new biotechnologies RF‐2011‐02349504 Sicilia In vivo manipulation of gamma delta Tcell with zoledronate and low dose IL2: improving the efficacy of BRAF inhibitors through a combined targeted/immunotherapy in metastatic melanoma. Cordova Adriana Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349505 Nutritional management of liver fat in Istituto Superiore di Sanita' diabetes: effects of different dietary fatty acids. D'Archivio Massimo Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349510 CROB GENOMIC CHARACTERISTICS OF REGULATORY T‐CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA: RELATIONSHIP TO CLINICAL OUTCOME AND POTENTIAL IMPLICATION FOR TREATMENT D'Arena Giovanni Clinical Oncology 2 ‐ Translational Clinical Oncology Pagina 95 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349514 Transcranial Direct Current Stimulation combined with Speech Therapy in Acute and Chronic Post‐stroke Aphasic Patients: a double blind, sham‐controlled, randomized study Emilia‐Romagna TUGNOLI VALERIA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349515 HIGH THROUGHPUT TECNOLOGIES FOR UNCOVERING NEW DIAGNOSTIC BIOMARKERS FOR EARLY DIAGNOSIS OF CHRONIC ALLOGRAFT INJURY IN RENAL TRANSPLANTATION (CAI) Puglia Schena Francesco Paolo Biomedical Digestive, Kidney and Urological Systems The new biotechnologies RF‐2011‐02349516 Guidelines for Health Impact Assessment Emilia‐Romagna Natali Marinella Clinical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349525 Conventional multi‐port laparoscopic colectomy versus single‐incision colectomy for cancer: comparison of short‐ and long‐ term results by a randomized study Toscana Cianchi Fabio Clinical Oncology Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02349526 Effective and genetically‐driven bio‐clinical road map defining tailored, multidisciplinary, treatment strategies of metastatic colorectal cancer (MCRC) patients. Abruzzo Ricevuto Enrico Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349531 Therapeutic potential and safety assessment of SAN RAFFAELE MILANO gene‐corrected Neural Stem/Progenitor Cells (NSPC) derived from patient‐specific induced Pluripotent Stem Cells (iPSC) in murine models of Lysosomal Storage Diseases (LSD). Gritti Angela Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02349540 Design and implementation of a national network for remote identification of parasite arthropodes. Pascucci Ilaria Biomedical Veterinary Food safety and animal welfare IZSAM Pagina 96 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349543 Automated Good Manufacturing Production of Adipose‐derived Mesenchymal Stem Cells for clinical use: validation, characterization and biosafety. RIZZOLI Roseti Livia Clinical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02349546 Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in mantle cell lymphoma (MCL) treated with R‐HDS Lombardia Pogliani Enrico Maria Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349547 Veneto Early integration of palliative care with standard oncologic care in advanced non‐ small cell lung cancer. A prospective, multi‐center observational study to evaluate how this approach impact on patients survival and quality of life with an additional ana BONETTI ANDREA Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02349548 Atherogen Genetic Dyslipidemias (AGD): are they missed diseases?Estimate of frequency of AGD diagnoses in the Tuscany hospitals and strategy design to identify probands with AGD and trigger early diagnosis in family members Toscana Sampietro Tiziana Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02349551 EXOME SEQUENCING BASED DETECTION OF VARIANTS RELEVANT TO THE CLINICAL SPECTRUM OF NEONATAL BRONCHO PULMONARY DYSPLASIA AND RESPIRATORY DISTRESS SAN RAFFAELE MILANO Carrera Paola Biomedical Genes, Genomes and Genetics The new biotechnologies RF‐2011‐02349556 Impact of asbestos‐mediated inflammation in mesothelioma genesis and progression. Implication for early diagnosis, prognosis and therapy HUMANITAS SICA ANTONIO Biomedical Oncology 1 ‐ Basic Translational Oncology Pagina 97 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349566 Randomized controlled study for the implementation of a new interprofessional model for the management of palliative care in oncological patients Toscana cecchi stefania Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02349571 Cerebral Amyloid Angiopathy: new markers for early diagnosis and insights in pathogenetic mechanism AUXOLOGICO ADOBBATI Clinical LAURA MARIA ADELAIDE Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349584 Role of microRNAs in successful aging Abruzzo Mezzetti Andrea Biomedical Biology of Development and Aging Metabolism disorders and cardiovascular disease RF‐2011‐02349586 ROLE AND IMPACT OF DNA VIRUSES IN AUTOIMMUNE DISEASES Emilia‐Romagna ARCANGELET MARIA TI CRISTINA Biomedical Immunology Infection and immunity RF‐2011‐02349589 INHIBITION OF DRUGGABLE GENE ABERRATIONS IN ER‐POSITIVE OR TRIPLE NEGATIVE OPERABLE BREAST CANCER. A WINDOW OF OPPORTUNITY TRIAL Emilia‐Romagna Frassoldati Antonio Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349592 ISTITUTO TUMORI Mechanism(s) underlying differential protection of trastuzumab‐containing therapy MILANO depending on site of relapse. Tagliabue Elda Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349611 Integrated lipidomic profiling in diabetes and cardiovascular disease in a cohort of subjects in a mediterranean area of southern Italy: a nested case control study Caruso Maria Gabriella Biomedical Biological Chemistry and Macromolecular Biophysics Metabolism disorders and cardiovascular disease RF‐2011‐02349625 I.E.O. The Hereditary Diffuse Gastric Cancer syndrome: from susceptibility genes to clinical management BONANNI BERNARD O Biomedical Genes, Genomes and Genetics Oncology DE BELLIS Pagina 98 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349635 Non Alcoholic Fatty Liver Disease (NAFLD) , Lombardia vitamin D and cardiometabolic risk: a proof of concept study belli luca saverio Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349636 Characterization of specific factors that prevent HIV‐1‐induced cell death in Long Term Non Progressors and Elite Controllers. From pathogenesis to new treatments. SPALLANZANI Nardacci Roberta Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02349644 Molecular and cellular correlates of vitamin D‐ dependent antimicrobial activity in an ovine model of local immune functions IZSSA Marogna Gavino Biomedical Veterinary Infection and immunity RF‐2011‐02349645 Early diagnosis, tumor response to neoadjuvant treatments and diagnosis of tumor recurrence using new and non‐invasive biomarkers in colon and rectal cancer I. O. V. Pucciarelli Salvatore Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349652 HIV INFECTION AND ANTIRETROVIRAL TREATMENT: EFFECTS ON BONE‐ MARROW HEMATOPOIETIC STEM CELLS SPALLANZANI Bordoni Veronica Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02349653 Toscana Circulating endothelial progenitor cells as potential predictive and prognostic markers in metastatic colorectal cancer patients CAPORALE ROBERTO Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349657 Keratoconus and autoimmune thyroid disorders HUMANITAS VINCIGUERRA PAOLO Clinical Brain Disorders and Clinical Neuroscience Infection and immunity RF‐2011‐02349658 STUDY OF CONSORTIA OF PROBIOTICS USED TO IMPROVE HUMAN HEALTH Istituto Superiore di Sanita' Scalfaro Biomedical Infectious Diseases and Microbiology Food safety and animal welfare Concetta Pagina 99 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349659 Non‐peptidic compounds with Nerve Growth Factor‐mimetic activity as novel therapeutic agents for neurodegenerative diseases Toscana Torcia Maria Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349661 Markers of refractoriness in Gilles de la Tourette syndrome: pharmachological therapies and deep brain stimulation. GALEAZZI Porta Mauro Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349662 Role of Periostin in prostate and breast carcinogenesis. Integrated approaches for the identification of novel prognostic and therapeutic targets. IRCCS AOU San Martino‐ IST (Genova) Boccardo Francesco Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349663 Analysis of the possible pathogenic roles of the inflammosome and the microbiota in Alzheimer's disease DON GNOCCHI Clerici Mario Salvatore Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349666 Attention to memory: mechanisms of competition during memory retrieval in mild cognitive impairment SANTA LUCIA Macaluso Emiliano Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02349667 Lazio IMPLEMENTATION AND ASSESMENT OF AN ORGANIZATIONAL SIMULTANEOUS CARE MODEL Clinical ALOE SPIRITI MARIA ANTONIET TA Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349671 Exploring the role of the prokineticin system CARLO BESTA in experimental autoimmune encephalomyelitis: a preclinical study towards the definition of possible novel targets of therapy for human multiple sclerosis Pedotti Rosetta Biomedical Immunology Neurological diseases RF‐2011‐02349672 Development and validation of a personal Toscana dosimeter for the exposure to electromagnetic fields of Magnetic Resonance healthcare personnel LANDINI LUIGI Biomedical Bioengineering Sciences and Technologies The new biotechnologies Pagina 100 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Ricceri Laura Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Food Safety: protection of the public health IZSME through the determination of some endocrine disruptors in water and foods of large consumption Gallo Pasquale Biomedical Veterinary Food safety and animal welfare RF‐2011‐02349688 ASSISTENTIAL AFTERMATH OF DISTRESS IN MATERNIY WARD PROFESSIONALS FACING MISCARRIAGE, STILLBIRTH AND PERINATAL GRIEF Piemonte Randaccio Sara Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349690 EXOSOME‐MEDIATED CONTROL OF HEMATO‐ENDOTHELIAL CELL DIFFERENTIATION Istituto Superiore di Sanita' Testa Ugo Biomedical Cell Biology Oncology RF‐2011‐02349692 Point‐of‐care lung ultrasonography in the bedside evaluation of patients in the critical care and emergency settings Piemonte Volpicelli Giovanni Clinical Cardiovascular and Respiratory Sciences The new biotechnologies RF‐2011‐02349693 Vibrio and viruses in shellfish: old and emerging pathogens. Evaluation of exposure levels for the implementation ofprevention strategies. Istituto Superiore di Sanita' Suffredini Elisabetta Biomedical Veterinary Food safety and animal welfare RF‐2011‐02349696 Pathogenesis of hemolytic uremic syndrome associated with Shiga toxin‐ producingEscherichia coli infections: early enrolment of patients with bloody diarrhea, application of over‐hydration protocols, and study of the kinetic of the toxins in blood Istituto Superiore di Sanita' Morabito Stefano Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349679 Counteracting oxidative stress in Rett syndrome RF‐2011‐02349684 Istituto Superiore di Sanita' Pagina 101 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Clinical Brain Disorders and Clinical Neuroscience Neurological diseases Schiappacassi Monica Biomedical Oncology 1 ‐ Basic Translational Oncology Lipoprotein(a) and soluble lectin‐like oxidized Lazio LDL receptor‐1 (sLOX‐1) as a potential causal genetic risk factor for atherosclerosis in a prospective population‐based study (PLIC study) CORTESE CLAUDIO Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02349704 Mechanism of inhibition and reversion of DE BELLIS omega‐3‐Polyunsaturated Fatty Acids on the growth of intestinal polyps in APC Min/+ mice Notarnicola Maria Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349707 GENETICS OF ENDOTHELIAL FUNCTION CARLO BESTA IN UNDERSTANDING THE PATHOGENESIS OF LACUNAR STROKE AND SMALL VESSEL DISEASE Bersano Anna Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349709 Pulmonary Embolism: diagnosis, treatment, management and outcomes in a general hospital with a fully computerized information system. Polo Friz Hernan Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349712 Genomic complexity of chronic lymphocytic Emilia‐Romagna leukemia (CLL): clinicobiologc implications and pharmacoeconomic evaluation at the beginning of the kinase‐targeted treatment era Cuneo Antonio Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349715 Preclinical and phase II clinical study of cisplatin, cetuximab and valproic acid in recurrent and/or metastatic squamous cell carcinoma of the head and neck Caponigro Francesco Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349698 Individual risk in clinically isolated syndromes SAN RAFFAELE MILANO of conversion to multiple sclerosis and disease progression: an integrated public health clinical genomics approach Comi RF‐2011‐02349701 CDKs blockade for molecular targeting in human cancer. RF‐2011‐02349703 C.R.O. AVIANO Lombardia PASCALE Giancarlo Pagina 102 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO RF‐2011‐02349717 A new therapeutic window in neurorehabilitation RF‐2011‐02349727 DESTINATARIO ISTITUZIONALE FATEBENEFRATELLI AREA P.I. Classificazione Area Strategica. Miniussi Carlo Biomedical Biobehavioral and Behavioral Processes Neurological diseases How is it possible to define rehabilitation care Emilia‐Romagna appropriateness? The impact of an alternative evaluation system on the inappropriateness of health care resources Brianti Rodolfo Clinical Healthcare Delivery and Methodologies Neurological diseases RF‐2011‐02349728 Measured physiological and psycological outcomes with hypnotic behavioral adjuncts as an experimental tool in laboratories of interventional cardiac procedures Piemonte Marra Sebastiano Clinical Biobehavioral and Behavioral Processes Metabolism disorders and cardiovascular disease RF‐2011‐02349730 New molecular predictive markers in Colorectal Cancer (CRC) Sicilia BAZAN VIVIANA Biomedical Genes, Genomes and Genetics Oncology RF‐2011‐02349731 Protein characterization of neglected endemic IZSPB zoonotic agents in Italy: Bacillus anthracis, Brucella spp and Francisella spp. Fasanella Antonio Biomedical Infectious Diseases and Microbiology The new biotechnologies RF‐2011‐02349733 OVERWEIGHT/OBESITY/SEVERE OBESITY: Istituto Superiore di Sanita' TIME TRENDS AND LONGTERM BENEFITS OF WEIGHT REDUCTION Giampaoli Simona Biomedical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease RF‐2011‐02349734 Effects of mandibular stretching on arterial blood pressure in normal volunteers and in patients with arterial hypertension: a single blinded randomized study Toscana Ghione Sergio Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349740 Cellular biomarkers of diabetic pathophysiology and complications Veneto Avogaro Angelo Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349741 Development of novel 'tailored' therapy in acute myeloid leukemia (AML) with NPM1 gene mutations Umbria Martelli Maria Paola Biomedical Oncology 2 ‐ Translational Clinical Oncology Pagina 103 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349742 SAN GALLICANO DEVELOPMENT OF LABORATORY PROCEDURES TO ASSESS BIOFILM PRODUCTION AND DRUG RESISTANCE OF BIOFILM‐FORMING BACTERIA FOR NOSOCOMIAL SURVEILLANCE AND THERAPEUTIC MANAGEMENT Prignano Grazia Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349749 NEW ANTIBACTERIAL COATINGS FOR TITANIUM PROSTHESIS TO REDUCE PERIMPLANT INFECTIVE RISK AND IMPROVE OSSEOINTEGRATION Giavaresi Gianluca Biomedical Musculoskeletal, Oral and Skin Sciences The new biotechnologies RF‐2011‐02349752 Umbria Laparoscopic sleeve gastrectomy versus conventional medical therapy in patients with newly diagnosed type 2 diabetes and Body Mass Index 30‐34.9 Kg/m2: a randomized clinical trial Parisi Amilcare Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349764 Evaluation of muscle mass and physical fitness Campania in overweight/obese patients with metabolic syndrome or type 2 diabetes enrolled in a physical education empowering process with or without functional endocrine diseases Silvia Savastano Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349765 IDENTIFICATION OF NOVEL MOLECULAR MECHANISMS IN THE ETHIOPATHOGENESIS OF OVARIAN CANCER Abruzzo CARTA GASPARE Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349772 Functional topography of the spinal motor output after spinal cord injury SANTA LUCIA Cappellini Germana Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02349774 Treatment of extremely high lipoprotein(a) levels with LDL‐apheresis in young patients with documented cardiovascular disease: a proof of concept trial Toscana Marcucci Rossella Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RIZZOLI Pagina 104 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349782 In vitro and in vivo effects of post‐transplant cyclophosphamide (PT‐CY) in patients receiving hematopoietic stem cell transplantation from HLA haploidentical family donors. IRCCS AOU San Martino‐ IST (Genova) Bacigalupo Andrea Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349785 DEVELOPMENT OF A NEW NON‐ RECOMBINANT MUCOSAL VACCINE DELIVERY SYSTEM Toscana GHELARDI EMILIA Biomedical Immunology The new biotechnologies RF‐2011‐02349788 Increased severity of respiratory viral infections in the elderly: identification of thiols level as biomarker and therapeutic target. SAN RAFFAELE PISANA CIRIOLO MARIA ROSA Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349790 Role of DNA‐PK in neurodegeneration and aging: enhancement of DNA repair as novel therapeutic approach Istituto Superiore di Sanita' MERLO DANIELA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349791 Sentinel animals to monitor asbestos pollution around the former Balangero mine Piemonte Mirabelli Dario Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349793 Correlation between estrogen depletion and Associazione Oasi Maria SS Alzheimer¿s disease: analysis of gene expression and brain functions in humans and animal models Lanzone Antonio Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02349794 SECURITY STANDARDIZATION AND ADAPTING OF MODERN RADIOTHERAPY THROUGH IN‐VIVO DOSIMETRY Fidanzio Andrea Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349796 Definition of a new predictive model to assess Lombardia the complexity of patients hospitalized in Internal Medicine, with particular reference to cardiovascular outcomes Mazzone Antonino Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease Lazio Pagina 105 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349798 Epithelial ovarian cancer: affecting tumor growth by targeting aberrant metabolism. ISTITUTO TUMORI MILANO Mezzanzanica Delia Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349801 The possible role of transforming growth factor beta1 and vitamin D in regulating disease activity and brain atrophy in patients with Multiple Sclerosis. SANTA LUCIA Nocentini Ugo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349802 Human lactation and medication prescription: Istituto Superiore di Sanita' promoting appropriateness for optimal infant feeding. Giusti Angela Clinical Healthcare Delivery and Methodologies Food safety and animal welfare RF‐2011‐02349805 Preclinical characterization of a potent antimicrobial peptide for the development of a new drug for Cystic Fibrosis Toscana Pini Alessandro Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349806 Mitochondrial targeting in LRRK2‐associated parkinsonism (PARK8) SANTA LUCIA Tozzi Alessandro Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349807 Occupational health risk in dynamic olfactometry. Risk assessment for workers in the olfactometric laboratory and establishment of safety procedures for the implementation of the European Standard method for determination of odour concentration. MAUGERI Cottica Danilo Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349811 The use of top soils improvers from municipal Istituto Superiore di Sanita' wastewater treatment plants, on pasture: risk assessment of the associated microbial and organic chemical contamination on grazing food producing animals, and on food safety and food security (SOIL‐SAFE) Brambilla Gianfranco Biomedical Veterinary Food safety and animal welfare Biomedical Pagina 106 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Masala Giovanna Biomedical Oncology 2 ‐ Translational Clinical Oncology Priano Lorenzo Clinical Emerging Technologies and Training in Neurosciences Neurological diseases Istituto Superiore di Sanita' Ascione Alessandro Biomedical AIDS and Related Research Infection and immunity Biomarkers and Asphyxia Piemonte Gazzolo Diego Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349823 A susceptibility marker for Amyotrophic Lateral Sclerosis: genetic and functional analysis of polymorphisms of P2RX7 gene coding for purinergic P2X7 receptor for extracellular ATP, in a cohort of ALS patients. SANTA LUCIA Volonté Cinzia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349826 Structural connectivity in DYT1 and DYT6 dystonia CARLO BESTA Chiapparini Luisa Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349827 From bench to bedside in deciphering the modulatory mechanisms of the molecular damage in hereditary spastic paraplegias MEDEA Martinuzzi Andrea Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Toscana RF‐2011‐02349812 A randomized intervention trial in breast cancer patients to evaluate a protocol aimed to obtain dietary and physical activity sustainable and permanent modifications in breast cancer patients and its effects on weight and metabolic aspects. RF‐2011‐02349813 DEVELOPMENT OF A FULL WIRELESS AUXOLOGICO POLYGRAPHIC DEVICE FOR DIAGNOSIS OF SLEEP DISORDERS AND REMOTELY ATTENDED HOME MONITORING RF‐2011‐02349816 Development of anti‐PD‐1 single chain antibodies with finely balanced affinity for effective immunotherapy against HIV RF‐2011‐02349818 Pagina 107 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349828 Exposure and health effects of Ultrafine Particles at urban hotspots INAIL gariazzo claudio Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349830 Pathophysiological approach to the interventional therapy of limb atherosclerotic disease ‐ A biomedical, mechanistic study Emilia‐Romagna Ferrari Roberto Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02349833 Prospective Appraisal of the Prevalence of Primary Aldosteronism in HYpertensive Patients presenting With Non Valvular AtrialFibrillation (PAPPHY Study): Optimization of Diagnosis and Investigation of the Mechanisms. Veneto Rossi Gian Paolo Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349834 Pilot study of a combination of an mTOR inhibitor (everolimus) and capecitabine administered with a metronomic schedulein patients undergoing liver transplantation for hepatocellular carcinoma at high risk of recurrence. Emilia‐Romagna Brandi Giovanni Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349837 Role of brain/cognitive reserves on neurodegenerative pathology SANTA LUCIA Petrosini Laura Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349843 SEPSIS TEAM: A MODEL OF INNOVATIVE MANAGEMENT OF THE PATIENT REFERRED TO EMERGENCY DEPARTMENT WITH A CONDITION OF SEVERE SEPSIS/SEPTIC SHOCK Emilia‐Romagna Francesco Cristini Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349854 An effective vaccine to prevent mucosal HIV infection based on an HIV‐1 env DNA prime ‐ gp140 trimeric protein boost immunization regimen in the presence of CCL28: proof of efficacy in cynomolgous macaques. SAN RAFFAELE MILANO Scarlatti Gabriella Biomedical AIDS and Related Research Infection and immunity Pagina 108 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Clinical Classificazione Area Strategica. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Neurological diseases RF‐2011‐02349855 Comparative study on the clinical efficacy and Veneto manegement of different feeding strategies in elderly patients with advanced dementia. SERGI GIUSEPPE RF‐2011‐02349857 BONE AND MUSCLE IN SPINAL MUSCULAR AUXOLOGICO ATROPHY: FROM BENCH TO BEDSIDE. Bianchi Maria Luisa Biomedical Musculoskeletal, Oral and Skin Sciences Neurological diseases RF‐2011‐02349858 Investigations on the genetic predisposition to SAN RAFFAELE PISANA the copper metabolism dysfunction associated with Alzheimer's disease Squitti Rosanna Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02349859 Detection of blood‐borne EMT cells and risk of metastasis in colorectal cancer patients. HUMANITAS LAGHI LUIGI ANDREA GIUSEPPE Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349861 Phenotypes in Dyslexia with genetic alteration: sensory and neuronal deficits. STELLA MARIS Morrone Maria Concetta Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02349862 Role of miR‐494 and other microRNAs in Src kinase inhibition of colorectal cancer stem cells Umbria Liberati Anna Marina Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349863 Effectiveness and costs‐effectiveness analysis of a caring model for hospitalized cancer patients with severe acute clinical problems Emilia‐Romagna Biasco Guido Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02349864 Discovery and translational research of aggressive B‐cell lymphomas of still unknown pathobiology Toscana De Falco Giulia Biomedical Oncology 1 ‐ Basic Translational Oncology Pagina 109 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349865 Istituto Superiore di Sanita' Development of immunoassays for the evaluation of human exposure to Aedes mosquitoes: a novel tool for the assessment of efficacy of vector control strategies and estimation of arboviral disease risk. DI LUCA MARCO Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349866 Unveiling the role of c‐MET and ALK gene alterations as druggable targets in pulmonary sarcomatoid carcinoma, a therapeutically challenging subtype of lung cancer ISTITUTO TUMORI MILANO Sozzi Gabriella Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349872 CDKL5 DISORDER: identification of the molecular mechanisms underlying the neurological phenotype Istituto Scienze Neurologiche Parmeggiani Antonia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349875 Developmemt of a novel intra‐operative spectroscopic diagnostic technology for diagnosis and better delineation of human brain tumours. Toscana GIORDANO FLAVIO Biomedical Oncology 2 ‐ Translational Clinical Neurological diseases RF‐2011‐02349878 The cure of cancer: Estimation of time to cure C.R.O. AVIANO and number of cured patients among persons living with neoplasms in Italy Dal Maso Luigino Biomedical Population Sciences and Epidemiology Oncology RF‐2011‐02349886 BIOLOGICAL AGING AND URBAN POLLUTION Veneto MAESTRELLI PIERO Biomedical Cardiovascular and Respiratory Sciences Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349896 HIV‐infected pregnant women treated with HAART: registry of pharmacokinetic parameters of new and commonly used antiretrovirals; mitochondrial toxicity and apoptosis in pregnant women and utero‐ exposed newborn SPALLANZANI Bellagamba Clinical AIDS and Related Research Infection and immunity Rita Pagina 110 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349897 Viral microRNAs: a secret weapon for host gene expression alteration in B‐cell lymphomas Toscana leoncini lorenzo Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349902 Identification and comparison of stool and plasma microRNA signatures as colorectal cancer markers Piemonte Rosina Floriano Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349911 Impact of JC and BK polyomaviruses infection Emilia‐Romagna on human infertility and recurrent pregnancy loss Marci Roberto Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349912 A preclinical translational study for Campania pharmacological inhibition of G protein Receptor Kinase 2 for the treatment of cardiac dysfunction: A metabolic approach. Iaccarino Guido Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349914 Association between long‐term exposure to air pollution and neurological and metabolic impairment in adults of two large Italian longitudinal studies Piemonte Galassi Claudia Clinical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02349918 Searching for early and predictive markers of individual risk for head and neck cancer Toscana GALLO ORESTE Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02349919 DEVELOPMENT OF A NEW ARTIFICIAL HEART FOR PEDIATRIC PATIENTS WITH END‐STAGE HEART FAILURE OSPEDALE BAMBINO GESU' Amodeo Antonio Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349920 Dissecting the role played by mechanotransduction on Cardiac Stem Cell and cardiomyocyte dysfunction. Friuli‐Venezia Giulia Beltrami Carlo Alberto Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349921 THE ROLE OF THE BRAIN‐ADIPOCYTE AXIS ACTIVITY IN POTENTIATING ANTIDEPRESSANT EFFICACY Istituto Superiore di Sanita' Branchi Igor Biomedical Biobehavioral and Behavioral Processes Neurological diseases Pagina 111 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Carlesimo Giovanni Augusto Clinical Brain Disorders and Clinical Neuroscience Neurological diseases Composition and dynamics of cholesterol‐rich Istituto Superiore di Sanita' membrane microdomains in malaria parasite infection ‐ identification of potential targets for novel intervention strategies Ponzi Marta Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02349931 New strategies for the eradication of HIV reservoirs Re Maria Carla Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02349935 HIV eradication: pharmacological modulation Sicilia of HIV latent reservoir by targeting of sirtuin family of de‐acetylating enzymes Nunnari Giuseppe Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02349938 From Bench to Bedside: an Integrated Approach to RASopathies Istituto Superiore di Sanita' Tartaglia Marco Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02349940 Risk stratification of hospital‐acquired infection, an Artificial Neural Network approach Piemonte Lomolino Grazia Clinical Risk, Prevention and Health Behavior Infection and immunity RF‐2011‐02349941 Investigation of mechanism of tumor development and new systemic drug treatment strategies to tackle the rising burden of hepatocellular carcinoma complicating Non Alcoholic Fatty Liver Disease. Emilia‐Romagna PISCAGLIA FABIO Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349948 Investigation of genetic molecular mechanisms underlying the risk of cardiovascular events: role of rs5065 human atrial natriuretic peptide gene variant NEUROMED Volpe Massimo Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02349924 The use of classical conditioning with a telemedicine approach for anomia rehabilitation in chronic aphasia: a clinical outcome research RF‐2011‐02349925 SANTA LUCIA Emilia‐Romagna Pagina 112 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02349952 Significance of Sentinel Node Micrometastasis C.R.O. AVIANO in Breast Cancer Progression Massarut Samuele Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02349953 PROMOTING MOTOR RE‐LEARNING IN PATIENTS WITH STROKE BY ENHANCING NON INVASIVELY ASSOCIATED CEREBELLAR‐CORTICAL PLASTICITY. SANTA LUCIA Koch Giacomo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02349955 Heart‐liver axis in metabolic syndrome: common damage mechanisms as an input for patient management OSPEDALE BAMBINO GESU' Comparcola Donatella Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02349957 New strategies for liver allocation in HCV‐ infected transplant candidates Piemonte Salizzoni Mauro Clinical Infection and immunity Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02349958 Engineering Commensal Bacteria for the Delivery of Therapeutic Proteins SAN RAFFAELE MILANO Vangelista Luca Biomedical Bioengineering Sciences and Technologies Infection and immunity RF‐2011‐02349965 Ectopic calcifications: from molecular mechanisms towards therapeutic perspectives Emilia‐Romagna Quaglino Daniela Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02349978 Regulatory and effector T cell populations Lazio count during chronic graft versus host disease and extracorporeal photopheresis (ECP): flow cytometric cGVHD activity monitoring. Piccirillo Nicola Clinical Immunology Oncology RF‐2011‐02349985 Production of novel diagnostic and therapeutic antibodies directed against stem cells in colorectal and lung cancer De Maria Ruggero Biomedical Marchiano Oncology 2 ‐ Translational Clinical Oncology REGINA ELENA Pagina 113 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02349986 HUMANITAS ICT for Quality Assurance and Advanced Information Management in Immunology and Oncology Biobanking: a Bridge Between Care and Research RF‐2011‐02349996 Framework for Genomic Analysis and Molecular Epidemiology in foodborne bacterial pathogens (acr.: GAME‐food) RF‐2011‐02350001 AREA P.I. Classificazione Area Strategica. Sini Elena Clinical Healthcare Delivery and Methodologies Infection and immunity IZSAM Calistri Paolo Biomedical Veterinary Food safety and animal welfare Effects of robotic‐aided rehabilitation on the wrist joint in hemiparetic patients: an fMRI study Istituto Superiore di Sanita' Giansanti Daniele Clinical Musculoskeletal, Oral and Skin Sciences Neurological diseases RF‐2011‐02350009 Effect of lower limb end‐effector robot‐ assisted therapy with Virtual Realty on gait training in Parkinson Patients. SAN RAFFAELE PISANA FRANCESCHI MARCO NI Clinical Biobehavioral and Behavioral Processes Neurological diseases RF‐2011‐02350018 Measurement of salivary melatonin in shift workers and in patients with circadian disorders Emilia‐Romagna Parrino Liborio Clinical Emerging Technologies and Training in Neurosciences Diseases of environmental origin, with reference also to the workplace RF‐2011‐02350019 Natural history of Myotonic Dystrophy type 1. Epidemiology in the Lazio region, clinical protocol standardization, and assessment of clinical and molecular endpoints in a longitudinal cohort study. SANTA LUCIA Massa Roberto Clinical Population Sciences and Epidemiology Neurological diseases RF‐2011‐02350023 Evaluation of the potential application of bivalve shellfish as bioindicators of pollution for viral pathogens in coastal waters of southern Italy IZSME fusco giovanna Biomedical Veterinary Food safety and animal welfare RF‐2011‐02350026 Proximal versus Distal approach in the upper limb rehabilitation in stroke patients using robotic platforms: effects on the motor performance and functional recovery. SAN RAFFAELE PISANA LE PERA DOMENIC Clinical A Biobehavioral and Behavioral Processes Neurological diseases Pagina 114 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350034 Characterization of colon cancer stem cells for Basilicata the identification of new prognosticmarkers and/or targets for novel anticancer therapies Sgambato Alessandro Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350035 Dissecting SOX2 role in breast cancer progression: from the epithelial‐to‐ mesenchymal transition to metastasis onset PASCALE Pentimalli Francesca Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350046 COronary endothelium and systemic METabolism crosstalk in the progression of cardiac dysfunction. CO‐MET study Toscana Neglia Danilo Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350056 Artificial Neural Network in development of Innovative Diagnostic systems for Atherosclerotic disease (The ANN‐IDA project) MONZINO Ballerini Giovanni Biomedical Metabolism disorders Surgical Sciences, Biomedical Imaging, and cardiovascular disease and Bioengineering RF‐2011‐02350059 Effects of epi‐drugs on epigenetic modifications induced by environmental pollutants: implications on tumour biology, apoptosis, cell cycle, and metabolic and endocrine disorders. NEUROLESI TETI DIANA Biomedical Genes, Genomes and Genetics Diseases of environmental origin, with reference also to the workplace RF‐2011‐02350075 A wait and see approach to identify predictors ISTITUTO TUMORI of aggressiveness in sporadic desmoid tumor MILANO Gronchi Alessandro Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350078 GALACTOSYLATED PRODRUG OF KETOROLAC WITH BETTER PHARMACOKINETIC PROPERTIES AND REDUCED TOXICITY Sarnelli Giovanni Interdisciplinary Molecular Sciences and Training The new biotechnologies Campania Clinical Pagina 115 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Toscana AREA P.I. Classificazione Area Strategica. Silvestri Stefano Biomedical Oncology 1 ‐ Basic Translational Oncology Boemi Massimo Clinical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease Friuli‐Venezia Giulia zanconati fabrizio Biomedical Oncology Surgical Sciences, Biomedical Imaging, and Bioengineering Early detection of cardiotoxicity in cancer patients ONCOLOGICO DI BARI Oliva Stefano Clinical Cardiovascular and Respiratory Sciences Oncology RF‐2011‐02350096 Prevention of nosocomial Legionnaires' disease: use of spoligotyping in evaluating L. pneumophila susceptibility to chlorine and monochloramine. Sicilia Giammanco Anna Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02350097 Skeletal muscle in Spinal and Bulbar Muscular Veneto Atrophy (SBMA): therapeutic target and delivery route for potential treatments Sorarù Gianni Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350106 SAN RAFFAELE MILANO Clinical validation of an optimized MRI protocol for early diagnosis and monitoring of progressive multifocal leukoencephalopathy gerevini simonetta Clinical Infectious Diseases and Microbiology Neurological diseases RF‐2011‐02350111 Early Diagnosis and rehabilitation in Alzheimer's disease: a multicenter experimental study directed to patients related ASL/AL of Alessandria. Arduino Marinella Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350079 Asbestos dosage in biological tissues and fluids: standardization of sample preparation and analytical methods within National Health Service, Universities and Regional Environmental Protection Agencies laboratories. RF‐2011‐02350082 The "TRIPL‐A Study". A TRIal to promote I.N.R.C.A. PhysicaL Activity among patients in the young‐ old age affected by Type 2 diabetes RF‐2011‐02350092 Phase contrast mammography with synchrotron radiation in the follow‐up of patients treated with conservative surgery for breast carcinoma RF‐2011‐02350093 Piemonte Pagina 116 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Mandalà Giorgio Clinical Brain Disorders and Clinical Neuroscience Neurological diseases Biobank for genomic investigations of specific Campania genetic factors that confer susceptibility to stress‐induced (Takotsubo) cardiomyopathy Rodolfo Citro Clinical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02350124 THE ROLE OF THE GUT MICROBIOTA IN ALZHEIMER'S DISEASE PATHOGENESIS Galluzzi Samantha Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350125 Identifcation of the genetic landscape of T‐cell Veneto lymphoblastic lymphoma of childhood Rosolen Angelo Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350130 Prescription of Physical Activity to prevent the Veneto onset of type 2 diabetes Joppi Roberta Clinical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease RF‐2011‐02350131 PINOCCHIO: computer‐aided Planning and monItoriNg biological bOne reConstructions in CHIldren Oncology. RIZZOLI Taddei Fulvia Biomedical Oncology Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02350134 Discovery of Tat mimicking compounds to fight HIV latency Istituto Superiore di Sanita' Sgarbanti Marco Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02350140 Endothelial cell alterations in metabolic syndrome, obesity and diabetes: Gender, molecular and cellular mechanisms in prevention of cardiovascular risk. MULTIMEDICA Noonan Douglas M Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02350154 A minimal residual disease‐driven approach to Toscana the patient affected by follicular lymphoma receiving R‐CHOP Galimberti Sara Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350113 Cognitive rehabilitation after stroke: a randomized controlled trial to compare the effectiveness of different protocols. RF‐2011‐02350122 Sicilia FATEBENEFRATELLI Clinical Pagina 117 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350156 OSPEDALE BAMBINO Mother‐to‐infant transmission of infectious diseases: development of clinical pathways for GESU' an appropriate/comprehensive care of pregnant women with infections and their infants. Auriti Cinzia Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02350161 PERIOPERATIVE MARKERS OF NEUROLOGICAL AND LUNG DAMAGE IN INFANTS WITH CONGENITAL HEART DISEASES. A THREE‐YEAR FOLLOW‐UP STUDY OSPEDALE BAMBINO GESU' Cogo Paola Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350164 Food nanomaterials exposure assessment Istituto Superiore di Sanita' Cubadda Francesco Biomedical Veterinary Food safety and animal welfare RF‐2011‐02350172 Clinical relevance of miRNA profiles in HCV‐ related human neoplasias PASCALE BONELLI Patrizia Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350174 Development and application of a novel Veneto Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) functional test in leukocytes Melotti Paola Biomedical Cardiovascular and Respiratory Sciences The new biotechnologies RF‐2011‐02350185 Piemonte Identification and protein profiling of extracellular vesicles in the cerebrospinal fluid of patients with Mild Cognitive Impairment and Alzheimer¿s disease: a new potential diagnostic tool Rainero Innocenzo Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350186 Development of cultured red blood cells with Istituto Superiore di Sanita' rare phenotypes for diagnostic and clinical use Migliaccio Anna Rita Biomedical Vascular and Hematology The new biotechnologies RF‐2011‐02350189 Potential Role of blood miRNA as non invasive biomarkers for early detection of stroke and hemorrhagic transformation Aridon Paolo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases Sicilia Pagina 118 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350192 Allergymonitor: daily monitoring of young allergic outpatients for improving therapeutical adherence to immunotherapy and pharmacotherapy Veneto Peroni Diego Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02350193 Assessment of strategies for identifying undiagnosed type 2 diabetes mellitus Veneto Bonora Enzo Clinical Population Sciences and Epidemiology Metabolism disorders and cardiovascular disease RF‐2011‐02350214 STELLA MARIS Muscle imaging in neuromuscular disorders: conventional, high and ultrahigh field imaging studies for coming into a focus Battini Roberta Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02350218 Predictive value of invasive measurement of left ventricular function during cardiac resynchronization therapy (CRT). Sicilia Cipolla Tommaso Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350220 Roles of mesopontine‐subthalamic nucleus projections in the control of basal ganglia functions and in Parkinson disease Lazio Mazzone Paolo Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350225 IDENTIFICATION OF NEW STRAINS OF POTENTIALLY PROBIOTIC BACTERIA FROM HUMAN FECES AND FOODS: SUBSEQUENT INVESTIGATION OF THEIR ACTIVITY ON THE BROKERS OF THE SYSTEMIC AND INNATE IMMUNE SYSTEM. POSSIBLE USE OF THE ISOLATE STRAINS ALSO AS DELIVERY SYSTEM FOR Emilia‐Romagna Zuliani Giovanni Biomedical Immunology Infection and immunity RF‐2011‐02350226 A study on feasibility, pharmacokinetics and efficacy of intra‐operative hyperthermic chemotherapy for the treatment of pleural malignancies. Toscana ambrogi marcello carlo Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350227 Genetic basis of taste perception, life style, health status and colorectal cancer risk. Piemonte Polizzi Salvatore Biomedical Genes, Genomes and Genetics Oncology Pagina 119 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350228 Steroid myopathy: pathogenesis and prevention MAUGERI Bottinelli Roberto Biomedical Musculoskeletal, Oral and Skin Sciences Infection and immunity RF‐2011‐02350230 Predictive markers of cardiovascular diseases: role of miRNAs in endothelial damage. IRCCS AOU San Martino‐ IST (Genova) Palombo Domenico Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02350232 Ankrd2 as a novel repressor of immune and HUMANITAS inflammatory responses through regulation of myokine expression. BANG MARIE LOUISE Biomedical Musculoskeletal, Oral and Skin Sciences Infection and immunity RF‐2011‐02350243 Targeting the CCR2 and CCL2 system to modulate macrophage recruitment and polarization in amyotropic lateral sclerosis HUMANITAS BONECCHI RAFFAELL Biomedical A Immunology Infection and immunity RF‐2011‐02350244 Occupational and environmental exposure to dangerous chemicals and reproductive pathologies Campania Colacurci Nicola Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diseases of environmental origin, with reference also to the workplace RF‐2011‐02350246 Improving social dysfunction through Istituto Superiore di Sanita' oxytocin administration in non‐human infants exposed to maternal neglect early during postnatal life Alleva Enrico Biomedical Biobehavioral and Behavioral Processes Neurological diseases RF‐2011‐02350247 Human infection from exposure to norovirus (NoV): improving and harmonization of diagnostic techniques, correlation between clinical cases and contaminated food and assessment of dose‐response IZSVE Arcangeli Giuseppe Biomedical Infectious Diseases and Microbiology Food safety and animal welfare RF‐2011‐02350256 18F‐AH‐111585 PET/CT in the diagnosis and evaluation of tumor angiogenesis in primary brain tumors HUMANITAS CHITI ARTURO Clinical Oncology 2 ‐ Translational Clinical Oncology Pagina 120 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350257 Toscana Antimicrobial peptide‐based nanotherapeutics to prevent biofilm formation or to eradicate pre‐formed biofilms associated with catheter‐related, antibiotic resistant nosocomial infections Batoni Giovanna Biomedical Bioengineering Sciences and Technologies Infection and immunity RF‐2011‐02350262 Novel therapeutic strategies for aggressive leukemia/lymphoma using mono‐ and bispecific antibodies and cell therapy in orthotopic murine models Lombardia Golay Josee Therese Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350267 Improving the prognosis of melanoma patients through the use of new metastatic markers associated to the Notch pathway. Lombardia BULFAMANTE GAETANO Biomedical PIETRO Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350268 Thin‐Cap Coronary Fibroatheroma assessed Basilicata by Virtual Histology Intravascular Ultrasound (VH‐IVUS) and Optical Coherence (OCT) or Multidetector Computed (MCT) Tomographies: how to detect non‐invasively lesions potentially prone to rupture. Puddu Paolo Emilio Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350276 Toscana Novel multi‐analyte point‐of‐care testing device for rapid diagnosis and management of sepsis and severe infection. Esin Semih Biomedical Interdisciplinary Molecular Sciences and Training Infection and immunity RF‐2011‐02350279 Electro‐clinical features, brain networks, and gene expression in Ring20 epilepsy syndrome Lombardia Canevini Maria Paola Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350280 Genetic dissection of cystic fibrosis host susceptibility to Pseudomonas aeruginosa infections using a highly genetically diverse mouse resource population, the Collaborative Cross mice SAN RAFFAELE MILANO Bragonzi Alessandra Biomedical Infectious Diseases and Microbiology Infection and immunity Pagina 121 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350286 Role of autophagy core complex in tumor onset and progression SANTA LUCIA di bartolomeo sabrina Biomedical Cell Biology Oncology RF‐2011‐02350288 STRATEGIES TO DECREASE THE INCIDENCE OF INFECTIONS/COLONIZATIONS BY GRAM NEGATIVE MULTIDRUG‐RESISTANT BACTERIA IN INTENSIVE CARE UNITS. A PROSPECTIVE, MULTICENTER TRANDOMIZED STUDY. Emilia‐Romagna Mussini Cristina Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02350289 Metabolic tumour volume as assessed by 18F‐ FDG PET/CT for tailoring therapy in patients with locally advanced rectal cancer candidate for neoadjuvant chemoradiation. Liguria ciarmiello andrea Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350290 Impact of intensive follow up on diagnostic anticipation in high risk stage I‐III breast cancer patients. A phase II, multicenter randomized study. IRCCS AOU San Martino‐ IST (Genova) Del Mastro Lucia Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350302 Translational value of pathophysiological pathways and therapeutic agents on lipid dysmetabolism in the hepatobiliary and cardiovascular system: a bench‐to‐bedside project. Puglia Portincasa Piero Biomedical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02350303 Development of pre‐operative investigation OSPEDALE BAMBINO tools and surgical procedures for the GESU' treatment of movement disorders in childhood Marras Carlo Efisio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350309 Improving Prognostic Accuracy in Severe Traumatic Brain Injury with Diffusion Tensor Imaging MRI Combined with Cerebral Microdialysis Measurements of Axonal Proteins Magnoni Sandra Brain Disorders and Clinical Neuroscience Neurological diseases MAGGIORE Biomedical Pagina 122 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350312 Prospective study of molecular prognostic and Toscana predictive factors and pharmacokinetic analysis in patients with Gastrointestinal Stromal Tumor treated with targhet therapy gasperoni silvia Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350315 Early detection of chronic obstructive pulmonary disease induced by industrial pollutants by analysis of volatile organic compounds from exhaled breath. Puglia Perchiazzi Gaetano Clinical Cardiovascular and Respiratory Sciences Diseases of environmental origin, with reference also to the workplace RF‐2011‐02350318 Role of Interleukins and LOX‐1 in Niemann‐ Pick Type C Disease Neurodegeneration: possible new therapeutic targets and biomarkers. Istituto Superiore di Sanita' FRANK CLAUDIO Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350319 Effect of cognitive stimulation with Liguria computerized‐training (Rehacom) on cerebral metabolism evaluated by 18F‐FDG‐PET in patients with mild cognitive impairment (MCI) Del Sette Massimo Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02350320 Acyclovir treatment for external genital warts HPV‐related and relevance of co‐infections. Proof of concept project. SPALLANZANI Piselli Pierluca Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02350322 Titanium‐based third generation biomimetic scaffolds for bone tissue regeneration SAN MATTEO BENAZZO FRANCESC Biomedical O Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02350324 Veneto A GENETIC, CLINICAL AND SOCIAL INVESTIGATION OF DEMENTIA IN NORTH‐ EASTERN ITALY GALLUCCI MAURIZIO Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350327 Implementation of a next generation multigene test for prognostic stratification and tailored therapy in glioblastoma patients Brandes Alba Oncology 2 ‐ Translational Clinical Oncology Emilia‐Romagna Biomedical Pagina 123 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350330 Using available stimulation techniques to delay the onset of dementia S.CAMILLO Venneri Annalena Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350338 Mechanisms of diabetes resolution after bariatric surgery: role of the gut Toscana Nannipieri Monica Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350339 Effects of repetitive transcranial magnetic stimulation after early stroke: a study in children and developing rats STELLA MARIS Cioni Giovanni Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350340 Microbubble driven multimodal imaging and drug delivery for gliomas CARLO BESTA Di Meco Francesco Clinical Neurological diseases Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02350341 Early treatment of exercise‐induced pulmonary hypertension in systemic sclerosis Toscana matucci cerinic marco Clinical Immunology Infection and immunity RF‐2011‐02350347 An integrated genomic, transcriptomic and epigenomic approach in multiplex multiple sclerosis families. SAN RAFFAELE MILANO Martinelli Boneschi Filippo Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02350348 Acoustic Spectroscopy of Lung Toscana Demi Marcello Biomedical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02350351 Exploitation of genetically engineered oral carcinoma relapse models for development and pre‐clinical assessment of targeted combinatorial therapeutic strategies Emilia‐Romagna Sesenna Enrico Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350353 Genetic, immunologic and viral determinants of HIV‐1 disease progression Lombardia Riva Agostino Biomedical AIDS and Related Research Infection and immunity Pagina 124 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Santillo Elpidio Biomedical Biology of Development and Aging Metabolism disorders and cardiovascular disease Inflammatory and oxidative stress biomarkers Istituto Superiore di Sanita' associated with carotid atherosclerotic disease progression: a multi‐marker strategy to identify patients at risk of clinical events Profumo Elisabetta Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02350363 Manipulation of the extra‐uterine STELLA MARIS environment through infant massage in preterm infants: effects on brain structure and function (a RCT) Guzzetta Andrea Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350366 SAN RAFFAELE MILANO Genomics, epigenomics and transcriptomic investigation of defective peripheral tolerance in IPEX‐like patients Bacchetta Rosa Biomedical Genes, Genomes and Genetics Infection and immunity RF‐2011‐02350369 Biomechanical Characterization of carotid Plaque by Innovative Ultrasound in Stroke (BioCaPS) Toscana Palombo Carlo Biomedical Neurological diseases Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02350374 Effects of action observation therapy on rehabilitation of motor deficits of the dominant right upper limb in patients with MS: a study with structural and functional MRI. SAN RAFFAELE MILANO Rocca Maria Assunta Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350377 In situ proteomics profiling of membranous glomerulonephritis Lombardia Ferrario Franco Biomedical Digestive, Kidney and Urological Systems The new biotechnologies RF‐2011‐02350379 OXYGEN‐LOADED NANOBUBBLES (OLNs) AUXOLOGICO EFFECTS ON HYPOXIA‐DEREGULATED PRO‐ANGIOGENIC FACTORS IN GLIOMA, INFLAMMATION AND INFECTION MODELS. Brioschi Andrea Clinical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02350354 Endothelial progenitor cells, cardiovascular health and longevity.A prospective study in centenarians and their offspring from Marche. RF‐2011‐02350358 I.N.R.C.A. Pagina 125 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350383 Development of a cheap point‐of‐care assay for molecular diagnosis of legionellosis Istituto Superiore di Sanita' Scaturro Maria Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02350385 Estrogen, inflammation and cholesterol homeostasis: a "Bermuda Triangle" for CVD risk? Sicilia carruba giuseppe Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350387 Role of microRNAs in esophageal Sicilia carcinogenesis and the possible correlation between microRNA serum levels and different stages of esophageal disease Fiorentino Eugenio Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350388 Cell Stess Derived Primary Cell Transformation SDN Laukkanen Mikko Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350396 Nanoparticles as drug delivery system for the therapy of Mesothelioma and Pancreatic Cancer. PASCALE Iaffaioli Rosario Vincenzo Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350409 PYB ‐ Protect Your Back (Effectiveness of Back Istituto Superiore di Sanita' Protector in preventing spinal cord injuries) Giustini Marco Biomedical Risk, Prevention and Health Behavior Neurological diseases RF‐2011‐02350421 Restoring innate immunity by in vivo gene editing: Development of novel approaches to correct abnormal cilia motility in the respiratory airways and cure the primary ciliary dyskinesia in pediatric patients Toscana Pifferi Massimo Biomedical Genes, Genomes and Genetics Infection and immunity RF‐2011‐02350422 Effects of a controlled exercise intervention in modulating endothelial dysfunction and related humoral markers in coronary patients with type 2 diabetes DON GNOCCHI Ferratini Maurizio Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Pagina 126 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350423 New molecurar markers to characterize benign and malignant thyroid cells. Toscana Vitti Paolo Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350428 Molecular modeling of advanced/metastatic soft tissue sarcomas to develop evidence‐ based therapeutic targets and circulatory biomarkers RIZZOLI Benassi Maria Serena Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350430 Creation and Preclinical validation of stem cell‐functionalized bio‐substitutes for oral bone defects treatment Piemonte Carossa Stefano Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02350437 Application of nanomechanical assays to detection of algal toxins IZSLER Bertasi Barbara Biomedical Veterinary Food safety and animal welfare RF‐2011‐02350439 TRAIL‐producing UC‐MSCs as cytotherapy to defeat multiple myeloma: a preclinical study. ONCOLOGICO DI BARI SILVESTRIS FRANCESC Biomedical O Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350440 Fighting drug resistance in non‐small cell lung Piemonte cancer (NSCLC): a combinatorial approach based on anti‐Kit ligand vaccination Brizzi Maria Felice Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350444 Role of maternal intrapartum antibiotic prophylaxis on neonatal gut microbiota flora and onset of later allergy related diseases Zuccotti Gian Vincenzo Biomedical Immunology Infection and immunity RF‐2011‐02350445 Autoreactive T cell expansion under the SAN RAFFAELE MILANO influence of interleukin‐7 in patients with type I diabetes during beta cell replacemement therapy Monti Paolo Biomedical Immunology Infection and immunity RF‐2011‐02350449 Dissection of the effects of mesenchymal stem IRCCS AOU San Martino‐ cells on glial cells involved in neurogenesis IST (Genova) Uccelli Antonio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Lombardia Pagina 127 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350451 Role of deubiquitinases in resistance to treatment of ovarian carcinoma ISTITUTO TUMORI MILANO Perego Paola Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350453 Fertility preservation in young Oncological female patients REGINA ELENA Vizza Enrico Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Oncology RF‐2011‐02350455 Electromagnetic guided in‐situ laser fenestration of endovascular endoprosthesis Toscana Ferrari Mauro Biomedical Metabolism disorders Surgical Sciences, Biomedical Imaging, and cardiovascular and Bioengineering disease RF‐2011‐02350457 Multiplatform approach to dissect Wilms tumor heterogeneity ISTITUTO TUMORI MILANO Perotti Daniela Biomedical Oncology 2 ‐ Translational Clinical RF‐2011‐02350459 Impact of Carotid Endarterectomy and STenting on RhEological parameters and Autonomic Modulation (ICE‐STREAM study). SAN RAFFAELE MILANO Marrocco Trischitta Massimilian Clinical o Metabolism disorders Surgical Sciences, Biomedical Imaging, and cardiovascular disease and Bioengineering RF‐2011‐02350460 Genetics of dementia: transcriptional profiles in leukocytes for the identification of biomarkers associated to disease onset, phenotype and progression. FATEBENEFRATELLI Bonvicini Cristian Biomedical Biobehavioral and Behavioral Processes Neurological diseases RF‐2011‐02350464 New self‐powered devices for cochlear stimulation based on piezoelectric nanomaterials Toscana Berrettini Stefano Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02350465 Renal stress Echo: a new non invasive non ionizing imaging tool to assess renal sympathetic activity in arterial hypertension and cardiometabolic disease Toscana Fommei Enza Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Oncology Pagina 128 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02350468 Toscana Causes, diagnosis and treatment of unexplained neurobehavioral disorders: role of thyroid hormone cell membrane transporters and environmental contaminants. RF‐2011‐02350469 Biological bank to identify markers of disease activity related to clinical variables and modifying drugs in multiple sclerosis RF‐2011‐02350470 AREA P.I. Classificazione Area Strategica. Tonacchera Massimo Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases Emilia‐Romagna Granieri Enrico Clinical Immunology Neurological diseases New role of S‐nitrosoglutathione reductase (GSNOR) in aging and Alzheimer disease: How epigenetics regulates S‐nitrosylation‐ based signaling and nitrosative stress. SAN RAFFAELE PISANA Filomeni Giuseppe Biomedical Biology of Development and Aging Neurological diseases RF‐2011‐02350475 Metabolism, immune tolerance control and leukemia progression of Myelo Dysplastic Syndromes (MDS): a study of predictive criteria for clinical response to immune‐ modulating treatments. Basilicata Vita Giulia Biomedical Immunology Oncology RF‐2011‐02350484 Tumor Infiltrating Lymphocytes (TIL) and melanoma: prognostic markers and new terapeutic targets ISTITUTO DERMOPATICO Cavani DELL'IMMACOLATA Andrea Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350485 NEUROSTEROIDS AS DETERMINANTS OF ANTIEPILEPTIC DRUG REFRACTORINESS IN TEMPORAL LOBE EPILEPSY Emilia‐Romagna Biagini Giuseppe Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350488 Imaging the fate of stem cells in vivo by near infrared technology: a translational study for longitudinal tracking in a rodent model of Parkinsons disease AUXOLOGICO Cova Lidia Biomedical Emerging Technologies and Training in Neurosciences The new biotechnologies RF‐2011‐02350491 Role of the miR‐132~212 cluster in B‐cell receptor signaling in chronic lymphocytic leukemia: novel targets with therapeutic potential C.R.O. AVIANO Gattei Valter Biomedical Oncology 1 ‐ Basic Translational Infection and immunity Pagina 129 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350510 NEXT GENERATION SEQUENCING OF GLIOBLASTOMA IMMUNOEDITING AFTER DENDRITIC CELL IMMUNOTHERAPY CARLO BESTA Finocchiaro Gaetano Biomedical Oncology 2 ‐ Translational Clinical The new biotechnologies RF‐2011‐02350511 Realization of a database of clinical data for improving the outcome of the univentricular heart patient Istituto Superiore di Sanita' D'Avenio Giuseppe Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350512 High throughput technologies for uncovering new diagnostic biomarkers involved in the accelerated vascular ageing of patients with chronic kidney disease Puglia Pertosa Giovanni Battista Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350517 Inflammatory mechanisms underlying cortico‐ SANTA LUCIA hippocampal hyperexcitability in Alzheimer's disease: from in vitro and in vivo murine models to patient Berretta Nicola Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350520 Recurrent herpes virus infections as risk factor SAN RAFFAELE PISANA for Alzheimer`s disease PALAMARA ANNA TERESA Biomedical Infectious Diseases and Microbiology Neurological diseases RF‐2011‐02350531 Circulating Microvesicles: a Novel Biological Marker in Crohn's Disease Lazio Pola Roberto Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease RF‐2011‐02350532 Occurrence of Ostreopsis genus blooms in Tyrrhenian sea : tools to prevent human intoxication due to palytoxins contaminated seafood. Istituto Superiore di Sanita' Croci Luciana Biomedical Veterinary Food safety and animal welfare RF‐2011‐02350536 Improvement of diagnosis and immunotherapy appropriateness in mould allergic patients by characterization and standardization of mould allergenic extract. Istituto Superiore di Sanita' Pini Carlo Biomedical Immunology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02350537 Identification of environmental and genetic risk factors in Autism Spectrum Disorders Istituto Superiore di Sanita' Scattoni Maria Luisa Biomedical Biobehavioral and Behavioral Processes Neurological diseases Pagina 130 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02350540 Palitoxins: toxicity studies and development of IZSPLV new rapid methods of detection RF‐2011‐02350541 Inflammatory links between obesity, asthma and adaptive immunity in childhood RF‐2011‐02350542 AREA P.I. Classificazione Area Strategica. ERCOLINI CARLO Biomedical Veterinary Food safety and animal welfare Istituto Superiore di Sanita' Barletta Bianca Biomedical Immunology Infection and immunity Targeting late recurrence after adjuvant treatment for early breast cancer I.E.O. COLLEONI MARCO ANGELO Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350547 Neuroendocrine storm and postoperative depression in cardiac surgery Toscana Iervasi Giorgio Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350548 Estrogenic endocrine disruptors impact on autoimmunity onset and progression: the paradigm of Systemic Lupus Erythematosus Istituto Superiore di Sanita' Pierdominici Marina Clinical Immunology Infection and immunity RF‐2011‐02350549 Effect of bethametasone on acute attacks in episodic ataxia patients ‐ a pilot study Lazio Ristori Giovanni Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350550 Role of hypothermia in organ dysfunction after cardiac arrest Sicilia Gullo Antonino Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350552 Eating disorders and risk factors for metabolic Emilia‐Romagna and cardiovascular diseases. A follow‐up study after ten years from the initial diagnosis Scanelli Giovanni Clinical Biobehavioral and Behavioral Processes Metabolism disorders and cardiovascular disease RF‐2011‐02350556 Low‐cost cardio‐pulmonary monitoring system for avoidable death prevention in the hospital general ward Bini Roberto Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Piemonte Pagina 131 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350561 The early diagnosis of Alzheimer disease: new Toscana tools for the olfactory dysfunction evaluation. Sartucci Ferdinando Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350562 Identification of immune correlates of clinical Toscana activity and/or disease outcome in melanoma and mesothelioma patients undergoing immunotherapy or targeted therapy Maio Michele Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350564 Effects of a late add‐on therapy of pegylated Lombardia interferon (peg‐IFN¿) to ongoing nucleos(t)ide analogs (NUCs) in patients with chronic hepatitis B (CHB): dissecting systemic and hepatic immune restoration Marchetti Giulia Carla Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02350566 MicroRNA regulation in the pathogenesis of MD and in the mechanism of action of antidepressant drugs Bocchio‐ Chiavetto Luisella Biomedical Biobehavioral and Behavioral Processes Neurological diseases RF‐2011‐02350567 Focus on incidence and diversity of intestinal Piemonte methanogens and host‐gut microbiota metabolic interactions in healthy and diseased human groups. cassader maurizio Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350569 A MULTICENTRE PHASE II RANDOMIZED STUDY OF FULVESTRANT VERSUS FULVESTRANT + METFORMIN AS FIRST‐ AND SECOND‐LINE ENDOCRINE TREATMENT IN NON DIABETIC POSTMENOPAUSAL WOMEN WITH HORMONE RECEPTOR POSITIVE, HER‐2 NEGATIVE ADVANCED BREAST CANCER. THE META TRIAL. Vici Patrizia Clinical Oncology 2 ‐ Translational Clinical Oncology FATEBENEFRATELLI REGINA ELENA Clinical Pagina 132 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350571 Heterotypic interactions in thrombo‐ inflammatory processes associated with the thrombotic vascular occlusion in sepsis:the role of vitamin K‐dependent protein C SAN RAFFAELE MILANO Maugeri Norma Biomedical Immunology Infection and immunity RF‐2011‐02350573 Organic pollutant and plastic‐associated chemical effects on cardiovascular diseases: a sex‐gender issue Toscana Abbate Rosanna Clinical Cardiovascular and Respiratory Sciences Diseases of environmental origin, with reference also to the workplace RF‐2011‐02350578 IDENTIFICATION OF EPILEPTOGENIC NETWORKS IN SURGICAL EPILEPSIES BY A NON‐INVASIVE MULTIMODAL APPROACH CARLO BESTA Spreafico Roberto Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350588 Integrated approach to investigate the effect of environmental pollution on reproductive outcomes Emilia‐Romagna Colacci Annamaria Biomedical Genes, Genomes and Genetics Diseases of environmental origin, with reference also to the workplace RF‐2011‐02350590 Infective exacerbations of COPD, comorbidity Puglia and gender differences MORETTI ANNA MARIA Clinical Cardiovascular and Respiratory Sciences Infection and immunity RF‐2011‐02350593 Identification of inducers of skin wound repair for the treatment of non‐healing ulcers in diabetic patients ISTITUTO DERMOPATICO Napolitano DELL'IMMACOLATA Monica Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350597 Viral infections and related neurological and intestinal damages as possible factors triggering autism spectrum disorders Campania bravaccio carmela Clinical Brain Disorders and Clinical Neuroscience Infection and immunity RF‐2011‐02350598 MicroRNA Signature of Vascular Complications in Type 1 Diabetes Piemonte Cavallo Perin Paolo Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Pagina 133 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. gontero paolo Clinical Oncology 2 ‐ Translational Clinical Oncology Veneto Awareness and competence in mild to moderate Alzheimer's disease patients: clinical and forensic implications. Gambina Giuseppe Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350612 DEACETILASE INHIBITORS AS NEW TOOLS Piemonte TO CONTROL LOCAL INVASION AND METASTASIS OF ENDOCRINE‐RELATED TUMORS Fortunati Nicoletta Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350613 High‐throughput mutation profiling of Sézary ISTITUTO DERMOPATICO Russo Syndrome: implications for pathogenesis, DELL'IMMACOLATA classification, and potential therapeutic developments. Giandomeni Biomedical co Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350615 Characterization of the role of Mycobacterium Sardegna avium subspecies paratuberculosis (Map) as a trigger in Type 1 Diabetes Sechi Leonardo Antonio Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02350617 Determinants of Type 1 Diabetes (T1DM) clinical onset and progression in paediatric immigrant population Piemonte cerutti franco Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350619 Myocardial Infarction in Low Risk Patients: Integrating Risk Assessment with Tissue Biomarkers and Metabolomics Toscana Ferrannini Eleuterio Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350620 A diagnostic innovative software for surgical planning in hip arthroplasty for patients with hip dysplasia to optimize functional recovery. RIZZOLI Benedetti Maria Grazia Clinical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02350600 Validation of Reticulocalbin 1 (RCN‐1) as a new marker for renal cell carcinoma (RCC) in a large retrospective study by IHC and regulation analysis of protein expression. RF‐2011‐02350607 Piemonte Pagina 134 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350623 IZSME Paratuberculosis in sheep and goats herds in Calabria and human exposure to Mycobacterium avium subspecies paratuberculosis (MAP) trough dairy products Casaliuovo Francesco Biomedical Veterinary Food safety and animal welfare RF‐2011‐02350624 The use of biomarkers in the clinical study of Istituto Superiore di Sanita' multiple exposure to chemicals: new diagnostic strategies to evaluate human health risk. Mancinelli Rosanna Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace RF‐2011‐02350625 From the Aosta Valley to Sicily it is always melanoma but...: multicenter analysis of melanoma risk factor distribution in the Italian population and identification of a "melanoma risk index" for clinical purposes Piemonte QUAGLINO PIETRO Clinical Population Sciences and Epidemiology Oncology RF‐2011‐02350632 Comprehensive evaluation of the potential of engineered nanoparticles to induce bronchial hyperreactivity in exposed workers. Lazio ROGLIANI PAOLA Biomedical Bioengineering Sciences and Technologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02350634 Papillary Thyroid Cancer gender disparity: is the estrogen cancerogenesis related to stemness factors? Veneto Merante Boschin Isabella Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Oncology RF‐2011‐02350636 Occupational Mycobacterium tuberculosis SPALLANZANI infection among healthcare workers: assessing the burden and developing modern strategies for risk assessment and health surveillance Puro Vincenzo Clinical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02350640 Investigation on the sensitivity of dorsal raphe Toscana serotonergic neurons to hypercapnic stimuli in a transgenic mouse model of Sudden Infant Death Syndrome (SIDS) characterized by selective alteration of serotonergic neuron autoinhibition. CORRADETTI RENATO Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Pagina 135 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02350641 AREA P.I. Classificazione Area Strategica. Sicilia Soto Parra Hector Jose Clinical Oncology 2 ‐ Translational Clinical Oncology Assessment of Predictive Biomarkers of Outcome and Treatment Response in Primary Tumor and in Circulating Tumor Cells of Non‐Small Cell Lung Cancer Patients by Organization of a Clinical and Molecular Network in Sicily RF‐2011‐02350642 Prediction of preeclampsia:a proteomic approach for identification of novel biomarkers Istituto Superiore di Sanita' Margutti paola Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Infection and immunity RF‐2011‐02350645 Cell‐on‐Chip technology as an alternative to Istituto Superiore di Sanita' mouse model to evaluate allergenic potential of airborne substances and of preparations for allergen‐specific immunotherapy. AFFERNI CLAUDIA Biomedical Immunology Infection and immunity RF‐2011‐02350653 Erdheim‐Chester disease at the crossroad between clonality and inflammation: implications for therapy SAN RAFFAELE MILANO Ferrarini Marina Biomedical Immunology Infection and immunity RF‐2011‐02350657 Novel biological agents for the treatment of hormone‐refractory prostate cancer IRCCS AOU San Martino‐ IST (Genova) Ferone Diego Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350658 Translational approach to the cardiovascular effects of antipsychotics Piemonte Vacca Giovanni Biomedical Emerging Technologies and Training in Neurosciences Metabolism disorders and cardiovascular disease RF‐2011‐02350660 Influence of adipose derived mesenchymal stem cells and adipocytes on residual cancer cells growth in tumor bed. IRCCS AOU San Martino‐ IST (Genova) Santi Pier Luigi Biomedical Oncology 2 ‐ Translational Clinical Oncology Pagina 136 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE P.I. AREA Classificazione Area Strategica. DI GAUDIO FRANCESC Clinical A Healthcare Delivery and Methodologies Oncology Cell Biology Oncology RF‐2011‐02350661 Sicilia Risk assessment of patients and medical operators in diagnostic and therapeutic cancer procedures: clinical, chemical, physical and humanization aspects RF‐2011‐02350663 Involvement of p63 in tumor development, invasion and metastasis, and its relationship with the other members of the p53 family ISTITUTO DERMOPATICO Melino DELL'IMMACOLATA Gerry RF‐2011‐02350665 A pathology for the MET oncogene: 'cancers of unknown primary origin' (CUPs) Piemonte COMOGLIO Paolo Maria Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350666 Can mental training based on motor imagery speed up the rehabilitation of walking? Efficacy of a controlled procedure and neurofunctional bases of recovery in patients with total knee arthroplasty GALEAZZI Paulesu Eraldo Clinical Biobehavioral and Behavioral Processes Neurological diseases RF‐2011‐02350671 Cancer and adolescence: what clinical and sociological approach? A preliminary project in Italy C.R.O. AVIANO Mascarin Maurizio Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02350672 Clinical implications of gene polymorphism (TAAA)n of sex hormone‐binding globulin in breast cancer patients with or without hormone‐therapy. ONCOLOGICO DI BARI Quaranta Michele Biomedical Genes, Genomes and Genetics Oncology RF‐2011‐02350673 Screening for Autoimmune Polyglandular Syndrome Type 2 in patients with autoimmune thyroiditis: definition of methodology and cost‐benefit analysis. Toscana Pacini Furio Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Infection and immunity RF‐2011‐02350683 Ebstein‐virus (EBV) and Human herpesvirus 6 SAN RAFFAELE MILANO (HHV‐6) infection in Multiple Sclerosis: a trigger for autoimmunity Malnati Mauro Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Biomedical Pagina 137 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350684 Emilia‐Romagna Impact of the association between elastography and fine‐needle aspirate mutational testing in the prediction of malignancy of thyroid nodules with indeterminate cytology: a prospective analysis. Ceresini Graziano Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350686 I.E.O. Investigating epigenetic patterns induced by different diets and food for cancer‐‐preventive health enhancement LUZI LUCILLA Biomedical Genes, Genomes and Genetics Food safety and animal welfare RF‐2011‐02350689 Role of regulatory cells and cytokines in the Istituto Superiore di Sanita' extent of colonic involvement in patients with ulcerative colitis: implications for patient‐ oriented therapy Boirivant Monica Biomedical Digestive, Kidney and Urological Systems Infection and immunity RF‐2011‐02350693 To unravel the molecular basis of neurodevelopmental disorders CASA SOLLIEVO SOFFERENZA Carella Massimo Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02350698 Development of functionalized magnetic nanoparticles (VIVIT‐MNP) for IBD treatment: possible involvement of NFAT transcription factor Lombardia Sampietro Gianluca Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02350700 The Lectin pathway as a therapeutic target in stroke Lazio Rasura Maurizia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350703 In vitro assessment of lactic acid bacteria for suitability as probiotics in calves to improve health in newborns and to contrast neonatal mortality Istituto Superiore di Sanita' MARIANELLI CINZIA Biomedical Veterinary Food safety and animal welfare Pagina 138 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Ugolini Donatella Clinical Oncology 2 ‐ Translational Clinical Oncology Gene mutation profiling in primitive non‐ Piemonte small cell lung cancer and corresponding metastases. Prognostic‐predictive implications. Alabiso Oscar Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350708 Development of miniaturized assays for the timely diagnosis of rare diseases Piemonte ROCCATELLO DARIO Biomedical Musculoskeletal, Oral and Skin Sciences The new biotechnologies RF‐2011‐02350711 Attenuation of the Hippo pathway by praja2 reduce glioblastoma growth NEUROMED Arcella Antonietta Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350712 Virological and immunological studies on HIV Istituto Superiore di Sanita' infection in fragile populations in Italy: social and health implications. sanarico nunzia Clinical AIDS and Related Research Infection and immunity RF‐2011‐02350715 Aging‐related platelet transcriptome variations in atherothrombosis Umbria GRESELE PAOLO Biomedical Biology of Development and Aging Metabolism disorders and cardiovascular disease RF‐2011‐02350718 SARCOGLYCANS: SIGNALLING FUNCTION IN DIFFERENT CELLULAR COMPARTMENTS AND POSSIBLE ROLE IN GENETIC THERAPIES. NEUROLESI VENZA MARIO Biomedical Genes, Genomes and Genetics The new biotechnologies RF‐2011‐02350719 ROLE OF WT1 AND ITS ISOFORMS IN HEMATOPOIETIC MALIGNANCIES Campania IZZO PAOLA Clinical Genes, Genomes and Genetics Oncology RF‐2011‐02350722 Role of transmembrane chemokines in neuroprotection following brain ischemia NEUROMED Limatola Cristina Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350704 IS IT TIME TO SELECT PATIENTS WITH MALIGNANT PLEURAL MESOTHELIOMA (MPM) WHO MIGHT BENEFIT FROM AGGRESSIVE TREATMENT AND PROSPECTIVELY ANALYZE ONCOLOGIC AND FUNCTIONAL RESULTS? RF‐2011‐02350706 IRCCS AOU San Martino‐ IST (Genova) Pagina 139 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350723 Preclinical Development of Novel Small Androgen Receptor Modulating Molecules (SARMs) in Experimental Human Prostate Cancer Model. Istituto Scientifico Romagnolo Tesei Anna Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350727 Molecular determinants of malignancy, invasiveness and response to therapy of Oro‐ pharyngeal squamous cell carcinomas. A molecular and Redox proteomics compaative analysis of HPV positive and HPV negative invasive tumours. REGINA ELENA De Marco Federico Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350730 Sicilia Optimization, on the basis of Monte Carlo dosimetry, of the therapeutical effectiveness and toxicity of Peptide Receptor Radionuclide Therapy in patients with neuroendocrine tumors Minutoli Fabio Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350731 The italian network of fertility preservation in Lazio women with cancer. Maneschi Francesco Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350732 ANTI‐HPV CANCER THERAPY BY ENGINEERED EXOSOMES INCORPORATING siRNAs AND miRNAs Istituto Superiore di Sanita' Chiantore Maria Vincenza Biomedical Bioengineering Sciences and Technologies Oncology RF‐2011‐02350733 Co‐transcriptional and post‐transcriptional regulation of gene expression by EWS and EWS‐FLI1 in the pathogenesis of Ewing's Sarcoma SANTA LUCIA PARONETTO MARIA PAOLA Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350734 A mathematical‐experimental model of beta‐ ARCISPEDALE amyloid diffusion in Alzheimer disease and its application to early diagnosis marcello Clinical Brain Disorders and Clinical Neuroscience Neurological diseases norina Pagina 140 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. DESSOLE SALVATOR Biomedical E Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Lazio ANALYSIS OF NEW FEATURES OF THYROID CANCER FROM A LARGE SCALE DATABASE TO IMPROVE THE QUALITY OF CLINICAL PRACTICE AND REDUCE PUBLIC HEALTH COSTS Bellantone Rocco Clinical Domenico Alfonso Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350750 Computerized registry of cardiovascular emergencies Umbria Boschetti Enrico Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02350753 Advanced MRS, ASL perfusion and structural MRI in pediatric migraine: a longitudinal study and correlations with clinical and neurophysiological findings. OSPEDALE BAMBINO GESU' Valeriani Massimilian Clinical o Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350754 Role of metabotropic glutamate receptor in absence epilepsy NEUROMED Nicoletti Ferdinando Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350763 Identification of molecular signature in thyroid carcinoma to improve Fine Needle Aspiration Biopsy Accuracy Sicilia Frasca Francesco Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350764 Improving cost effectiveness of anti‐ osteoporotic drugs by increasing compliance and persistence. Piemonte ISAIA GIOVANNI Clinical CARLO Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02350735 Identification of potential early biomarkers of pre‐eclampsia in pregnant women RF‐2011‐02350736 Sardegna Biomedical Pagina 141 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350768 The development of metabolic syndrome, insulin resistance and vitamin D deficiency during androgenic deprivation therapy in prostate cancer: role on prostate cancer prognosis and cardiovascular morbidity. Campania Pivonello Rosario Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Oncology RF‐2011‐02350769 Potential role of HDL Cholesterol Efflux Capacity in the evaluation of cardiovascular risk in patients with Familial Hypercholesterolemia (FH) IRCCS AOU San Martino‐ IST (Genova) pisciotta livia Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350771 DEVELOPMENT AND EVALUATION OF AN Lazio INTEGRATED STEPPED EDUCATION AND CARE TRAINING MODEL FOR THE SELF REGULATION OF HEALTH BEHAVIORS (HB) TO PREVENT AND TREATH THE METABOLIC SYNDROME IN PRIMARY AND SECONDARY SERVICES. Ferracuti Stefano Clinical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease RF‐2011‐02350773 Immunologic, autonomic and metabolic components of exercise medicine in cancer survivors HUMANITAS LUCINI DANIELA Clinical Risk, Prevention and Health Behavior Oncology RF‐2011‐02350774 Targeting inflammasome for seizure prevention CARLO BESTA Librizzi Laura Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350788 Prognostic and predictive potential of miRNA SAN MATTEO signatures linking cancer to inflammatory and fibrotic diseases ROSSI SANDRO Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350789 Biomolecular and Biosensor innovative approaches to guarantee Protected Designation of Origin (PDO) Water Buffalo Mozzarella Cheese CORRADO FEDERICA Biomedical Veterinary Food safety and animal welfare IZSME Pagina 142 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350790 Evaluation of the antitumor response of a co‐ Toscana treatment with LHRH analogues in women with endometrial cancer at the initial diagnosis NOCI IVO Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350793 IZSUM Evaluation of the immune response against Mycobacterium avium subsp. paratuberculosis in humans and animals Mazzone Piera Biomedical Veterinary Infection and immunity RF‐2011‐02350795 Immuno‐predictors of cardiovascular risk in patients with psoriatic arthritis ARCISPEDALE Salvarani Carlo Clinical Immunology Metabolism disorders and cardiovascular disease RF‐2011‐02350797 Building of MM associated vascular niche to dissect MM‐endothelial cells dialogue SAN RAFFAELE MILANO Ferrero Elisabetta Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350798 MONDINO The development of standardized tests in order to evaluate the role of the cerebellum in cognitive functions Vecchi Tomaso Elia Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350800 Short term cultures of surgical tissue slices to evaluate the sensitivity of breast cancer subtypes to the anti‐tumor effects of all‐trans retinoic acid and derived retinoids: identification of the cellular and molecular determinants Gardini Giorgio Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350801 Implementation of Chronic Care Model, using Toscana Tele‐care and Home care, in patients with multiple comorbidities: evaluation of the cost‐ effectiveness and quality of life Paggiaro Pierluigi Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease ARCISPEDALE Pagina 143 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350804 Preclinical characterization of new molecular and nanoconjugated imaging agents for stratification and monitoring of cancer anti‐ angiogenesis treatment with Bevacizumab Toscana Pupi Alberto Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350805 A National Electronic Library for Oncology (aNELO) REGINA ELENA Cognetti Francesco Biomedical Healthcare Delivery and Methodologies Oncology RF‐2011‐02350807 Safety of workers with implanted medical devices in MRI environment: criteriafor occupational risk evaluation Istituto Superiore di Sanita' Giovanni Calcagnini Biomedical Diseases of Surgical Sciences, Biomedical Imaging, environmental origin, with reference also to and Bioengineering the workplace RF‐2011‐02350811 The impact of HBV and HCV expression and SPALLANZANI replication on cellular differentiation, metabolism and oncogenesis in extra‐ or intra‐ hepatic stem cells induced to differentiate along the hepatocytic lineage Valli Maria Beatrice Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02350812 Single‐dose intravenous iron in patients with functional iron deficiency after acute myocardial infarction: impact on hospital‐ acquired anemia, cardiovascular and functional status AUXOLOGICO Malfatto Gabriella Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350814 Molecular and cellular mechanisms of vestibular compensation Piemonte Albera Roberto Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02350816 Rapid eye movement sleep behavior disorder (RBD): Prevalence study in Italian general population aged > 50 years SAN RAFFAELE MILANO Ferini Strambi Luigi Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350822 Gold compounds, potential anticancer agents with an innovative mode of action: mechanistic studies and in vivo evaluation Toscana Mazzei Biomedical Oncology 2 ‐ Translational Clinical Oncology Teresita Pagina 144 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350825 Immunological and virological monitoring of opportunistic virus infections in systemic lupus erythematosus patients SAN MATTEO Calarota Sandra Amelia Biomedical Immunology Infection and immunity RF‐2011‐02350830 Obesity and inflammation: new mechanistic insights from whole exome sequencing and analysis of microRNA regulation by dietary polyphenols. Istituto Superiore di Sanita' Scazzocchio Beatrice Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350831 Innovative treatment of Primary Progressive Aphasias (PPA) using transcranial direct current stimulation (tDCS) combined with language training FATEBENEFRATELLI Cotelli Maria Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350832 Immune therapy with T regulatory type 1 (Tr1) SAN RAFFAELE MILANO cells in patients with type 1 diabetes undergoing islet transplantation Roncarolo Maria Grazia Biomedical Immunology Infection and immunity RF‐2011‐02350836 New nano‐systems for targeted delivery of cytokines to tumors SAN RAFFAELE MILANO Corti Angelo Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350839 Telemedicine network for diagnosis and care of congenital heart malformations Toscana Festa Pierluigi Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02350842 In search of new drugs and drug‐targets for the diagnosis and therapy of Invasive Fungal Infections (IFIs) Istituto Superiore di Sanita' Sandini Silvia Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02350851 Development of innovative methods for radiobiological optimization of molecular radiotherapy treatments I.E.O. CREMONESI MARTA Clinical Bioengineering Sciences and Technologies The new biotechnologies Pagina 145 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350852 Phase I/II clinical trial of dendritic cell therapy I.E.O. for the treatment of metastatic melanoma based on an innovative way to generate a whole repertoire of tumor peptides via gap junction pores TESTORI ALESSAND Clinical RO Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350853 Identification and validation of novel stem cell I.E.O. markers for the stratification of breast cancer patients. DI FIORE PIER PAOLO Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350855 Development and validation of software tools I. O. V. to use radiation dose data extracted from digital medical images for radiation protection purposes Gennaro Gisella Maria Clinical Oncology Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02350857 Role of anoctamin‐1 in iodide transport and implications for the efficacy of radioiodine‐ based cancer therapy. Emilia‐Romagna Tallini Giovanni Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Oncology RF‐2011‐02350858 Predictive and prognostic value of molecular markers for glioma in clinical decision making CARLO BESTA Silvani Antonio Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350859 Microglia‐based device as a biosensor for Amyotrophic Lateral Sclerosis pathogenesis SANTA LUCIA Amadio Susanna Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350861 Gender effect on the pleiotropic actions of statins on lipoproteins and platelets from elderly women affected by Type 2 diabetes mellitus I.N.R.C.A. Rabini Rosa Anna Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease Pagina 146 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350863 Characterization of molecular markers that are associated with DNA‐damage repair pathways to identify rectal cancer patients who are responsive to chemioradiotherapy Piemonte Venesio Tiziana Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350865 Colorectal carcinogenesis: Study, in vivo and in vitro, of the molecular mechanisms of cell differentiation of the human colon cancer cells DE BELLIS Messa Caterina Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350869 Decisions of health care management and cost NEUROLESI accounting in Neuroscience and Severe Acquired Brain Damage (SABD) Catalfo Pierluigi Clinical Healthcare Delivery and Methodologies Neurological diseases RF‐2011‐02350871 Effects of n‐6:n‐3 fatty acid ratio of fat Piemonte emulsions on the fatty acid composition in red blood cell membranes and plasma lipoproteins Massarenti Paola Clinical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease RF‐2011‐02350873 AUDIT clinico e percorsi di miglioramento Lombardia nelle cure dei pazienti con infezione nelle unità di pneumologia ad alta intensità di cura (UTIR, unità di terapia intensiva respiratoria e UMR, Unità di Monitoraggio Respiratorio) della REGIONE LOMBARDIAClinical Centanni Stefano Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02350874 EFFECTS OF NUTRACEUTICAL SPIRULINA ENRICHED‐DIET DURING PREGNANCY AND LACTATION ON NEURODEVELOPMENTAL DISORDERS AND SUSCEPTIBILITY TO INFLAMMATION OF THE PROGENY De Simone Roberta Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02350875 Use of Limbal Adult Stem Cells for Osteo and Sicilia Condrocyte Differentiation and Application in Bone and in Cartilage Regeneration and Tissue Engineering (ABADIR PROJECT) GIORDANO CARLA Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies Istituto Superiore di Sanita' Pagina 147 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350876 Mechanisms and actions of Regorafenib (Stirvaga), a new hepatocarcinoma (HCC) therapy DE BELLIS Carr Brian Irving Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02350877 Economic Impact of Target Agents and their Side Effects Piemonte Fusco Vittorio Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350884 RESPIRATORY TRAINING IN HEART FAILURE: A NON‐INVASIVE METHOD TO INCREASE THE CHOLINERGIC ANTI‐ INFLAMMATORY PATHWAY MAUGERI La Rovere Maria Teresa Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350888 Immunomodulation by mesenchymal stem cells as a potential therapeutic strategy for endometriosis. SAN RAFFAELE MILANO Candiani Massimo Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies RF‐2011‐02350889 Prospective Characterization of Circulating Tumor Cells in Patients with Hormone Receptor Positive Metastatic Breast Cancer I.E.O. SANDRI MARIA TERESA Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350890 Biomarkers investigation in multiple sclerosis: Sicilia analysis of microvesicles isolated by CSF driven by patients with different disease phenotypes. Evaluation of their effects on an experimental model of blood brain barrier and microRNA pattern expression ana Ragonese Paolo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350891 Discovery and validation of clinical biomarkers for lung neuroendocrine neoplasms from formalin‐fixed paraffin‐ embedded tissues Fanciulli Giuseppe Biomedical Oncology 2 ‐ Translational Clinical Oncology Sardegna Pagina 148 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. NITSCH LUCIO Biomedical Oncology 2 ‐ Translational Clinical Oncology AUXOLOGICO Cardiotrophin‐1 as a biomarker of left ventricular dysfunction in Hypertensive Heart Disease Zanchetti Alberto Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350900 Chest pain in the Emergency Department : the IRCCS AOU San Martino‐ IST (Genova) role of diabetes, dyslipidemia and obesity in the incidence of ACS in population with/without a history of CAD. Mortality, reinfarction and survival related factors ballarino paola Clinical Population Sciences and Epidemiology Metabolism disorders and cardiovascular disease RF‐2011‐02350903 Medication overuse headache as a form of dependence Emilia‐Romagna Zoli Michele Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350906 'Septosomes': System Biology and Pathogenetic Role of Exosomes in Sepsis‐ associated Immune‐paralysis and Organ Failures Piemonte Cantaluppi Vincenzo Biomedical Immunology Infection and immunity RF‐2011‐02350914 Analytical and clinical validation of assays for PARP1/PAR related biomarkers. ONCOLOGICO DI BARI Mangia Annita Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350917 CANCER IN IMMUNOCOMPROMISED C.R.O. AVIANO POPULATIONS, HIV‐INFECTED (HIV) PATIENTS, ORGAN TRASPLANT RECIPIENTS (OTRs) and HIV‐OTRs: NEW PREVENTIVE and TREATMENT STRATEGIES FOR SOLID TUMOURS Vaccher Emanuela Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350923 Producing iPS cells: a biobank service for translational genetic research Coviello Domenico Biomedical Genes, Genomes and Genetics The new biotechnologies RF‐2011‐02350897 Primary cancer cells as models to test new drugs and to personalize the therapy RF‐2011‐02350898 Campania Liguria Pagina 149 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Toscana AREA P.I. Classificazione Area Strategica. Rossi Marco Clinical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease Saggioro Daniela Biomedical Oncology 2 ‐ Translational Clinical Oncology SDN Daniele Aurora Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease IZSSA Cabras Piera Angela Biomedical Veterinary Food safety and animal welfare REALE STEFANO Biomedical Cell Biology Neurological diseases Provincia autonoma Bolzano Schönhuber Evaluation of clinical feasibility and effectiveness of a robotic device for early stage rehabilitation of stroke patients Rudolf Biomedical Emerging Technologies and Training in Neurosciences Neurological diseases Animal and human monoamine oxidases inhibition as a new strategy against anthracyclines‐induced mitochondrial cardiotoxicity in cancer therapy CARLO Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350927 Study of macro‐ and micro‐vascular damage in patients chronically exposed to cigarette smoking and of the impact of this assessment on the adherence of smokers to smoking cessation programs RF‐2011‐02350928 Genetic polymorphisms in genes of drug‐ I. O. V. related and DNA repair pathways as predictive markers of the therapeutic efficacy in esophageal carcinoma RF‐2011‐02350933 ANALYSIS OF ADIPONECTIN SYSTEM AS NEW TARGET FOR DIAGNOSIS AND THERAPY OF CHRONIC OBSTRUCTIVE PULMONARY PATIENTS WITH COEXISTENT CARDIOVASCULAR DISEASE RF‐2011‐02350942 Risk of human and animal exposure to cyanotoxins through fresh‐ and brackish‐ water reared organisms in connected ponds systems RF‐2011‐02350943 Finding of common potential new biomarkers IZSSI for development of diagnostic tools in different neurodegenerative diseases and discovery of new therapeutic agents RF‐2011‐02350946 RF‐2011‐02350948 I.E.O. CIPOLLA Pagina 150 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350950 Development of a model for quantitative risk assessment of tick‐borne diseases in Italian urban parks Istituto Superiore di Sanita' Vescio Maria Fenicia Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02350951 Antibody deficiency disorders as risk factors for gastric cancer Emilia‐Romagna Simona Ferrari Clinical Immunology Oncology RF‐2011‐02350955 Neurocognitive deficits related to Toscana cardiosurgery intervention with extracorporeal circulation. Correlations between neuropsychological performances and functional MRI techniques (Spectroscopy, Diffusion and Morphometry) Montanaro Domenico Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350960 A mirror‐neurons based stimulation protocol (MNSP) to improve language and behavior in mild to moderate people with Alzheimer Disease DON GNOCCHI Farina Elisabetta Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350961 Integrated panel of biomarkers to evaluate seafood exposure to emerging contaminants along the Ligurian coasts and associated human health risks (IBIDEM) IZSPLV Squadrone Stefania Biomedical Veterinary Food safety and animal welfare RF‐2011‐02350962 Efficacy of Magnetic Fields stimulation for the Piemonte treatment of human gastric cancer associated, or not, to pathogen Helicobacter pylori infection. Ponzetto Antonio Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02350967 Veneto THE OUTCOME OF DEPRESSION AND TYPE 2 DIABETES MELLITUS WHEN THEY ARE COMORBID: A COMPARISON BETWEEN TELEMEDICINE‐ASSISTED CARE AND TREATMENT AS USUAL Burti Lorenzo Clinical Biobehavioral and Behavioral Processes Neurological diseases Pagina 151 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350971 The role of early systematic best palliative care Istituto Scientifico versus on request palliative care consultation Romagnolo during standard oncologic treatment for patients with advanced gastric or pancreatic cancers: a randomized, controlled, multicenter trial Maltoni Marco Cesare Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02350972 MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF MECHANISMS INVOLVED IN IRON HOMESTASIS AND HEME SYNTHESIS IN ß THALASSEMIC ERYTHROPOIESIS MAGGIORE Cappellini Maria Domenica Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02350975 Immunological and virological predictors of clinical outcome in chronic HBV patients discontinuing anti‐viral treatment SPALLANZANI D'offizi Gianpiero Biomedical Immunology Infection and immunity RF‐2011‐02350978 Upper limb dysfunction in acquired brain injury: Comparison of the clinical effectiveness of 2 intensive rehabilitation therapy programs in children MEDEA Strazzer Sandra Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350980 Disruption of white matter integrity in bipolar SAN RAFFAELE MILANO disorder: changes of diffusion tensor imaging measures as markers of the biological underpinnings of the progressive deterioration of cognition and of the cognitive control of emotions. Benedetti Francesco Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350982 Incidence, persistence and clearance of anal Human Papillomavirus infection in a cohort of immunocompetent and immunocompromised males: a longitudinal study. Giuliani Massimo Biomedical Infectious Diseases and Microbiology Infection and immunity SAN GALLICANO Pagina 152 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02350984 Intraventricular injection of Peripheral Blood Stem Cells during coronary artery bypass grafting in patients with heart failure induced by previous myocardial infarction. Campania LUCCHETTI VINCENZO Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02350993 Investigation of a novel engineered probiotic to treat Clostridium difficile infection SAN RAFFAELE MILANO Furci Lucinda Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02350996 Perturbed hydrogen sulphide content in Amyotrophic Lateral Sclerosis: a possible player in motor neurons degeneration? SANTA LUCIA Longone Patrizia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02350999 Early identification of left ventricular PASCALE dysfunction due to anthracyclines and target‐ therapy: role of novel imaging techniques and microRNA. Maurea Nicola Biomedical Cardiovascular and Respiratory Sciences Oncology RF‐2011‐02351002 Lombardia Molecular profiling of adult Acute Lymphoblastic Leukemia for risk stratification and treatment definition Rambaldi Alessandro Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351004 Postoperative radiotherapy to the chest wall or the breast plus draining nodes in breast cancer patients: dosimetric comparison between 3DCRT, IMRT, helical tomotherapy and TomoDirect tomotherapy. Umbria Aristei Cynthia Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351007 MODULATION OF INTERHEMISPHERIC CONNECTIVITY AS A POTENTIAL TREATMENT IN STROKE PATIENTS: A COMBINED TRANSCRANIAL MAGNETIC STIMULATION AND FUNCTIONAL MAGNETIC RESONANCE IMAGING APPROACH. NEUROLESI Quartarone Angelo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases Pagina 153 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351009 A multidisciplinary investigation for the improvement of aortic endografting: from biomedical engineering concepts to clinical implementation. SAN DONATO Trimarchi Santi Clinical Metabolism disorders Surgical Sciences, Biomedical Imaging, and cardiovascular disease and Bioengineering RF‐2011‐02351010 Glioma‐associated stem cells: an innovative patient based approach for prognostic, predictive and therapeutic purposes. Friuli‐Venezia Giulia skrap miran Clinical Brain Disorders and Clinical Neuroscience Oncology RF‐2011‐02351012 In vivo safety and tolerability of sorghum based gluten free products in coeliac patients Campania Malamisura Basilio Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Food safety and animal welfare RF‐2011‐02351013 Improving appropriateness of biopharmaceutical treatments in Multiple Sclerosis: early identification of non responders, dosage and timing redefinition, mechanism of action and neurotoxicity of an "old" and a "new" drugs. Piemonte Bertolotto Antonio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351015 Toscana Realization of a protocol for the rapid identification of etiological agent/s responsible for sepsis directly from peripheral blood of septic subjects, by integration of molecular biology, mass‐spectrometry and classical methods. Degl'innocenti Roberto Biomedical Infectious Diseases and Microbiology The new biotechnologies RF‐2011‐02351018 Risk of cardiovascular disease in breast cancer Toscana patients: a population based study CALDARELLA ADELE Biomedical Population Sciences and Epidemiology Oncology RF‐2011‐02351021 Modeling and taming the genotoxicity of viral SAN RAFFAELE MILANO vector integration Montini Biomedical Genes, Genomes and Genetics The new biotechnologies Eugenio Pagina 154 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351024 Genetic polymorphisms and noninvasive scores for screening patients with progressive nonalcoholicfatty liver disease (NAFLD): an international multicenter collaborative study Piemonte Musso Giovanni Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease RF‐2011‐02351026 Chemotherapies of stem‐cells‐based solid vascularized tumors: from the bench to the bedside passing through equations I.E.O. D'ONOFRIO ALBERTO Biomedical Bioengineering Sciences and Technologies Oncology RF‐2011‐02351043 The BRCAness profile: from the molecular basis to the clinical relevance Toscana Caligo Maria Adelaide Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02351044 Origin and significance of residual viremia in SPALLANZANI virologically suppressed HIV‐infected patients. Abbate Isabella Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02351045 Istituto Superiore di Sanita' Molecular signature of the progression of hepatitis C virus (HCV) chronic infection to hepatocellular carcinoma: exosome associated microRNAs and protein profiling in experimental and clinical settings ruggieri anna Clinical Oncology 2 ‐ Translational Clinical Infection and immunity RF‐2011‐02351046 The purinergic P2X7 receptor on human cardiac fibroblast: a new therapeutic target to control cardiac remodelling in chronic heart failure? Toscana Laghi Pasini Franco Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351047 GENetics of familial and sporadic Lone Atrial Fibrillation (GenLAF) SAN MATTEO ARBUSTINI ELOISA Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351048 Marine omega‐3 fatty acids and vitamin D for SAN MATTEO QTc prolongation in people with psychosis on antipsychotic drugs. DE FERRARI GAETANO Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Pagina 155 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Mantovani Alberto Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diseases of environmental origin, with reference also to the workplace NEW BIOMARKERS IN WORKERS EXPOSED MAUGERI TO INORGANIC ARSENIC Minoia Claudio Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351056 Epigenetic analyses in heart failure Piemonte Bergerone Serena Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02351058 New targets for therapy in breast cancer: dietary induced inhibition of mammalian target of rapamycin (mTOR) SDN Fontana Luigi Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351061 Pediatric Cardiomyopathy: new genetic diagnostic approach by next generation sequencing (NGS) and its relation to therapeutic efficacy SDN FRISSO GIULIA Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02351064 ALTERED HOST‐MICROBE INTERACTION IN HIV: A POTENTIAL TARGET FOR INTERVENTION WITH PROBIOTICS Lombardia BANDERA ALESSAND Clinical RA AIDS and Related Research Infection and immunity RF‐2011‐02351065 Development of guidelines for the management of cluster of cancer and other diseases in areas with environmental criticalities and translation for public health decision‐makers. Toscana Petronio Maria Grazia Clinical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351066 THE MENTAL HEALTH OF UNIVERSITY STUDENTS: AN ITALIAN WEB‐BASED SURVEY FATEBENEFRATELLI De Girolamo Giovanni Clinical Risk, Prevention and Health Behavior Neurological diseases RF‐2011‐02351051 Neonatal development, neuro‐endocrine programming and mother‐child exposure to pesticides: a translational prevention study (NATAL) RF‐2011‐02351053 Istituto Superiore di Sanita' Pagina 156 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Campiglio Manuela Biomedical Oncology 2 ‐ Translational Clinical Oncology Michetti Fabrizio Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases MELE ALFONSO Biomedical Oncology 2 ‐ Translational Clinical Infection and immunity Direct management of litigation: a real chance Toscana to improve the Italian National Health System Norelli Gian‐ Aristide Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351075 Orthopoxvirus infection in Italy: diffusion and SPALLANZANI evaluation of innovative vaccine candidates Castilletti Concetta Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351076 Non‐coding RNAs as prognostic markers for treatment personalization of cutaneous melanoma Veneto PILATI PIERLUIGI Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351077 Dissecting the pathogenesis and possible reversibility of cachexia in end‐stage chronic heart failure Sicilia Gridelli Bruno Biomedical Musculoskeletal, Oral and Skin Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351078 The use of nanoparticles in food technology: silver nanoparticles behaviour in complex food matrices and antibacterial resistance implications IZSVE Cibin Veronica Biomedical Veterinary Food safety and animal welfare RF‐2011‐02351069 CDCP1 as a Therapeutic Target in Triple‐ Negative Breast Cancer ISTITUTO TUMORI MILANO RF‐2011‐02351071 SAN RAFFAELE PISANA Cellular and Molecular events related to neuroprotection and modulation of endogenous neurogenesis: role of estrogens in an in vivo model of hippocampal neurodegeneration. RF‐2011‐02351073 Serum and tissue miRs as biomarkers for diagnosis and prognosis of B‐NHL in chronically HBV or HCV‐infected patients RF‐2011‐02351074 Istituto Superiore di Sanita' Pagina 157 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351092 "Detection of pathological prion protein in cerebrospinal fluid by real‐time quaking induced conversion (QuIC): Evaluation and standardization of a novel disease‐specific laboratory test for the diagnosis of sporadic Creutzfeldt‐Jakob disease." Istituto Scienze Neurologiche Parchi Piero Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351093 Intestinal microbiota and chronic inflammatory disease in children. Toscana Lionetti Paolo Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351102 Muscle toxicity of proteasome inhibitor bortezomib Veneto VATTEMI GAETANO Biomedical NICOLA ALFIO Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351104 Piemonte Antibiotic strategy and response to microbiologic tests: a study of appropriateness and promptness in case of sepsis. rocchetti andrea Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351113 Fighting impaired blood flow and supporting skeletal muscle regeneration in diabetes and peripheral artery disease (PAD): an approach based on unacylated ghrelin (UAG) administration Piemonte Dentelli Patrizia Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02351114 Role of autophagy and cell oxidation in Hungtinton Disease (HD) Piemonte Gallone Salvatore Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351116 NEW ALLOCATION CRITERIA FOR LIVER TRANSPLANTATION IN PATIENTS WITH AND WITHOUT HEPATOCELLULAR CARCINOMA BASED ON TRANSPLANT BENEFIT PRINCIPLES: A MULTICENTER, PROSPECTIVE STUDY. Emilia‐Romagna Cescon Matteo Clinical Healthcare Delivery and Methodologies Oncology Pagina 158 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. De Luca Maria Clinical Brain Disorders and Clinical Neuroscience Neurological diseases ROCCA ANDREA Biomedical Oncology 2 ‐ Translational Clinical Oncology MATTEOLI MICHELA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases IDENTIFICATION OF NEW STRATEGIES TO Sicilia IMPROVE THE OUTCOME OF TRAUMATIC BRAIN INJURY AND BRAIN ISCHEMIA: PRECLINICAL AND CLINICAL STUDIES ON NEW TARGETS AND ALREADY CLINICALLY AVAILABLE DRUGS Cuzzocrea Salvatore Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351129 Process modelling as a tool to support integrated care pathway implementation in lung cancerpatients. Friuli‐Venezia Giulia Fasola Gianpiero Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02351132 Prevention of antibody‐mediated chronic allograft injury in a prospective longitudinal study in renal transplant patients Veneto Cozzi Emanuele Biomedical Immunology The new biotechnologies RF‐2011‐02351133 Rehabilitative Homework tool in young adults STELLA MARIS with Down syndrome to prevent cognitive decline: neuropsychological and clinical study. Bargagna Stefania Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351137 Pathophysiology of central fatigue in patients with multiple sclerosis: an integrated neurophysiologic and neuroimaging approach. Girlanda Paolo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases SANTA LUCIA RF‐2011‐02351123 Comprehensive diagnostic and rehabilitation tools in the assessment and treatment of Neglect dyslexia RF‐2011‐02351125 Istituto Scientifico Multifactorial study, with metabolomic Romagnolo profiling and circulating tumor cell characterization, of microscopic residual disease and its evolution after surgery for early breast cancer RF‐2011‐02351126 The Impact of Prenatal Immune Deregulations on Synaptopathies: the case of maternal cytomegalovirus infection. RF‐2011‐02351127 HUMANITAS NEUROLESI Pagina 159 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. D'Amico Gennaro Clinical Digestive, Kidney and Urological Systems Infection and immunity A novel in‐vivo diagnostic test for Creutzfeldt‐ Istituto Superiore di Sanita' Jakob disease (CJD) patients by nasal brushing Pocchiari Maurizio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351149 Dominant optic atrophy (DOA) and OPA‐ Istituto Scienze thies in Italy (ITA‐DOA): minimal prevalence, Neurologiche genetics and phenotypes, and cell models of disease towards a therapy. Carelli Valerio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351150 New insight in the prevention of knee osteoarthritis progression: correlation between joint biomechanics and molecular cartilage homeostasis RIZZOLI Leardini Alberto Biomedical Musculoskeletal, Oral and Skin Sciences The new biotechnologies RF‐2011‐02351152 Topical propranolol administration to preserve visual function in newborns with retinopathy of prematurity. Toscana Filippi Luca Biomedical Cell Biology Neurological diseases RF‐2011‐02351153 A genomic and proteomic approach to explore Istituto Superiore di Sanita' phenotype variability in Gerstmann‐Sträussler‐ Scheinker syndrome (GSS) linked to P102L mutation in the PRNP gene Ladogana Anna Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351155 Mental and physical health status of workers receiving redundancy payment Piemonte d'Errico Angelo Clinical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351156 Serum miRNAs as circulating biomarkers for the early diagnosis of ovarian cancer I.E.O. COLOMBO NICOLETT Clinical A Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351139 Phase IV clinical trial of anti‐viral treatment for Hepatitis C infection in compensated cirrhosis RF‐2011‐02351145 Sicilia Pagina 160 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351157 ROLE OF DORSOLATERAL PREFRONTAL CORTEX IN LONG TERM RECOGNITION MEMORY: TRANSCRANIAL MAGNETIC STIMULATION APPROACHES FOR TREATMENT OF LONG TERM MEMORY DEFICITS IN AMNESIC PATIENTS SANTA LUCIA TURRIZIANI PATRIZIA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351158 Beta‐adrenoceptor antagonism and biased agonism in the control of pathological neovascularization Istituto Superiore di Sanita' costa tommaso Biomedical Biological Chemistry and Macromolecular Biophysics Metabolism disorders and cardiovascular disease RF‐2011‐02351160 Reduction/elimination of exposure to ionizing OSPEDALE BAMBINO radiation in interventional electrophysiology GESU' procedures in children using technology based on 3D mapping systems. Drago Fabrizio Biomedical Cardiovascular and Respiratory Sciences The new biotechnologies RF‐2011‐02351164 Hypothyroidism and Endometrial function during Blastocyst Implantation. Lazio VALENSISE HERBERT Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351165 Translational genetics of hereditary spinocerebellar degenerations: high‐ throughput exome sequencing and model organisms for the identification and characterization of novel disease genes CARLO BESTA Taroni Franco Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02351168 A multicentre randomized trial on the use of early non‐invasive ventilation to reduce the need for intensive care unit. SAN RAFFAELE MILANO Cabrini Luca Clinical Infection and immunity Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02351170 NEW STRATEGY FOR DRUG DELIVERY IN PHOTODYNAMIC THERAPY OF GLIOBLASTOMA Istituto Superiore di Sanita' MOLINARI AGNESE Biomedical Brain Disorders and Clinical Neuroscience Oncology Pagina 161 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione Area Strategica. defabianis patrizia Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases Modulation of treatment of elderly patients C.R.O. AVIANO with Diffuse Large B‐cell Lymphoma guided by Comprehensive Geriatric Assessment combined with metabolomic investigations to identify specific patients frailty profiles predictive of treatment toxicity Spina Michele Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351189 Multidisciplinary Intervention Protocol in metabolic emergencies in Anorexia Nervosa Emilia‐Romagna Manzato Emilia Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02351193 NETWORK DEGENERATION IN MOTOR NEURON DISEASES (MND): A STUDY OF THE STRUCTURAL AND FUNCTIONAL CONNECTOMES IN AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MND SAN RAFFAELE MILANO Filippi Massimo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351195 The activation of vestibular system as a possible tool for inducing analgesia, speeding up recovery from stroke and facilitating recovery from vegetative and minimal conscious state Toscana Bonfiglio Luca Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351200 Colonization and infection by extensively‐ drug resistant carbapenemase‐producing Enterobacteriaceae: towards a better understanding of the emergence and dynamics of colonization within the complex ecosystem of the human gut microbiome, of relationships be Toscana Rossolini Gian Maria Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351175 A simple set of tools for large‐scale multi‐ parametric screening of sensory‐motor functions of the cervico‐cranial area. A combined longitudinal and cross‐sectional study in 4‐14 years old children RF‐2011‐02351178 Piemonte AREA P.I. Pagina 162 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Brain Disorders and Clinical Neuroscience Neurological diseases Giovambatti Clinical sta Integrative, Functional, and Cognitive Neuroscience Neurological diseases Splendiani Alessandra Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Lazio campione elena Clinical Oncology 2 ‐ Translational Clinical Oncology SANTA LUCIA Galati Gaspare Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases EGFR‐TK inhibitors vs Chemotherapy: SAN RAFFAELE MILANO Improving Treatment Selection for Non Small Cell Lung Cancer (NSCLC) Patients using VeristratTM Serum Proteomic Profile Classification and Serum Amyloid A Gregorc Vanesa Clinical Oncology 2 ‐ Translational Clinical Oncology Study of genetic variability oF HCV genotype 4 strains circulating in Lazio and analysis of their resistance pattern correlated to new DDA drug Garbuglia Anna Rosa Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351202 Inhibition of endocannabinoids‐hydrolyzing enzymes as a new therapeutic target for migraine treatment: studies in animal models and preliminary evaluation in humans MONDINO Tassorelli Cristina RF‐2011‐02351203 Evaluation of the effects of cocoa flavanol on cognitive function in subjects at high cardiovascular risk Abruzzo Desideri RF‐2011‐02351205 Role of environmental light in the epidemiology of Parkinson¿s disease. Abruzzo RF‐2011‐02351207 Clinical and genetic study of the predisposition to Renal Cancer in women affected by uterine fibroids and families with Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome RF‐2011‐02351216 Cortico‐cortical functional connectivity and recovery of post‐stroke spatial attention and awareness disorders RF‐2011‐02351222 RF‐2011‐02351223 SPALLANZANI Biomedical Pagina 163 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Calabrò Rocco Salvatore Clinical Brain Disorders and Clinical Neuroscience Neurological diseases Stress‐Activated Protein Kinases MLK3 and SAN RAFFAELE MILANO p38 as novel therapeutic targets in chemokine‐ driven leukocyte extravasation and non‐ resolving inflammatory processes Pardi Ruggero Biomedical Immunology Infection and immunity RF‐2011‐02351230 In vitro and in vivo antimicrobial activities of Campania innovative and unconventional drug combinations to treat infections caused by multi‐drug‐resistant (MDR), extensively‐drug‐ resistant (XDR) or pandrug‐resistant (PDR) Acinetobacter baumannii and Pseudomonas Zarrilli Raffaele Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351243 Smoking reduction in a population at high Provincia autonoma Trento risk of cardiovascular mortality. Randomized control trial of intervention to implement and improve tobacco control strategies in psychiatric settings versus combined pharmacological and psychological intervention MANTOVANI WILLIAM Clinical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease RF‐2011‐02351250 Prevention of chronic kidney disease (CKD) progression by hypoxia‐inducible‐prolyl‐ hydroxylases (HIF‐PHs) inhibition: role of SIRT1 and autophagy Esposito Ciro Biomedical Digestive, Kidney and Urological Systems The new biotechnologies RF‐2011‐02351253 Early Retinal Neuroprotection as a Novel Tool SAN RAFFAELE MILANO to Achieve the Primary Prevention of Diabetic Retinopathy Zerbini Gianpaolo Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351224 Sexual function in epileptic male patients RF‐2011‐02351229 NEUROLESI MAUGERI Pagina 164 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351259 Pre‐eclampsia: the role of genetics in understanding the etiopathogenesis and evaluation of early predictive biomarkers SAN RAFFAELE MILANO Smid Maddalena Biomedical Marina Barbara Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies RF‐2011‐02351263 Educational intervention to reduce sugar‐ sweetened beverages purchase at the supermarket. A community trial. Piemonte Bo Simona Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351266 Clinical evaluation of the mirror implantable microscope (LMI) in improving visual acuity in patients with end‐stage or dry age‐related macular degeneration. Veneto Bellucci Roberto Clinical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02351272 An integrated genomic and immunological Emilia‐Romagna approach to novel monitoring and therapeutic strategies for HBV and HCV infections Ferrari Carlo Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351274 Imaging pREdictors of outcome after Surgical myOcardiaL revascUlarizaTION [RESOLUTION trial] Lazio Galiuto Leonarda Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351275 Identification of biological markers as predictors of brain plasticity and indicators of the efficacy of rehabilitation in post‐stroke patients AUXOLOGICO Mauro Alessandro Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351276 IDENTIFICATION OF AN AUTOIMMUNE AETIOLOGY, AS DETERMINED BY SERUM AUTOANTIBODIES TO LGI1 AND OTHER CELL‐SURFACE MEMBRANE PROTEINS, IN TEMPORAL LOBE EPILEPSIES OF OTHERWISE UNKNOWN AETIOLOGY Istituto Scienze Neurologiche Michelucci Roberto Brain Disorders and Clinical Neuroscience Neurological diseases Biomedical Pagina 165 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351277 Bionanotechnology and stem cells to control peri‐implantitis infection Veneto Bressan Eriberto Biomedical Bioengineering Sciences and Technologies Infection and immunity RF‐2011‐02351278 AFTEREIGHT study: anticipated boost with intraoperative electrons (IORT) followed by short‐course hypofractionated whole breast radiotherapy in early breast cancer patients. I.E.O. LUINI ALBERTO Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02351295 biomarkers characterization in the glatiramer acetate therapy of relapsing multiple sclerosis Puglia De Masi Roberto Biomedical Emerging Technologies and Training in Neurosciences Neurological diseases RF‐2011‐02351296 Molecular identification of new poor prognostic subgroups of childhood Acute Lymphoblastic Leukemia as candidate for targeted therapies Lombardia Cazzaniga Giovanni Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351305 Compound Seropositivity of neutralizing antibodies against Adipogenic Adenoviruses (ADV36+ and ADV 37+): effect of nutritional intervention on overweight‐obesity, Non‐ Alcoholic‐Fatty‐Liver‐Disease (NAFLD) and on Insulin Resistance. Sicilia Catalano Daniela Biomedical Digestive, Kidney and Urological Systems Infection and immunity RF‐2011‐02351306 Role of autophagy impairment in the progression from steatohepatitis to hepatocarcinoma in Hepatitis C patients. SPALLANZANI Fimia Gian Maria Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351307 A Next‐Generation Sequencing approach to MONZINO assess blood‐based transcriptomic biomarkers in Coronary Artery Disease Colombo Gualtiero Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Clinical Pagina 166 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. MIGLIORI Franco Clinical Musculoskeletal, Oral and Skin Sciences Metabolism disorders and cardiovascular disease Cytokine profile in ocular surface diseases and Sicilia upper airways disorders: development of medical devices for ophthalmology and otorhinolaryngology use. Avitabile Teresio Clinical Brain Disorders and Clinical Neuroscience Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351314 A long term control of biofilms and Legionella Istituto Superiore di Sanita' contamination of dental unit waterline to prevent patients and occupational infections using a natural terpinen‐4 ol. ricci maria luisa Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351315 HPV positive oropharyngeal cancer: characterization of immunological and viral profiles, and their role in the response to treatment SAN MATTEO PEDRAZZOLI PAOLO Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351319 Treatment of early osteoarthritis by death‐ inducible, IL‐10 expressing adipose‐derived stem cells: a novel, safe, anti‐inflammatory and regenerative approach. GALEAZZI Peretti Giuseppe Biomedical Musculoskeletal, Oral and Skin Sciences The new biotechnologies RF‐2011‐02351320 Determinants of functional recovery in elderly ARCISPEDALE hip fracture subjects admitted to orthogeriatric units: a multicentre observational study Pioli Giulio Clinical Musculoskeletal, Oral and Skin Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351323 S.CAMILLO Longitudinal comparative study to assess progression and predictive factors of ognitive decline in patients with advanced Parkinson's disease treated with deep brain stimulation of the subthalamic nucleus stimulation and pharmacological therapy pilleri manuela Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351310 Ultimate and stable healing of chronic ulcers of the lower limbs with long lasting patient recovery: a great achievement of dramatic social impact with minimal financial commitment. RF‐2011‐02351311 IRCCS AOU San Martino‐ IST (Genova) Pagina 167 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Curti Antonio Biomedical Oncology 2 ‐ Translational Clinical Oncology Vannucchi Alessandro Biomedical Maria Oncology 2 ‐ Translational Clinical Oncology Toscana Marcocci Claudio Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease SAN RAFFAELE MILANO Montorsi Francesco Clinical Oncology 2 ‐ Translational Clinical Oncology Tissue proteome and secretome of benign and Toscana malignant parathyroid tumors: identification of molecular and biochemical biomarkers for early diagnosis of parathyroid cancer Cetani Filomena Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351350 Reduced aspirin action in preventing cardiovascular events in diabetic patients: molecular and cellular studies on megakaryocyte progenitor cells and platelets. Guerriero Raffaella Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02351351 Identification of new causative mechanisms SAN RAFFAELE MILANO underling Brugada Syndrome and advanced functional analysis in patient‐specific induced pluripotent stem‐cell models. Ferrari Maurizio Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Emilia‐Romagna RF‐2011‐02351324 INTERACTION OF ACUTE MYELOID LEUKEMIA CELLS WITH NATURAL KILLER CELLS: BIOLOGICAL ASPECTS AND CLINICAL IMPLICATIONS RF‐2011‐02351329 Identification of biomarkers associated with Toscana clinical response and/or toxicity to treatment with the JAK2 inhibitor ruxolitinib in patients with myelofibrosis RF‐2011‐02351338 Project Title: Development of a dedicated evaluation track within the Hospital and a network between the Hospital and family doctors for the identification, evaluation and management of patients with osteoporotic fractures RF‐2011‐02351342 CHEMOPREVENTIVE EFFICACY OF GREEN TEA EXTRACTS IN PROSTATE CANCER PROGRESSION. CLINICAL AND MOLECULAR STUDY ON MECHANISM OF ACTION RF‐2011‐02351343 Istituto Superiore di Sanita' Pagina 168 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione Area Strategica. Cristaudo Antonio Clinical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace Inhibition of the Hedgehog Signaling Pathway Toscana for the Treatment of Patients with Osteosarcoma frediani bruno Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351358 Dietary advanced glycation end products and Istituto Superiore di Sanita' cardiovascular risk: animal and human studies Riganò Rachele Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351361 Intranasal delivery of nano‐modified drugs for Toscana the treatment of glioblastoma vannozzi riccardo Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02351364 Applied Helicobacter pylori immunoproteomic, molecular and 3D structural approaches in gastric diseases to better understand the process of tumorigenesis and diagnostic biomarker discovery in early stage Gastric cancer C.R.O. AVIANO De Re Valli Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351367 MicroRNA: new markers for the diagnosis of occult hepatitis B Istituto Superiore di Sanita' Ciccaglione Anna Rita Biomedical Infectious Diseases and Microbiology The new biotechnologies RF‐2011‐02351369 Measuring outcomes to estimate the value of health interventions in breast cancer care C.R.O. AVIANO Crivellari Diana Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02351377 Epidemiological profiles and cost patterns of cancer patients (EpiCost) Istituto Superiore di Sanita' Francisci Silvia Giovanna Luisa Biomedical Healthcare Delivery and Methodologies Oncology RF‐2011‐02351383 Safety of general anaesthesia (GA) in neonatal Emilia‐Romagna and pediatric age: neurotoxicity of drugs as revealed by neuropsychological indexes and biomarkers Baroncini Simonetta Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351354 Toxicological risk assessment of metal and metal‐nanoparticles (MNp) in tattoing and after tattoo laser removal by in‐vivo and in‐ vitro studies RF‐2011‐02351357 SAN GALLICANO AREA P.I. Pagina 169 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351388 Prevention of restenosis after percutaneous transluminal angioplasty (PTA) MULTIMEDICA Losa Sergio Clinical Metabolism disorders Surgical Sciences, Biomedical Imaging, and cardiovascular disease and Bioengineering RF‐2011‐02351390 Role of angiotensin‐converting enzyme inhibitors on cardioprotection against anticancer therapy‐induced cardiotoxicity: in vivo clinical evidences along with in vitro studies. I.E.O. CARDINALE DANIELA MARIA Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351391 Prevention of haemorrhagic events by minimally invasive monitoring of anticoagulant therapy Toscana Paolicchi Aldo Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02351394 The role of purinome in kidney chronic allograft dysfunction: extracellular ATP as a new possible early marker and trigger of fibrosis Emilia‐Romagna La Manna Gaetano Clinical Digestive, Kidney and Urological Systems The new biotechnologies RF‐2011‐02351398 Identification of mycobacterial cell surface molecules as molecular markers of disease Campania Donnarumma Giovanna Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351403 Can we predict the cognitive status in mild SAN RAFFAELE PISANA cognitive impairment (MCI) subjects who had a traumatic brain injury (TBI) basing on neurophysiological and biological markers? DEL PERCIO CLAUDIO Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351405 BIOSAFETY OF HUMAN MESENCHYMAL STEM CELLS: GENOMIC AND MEMBRANE STABILITY FOR A BETTER CLINICAL APPROACH TODROS TULLIA Biomedical Genes, Genomes and Genetics The new biotechnologies RF‐2011‐02351409 Spatially variant prescription of dose radiation CROB from hypoxic tumor distribution assessed by VEGF expression and biological imaging: a phases I‐II study in non small cell lung cancer Nappi Antonio Biomedical Oncology 2 ‐ Translational Clinical Oncology Piemonte Pagina 170 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RIZZOLI AREA P.I. Classificazione Area Strategica. Blalock William Biomedical Vascular and Hematology Oncology Ficorella Corrado Biomedical Oncology 2 ‐ Translational Clinical Oncology Salonia Andrea Clinical Oncology 2 ‐ Translational Clinical Oncology A CLINICAL AND MORPHOLOGICAL Toscana INVESTIGATION OF BOTULINUM TOXIN‐A TREATMENT FOR NEUROGENIC DETRUSOR OVERACTIVITY: OUTCOMES, CORRELATION BETWEEN URODYNAMIC PATTERN AND EXPRESSION OF UROTHELIUM AND SUBUROTHELIUM ION CHANNELS AND NEUROKININ RECEPTORS IN SPINA Del popolo Giulio Giuseppe Biomedical Digestive, Kidney and Urological Systems Neurological diseases RF‐2011‐02351428 Surveillance on the use of oral anticoagulant drugs in patients with atrial fibrillation MAGGIORE Moia Marco Clinical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02351432 The complement and coagulation systems as therapeutic targets in subarachnoid hemorrhage: studies in patients and in experimental models. MAGGIORE Stocchetti Nino Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351410 Nuclear Signaling Mediated by the Innate Immune/Inflammtory Kinase PKR as a Therapeutic Target and Prognostic Indicator of Disease Progression and Therapeutic Response in Myelodysplastic Syndromes and Acute Leukemia RF‐2011‐02351419 TrkAIII expression in Glioblastoma: Abruzzo Significance in prognosis, relationship to therapeutic response and role in pathogenesis and progression. RF‐2011‐02351426 ENDOCRINE AND INTRACRINE METABOLISM OF SEX STEROIDS ‐ PROSTATE HEALTH AND CANCER OUTCOMES FROM A 20‐YEAR POPULATION‐BASED STUDY RF‐2011‐02351427 SAN RAFFAELE MILANO Pagina 171 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351438 PRECLINICAL AND CLINICAL PILOT STUDIES TO ACCESS THE SAFETY AND EFFICACY OF THE USE OF HUMAN ADIPOSE TISSUE‐DERIVED MESENCHYMAL STEM CELLS TO PROMOTE TOLERANCE INDUCTION AND Sicilia Spada Marco Biomedical Immunology The new biotechnologies RF‐2011‐02351439 STUDY ON THE ANTIDEPRESSANT ACTIVITY OF FINGOLIMOD IN EXPERIMENTAL ANIMAL MODELS AND PATIENTS WITH MULTIPLE SCLEROSIS NEUROMED Bruno Valeria Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351443 Recovery of Women Living in Disadvantaged Areas of the Abruzzo Region and Not Adhering to Screening for Cervical Cancer Abruzzo Altobelli Emma Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02351450 Alteration of steroid hormone pathways and vitamin D in testicular germ cell tumors PASCALE Franco Renato Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351454 Microglial markers of central sensitization in neuropathic pain. A translational study Veneto Tamburin Stefano Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351455 Identification and validation of new molecular Campania targets in the treatment of EGFR‐resistant NSCLC BIANCO ROBERTO Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351459 INTEGRATION OF GENOMIC MEDICINE: THE USE OF ADPKD AS A MODEL Emilia‐Romagna magistroni riccardo Biomedical Genes, Genomes and Genetics The new biotechnologies RF‐2011‐02351460 Overweight, Obesity and Risk of Western Disease(WD): a cohort prospective study in a mediterranean area DE BELLIS Osella Alberto Ruben Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Pagina 172 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Giovanni Biomedical Oncology 2 ‐ Translational Clinical Oncology Conca Biomedical Biobehavioral and Behavioral Processes Neurological diseases Pichiecchio Anna Biomedical Musculoskeletal, Oral and Skin Sciences Neurological diseases Marche DEALES ALBERTO Clinical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace EFFECT OF ATORVASTATIN ON OXIDATIVE STRESS AND INFLAMMATION AND ON OXIDATIVE STRESS‐INDUCED UNFOLDED PROTEIN RESPONSE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: RELATION WITH ARTERIAL STIFFNESS AND LUNG FUNCTION DECLINE Veneto cominacini luciano Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351472 Influence of cell‐cell adhesion molecules expression on the metastatic growth of colon cancer stem cells in liver. ONCOLOGICO DI BARI Bellizzi Antonia Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02351474 Dysregulated RNA metabolism in multiple myeloma SAN RAFFAELE MILANO Tonon Giovanni Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02351461 Evaluation of the activity of HIV protease or reverse transcriptase inhibitors against experimental models of uterine cervical tumours Istituto Superiore di Sanita' Barillari RF‐2011‐02351462 Biological endophenotypes associated to the electroconvulsive therapy in treatment resistant depression. Provincia autonoma Bolzano Andreas RF‐2011‐02351467 Facioscapulohumeral muscular dystrophy: to MONDINO define non‐invasive outcome measures and elucidate molecular mechanisms underlying muscle degeneration by means of longitudinal muscle MRI studies, immunological assessment and biomolecular characterization of a RF‐2011‐02351470 Health Care Professionals as Second Victims After Adverse Events RF‐2011‐02351471 Pagina 173 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351475 Targeting streptococcal infections in the management of patients with psoriasis Toscana Caproni Marzia Clinical Musculoskeletal, Oral and Skin Sciences Infection and immunity RF‐2011‐02351476 A preclinical cohort of rare pediatric liver tumorgrafts to test the efficacy of conventional and innovative anticancer therapy and unravel the functional basis of tumorigenesis BURLO GAROFALO cairo stefano Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351482 Randomised Controlled Trial on lifestyle impact on health outcomes in the general population invited to mammography and colorectal cancer screening programmes. Piemonte Giordano Livia Biomedical Risk, Prevention and Health Behavior Oncology RF‐2011‐02351484 Evaluation of rubella immunity among pregnant women and development and evaluation of a postpartum and post‐abortion rubella vaccination protocol in a sample of Italian hospitals Istituto Superiore di Sanita' Rota Maria Cristina Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351485 Clinical relevance of biomarkers involved in EGFR signalling pathway in the outcome of KRAS wild‐type colorectal cancer patients treated with cetuximab‐based therapy Campania Ciardiello Fortunato Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351486 Alternative splicing of PRK2 in Parkinson's disease Sicilia Zappia Mario Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02351487 Development of new strategies for the optimization of bone substitutes in clinical applications Abruzzo Adriano Piattelli Clinical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02351488 A PHASE II STUDY OF AUTOLOGOUS Emilia‐Romagna BONE MARROW ‐ DERIVED STEM CELL TRANSPLANTATION FOR THE TREATMENT OF CHRONIC END STAGE LIVER DISEASE Andreone Pietro Clinical Digestive, Kidney and Urological Systems The new biotechnologies Pagina 174 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351490 THE USE OF SENTINEL ANIMALS TO EVALUATE THE ROLE OF ENVIRONMENTAL CHEMICAL POLLUTION IN YOUNG WOMEN WITH BREAST CANCER LIVING IN SINs (NATIONAL iNTEREST SITES) IZSME Baldi Loredana Biomedical Veterinary Food safety and animal welfare RF‐2011‐02351491 Peptidomimetic inhibitors of aspartyi proteinases as novel therapeutics to fight mucosal candidiasis Umbria Vecchiarelli Anna Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02351516 Improving therapeutical potential of histone deacetylases inhibitors in non‐small cell lung cancer REGINA ELENA Del Bufalo Donatella Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351519 Toxic and infective agents as potential cause of congenital malformations of domestic ruminant calves in southern Italy. IZSME Esposito Mauro Biomedical Veterinary Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351523 Proof‐of‐principle investigation of NAMPT inhibitors in cancer and inflammatory states Piemonte Boldorini Renzo Luciano Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351524 Testing EunetHTA Core Model for national HTA reporting on relevant techonologies Agenzia per i Servizi Sanitari Regionali Cicchetti Americo Biomedical Healthcare Delivery and Methodologies The new biotechnologies RF‐2011‐02351532 Birth outcomes in women with cancer: a population based cohort study ISTITUTO TUMORI MILANO Tagliabue Giovanna Clinical Population Sciences and Epidemiology Oncology RF‐2011‐02351538 The Mitochondrial culprit in Amyotrophic Lateral Sclerosis: unravelling a novel molecular pathway to regulate VDAC1 in the disease's etiology SANTA LUCIA Spalloni Alida Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Pagina 175 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Lavorgna Giovanni Biomedical Oncology 2 ‐ Translational Clinical Oncology MONDINO Understanding the interaction between inflammatory factors profile in stroke patients to design a tailored therapeutic approach Candeloro Elisa Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351549 Acute coronary syndrome and long term outcome: the role of nitric oxide synthesis in red blood cells MONZINO Marenzi Giancarlo Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351552 A genome‐based and functional approach to improve the diagnosis and define the molecular basis of syndromic and non‐ syndromic intellectual disability Piemonte Brusco Alfredo Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351554 Mechanisms of extracranial organ damage after acute brain injury: role of protective mechanical ventilation in reducing incidence of acute respiratory distress syndrome and attenuating systemic inflammation in acute neurologically ill patients Piemonte Mascia Luciana Biomedical Cardiovascular and Respiratory Sciences Neurological diseases RF‐2011‐02351555 Methylene blue in hypotensive vasoplegic patients. A randomized trial. SAN RAFFAELE MILANO Landoni Giovanni Clinical Metabolism disorders Surgical Sciences, Biomedical Imaging, and cardiovascular disease and Bioengineering RF‐2011‐02351556 In vivo model for tissue engineering of urethral reconstruction on bio‐absorbable scaffold or recellularized matrixes Sicilia Cimador Marcello Biomedical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02351559 Can we predict the degradation of cognitive status in hearing loss subjects with mild cognitive impairment based on "fluid", neurophysiological and neuroimaging markers? SAN RAFFAELE PISANA Babiloni Claudio Clinical Brain Disorders and Clinical Neuroscience RF‐2011‐02351539 Validation of a Prognostic Gene Signature in Urine Samples from Prostate Cancer Patients RF‐2011‐02351546 SAN RAFFAELE MILANO Neurological diseases Pagina 176 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351560 Integration of Diagnostic tools for fibromyalgia: can tailored therapies be more effective and less expensive? Piemonte Torta Riccardo Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02351568 MicroRNA detections in Exhaled Breath Condensate and blood of Malignant Mesothelioma Patients and Healthy Subjects exposed to Asbestos. MAGGIORE Riboldi Luciano Biomedical Oncology 1 ‐ Basic Translational Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351570 Role of intestinal microbiota in the Emilia‐Romagna occurrence of systemic septic complications in patients with post‐traumatic spinal cord and cerebral injury. Barbara Giovanni Biomedical Digestive, Kidney and Urological Systems Infection and immunity RF‐2011‐02351571 Vaccination strategies to prevent infections in OSPEDALE BAMBINO splenectomized patients GESU' Carsetti Rita Biomedical Immunology Infection and immunity RF‐2011‐02351581 Discovery and validation of circulating Emilia‐Romagna biomarkers for the early diagnosis, assessment of prognosis and response to treatments in primary liver tumors on cirrhosis Bolondi Luigi Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351583 Acute coronary syndromes in diabetic and non‐diabetic patients: differences in the inflammatory, immunological, and coagulation events. Campania Rossi Francesco Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351596 A multidisciplinary approach to optimize the clinical management of patients and make it ready to the new diagnostic and therapeutic opportunities. The case of arrhythmogenic inherited diseases. Piemonte Giustetto Carla Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351604 Molecular featutes and treatment of plexiform CARLO BESTA neurofibromas in neurofibromatosis 1. Eoli Marica Clinical Brain Disorders and Clinical Neuroscience Neurological diseases Pagina 177 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351606 A novel approach for detecting vector‐borne viruses in Sardinia and evaluation of Bluetongue virus evolution. IZSAM Savini Giovanni Biomedical Veterinary Food safety and animal welfare RF‐2011‐02351612 Molecular basis of Treatment‐Resistant Depression FATEBENEFRATELLI Scassellati Catia Biomedical Biobehavioral and Behavioral Processes Neurological diseases RF‐2011‐02351613 Aphasia. Theory for Therapy. S.CAMILLO Semenza Carlo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351616 Combining Unconventional T cells with Vaccination in Renal Cell Carcinoma Immunotherapy Puglia Ranieri Elena Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351635 Antibiotic resistant bacteria and ready to eat salads: are they really ready to be consumed? IZSME Amoroso Maria Grazia Biomedical Veterinary Food safety and animal welfare RF‐2011‐02351639 Effectiveness of oncology drugs of AIFA Oncology Register IRCCS AOU San Martino‐ IST (Genova) REBESCO BARBARA Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351646 Assessment of animal welfare in extensive farms of Mediterranean Area: dairy ewes and buffaloes IZSSA Nicolussi Paola Biomedical Veterinary Food safety and animal welfare RF‐2011‐02351652 Diagnostic, prognostic, and monitoring markers based on muscular, neurophysiological and neuroimaging markers in dystonic patients. A pilot clinical study SDN Marzano Nicola Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351653 STRATEGIES FOR THE CONTROL OF SKIN INFECTIONS BY DRUG RESISTANT BACTERIA WITH NATURAL PRODUCTS. Istituto Superiore di Sanita' Mondello Francesca Biomedical Infectious Diseases and Microbiology Infection and immunity Pagina 178 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351655 Piemonte Identification of molecular targets and markers to manage hormone‐resistant obesity‐ associated breast cancer: from in vitro and in vivo models to human tumors Nicoletta Biglia Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351656 GISSI Outliers ‐ The CAPIRE (Coronary Atherosclerosis in outlier subjects: Protective and Individual Risk factor Evaluation) study ‐ The Life Style sub‐study MAUGERI Sommaruga Marinella Biomedical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease RF‐2011‐02351659 Assessing the exposure of children and other vulnerable population groups to priority dietary contaminants Istituto Superiore di Sanita' D'Amato Marilena Biomedical Veterinary Food safety and animal welfare RF‐2011‐02351660 ARIEL‐ Air Pollution and Cardiovascular Risk Investigations: the Epigenomic Link MAGGIORE Pesatori Angela Cecilia Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02351663 Clinical Impact of Image guided hypofractionated intensity modulated radiotherapy in the treatment of prostate, lung and head and neck cancers Emilia‐Romagna Bertoni Filippo Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351666 Sleep disorders in neuromuscular diseases: a Lazio comprehensive clinical and polisomnographyc study regarding myotonic dystrophies type 1 and type 2 and spinal bulbar muscular atrophy (SBMA). romigi andrea Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351675 Rational and innovative design of immunogens based on HIV‐1 clade C Env proteins specifically mutated in glycan moieties for broadly effective vaccine purpose Istituto Superiore di Sanita' Cenci Alessandra Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02351680 A diagnostic and therapeutic consensus approach to multiple sclerosis in the neurological network of Verona province Veneto Benedetti Maria Donata Brain Disorders and Clinical Neuroscience Neurological diseases Clinical Pagina 179 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351688 Istituto Superiore di Sanita' Development of a biotech system for natural compound production, by plant in vitro tissue culture, for the prevention and treatment of human dismetabolic diseases. Loizzo Stefano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351704 Implementation of a pathology network to improve identification and clinical management of patients with familial hypercholesterolemia MULTIMEDICA Catapano Alberico Luigi Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02351708 Chemogenomics in drug discovery for regenerative therapies of common and rare myelin diseases Istituto Superiore di Sanita' Agresti Cristina Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351712 Use of polydeoxyribonucleotide for treating diabetic foot ulcers Sicilia Altavilla Domenica Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351721 Interactions between Circulating Tumor Cells DE BELLIS (CTCs) and the hepatic microenvironment in human metastatic colorectal cancer: The ADAM‐9 protein as a target for tumor/stromal therapy. Lolli Ivan Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02351723 Advanced and innovative procedures for diagnosis and management of patients affected by Limb Girdle Muscle Dystrophies (LMGD) and other related myopathies. NEUROLESI Toscano Antonio Clinical Musculoskeletal, Oral and Skin Sciences Neurological diseases RF‐2011‐02351726 Paracrine role of Mesenchymal Stem Cells (MSCs) for cell therapy in ALS Piemonte Mazzini Letizia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Pagina 180 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351728 Containment of a region‐wide outbreak of Carbapenem‐resistant Klebsiella pneumoniae in seven lombardian hospital: molecular characterization, epidemiology and outcome. Lombardia Rossi Marianna Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351729 Psychological implications in robotic rehabilitation for sub‐acute stroke patients Veneto Masiero Stefano Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02351730 Efficacy of Etanercept vs Adalimumab in retreating psoriatic patients who previously failed treatment with the same molecule SAN GALLICANO Ardigò Marco Clinical Musculoskeletal, Oral and Skin Sciences Infection and immunity RF‐2011‐02351732 Omic and biosensor new approaches to detect IZSME hormonal growth promoters in food‐ producing animals DE ROMA ANTONELL Biomedical A Genes, Genomes and Genetics Food safety and animal welfare RF‐2011‐02351734 Instrumental and clinical validation of a new Emilia‐Romagna diagnostic‐therapeutic approach to the dysfunction of movement for rehabilitation in non‐specific low back pain Pillastrini Paolo Clinical Bioengineering Sciences and Technologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351735 Project Title: Respiratory viral infections: evaluation of the clinical value of virological diagnosis and study of the role of innate immune response in determining increased severity SPALLANZANI Lalle Eleonora Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351746 RISK OF INFECTION IN RHEUMATOID ARTHRITIS (RA): INVOLVEMENT OF INNATE IMMUNITY AND BIOLOGIC THERAPIES. Campania de Paulis Amato Biomedical Immunology Infection and immunity Pagina 181 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351751 Incidence and outcome of ocular infections caused by multi drug‐resistant microorganisms in intensive care unit patients: clinical, epidemiological and therapeutic management. Sicilia CILLINO SALVATOR Clinical E Infectious Diseases and Microbiology RF‐2011‐02351762 CONFOCAL MICROSCOPY TO ENHANCE THE TREATMENT OF MELANOMA AND NON MELANOMA SKIN CANCERS MAUGERI Faga Angela Surgical Sciences, Oncology Biomedical Imaging, and Bioengineering RF‐2011‐02351764 Zoonotic risks assessment of the handling and IZSPLV consumption of meat from main wild ungulates (wild boar/Sus scrofa, roe deer/Capreolus capreolus) hunted in Nord Italy (Aosta Valley Region) and South Italy (Calabria Region) ORUSA RICCARDO Biomedical Veterinary Food safety and animal welfare RF‐2011‐02351766 AVIAN BOTULISM IN LAZIO REGION: IZSLT DEVELOPMENT OF A FIELD MODEL TO UNDERSTAND THE PATHOGENESIS OF AN EMEGERGING DISEASE Bossù Teresa Biomedical Veterinary Food safety and animal welfare RF‐2011‐02351768 A new scenario for ALS/FTD: genetic contribution in outlier phenotypes Mandich Paola Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02351769 ARCISPEDALE Randomized Controlled Trial on the efficacy of LLLT (Low Level Laser Therapy) in combination with standard treatment, in preventing and treating chemo/radiotherapy‐ induced oral mucositis in head and neck cancer patients and in hematologic neoplasms patien Cavuto Silvio Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02351772 An economic, randomized, prospective phase III trial comparing the combination of anthracycline‐taxane vs bevacizumab‐ paclitaxel as first‐line treatment in women with HER‐2 negative metastatic breast cancer Ferretti Gianluigi Clinical Oncology 2 ‐ Translational Clinical Oncology IRCCS AOU San Martino‐ IST (Genova) REGINA ELENA Clinical Infection and immunity Pagina 182 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351776 Comparison of the long‐term efficacy of bariatric surgery and new antidiabetic (GLP‐1 based) therapy on diabetes remission and cardiovascular risk profile in obese type 2 diabetic patients Campania Capaldo Brunella Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351777 Development of a dedicated ICP‐MS based miR‐sassay to quantify circulating microRNA for the improvement of acute myocardial infarction diagnosis I.N.R.C.A. Procopio Antonio Biomedical Bioengineering Sciences and Technologies Metabolism disorders and cardiovascular disease RF‐2011‐02351778 Novel molecular mechanisms in pathogenesis of Male Breast Cancer (MBC) Sicilia RUSSO ANTONIO Biomedical Genes, Genomes and Genetics Oncology RF‐2011‐02351783 Sleep‐wake cycle and Sundown Syndrome in Alzheimer Disease: role of the orexinergic system and relationships with neurodegeneration biomarkers SANTA LUCIA Marciani Maria Grazia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351784 Endogenous obesogens accumulation and adipose tissue dysfunction: identification of toxogenomic, metabolomic and epigenetic signatures in adipocytes as a tool to understand environmental causes of human obesity AUXOLOGICO Marzullo Paolo Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351796 Virtual chromoendoscopy for early detection of oral carcinoma neoangiogenesis and in vivoconfocal microscopy for real time imaging of oral mucosa as adjunct in early diagnosis of oralneoplasia Campania Serpico Rosario Clinical Oncology Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02351799 Cerebral blood flow velocity in children with sickle cell disease before and after adenotonsillectomy Emilia‐Romagna Cazzato Salvatore Clinical Cardiovascular and Respiratory Sciences Neurological diseases Pagina 183 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02351805 Emilia‐Romagna Appropriateness of systemic anticancer therapy in advanced cancer patients: the use of AIFA monitored antineoplastic drugs in the end of life in Regione Emilia‐Romagna RF‐2011‐02351812 APPLICATIONS OF ULTRASTRUCTURAL CELL ANALYSIS IN THE FIELD OF REPRODUCTIVE TECHNOLOGIES RF‐2011‐02351818 AREA P.I. Classificazione Area Strategica. Leoni Maurizio Clinical Healthcare Delivery and Methodologies Oncology Ricci Giuseppe Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies Developement and characterization of a new RIZZOLI single step treatment for multiple orthopaedic diseases affecting bone or cartilage with the use of bone marrow derived cells and collagenic scaffold Giannini Sandro Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02351819 Role of LXR alpha and related target genes in Lombardia the pathogenesis of atherosclerosis. Evaluations in patients with different stages of atherosclerotic disease. PICONI STEFANIA Biomedical Cardiovascular and Respiratory Sciences Infection and immunity RF‐2011‐02351820 Forced Robotic Exercise Training effects on motor and cognitive functions of Parkinson's Disease patients Toscana BONGIOANNI Paolo Biomedical Emerging Technologies and Training in Neurosciences Neurological diseases RF‐2011‐02351827 Human oncogenic risk from consumption of beef red meat CROB Galasso Rocco Biomedical Oncology 1 ‐ Basic Translational Food safety and animal welfare RF‐2011‐02351833 Cardiac natriuretic peptides, human adipocytes, hypertension and dysmetabolism: in‐depth in vitro analysis and clinical study in elderly patients with type 2 diabetes mellitus or chronic heart failure I.N.R.C.A. Sarzani Riccardo Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease BURLO GAROFALO Pagina 184 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO RF‐2011‐02351838 Study on the use of vodcast in the treatment of Anorexia Nervosa RF‐2011‐02351840 DESTINATARIO ISTITUZIONALE Veneto AREA P.I. Siani Roberta SAN RAFFAELE MILANO Defective Glucose Metabolism in Polycystic Kidney Disease Defines a Novel Therapeutic Strategy: a Pre‐Clinical Proof‐of‐Concept Study Boletta RF‐2011‐02351842 The role of metformin in endometrial cancer type II: an in vitro and in vivo study ONCOLOGICO DI BARI RF‐2011‐02351843 Reduction of atrial fibrillation and stroke in systemic arterial hypertension: a randomized control trial comparing routine medical treatment versus primary care physicians guided drug regiment delivery through intensive blood pressure monitoring RF‐2011‐02351846 Clinical Classificazione Area Strategica. Biobehavioral and Behavioral Processes Neurological diseases Alessandra Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease Angioli Roberto Biomedical Oncology 2 ‐ Translational Clinical Oncology SAN DONATO Cappato Riccardo Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Use of amiodarone and derivatives for treatment/prophylaxis of viral hemorragic fevers. Veneto Baritussio Aldo Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351850 Genotype‐phenotype correlation in schizophrenia: role of rare variants FATEBENEFRATELLI Gennarelli Massimo Biomedical Biobehavioral and Behavioral Processes Neurological diseases RF‐2011‐02351852 zEC‐ zero Errors in Chemotherapy: process modelling for more effective ICT solutions in antiblastic treatment management I.E.O. NOLE' FRANCO Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02351853 Tailored screening for colorectal cancer. Piemonte Senore Carlo Clinical Risk, Prevention and Health Behavior Oncology Modulating screening interventions on individual risk profile Pagina 185 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351862 Ecological and biomolecular studies on Culicoides for an innovative approach to the control of Culicoides transmitted diseases IZSSI Torina Alessandra Biomedical Infectious Diseases and Microbiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351863 Identification of Determinants of Healthy Aging in Italy (IDAGIT) CARLO BESTA Leonardi Matilde Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351864 Safety and nutritional adequacy of donkey's milk in treating cow's milk allergic children Piemonte MONTI GIOVANNA Clinical Immunology Food safety and animal welfare RF‐2011‐02351867 Ghrelin as a new cardiometabolic risk biomarker: from population studies to tissue and cell biology in skeletal muscle and heart. Friuli‐Venezia Giulia Barazzoni Rocco Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351870 Prognostic, risk stratification potentiality and cost‐effectiveness analysis of a multi‐marker strategy in the management of children with congenital heart disease Toscana clerico aldo Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351872 Evaluation of in vitro drug‐sensitivity and phosphoproteomic expression profiles in patients diagnosed with renal carcinoma REGINA ELENA Gallucci Michele Clinical Digestive, Kidney and Urological Systems Oncology RF‐2011‐02351875 IMPACT OF EXPOSURE TO ESTROGEN‐ LIKE ENDOCRINE DISRUPTING CHEMICALS(EEDC) ON PUBERTAL DEVELOPMENT AND ESTABLISHMENT OF REFERENCERANGES FOR EXPOSITION IN CHILDHOOD. OSPEDALE BAMBINO GESU' Cianfarani Stefano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diseases of environmental origin, with reference also to the workplace Clinical Pagina 186 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease Michelangel Clinical o Integrative, Functional, and Cognitive Neuroscience Neurological diseases Vitale Francesco Biomedical Population Sciences and Epidemiology Infection and immunity Istituto Superiore di Sanita' Campitelli Laura Biomedical Immunology Infection and immunity REGINA ELENA Mariani Luciano Clinical Oncology 2 ‐ Translational Clinical Oncology Stefoni Sergio Clinical Digestive, Kidney and Urological Systems The new biotechnologies IZSSI Di marco Lo presti Vincenzo Biomedical Veterinary Infection and immunity Sicilia Firenze Alberto Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02351876 Vitamin D deficiency and obesity after kidney Piemonte transplantation: multicenter study on gene‐ environment interactions leading to "complex‐ phenotypes" in a human system associated with cardiovascular events and graft rejection. Stratta Piero RF‐2011‐02351877 Effects of Mirror Visual Feedback Therapy MAUGERI (MVFT) in neuropathic pain syndromes. Possible role played by sensory‐motor cortical reorganization evaluated by 3T‐fMRI. Buonocore RF‐2011‐02351879 Health impact assessment and health care costs of respiratory tract infections (RTIs) in general population and hospitalized patients Sicilia RF‐2011‐02351880 Evaluation of anti‐NA antibodies as possible correlates of protection from influenza disease: development of serological assays designed to detect a truly functional antibody response to influenza vaccination, with specific regard to the anti‐NA antibody RF‐2011‐02351881 Identification of novel biomarkers of recurrence in locally advanced cervical cancer RF‐2011‐02351887 Clinical and genetic new tools for Autosomal Emilia‐Romagna Dominant Polycystic Kidney Disease diagnosis RF‐2011‐02351889 Eco‐epidemiology of Mycobacterium bovis infection in Mediterranean area: a multi‐ disciplinary approach. RF‐2011‐02351890 Prevention interventions for promoting the health of men who have sex with men (MSM) in Palermo area. Biomedical Pagina 187 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Brain Disorders and Clinical Neuroscience Neurological diseases Gian Marco Clinical Digestive, Kidney and Urological Systems Infection and immunity Tarantini Giuseppe Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Antonelli Alessandro Clinical Immunology Infection and immunity Fattori Bruno Biomedical Biobehavioral and Behavioral Processes The new biotechnologies SANTA LUCIA Mandolesi Laura Biomedical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease PAIN‐ASSOCIATED CORTICAL HEMODYNAMIC PERTURBATION IN PRETERM NEWBORNS AND ITS RELATION WITH NEURODEVELOPMENTAL OUTCOME BURLO GAROFALO Bembich Stefano Clinical Brain Disorders and Clinical Neuroscience Neurological diseases Clinical and neurobiological correlates of repetitive transcranial magnetic stimulation (rTMS) in Alzheimer's disease MONDINO Costa Alfredo Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351897 Study of motor cortex electrical activity and neuroinflammatory hypothesis in ALS. SANTA LUCIA Zona Cristina RF‐2011‐02351902 Alloimmunity and infection: insight into pathogen‐driven alloreactivity to develop preventive strategies for late kidney graft failure GASLINI Ghiggeri RF‐2011‐02351904 Fractional flow reserve versus angiography‐ guided coronary revascularization in patients undergoing aortic valve replacement Veneto RF‐2011‐02351905 Evaluation of the pathogenetic role of Parvovirus B19V in systemic sclerosis and autoimmune thyroiditis. Toscana RF‐2011‐02351908 Development of an artificial larynx for clinical Toscana applications RF‐2011‐02351910 Physical Activity prevents the Cognitive Impairment in the Metabolic Syndrome (PACIMeS) RF‐2011‐02351920 RF‐2011‐02351922 Biomedical Clinical Pagina 188 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351923 miRNAs in lung tumorigenesis: expression signatures of serum circulating miRNAs in lung cancer patients and their functional analysis SDN Incoronato Mariarosari Biomedical a Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351926 High resolution molecular cytogenetics in colorectal cancer and oral premalignant lesions. Sicilia Castorina Sergio Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02351929 High throughput, population‐wide, reflex IRCCS AOU San Martino‐ testing of GI cancer: biologic characterization, IST (Genova) identification of individualized therapy targets and prevention of familial cases Mastracci Luca Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351930 Use of RNA aptamers as a novel tool for targeting Tumor Educated Myeloid Cells to control metastatic disease I. O. V. Marigo Ilaria Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02351931 Modulation of miRNA lung cancer risk biomarkers by low‐dose aspirin in former smokers Liguria De Censi Andrea Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351932 Behavioural and neurophysiological aspects of MEDEA communicative‐pragmatic abilities in healthy individuals and pathological conditions: assessment and rehabilitation Marini Andrea Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351933 SMART FOOD AND LIFESTYLE INTERVENTIONS FOR HEALTHY BRAIN AGING. Developing a comprehensive protocol to assess the preventive effects of lifestyle interventions on food habits, physical and cognitive activity and social and cultural participation on cogni Cappa Stefano Clinical Brain Disorders and Clinical Neuroscience Neurological diseases CARLO BESTA Pagina 189 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351934 Metabolomics of Multiple Myeloma SAN RAFFAELE MILANO Cenci Simone Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02351935 Development of a new multispectral imaging device for the evaluation of microcirculation and skin thickness in patients with Systemic Sclerosis. Veneto Cozzi Franco Clinical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02351936 Determination of the dose distribution in REGINA ELENA patients treated with high energy photon beams using transmitted dose planar distributions measured with a new gas detector technology (Gas Electron Multipliers) and a dedicated back‐projection algorithm. D'andrea Marco Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351943 Report‐AGE Project: clinical and molecular predictors of frailty in aged hospitalized populations with cardiovascular diseases I.N.R.C.A. Bustacchini Silvia Clinical Biology of Development and Aging Metabolism disorders and cardiovascular disease RF‐2011‐02351944 Focal Cortical Dysplasia Type I and Type II: Identification of causative genes and elucidation of disease pathomechanisms Toscana Guerrini Renzo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351947 The molecular basis of cognitive impairment in Williams‐Beuren Syndrome: a cell reprogramming‐based approach CASA SOLLIEVO SOFFERENZA Merla Giuseppe Biomedical Genes, Genomes and Genetics Neurological diseases RF‐2011‐02351948 Adolescents and young adults with cancer in Italy (AYACI) ISTITUTO TUMORI MILANO Gatta Gemma Clinical Population Sciences and Epidemiology Oncology RF‐2011‐02351949 Continuity of care and health expenditure for children with complex needs or chronic health conditions Emilia‐Romagna Faldella Giacomo Clinical Healthcare Delivery and Methodologies Oncology Pagina 190 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351958 Prematurity and low weight at birth as new conditions predisposing to an increased cardiovascular risk. A human study by means of metabolomics, instrumental cardiology, endothelial progenitor cells evaluation, paralleled by an animal experimental model. Sardegna MERCURO GIUSEPPE Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02351962 CLINICAL AND ADMINISTRATIVE WORKLOAD: PHYSICIANS WELLBEING, PERFORMANCE AND CONSEQUENCES ON PATIENT SAFETY. COMPARATIVE ANALYSIS AMONG THREE IMPORTANT ACUTE ITALIAN HOSPITALS Toscana Tartaglia Riccardo Clinical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351963 The oral modifications in very early and established Systemic Sclerosis Toscana Conforti Maria Letizia Clinical Musculoskeletal, Oral and Skin Sciences Infection and immunity RF‐2011‐02351964 Characterization and rescue of impaired dopaminergic signaling in primary torsion dystonia SANTA LUCIA Pisani Antonio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351967 Impact of Atorvastatin Use on Death or clinical Events Occurrence among HIV‐1 infected patients without hyperlipidemia. AUDEO Study SAN RAFFAELE MILANO Castagna Antonella Clinical AIDS and Related Research Infection and immunity RF‐2011‐02351969 Mechanisms of fluoropyrimidine toxicities in the perspective of personalized medicine. ARCISPEDALE Boni Corrado Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351973 Burden of disease of work related asthma Toscana Baldasseroni Alberto Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace Pagina 191 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351975 Daily monitoring of pediatric asthmatic outpatients: environment and health relationship. OSPEDALE BAMBINO GESU' Cutrera Renato Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02351978 THROMBOTIC MARKERS AS INNOVATIVE TOOLS FOR CANCER PROGNOSIS IN ONCOLOGICAL PATIENTS UNDERGOING HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY Lombardia Falanga Anna Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02351979 Genetic disorders of lung vascular development in children:A new, integrated approach for early recognition and molecular diagnosis. OSPEDALE BAMBINO GESU' Angioni Adriano Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02351981 Plasma exchange after the first demyelinating event in the central nervous system ‐ A pilot study Lazio Salvetti Marco Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351990 Repetitive Transcranial Magnetic Stimulation for the treatment of cognitive and motor disorders after stroke: a Multiple Integrated Techniques study. Piemonte De Mattei Marco Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02351992 Early detection of the onset of potential risk in IZSLT order to counteract and to prevent their spread. An introduction of an advanced computer system that, with a right level of automation, collect information available on the internet to monitor their conten Corzani Fabrizio Biomedical Veterinary Food safety and animal welfare RF‐2011‐02351994 Emilia‐Romagna FUNCTIONAL PROFILING OF MONOCYTE/MACROPHAGE POPULATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA: INVOLVEMENT IN CLINICAL OUTCOME MARASCA ROBERTO Biomedical Oncology 1 ‐ Basic Translational Oncology Pagina 192 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02351995 Facing dourine challenge: improvement of diagnostic tools and investigation of pathogenic mechanisms IZSAM Scacchia Massimo Biomedical Veterinary Food safety and animal welfare RF‐2011‐02351998 New Molecular Mechanisms of Leukemia Immune Evasion after Allogeneic Hematopoietic Stem Cell Transplantation SAN RAFFAELE MILANO Ciceri Fabio Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352002 Enabling assessment of attention and MAUGERI motivation during post‐stroke robot‐assisted rehabilitation to improve patient adherence to treatment and outcome. Pisano Fabrizio Clinical Musculoskeletal, Oral and Skin Sciences Neurological diseases RF‐2011‐02352004 A novel TRAIL‐based therapeutic by mesenchymal cells TARgeting PAncreatic Cancer (TARPAC) Emilia‐Romagna Dominici Massimo Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02352006 Gender and geographical specific circulating microRNA signatures as biomarkers of atherosclerosis, atherosclerosis progression and vascular events MONZINO Tremoli Elena Clinical Vascular and Hematology Metabolism disorders and cardiovascular disease RF‐2011‐02352016 Sicilia Healthcare Associated Infections and Automated Area Decontamination: a challenge for the intended application, the evidence base for effectiveness, affordability of implementation and cost constraints Cunsolo Rosario Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02352021 Application of novel biotechnologies for assessment of the vector competence of wild populations of Culicoides obsoletus for the Bluetongue virus IZSAM Goffredo Maria Biomedical Veterinary Food safety and animal welfare RF‐2011‐02352025 Host‐pathogen interactions: Chlamydiae cronic infections; a primary role in human diseases. Biomarkers and diagnostic tools for clinical evaluation. Toscana Prisco Domenico Biomedical Infectious Diseases and Microbiology Infection and immunity Pagina 193 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352027 Protein‐based carriers for targeted photodynamic therapy Emilia‐Romagna CAVANNA LUIGI Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02352033 Developing a Nutritional genomics approach for the prevention of Colon cancer Sicilia Virgilio CLARA MARIA Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352036 METABOHEARTFAIL‐GRAPE miRNAs IN REVERSING REMODELING THROUGH MODULATION OF CARDIAC AQUAPORIN‐ 7 AND GLYCEROL UPTAKE IN A SWINE MODEL OF NON‐ISCHEMIC CHRONIC HEART FAILURE Toscana Lionetti Vincenzo Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352042 Surface imaging in respiratory gated radiotherapy for breast cancer Piemonte Krengli Marco Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352046 Hepatitis C virus‐host lipoproteins interplay: development of new antiviral strategies. SPALLANZANI Tripodi Marco Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02352056 A randomized intervention study to assess the MONZINO effect of the Mediterranean Diet on the plasma fatty acid profile. Veglia Fabrizio Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352063 Biomarkers in Glaucoma. BIETTI Micera Alessandra Biomedical Brain Disorders and Clinical Neuroscience Infection and immunity RF‐2011‐02352068 GENERATION OF RED CELLS WITH RARE OR UNCOMMON BLOOD GROUP PHENOTYPES FROM HUMAN INDUCED PLURIPOTENT STEM CELLS (hiPSCs) Lazio MATTEOCCI ANTONELL Biomedical A Bioengineering Sciences and Technologies The new biotechnologies Pagina 194 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352071 Pharmacological resistance in pituitary tumours: insights from the study of Aryl hydrocarbon Receptor Interacting Protein (AIP) as a new mediator of somatostatin analogues Abruzzo Jaffrain Meri Lise Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Oncology RF‐2011‐02352074 Estimate of Late diagnosis and Late presentation of HCV infection in high‐risk and hard to reach population. SPALLANZANI Scognamiglio Paola Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02352076 Property of donkey's milk : application in human nutrition and its potential usein the preventions and therapy of metabolic infiammatory and cardiovascular diseases associated with obesity. IZSME Fraulo Pasquale Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352079 IMPACT OF VIDEOTHORACOSCOPIC, ROBOTIC AND OPEN LOBECTOMY ON QUALITY OF LIFE AND IMMUNE RESPONSE IN LUNG CANCER PATIENTS I.E.O. VERONESI GIULIA Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352083 Colorectal cancer stem cells, microenvironment and improved diagnosis for potential therapy Toscana Spisni Roberto Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02352084 Human Cardiac Stem Cell Regenerative Capacity in Paediatric Heart Failure Lazio Leone Antonio Maria Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352085 Genetic and Antigenic Evolution of West Nile virus Isolated in Italy and Characterization of Viral‐Host Mechanisms Regulating Infection and Pathogenesis IZSAM Monaco Federica Biomedical Veterinary Food safety and animal welfare RF‐2011‐02352088 Meeting senior members in the search for new Puglia associatesof the exclusive hamartromatous gene club Resta Nicoletta Biomedical Digestive, Kidney and Urological Systems Oncology Pagina 195 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352090 Clinical use of Hybrid Sonographic‐contrast enhanced PET/CT imaging ('Real Time' sonography and contrast enhanced PET‐CT) to detect and to biopsy abdominal lesions Liguria BISCALDI ENNIO Clinical Oncology Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02352096 Alcohol intake and abuse in workplaces: development of an integrated protocol based on screening questionnaire and new methods for biological sampling and analysis. Application in healthcare workers according to Italian legislation Emilia‐Romagna lodi vittorio Clinical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace RF‐2011‐02352098 Molecular events underlying the metastatic potential of cancer stem cells Sicilia Todaro Matilde Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352110 Innovative biomarkers for oxidative stress in diabetic retinopathy: evaluation of curcumin inhibition. BIETTI Varano Monica Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352111 Expression and function of P2 receptors in human psoriatic keratinocytes. Study of their role in psoriasis pathogenesis and research of new potential therapeutic targets Emilia‐Romagna Virgili Anna Biomedical Musculoskeletal, Oral and Skin Sciences Infection and immunity RF‐2011‐02352114 miRNAs role in Longevity and their relation to Sardegna cancer survival Deiana Luca Biomedical Biology of Development and Aging Oncology RF‐2011‐02352119 In vivo generation of Tregs with differential homing capabilities for dissociating the antitumor effects of clinical hematopoietic stem cell transplantation from graft‐versus‐ host disease Bondanza Attilio Biomedical Immunology Oncology SAN RAFFAELE MILANO Pagina 196 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352126 DEVELOPMENT OF NOVEL ANTIBODY‐ ENGINEERED GOLD NANOPARTICLES AS TARGETED DRUG DELIVERY FOR THE TREATMENT OF CHRONIC LUNG ALLOGRAFT DYSFUNCTION Veneto Rea Federico Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02352131 GLP‐1 agonists treatment vs endoscopic procedures in obesity and type II diabetes mellitus management: a randomized clinical trial. Piemonte Morino Mario Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352133 Evaluation of the molecular mechanisms and therapeutic efficacy of a new NGF mimetic compound with anti‐apoptotic activity in cardiac and cerebral ischemia/reperfusion (I/R) Toscana Pellegrini Giampietro Domenico Biomedical Edoardo Brain Disorders and Clinical Neuroscience Metabolism disorders and cardiovascular disease RF‐2011‐02352136 Unravelling the interplay between Helicobacter pylori and the host. Biomarkers and diagnostic tools for evaluation of H. pylori‐infected patients. Toscana D'Elios Mario Milco Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02352147 Empower through Communication: a Generative Model for Health‐Care Organizations NEUROLESI Timpano Francesca Clinical Healthcare Delivery and Methodologies Neurological diseases RF‐2011‐02352148 Optimal duration of treatment and optimal management of thromboembolic events in cancer patients (Morgagni‐Cancer Study) ARCISPEDALE GHIRARDUZZ ANGELO I Clinical Vascular and Hematology Oncology RF‐2011‐02352150 Molecular pathogenetic mechanisms and prognosis of sinonasal adenocarcinomas in relation to occupational exposure Piemonte Valente Clinical Oncology 2 ‐ Translational Clinical Oncology Guido Pagina 197 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352152 Analysis of late radiation damages in terms of neurocognitive outcome after focal radiotherapy for childhood malignant brain tumors by a correlation of absorbed dose levels and magnetic resonance diffusion tensor imaging (DTI) values ISTITUTO TUMORI MILANO Gandola Lorenza Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352155 modulation of HCN channels by GPR35 in chronic pain Toscana mannaioni guido Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352159 Chemical, biological, and clinical characterization of silver delivery systems for burns treatment Veneto Vindigni Vincenzo Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02352161 Innovative diagnostic tools for the control of patulin in the agri‐food chain Istituto Superiore di Sanita' BRERA CARLO Biomedical Veterinary Food safety and animal welfare RF‐2011‐02352167 HELP (Hepatitis and HIV Emergencies, Life & Campania protection Program for drug addicts and immigrants wide range information) Filippini Pietro Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02352169 Toscana Investigations of the molecular mechanisms linking poly(ADP‐ribosyl)ation to relapses and progression of multiple sclerosis chiarugi alberto Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352171 Genetic, molecular and bioinformatics approaches for early detection of HIV‐ associated neurocognitive disorders (BioHAND Study) Puglia Grima Pierfrancesc Biomedical o Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352174 MicroRNA profile in plasma and sputum in the low‐dose CT lung cancer screening trial Italung Toscana BISANZI SIMONETT Biomedical A Oncology 2 ‐ Translational Clinical Oncology Pagina 198 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Bulian Pietro Biomedical Oncology 2 ‐ Translational Clinical Oncology Spitoni Grazia Fernanda Clinical Brain Disorders and Clinical Neuroscience Neurological diseases Rossini Paolo Maria Clinical Emerging Technologies and Training in Neurosciences Neurological diseases CASA SOLLIEVO Exome sequencing in Individuals with Developmental Delay/Intellectual Disability of SOFFERENZA Unknown Etiology Bernardini Laura Biomedical Genes, Genomes and Genetics The new biotechnologies RF‐2011‐02352191 Structural imaging in systemic amyloidosis: an SAN MATTEO inescapable step toward the optimization and validation of more effective therapeutic approaches MERLINI GIAMPAOL Biomedical O Biological Chemistry and Macromolecular Biophysics Metabolism disorders and cardiovascular disease RF‐2011‐02352200 Definition of an Integrated Risk Assessment of Sicilia Health Care Worker Biomechanical Musculoskeletal Overload scelsa davide Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02352208 Enhancing and monitoring indoor and outdoor physical activity and its intracellular and quality of life effects in type 2 diabetic patients assanelli deodato Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease C.R.O. AVIANO RF‐2011‐02352176 A biopathological investigation of Nodular Lymphocyte Predominant Hodgkin Lymphoma in pediatric and adolescents patients. RF‐2011‐02352177 If the body changes ‐ dynamic relationships SANTA LUCIA between physical structure and mental/neural representations of the body: from brain to every day life RF‐2011‐02352178 Multimodal evaluation of stroke patient's mindbrain state during upper‐limb robot‐ aided therapy RF‐2011‐02352180 SAN RAFFAELE PISANA Lombardia Pagina 199 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352209 Veneto Morphological and molecular phenotype of lung cancer in chronic obstructive pulmonary disease CALABRESE FIORELLA Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352210 Achieving mucosal and systemic immunity by Istituto Superiore di Sanita' exploiting vitamin A metabolites as co‐ adjuvants in Tuberculosis vaccination Vendetti Silvia Biomedical Immunology Infection and immunity RF‐2011‐02352211 CHARACTERIZATION OF BIOMARKERS FOR CARDIOVASCULAR DISEASES AT EARLY PRESENTATION Veneto TESSARI PAOLO Biomedical Biological Chemistry and Macromolecular Biophysics Metabolism disorders and cardiovascular disease RF‐2011‐02352213 Human defensins: a new weapon or an old enemy? Campania Catania Maria Rosaria Biomedical Immunology Infection and immunity RF‐2011‐02352215 Inflammatory bowel diseases and environmental stressors: a system biology approach Campania Cuomo Rosario Biomedical Digestive, Kidney and Urological Systems Diseases of environmental origin, with reference also to the workplace RF‐2011‐02352216 Non pharmacological analgesic treatment in disorders of consciousness patients by using repetitive Transcranial Magnetic Stimulation NEUROLESI Bellinghieri Filippo Clinical Emerging Technologies and Training in Neurosciences Neurological diseases RF‐2011‐02352217 MITOCHONDRIAL CI and CIV OSPEDALE BAMBINO DEFICIENCIES: DIFFERENT CLINICAL AND GESU' BIOCHEMICAL RENSPONSE TO EPI‐743. AN INTEGRATED APPROACH TO IMPROVE BOTH THE CLINICAL MANAGEMENT AND THE UNDERSTANDING OF THE PATHOGENESIS OF THIS DISORDER Carrozzo Rosalba Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352224 Signals from deregulated skin metabolism control generalized metabolic syndrome in psoriasis Musculoskeletal, Oral and Skin Sciences Metabolism disorders and cardiovascular disease ISTITUTO DERMOPATICO KORKINA DELL'IMMACOLATA LIUDMILA Biomedical Pagina 200 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352228 PROGNOSTIC ROLE OF CARDIOPULMONARY EXERCISE STRESS TEST IN MODERATE‐TO‐SEVERE AORTIC STENOSIS SAN DONATO guazzi marco Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352234 Non‐Invasive Monitoring of Circadian Rhythm Disorders In Shift‐workers I.N.R.C.A. Basso Andrea Clinical Biobehavioral and Behavioral Processes Diseases of environmental origin, with reference also to the workplace RF‐2011‐02352236 Identifying low‐value health care interventions for patients with neurodegenerative diseases of the Central Nervous System and Stroke to support disinvestment decisions Emilia‐Romagna Grilli Roberto Clinical Healthcare Delivery and Methodologies Neurological diseases RF‐2011‐02352237 Link between clinical features of haematological patients, molecular and cytofluorimetric data: WT1 and relationship with other markers. Basilicata PIZZUTI MICHELE Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352238 Toscana Development of a Regional network for the improvement of the operators compliance to the management of the Italian Register of Oncologic Drugs (RFOM) of Italian Medicines Agency (AIFA) Boni Luca Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02352239 Genome wide association study and heritability of recently proposed cardiovascular risk factors such as arterial stiffness, endothelial dysfunction, blood pressure variability and pulse pressure amplification in an isolated population living in Ogliastra Salvi Paolo Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease AUXOLOGICO Pagina 201 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352240 Melanoma and non‐melanoma skin cancer: anatomic site, sun exposure, predictive and prognostic biomarkers SAN GALLICANO Catricalà Caterina Clinical Oncology 1 ‐ Basic Translational RF‐2011‐02352243 Non‐invasive treatment of facet joint osteoarthritis low back pain by Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS): techniques and protocols optimization, clinical study and immune response assessment Sicilia Midiri Massimo Clinical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02352247 A COMBINATION THERAPY COMPRISING Emilia‐Romagna A 'MEGADOSE' OF T CELL DEPLETED HEMATOPOIETIC STEM CELL TRANSPLANT, HIGH DOSE POST‐ TRANSPLANT CYCLOPHOPHAMIDE AND A REDUCED INTENSITY CONDITIONING FOR A STABLE AND LONG TERM ENGRAFTMENT AVERSA FRANCO Clinical Immunology Infection and immunity RF‐2011‐02352255 Developmental Coordination Disorder in OSPEDALE BAMBINO school‐age children born very preterm: GESU' validation of a screening tool and relationship with ante‐ and peri‐natal events. Cuttini Marina Clinical Biobehavioral and Behavioral Processes Neurological diseases RF‐2011‐02352258 THERE IS A PLACE FOR YOU: TO Piemonte PROMOTE A PREVENTION AND PREVIOUS DIAGNOSYS OF IST DISEASE IN IRREGULAR IMMIGRANT WOMEN Arras Maria Antonella Clinical Healthcare Delivery and Methodologies Infection and immunity RF‐2011‐02352259 Occupational and non‐occupational risk factors for retinal detachment: a multicentre population‐based case‐control study Mattioli Stefano Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace Emilia‐Romagna Diseases of environmental origin, with reference also to the workplace Pagina 202 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE CASA SOLLIEVO SOFFERENZA AREA P.I. Classificazione Area Strategica. Vescovi Angelo Luigi Biomedical Oncology 1 ‐ Basic Translational Oncology Menghini Deny Clinical Biobehavioral and Behavioral Processes Neurological diseases ISTITUTO TUMORI MILANO Biganzoli Elia Biomedical Genes, Genomes and Genetics Oncology Epigenetic change in DNA structure may serve as marker for neurological disease Marche PROVINCIALI LEANDRO Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352267 Strategies To Improve Human Cardiac Stem Cell Regenerative Capacity In Patients With Post‐Ischemic Left Ventricular Remodelling Lazio Crea Filippo Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352268 Study of bio‐molecular and immunological mechanisms of response and resistance to targeted therapy (antiBRAF, antiMEK, or both) in patients with metastatic melanoma ONCOLOGICO DI BARI Guida Michele Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352271 Search for cancer‐specific proteomic Veneto biomarkers in exosomes and red blood cells to rule out lung cancer risk in suspicious incidental nodules detected by imaging techniques Gion Massimo Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352261 Glioblastoma Cancer Stem Cells: a tool for identification of new diagnostic/prognostic markers and development of innovative therapeutics RF‐2011‐02352262 Improving reading and behavioural control in OSPEDALE BAMBINO dyslexia and ADHD with training on executive GESU' functions RF‐2011‐02352263 Meta‐analytic assessment of mesenchymal stem cell genomic features in soft tissue sarcomas: a link to cancer dormancy and micro‐metastatic spread for improved prognosis and response to the therapy assessment RF‐2011‐02352264 Pagina 203 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352272 IRCCS AOU San Martino‐ Longitudinal assessment of chemotherapy‐ induced impairment of cognitive function and IST (Genova) its correlation with structural changes in the cerebral white matter of patients with non‐ small cell lung cancer (NSCLC). Grossi Francesco Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352273 Telemonitoring in Pediatric Patients with Heart Failure and VAD Istituto Superiore di Sanita' grigioni mauro Biomedical Bioengineering Sciences and Technologies Metabolism disorders and cardiovascular disease RF‐2011‐02352275 Nanomaterials‐based diagnostic devices for melanoma I.E.O. TOSTI GIULIO Clinical Bioengineering Sciences and Technologies Oncology RF‐2011‐02352279 The role of the airways microbiome in the development of chronic lung infections in CF patients and implications for personalized antibiotic interventions Provincia autonoma Trento Ermanno Baldo Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02352281 Isolation and molecular characterization of Multi Drug Resistant Klebsiella pneumoniae from animal sources IZSSI Caracappa Santo Biomedical Infectious Diseases and Microbiology The new biotechnologies RF‐2011‐02352283 REGINA ELENA The role of epigenetic in thyroid cancer progression and resistance to radio‐iodine therapy. Focus on multiple promoter methylation of thyroid‐specific genes (TSH‐R, NIS, SLC26A4, SLC5A8), and non thyroid specific BRAF‐associated genes (TIMP3, DAPK, RAR‐B Carosi Mariantonia Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02352284 Lazio Pathophysiologic and prognostic role of OXidative stress in acute coronarY sindromes: GENder differences [OXYGEN trial] Villa Paola Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Clinical Pagina 204 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. RF‐2011‐02352285 Toscana Early discharge from the emergency department of nursing‐home dwelling older patients with community acquired pneumonia in comparison to normal hospitalization: a randomized clinical trial Monzani Fabio RF‐2011‐02352287 Gender and age‐related differences in motility DE BELLIS and permeability responses in human colon: role of muscarinic receptors Maselli RF‐2011‐02352289 Stereo‐body radiotherapy: a novel software expert system based on the optimization of treatment schedules Istituto Scientifico Romagnolo RF‐2011‐02352291 Assessment of the macrophage role in the natural history of myeloproliferative neoplasms RF‐2011‐02352293 DENOSUMAB FOR THE TREATMENT OF SYSTEMIC SCLEROSIS RELATED OSTEOPOROSIS: AN OPEN‐LABEL PILOT SAFETY STUDY. RF‐2011‐02352294 Clinical Classificazione Area Strategica. Healthcare Delivery and Methodologies Infection and immunity Maria Biomedical Antonietta Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease BENASSI MARCELLO Clinical Oncology 2 ‐ Translational Clinical Oncology SAN RAFFAELE MILANO Manfredi Angelo Andrea Biomedical Oncology 1 ‐ Basic Translational Oncology Basilicata D'Angelo Salvatore Clinical Musculoskeletal, Oral and Skin Sciences The new biotechnologies CIRCULATING CELL‐FREE BIOMARKERS IN Toscana THE DIAGNOSIS AND FOLLOW UP OF DIFFERENTIATED THYROID CANCER Pupilli Cinzia Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352295 NEUROPSYCHOLOGICAL AND fMRI STUDIES TO EVALUATE THE EFFECTS OF COGNITIVE REHABILITATION IN PARKINSON¿S DISEASE Provincia autonoma Trento Di Giacopo Raffaella Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02352296 Risk of metachronous cancer in genetically predisposed colorectal patients ISTITUTO TUMORI MILANO Bertario Lucio Clinical Oncology 2 ‐ Translational Clinical Oncology Pagina 205 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352297 STRATEGIES TO PROMOTE THE CONTINUOUS IMPROVEMENT OF PATIENT SAFETY AND QUALITY IN HEALTH CARE Campania Angelillo Italo F Clinical Healthcare Delivery and Methodologies Infection and immunity RF‐2011‐02352301 Overcome resistance of mTOR inhibitor in renal clear cell carcinoma targeting autophagy: a preclinical and clinical study. Lazio Vincenzi Bruno Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352303 GENOMIC AND PROTEOMIC STUDIES ON EARLY STAGE PULMONARY ADENOCARCINOMA: identification of pathogenesis markers relevant for cancer screening and personalized therapy. Abruzzo ANGELUCCI STEFANIA Biomedical Healthcare Delivery and Methodologies Oncology RF‐2011‐02352305 New Doxorubicin hepatic delivery by Veneto ultrasound microbubbles and effects of heme oxygenase‐1 induction and inhibition in the treatment of hepatocellular carcinoma in rats: evaluation of antineoplastic effects, prevention of development of tumors, preventio Sacerdoti David Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352307 EVALUATION OF THE ACTIVITY OF A NOVEL PARTIAL AGONIST OF A1 ADENOSINE RECEPTOR AS POTENTIAL THERAPEUTIC AGENT FOR DIABETES AND OBESITY MARTINOTTI STEFANO Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352308 ¿WHY ME?¿ PROJECT (WM?P). MEDEA INVESTIGATING WHITE MATTER CONNECTIVITY IN SCHIZOPHRENIA AT IMAGING, CELLULAR, AND TRANSPOSONE LEVELS IN MONOZYGOTIC DISCORDANT TWINS Brambilla Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases Abruzzo Paolo Pagina 206 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352310 Systemic and local characterization of clinical remission in rheumatoid arthritis patients treated with biologic agents: predictors, dynamics and pathologic stability. SAN MATTEO MONTECUCC CARLOMA Biomedical O URIZIO Musculoskeletal, Oral and Skin Sciences Infection and immunity RF‐2011‐02352311 Searching for genetic profiles associated with IgE variability in health care workers and bakers exposed to occupational allergens Veneto Olivieri Mario Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace RF‐2011‐02352315 A Randomized Clinical Double Blind Placebo Toscana Controlled Study of Human Fecal Microbioma in Irritable Bowel Syndrome Treated with Probiotic and a Boswellia Serrata Gum Extract Tritated in Boswellic Acids Firenzuoli Fabio Clinical Digestive, Kidney and Urological Systems Infection and immunity RF‐2011‐02352318 Immunological Mechanisms Involved in The Pathogenesis of Primary Aldosteronism Seccia Teresa Maria Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352320 A biological prospective study in patients with I.E.O. metastatic pancreatic neuroendocrine tumors treated with everolimus FAZIO NICOLA Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352321 Implementing Active Surveillance for low risk prostate cancer patients: a population‐based cohort study in the Oncological Network of Piemonte and Valle d'Aosta. The PROstate CanceR Active Surveillance sTudy (PROCRAST). Piemonte Ciccone Giovannino Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02352325 Development and validation of a multiplex real‐time PCR assay for the identification and discrimination of virulent Listeria monocytogenes strains in food IZSUM Petruzzelli Annalisa Veterinary Food safety and animal welfare Veneto Biomedical Pagina 207 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352326 Complementary and Alternative Medicine for the treatment of chronic pain: a pilot study NEUROLESI Lanzafame Pietro Clinical Biobehavioral and Behavioral Processes Neurological diseases RF‐2011‐02352327 Monitoring infection in complex wounds in pediatric patients OSPEDALE BAMBINO GESU' Bella Sergio Clinical Healthcare Delivery and Methodologies Infection and immunity RF‐2011‐02352328 Emilia‐Romagna Assessing colorectal cancer risk: are DNA viruses and genetic damage in circulating cells valuable biomarkers? RICCIARDIELL LUIGI O Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02352329 Role of bilateral STN DBS on impulse control CARLO BESTA disorders and related behaviors in Parkinson's disease: a quasi‐experimental clinical trial Romito Luigi Michele Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352331 Systemic Sclerosis and Chronic Graft versus Host Disease: application of novel predictive assays and generation of transgenic animal models Marche Gabrielli Armando Biomedical Immunology Infection and immunity RF‐2011‐02352332 Identification and validation of biomarkers in saliva and scraping of buccal cells for the early detection of oral lesions at risk of developing cancer Veneto MANFRIN ERMINIA Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352333 Synthesis of new compounds with antiRET Toscana activity and evaluation of their anti‐neoplastic activity (in vitro and in vivo) in papillary and medullary thyroid cancer Miccoli Paolo Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352336 Study Title: PATENT FORAMEN OVALE ‐ Campania SLEEP HYPOXIA ¿A multi‐center study to determine the response to percutaneous closure of patent foramen ovale (PFO) with the PFO Closure Device in patients diagnosed with PFO and significant oxygen desaturation in obs Onorato Eustaquio Biomedical Cardiovascular and Respiratory Sciences Neurological diseases Pagina 208 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Mauro Clinical Oncology Surgical Sciences, Biomedical Imaging, and Bioengineering ISTITUTO DERMOPATICO Failla Understanding sirtuin specificity and identification of selective therapeutics using a DELL'IMMACOLATA trans‐kingdom approach Cristina Maria Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02352341 ECG IN UN CLIK Lazio GERMANO GIUSEPPE Clinical ITALO WALTER Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352343 Innovative strategies for diagnostics and clinical care in hereditary neuromuscular diseases by omic approaches Veneto Pegoraro Elena Clinical Musculoskeletal, Oral and Skin Sciences Neurological diseases RF‐2011‐02352345 Discovery of new biomarkers predictive of outcome in comatose patients resuscitated from cardiac arrest IRCCS AOU San Martino‐ IST (Genova) Pelosi Paolo Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352351 Use of automated nucleic amplification assay Xpert MTB/RIF in the decision‐making process for respiratory isolation of patients with suspected tuberculosis in 3 tertiary care centers of Italian metropolitan areas (Rome, Milan and Turin) SPALLANZANI Lauria Francesco Nicola Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02352360 Discovering new candidate gene for nuclear envelopathies. Lazio D'Apice Maria Rosaria Clinical Genes, Genomes and Genetics The new biotechnologies RF‐2011‐02352365 Monitoring of the efficacy and safety of biologics for the treatment of psoriasis by evaluation of biomolecular indicators Lazio Orlandi Augusto Clinical Musculoskeletal, Oral and Skin Sciences The new biotechnologies RF‐2011‐02352337 Chemoprevention of radiation damages induced by radiodiagnostic procedures RF‐2011‐02352339 REGINA ELENA Caterino Pagina 209 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. SANTO Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies ISTITUTO DERMOPATICO Lacal DELL'IMMACOLATA Pedro Miguel Biomedical Oncology 1 ‐ Basic Translational Oncology Innovative Nanomedicines for the Efficacious Treatment of Dogs affected by Leishmaniasis IZSSI VITALE FABRIZIO Biomedical Veterinary Food safety and animal welfare RF‐2011‐02352379 Sensorimotor Integration. Physiology and Pathophysiology MAUGERI Schieppati Marco Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02352383 IRCCS AOU San Martino‐ Effects of Tumor‐associated Fibroblast and hypoxia on the availability of efficient NK cells IST (Genova) within the tumor core: characterization of molecular targets for therapy in melanoma and colon cancer. Vitale Massimo Biomedical Immunology Oncology RF‐2011‐02352399 Prediction of childhood visceral adiposity and BURLO GAROFALO hypertension by body composition measurement in early life in premature and small for gestational age infants. Demarini Sergio Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352409 Analysis of myocardial function after aortic valve replacement with a novel sutureless valve: coupling mathematical modelsto clinical research. Mignosa Carmelo Clinical Metabolism disorders Surgical Sciences, Biomedical Imaging, and cardiovascular disease and Bioengineering RF‐2011‐02352371 Cardiovascular disease in intrauterine growth restriction (IUGR). A clinical and proteo‐ metabolomic investigation. Veneto RF‐2011‐02352373 NOVEL AND SELECTIVE ANTI‐TUMOR STRATEGIES FOR THE TREATMENT OF GLIOMA RF‐2011‐02352374 Sicilia FERRARA Pagina 210 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352410 A tool to diagnose the impairment of aphasic SANTA LUCIA patients and direct rehabilitation by analysing speech errors Incoccia Chiara Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases RF‐2011‐02352418 Characterization of the interactions occurring Lazio inside the EGFR axis macromolecular complexes expressed in pancreatic ductal adenocarcinoma coppola roberto Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352419 Novel Clinical and Molecular Determinants of Campania Glucocorticoid Response in Obesity‐related Asthma Vatrella Alessandro Biomedical Cardiovascular and Respiratory Sciences Infection and immunity RF‐2011‐02352420 Enabling bedside neurophysiological assessment and communication in functional Locked‐in syndromes after acquired brain injury SANTA LUCIA Mattia Donatella Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352423 Advanced ovarian cancer as an immunologic, endocrine and metabolic disorder. Translational research for the development of a targeted approach of advanced ovarian cancer‐related symptoms. Sardegna Macciò Antonio Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352434 Disability diseases related: (Di.di.re) ICF as tools to weight disability in rehabilitation SAN RAFFAELE PISANA Giustini Alessandro Clinical Healthcare Delivery and Methodologies Neurological diseases RF‐2011‐02352437 QOLIBRI ‐ Quality of Life after Brain Injury: the new challenge for tomorrow SANTA LUCIA Buzzi Maria Gabriella Risk, Prevention and Health Behavior Neurological diseases RF‐2011‐02352438 ANALYSIS OF THE GENETIC AND EPIGENETIC BASIS OF HCV‐RELATED LYMPHOPROLIFERATIVE DISORDERS Toscana Zignego Anna Linda Biomedical Infectious Diseases and Microbiology Oncology RF‐2011‐02352440 Autonomic cardiovascular evaluation in low respiratory tract infections MAGGIORE Blasi Francesco Cardiovascular and Respiratory Sciences Infection and immunity Biomedical Biomedical Pagina 211 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐02352441 IZSPLV CHLORPYRIFOS, DELTAMETRIN AND DIAZINON, A REAL RISK FOR ANIMAL AND HUMAN HEALTH. EVALUATION OF GENOTOXICITY, OXIDATIVE STRESS, HORMONAL AND TISSUTAL RESPONSES IN FISH EXPERIMENTALLY EXPOSED TO PESTICIDES RF‐2011‐02352442 Long¿term exposure to ambient air pollution and pregnancy outcomes in women of three large Italian longitudinal studies RF‐2011‐02352445 AREA P.I. Classificazione Area Strategica. Marchis Daniela Biomedical Veterinary Food safety and animal welfare Lazio Cesaroni Giulia Clinical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace Biomarkers of effect as novel tools for the identification of PCB contamination in mussels and their impact on human health. IZSUM Piersanti Arianna Biomedical Veterinary Food safety and animal welfare RF‐2011‐02352446 DEVELOPMENT OF THE ITALIAN ICF COMPREHENSIVE CORE SET AND BRIEF CORE SET FOR THE LUNG CANCER PASCALE Pinto Monica Clinical Population Sciences and Epidemiology Oncology RF‐2011‐02352448 Humanization of Emergency Departments in Hospitals: new features and patient satisfaction for chronic metabolic and cardiovascular diseases Piemonte MINNITI DAVIDE Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02352456 Early use of extracorporeal membrane oxygenation in Cardiogenic Shock (ECMICS) Lombardia Pesenti Antonio Maria Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352457 A a case‐control record‐linkage study on occupational aspects of neurological diseases Istituto Superiore di Sanita' Vanacore Nicola Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352462 End‐ to‐side neurotization of median nerve from ulnar nerve with butyl 2 ¿ cyanoacrylate in rat. Experimental study NEUROLESI Papalia Igor Biomedical Neurological diseases Surgical Sciences, Biomedical Imaging, and Bioengineering Pagina 212 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Silvoni Stefano Clinical Brain Disorders and Clinical Neuroscience Neurological diseases CASA SOLLIEVO SOFFERENZA Scillitani Alfredo Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Sexual dysfunction after Traumatic Brain Injury and consequences on couple relationship: assessment and treatment. SANTA LUCIA Bivona Umberto Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352481 Study of the selectivity of botulinum toxins (BoNT‐A and BoNT‐C) for muscle fiber type units and their kinetics diffusion by exo‐ endocytosis: electro and impedence myography evaluation, biochemical pathway analysis and possible clinical implication in Sp Toscana Carboncini Maria Chiara Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐02352493 MULTICENTER, RANDOMIZED, CLINICAL TRIAL ON THE COMPARISON BETWEEN EARLY SURGERY AND CONVENTIONAL THERAPY IN INFECTIVE ENDOCARDITIS. THE EARLY STUDY. Piemonte Cecchi Enrico Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352495 Molecular, Pharmacogenomic and Metabolic factors associated with Recurrence in a Randomized Trial of adjuvant therapy with Aromatase Inhibitors PASCALE De Laurentiis Michelino Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352497 Analysis of Arterial Stiffness in women with Systemic Lupus Erythematosus: correlations with epidemiological, clinical and laboratory parameters, with the presence of hypovitaminosis D and evaluation of the effects of Cholecalciferol supplementation. Toscana Mosca Marta Clinical Immunology Infection and immunity RF‐2011‐02352477 Improvement of ALS patients communication S.CAMILLO by means of a BCI‐system based on ERP single‐ trial detection RF‐2011‐02352479 PHOSPHATE HOMEOSTATIS AND PATHOGENESIS OF MINERAL AND CARDIOVASCULAR DISORDERS RF‐2011‐02352480 Pagina 213 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352502 The gC1q domain of EMILIN1 as an ideal backbone to develop a versatile drug carrier C.R.O. AVIANO doliana roberto Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352507 Inflammatory biomarkers in phenotyped COPD: relation to extrapulmonary manifestations and dysmetabolism. Toscana Parronchi Paola Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352508 Circulating biomarkers as predictive and prognostic factors in patients with stage III melanoma: analysis of circulating melanoma cells (CMCs), circulating free‐DNA (cfDNA) and molecular characterization of BRAF and NRAS mutational status in primary tumor Lombardia Manganoni Ausilia Maria Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352510 New methodologies for non‐invasive, quantitative and Automatic MOnitoring of childbirth LABor (AMOLAB) Puglia Perrone Antonio Biomedical Surgical Sciences, The new biotechnologies Biomedical Imaging, and Bioengineering RF‐2011‐02352512 MicroRNA Signatures: Novel Biomarkers for early detection of Colorectal Cancer CASA SOLLIEVO SOFFERENZA Piepoli Ada Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352514 Preventing developmental dyslexia by neurocognitive videogames training MEDEA Facoetti Andrea Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352520 Project Title: Endoscopic Screening and onCologic appropRiate rEmoval of Early colorectal lesioNs. ENDOSCREEN Piemonte AREZZO ALBERTO Biomedical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02352531 New ultrasonic methods for OSTEOporosis diagnosis at the proximal FEMur (OSTEOFEM) Puglia Muratore Maurizio Biomedical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering Pagina 214 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352536 Gastrointestinal Tract Permeability and Inflammation in HIV‐Infected patients with mild to moderate Chronic Kidney Disease: a cross‐over, double blind, randomized clinical trial Emilia‐Romagna Guaraldi Giovanni Biomedical AIDS and Related Research Infection and immunity RF‐2011‐02352554 Melanoma: from next generation sequencing to personalized targeted therapy SAN GALLICANO Donati Pietro Clinical Healthcare Delivery and Methodologies Oncology RF‐2011‐02352557 Proteomic profiling of hematological Lazio malignancies by Reverse Phase Protein Array: an innovative traslational approach to identify biomarkers for prognosis and molecular therapy. Tafuri Agostino Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352567 Neural stem cells‐mediated therapy of Lysosomal storage diseases CASA SOLLIEVO SOFFERENZA Scarpa Maurizio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352570 Hyperthermic intra‐peritoneal chemotherapy (HIPEC) in Ovarian cancer recurrence: a Randomized multicentric trial on Survival Evaluation[HORSE trial] Umbria Fagotti Anna Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352574 Lab‐on‐chip technology and new clinical application Lazio Calla' Cinzia Biomedical Anna Maria Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02352575 Omics study of competitive action of starter add on fresh meat production (italian salami) to improve safety Abruzzo Sacchetta Paolo Biomedical Infectious Diseases and Microbiology Food safety and animal welfare RF‐2011‐02352578 Detection of Oxidative Base‐Specific Lesions in the Exon 1 of the K‐RAS and Other Cancer Related Genes of Patients with Newly Diagnosed Colorectal Adenocarcinoma and Colorectal Polyps Toscana Peluso Marco Biomedical Population Sciences and Epidemiology Oncology Pagina 215 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352582 N‐acetylcysteine in the treatment of neuropathic pain NEUROMED Battaglia Giuseppe Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352584 Klebsiella Pneumoniae carbapenemases (KPCs) positive strains in hospitalized decompensated cirrhotic patients: a nationwide epidemiologic survey and the evaluation of a new eradication treatment based on faecal‐microbiota transplantation Emilia‐Romagna Codeluppi Mauro Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02352585 Udder and milk changes during mycoplasma mastitis in sheep: identification of humoral and cellular response/indicators for clinical/disease staging and development of new approach of vaccination. IZSSI Loria Guido Ruggero Biomedical Veterinary Food safety and animal welfare RF‐2011‐02352587 PREDICTION OF AWAKENING FROM ACUTE COMA, USING THE BRAIN REACTIVITY TO PAIN‐RELATED‐ SOMATOSENSORY EVOKED POTENTIALS. Veneto Sorbara Carlo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352589 Effects pf pre‐surgical cognitive rehbilitation on memory outcome after temporal lobe epilepsy surgery CARLO BESTA Giovagnoli Anna Rita Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352590 microRNAs and Single Nucleotide Polymorphisms as potential screening biomarkers for early detection of colorectal cancer. Toscana Sani Cristina Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02352598 Investigation of the association between NF1 Campania gene and NF1‐related genes transcriptional profile and high risk of tumor‐development in patients affected by Neurofibromatosis type 1. Melis Daniela Biomedical Oncology 1 ‐ Basic Translational Oncology Pagina 216 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352602 Early Neurorehabilitation in Neurosubintensive Care Unit Lombardia Bonaiuti Donatella Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352603 SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) BASED DIAGNOSTIC KIT DEVELOPMENT FOR LEUKEMIA BIOMARKER DETECTION SAN RAFFAELE MILANO Peccatori Jacopo Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02352604 Investigating the relationship between animal IZSVE farming and antibiotic resistances in natural or environmental prokaryotic communities ferre nicola Biomedical Veterinary Food safety and animal welfare RF‐2011‐02352605 Provincia autonoma Trento Generation and validation of a new breast cancer prognostic signature by RNAseq‐based translatome profiling. Barbareschi mattia Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02352607 Protocol and tools towards an investigation of Piemonte low dose effects in advanced radiation therapy modalities. Stasi Michele Biomedical Healthcare Delivery and Methodologies Oncology RF‐2011‐02352609 AN ITALIAN REGISTER OF NEONATAL EPILEPTIC ENCEPHALOPATHY Emilia‐Romagna FERRARI FABRIZIO Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352617 NEW INSIGHTS FOR CAD PATIENT MANAGEMENT: in vivo assessment of coronary plaque morphology by means of OCT images and biohumoral markers (PLIMAB: PLaque IMAging Biomarkers) Toscana Berti Sergio Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352618 Estimate of breast cancer risk in relation to mammographic density by using a software for automatic evaluation of the density. Toscana Brancato Beniamino Biomedical Population Sciences and Epidemiology Oncology Pagina 217 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352623 Development of new disease biomarkers by laboratory applications as diagnostic and prognostic tools for Amyotrophic Lateral Sclerosis Toscana Siciliano Gabriele Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352624 Endocrine‐metabolic pattern and Mediterranean Diet biomarkers in the occurrence of breast cancer relapses ISTITUTO TUMORI MILANO Venturelli Elisabetta Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352633 MEDITERRANEAN DIET AND RECURRENCE DE BELLIS OF COLORECTAL ADENOMA AND CANCER : A RANDOMIZED CONTROLLED TRIAL Misciagna Giovanni Biomedical Risk, Prevention and Health Behavior Oncology RF‐2011‐02352636 Veneto The availability of "old" and "new" drug eluting stents in routine clinical practice: influence on the treatment choice among medical therapy vs. percutaneous coronary interventions vs. coronary by‐pass surgery and on 4‐year clinical outcome in patients w Olivari Zoran Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352638 ADIPOSE‐DERIVED MESENCHYMAL STEM CELLS AS NEW MINIMALLY INVASIVE REGENERATIVE TREATMENT TO TARGET EARLY OSTEOARTHRITIS: FROM PRE‐ CLINICAL PROCEDURE SELECTION TO CLINICAL APPLICATION IN A RANDOMIZED DOUBLE‐BLINDED CONTROLLED TRIAL Kon Elizaveta Clinical Musculoskeletal, Oral and Skin Sciences The new biotechnologies RF‐2011‐02352639 Piemonte Implementation of a network on the use of Human Biomonitoring Data in Environmental Epidemiology (HumanBioEnvEpi: HBEE‐ ITA)Realizzazione di una rete sull¿uso nell¿epidemiologia ambientale dei dati del biomonitoraggio umano (HumanBioEnvEpi: HBEE‐ITA) CADUM ENNIO Clinical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace RIZZOLI Pagina 218 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352643 NEOADJUVANT CHEMOTHERAPY AND RADICAL SURGERY IN TREATMENT OF LOCALLY ADVANCED CERVICAL CARCINOMA: 18F‐FDG‐PET/CT AND MOLECULAR BIOLOGY PREDICTIVE VALUE IN EARLY AND LATE ASSESSMENT OF RADICAL SURGERY FEASIBILITY AND ITS SURVIVAL IMPACT Sicilia scollo paolo Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352644 Development and validation of a predictive model of mortality and hospitalization in patients with diabetes using administrative databases. Puglia Giorgino Francesco Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352651 SOW Project: safety on work. An intervention to increase attention of workers, making them aware of risky behavior in psychoactive substances consumption. Campania curcio fabio Clinical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace RF‐2011‐02352655 New approach for the treatment of B‐cell disorders via antiCD20 nanoparticles Friuli‐Venezia Giulia Pozzato Gabriele Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02352656 MECHANOTRANSDUCTION FOR THE TREATMENT OF OSTEOPOROSIS: MECHANISM OF ACTION, PRECLINICAL AND CLINICAL EFFICACY OF EXTRACORPOREAL SHOCK WAVES (ESW) FOR THE PREVENTION OF PATHOLOGICAL FEMORAL NECK FRACTURES RIZZOLI Fini Milena Biomedical Musculoskeletal, Oral and Skin Sciences The new biotechnologies RF‐2011‐02352657 Multi‐Step versus Single‐Step strategy of Transjugular Intrahepatic Portosystemic Shunt (TIPS) Endoprosthesis Placement for Prevention of Post‐TIPS Hepatic Encephalopathy in Cirrhotic Patients with Refractory Ascites. Emilia‐Romagna Schepis Filippo Clinical Digestive, Kidney and Urological Systems Neurological diseases Pagina 219 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352658 Hospital Procedures for acute heart failure and integrated country/hospital healthcare Sicilia ferrara gaetano Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352659 Production of honey‐based materials from Italian honey and their application in medicine and surgery Piemonte Ribero Dario Biomedical The new biotechnologies Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02352660 SECONDARY PREVENTION OF GASTRIC Veneto CANCER: HOW INTEGRATING NEW MOLECULAR/SEROLOGICAL TESTS IN THE CLINICAL PRACTICE De Boni Michele Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352668 Gestational Diabetes: evaluation of vascular, metabolic, metabolomic and proteomic profile in mother‐fetus couple Veneto Lapolla Annunziata Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352671 FROM TISSUES TO SERUM IN CANINE MAMMARY CANCER: AN INTEGRATED CONCEPT OF MALIGNANT TUMOR PROGRESSION IZSUM Manuali Elisabetta Biomedical Veterinary Oncology RF‐2011‐02352672 Changing professional behaviors and measuring the quality of acute stroke care CASA SOLLIEVO SOFFERENZA Intiso Domenico Biomedical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02352675 SURVEILLANCE OF THE PREVALENCE OF PERIODONTITIS AND CHARACTERIZATION OF MICROBIOLOGICAL PROFILE IN A REPRESENTATIVE ADULT ITALIAN POPULATION. SPALLANZANI D'arezzo Silvia Biomedical Infectious Diseases and Microbiology Infection and immunity Pagina 220 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352676 Genetic Polymorphisms and pain sensitivity in Sicilia a Sicilian population of oncological patients Mercadante Sebastiano Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352677 Sudden death during sport activity: pre‐ participation identification of athletes at‐risk and early access to defibrillation for primary and secondary prevention Veneto Basso Cristina Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352680 Multifunctional Targeted Nanoparticles for minimally Invasive Diagnosis and Therapy of Inflammatory Bowels Diseases and their displasic lesions. I. O. V. Scarpa Marco Biomedical Digestive, Kidney and Urological Systems The new biotechnologies RF‐2011‐02352686 Understanding Pancreatic Acinar Cell Carcinoma for better understanding Pancreatic Ductal Carcinoma SAN RAFFAELE MILANO doglioni claudio Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02352688 IDENTIFICATION OF THE GENETIC Veneto BACKGROUND ASSOCIATED TO THE IMPAIRMENT OF RENAL TUBULAR INTRACELLULAR MACHINERY FOR ENDOCYTOSED PROTEINS. SELECTION OF NOVEL BIOMARKERS PREDICTING ONSET OR PRGRESSION OF CHRONIC RENAL FAILURE. Lupo Antonio Biomedical Genes, Genomes and Genetics The new biotechnologies RF‐2011‐02352689 Optimization of In vitro and In vivo tissue Veneto engineering of functional mammary gland and uterus for prospective translational clinical application in post‐oncologic reconstructive surgery. Bassetto Franco Biomedical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02352693 Prognostic and predictive implications of RARA amplification in HER2‐positive breast cancer Costa Alberto Clinical Oncology 2 ‐ Translational Clinical Oncology MAUGERI Pagina 221 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Messalli Enrico Michelino Biomedical Oncology 2 ‐ Translational Clinical Oncology S.CAMILLO Zorzi Marco Clinical Biobehavioral and Behavioral Processes Neurological diseases Contribution of the different risk factors to the prevalence of gestational diabetes mellitus. A cohort study. Emilia‐Romagna facchinetti fabio Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352705 Study and modelling of early alterations of microcirculation insepsis aimed at personalized treatment and identification of the outcome. Toscana Adembri Chiara Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02352708 Study of new biomarkers for diagnoses of disorders of bile acid synthesis by mass spectrometry and metabolomics approach Veneto GIORDANO GIUSEPPE Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease RF‐2011‐02352711 Search for new genetic biomarkers for early diagnosis and prevention of Familial Thoracic Aortic Aneurysms and Dissections Emilia‐Romagna rossi cesare Clinical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease RF‐2011‐02352712 Clinical and Economical Impact of a Multiplex SAN RAFFAELE MILANO PCR‐Based Assay for a rapid Detection of Pathogens Causing Sepsis in non‐hospitalized onco‐hematological Patients with neutropenic fever Corti Consuelo Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02352696 Endocannabinoid system and Human Ovarian Campania Tumors RF‐2011‐02352697 Behavioral and neurofunctional markers of spatial awareness deficits during multi‐ tasking: Implications for diagnosis and rehabilitation of right hemisphere stroke patients RF‐2011‐02352703 Pagina 222 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352717 Employment of mesenchymal stem cells as vectors for prodrug activating enzymes in prostate cancer therapy SAN RAFFAELE MILANO Cavarretta Ilaria Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02352719 A NOVEL ¿EX VIVO¿ SYSTEM FOR MONITORING THROMBUS FORMATION UNDER FLOW BASED ON ELECTRICAL IMPEDANCE TOMOGRAPHY C.R.O. AVIANO Mazzucato Mario Biomedical Vascular and Hematology The new biotechnologies RF‐2011‐02352720 Improving clinical pathways of patients candidated to cardiac surgery by process modeling MONZINO Cammelli Lorenzo Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02352725 Campania Identification of novel markers of disease through the analysis of the role and impact of mesenchymal stem cells and of miRNA/mRNA network on the progression of bicuspid aortic valve‐related aortopathy Cipollaro Marilena Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352728 Internet Addiction in adolescents: identification of possible neurobiological and personality markers. Toscana Marazziti Donatella Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352731 Aerobiological monitoring and allergy management in Abruzzo Abruzzo Ginaldi Lia Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace RF‐2011‐02352734 A MULTIMODALITY APPROACH TO PREVENT POSTOPERATIVE NEUROLOGICAL DYSFUNCTION IN PATIENTS UNDERGOING CARDIAC SURGERY Veneto Polesel Elvio Clinical Brain Disorders and Clinical Neuroscience Neurological diseases Pagina 223 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. Marchetti Piero Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Lazio Vullo Vincenzo Clinical AIDS and Related Research Infection and immunity MOLECULAR CHARACTERIZATION OF COXIELLA BURNETII FROM DOMESTIC RUMINANTS AND WILDLIFE SPECIES BY MLVA AND NGS TECHNIQUES IZSME BORRIELLO GIORGIA Biomedical Infectious Diseases and Microbiology The new biotechnologies RF‐2011‐02352755 Detection and molecular characterization of Cryptosporidium, Giardia and Toxoplasma oocysts/cysts in bivalve mollusks destined for human consumption. IZSSA Virgilio Sebastiano Biomedical Veterinary Food safety and animal welfare RF‐2011‐02352756 Comparative effectiveness: Hospital volumes and outcomes of treatments. Systematic reviews and observational study in Italian NHS. Agenzia per i Servizi Sanitari Regionali perucci carlo a. Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease RF‐2011‐02352767 Angiogenic pattern as early marker of colon cancer progression. A morphological and immunohistochemical study on colorectal adenomas according to modality of detection. Toscana messerini luca Biomedical Oncology 1 ‐ Basic Translational Oncology RF‐2011‐02352772 NEW DIAGNOSTIC METHODS FOR PERSONALIZED MEDICINE: AUTOMATIC GENERATION OF CLINICAL PATHWAY TROUGHT CORRELATION BETWEEN BIOCHEMICAL SCREENING AND STRESS IMAGING Marche Mazzanti Marco Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352739 Toscana Role of nanomultilayers with anti‐ inflammatory and tracking features in human islet transplantation for the treatment of type 1 diabetes RF‐2011‐02352748 The challenge of cardiovascular diseases in HIV‐positive patients: A Multiparametric Analysis RF‐2011‐02352753 Pagina 224 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352776 Risk assessment of developing atypical Hemolitic Uremic Syndrome by genetic and epigenetic investigations MAGGIORE Ardissino Gianluigi Biomedical Genes, Genomes and Genetics Infection and immunity RF‐2011‐02352782 Oxidative stress and vitamin D as potential contributors for cardiometabolic complications in subclinical and overt hypothyroidism. Toscana Vassalle Cristina Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352784 Novel Electrochemical Cancer Diagnostics I.E.O. GIORGIO MARCO Biomedical Bioengineering Sciences and Technologies Oncology RF‐2011‐02352789 Study of molecular based approach for the epidemiological characterization of strains of Listeria monocytogenes isolated in food and human cases in Italy IZSAM Prencipe Vincenza Biomedical Veterinary Food safety and animal welfare RF‐2011‐02352790 Study of exposition to chemical agents Abruzzo (asbestos, new technology chemical agents) in workers and common people after April 2009 earthquake POMPEI DOMENIC Clinical O Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐02352794 Development and monitoring of a Parkinson's Toscana disease network in Tuscany Bonuccelli Ubaldo Clinical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352796 Computer Assisted Evaluation of Fracture Risk RIZZOLI in Tumor Spine Lesions Schileo Enrico Biomedical Oncology Surgical Sciences, Biomedical Imaging, and Bioengineering RF‐2011‐02352797 Developing and testing a tool for priority setting in health care for non‐communicable diseases based on impact of prevention SALMASO STEFANIA Clinical Istituto Superiore di Sanita' Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease Pagina 225 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352802 The role of OPG, RANK and RANKL gene SNPs (single nucleotide polymorphisms) in susceptibility to acute myocardial infarction CASA SOLLIEVO SOFFERENZA Fanelli Raffaele Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352809 Role of mast cells in the pathogenesis of diabetic heart disease. SAN RAFFAELE MILANO Falcone Marika Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352813 Human Cardiac Stem Cell Therapy in Patients Lazio with Severe Heart Failure Undergoing LVAD Implantation. Massetti Massimo Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease RF‐2011‐02352814 Toscana (SIMBA) Simulation Interface for Miniaturized preterm BAby respiratory system model Cuttano Armando Clinical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02352818 Influenza vaccination of the elderly: Lazio effectiveness and determinants assessment by systematic literature review and by a historical cohort study based on 13 years of mass campaigns in Lazio and Piemonte regions Pezzotti Patrizio Clinical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02352822 Development and performance evaluation of different assays for the study of the presence of viable Toxoplasma gondii in vegetable and meat IZSPLV GENNERO MARIA SILVIA Biomedical Veterinary Food safety and animal welfare RF‐2011‐02352825 Definition of a "Myeloma Panel" to analyze the role played by clonal evolution in the resistance to therapy Emilia‐Romagna Cavo Michele Clinical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352828 Cost‐effectiveness of Transcatheter Aortic Piemonte Vale Implantation in high‐risk patients with severe aortic valve stenosis: a real world study in the Italian public health care system Gaita Fiorenzo Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease Pagina 226 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. RF‐2011‐02352834 Development and evaluation of Influenza Virus Polymerase Inhibitors for combination antiviral therapy Istituto Superiore di Sanita' Puzelli Simona Biomedical Infectious Diseases and Microbiology Infection and immunity RF‐2011‐02352852 Dynamics and ultrastructure of stress sensing SAN RAFFAELE MILANO Van Anken Eelco Biomedical Cell Biology The new biotechnologies RF‐2011‐02352866 Early detection of neurodegenerative diseases. Liguria The case of Alzheimer's disease CAMMARATA SERGIO Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases RF‐2011‐02352873 PERFUSION COMPUTED TOMOGRAPHY (PCT) AND VASCULAR ENDOTHELIAL GROWTH FACTOR‐A (VEGF‐A) SERUM AND LIQUOR LEVELS IN THE MANAGEMENT OF HIGH GRADE GLIOMAS NEUROMED Tomao Silverio Clinical Emerging Technologies and Training in Neurosciences Oncology RF‐2011‐02352877 Observational Retrospective Study crossed to a Clinical Prospective Study to assess the clinical effectiveness of rhBMP‐7 (eptotermin alfa) in long‐bone non‐unions and critical bone defects Lombardia CALORI GIORGIO MARIA Clinical Bioengineering Sciences and Technologies The new biotechnologies RF‐2011‐02352881 Development Of A Novel Adoptive Cell Istituto Superiore di Sanita' Transfer Approach (ACT) For Cancer Immunotherapy Based On The Use Of Autologous IFN‐DC For The Induction Of Anti‐Tumor Response And Implemented By Strategies Aimed At Extending The Replicative Lifespan Of The Anti‐Tumo Santini Stefano Maria Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐02352893 Lombardia Atherosclerotic effects of chronic low dose radiation exposure assessed with an integrated clinical, cellular and experimental approach: The Interventional Cardiologist Radiation Study Piccaluga Emanuela Biomedical Cardiovascular and Respiratory Sciences Diseases of environmental origin, with reference also to the workplace Pagina 227 di 228 BANDO 2011‐212 RICERCA FINALIZZATA ‐ Elenco Progetti Ordinari Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione Area Strategica. The new biotechnologies RF‐2011‐02352895 INNOVATIVE THERAPY FOR OSTEOARTHRITIS: FROM CLASSICAL VISCOINDUCTION TO INTRA‐ARTICULAR INFILTRATION OF MULTILAYERED HYALURONIC ACID AND CHITOSAN MICROCAPSULES FOR PRECISE POINT OF CARE DELIVERY AND CONTROLLED RELEASE PROFILE Lazio Migliore Alberto Clinical Bioengineering Sciences and Technologies RF‐2011‐02352896 Work‐oriented upper extremity functional evaluation: development of an integrated measurement platform for identification of return‐to‐work strategies Toscana SARTORELLI PIETRO Clinical Diseases of Surgical Sciences, Biomedical Imaging, environmental origin, with reference also to and Bioengineering the workplace RF‐2011‐02352914 Development of an integrated risk communication web‐based model associated with the consumption of food additives IZSVE ravarotto licia Biomedical Healthcare Delivery and Methodologies Food safety and animal welfare Pagina 228 di 228