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EP — Europace Volume 18 No. 9 September 2016 EDITORIALS Pharmacoepidemiological comparisons between acenocoumarol and dabigatran: interpretation of data reflecting clinical practice Peter Brønnum Nielsen 1283 Longevity of implantable cardioverter-defibrillators: still a long way to go Jens Brock Johansen, Jens Cosedis Nielsen, and Niels C.F. Sandgaard 1285 REVIEWS Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop Blanca Rodriguez, Annamaria Carusi, Najah Abi-Gerges, Rina Ariga, Oliver Britton, Gil Bub, Alfonso Bueno-Orovio, Rebecca A.B. Burton, Valentina Carapella, Louie Cardone-Noott, Matthew J. Daniels, Mark R. Davies, Sara Dutta, Andre Ghetti, Vicente Grau, Stephen Harmer, Ivan Kopljar, Pier Lambiase, Hua Rong Lu, Aurore Lyon, Ana Minchole, Anna Muszkiewicz, Julien Oster, Michelangelo Paci, Elisa Passini, Stefano Severi, Peter Taggart, Andy Tinker, Jean-Pierre Valentin, Andras Varro, Mikael Wallman, and Xin Zhou 1287 Extra-cardiac stimulators: what do cardiologists need to know? Alexandre Guinand, Stéphane Noble, Angela Frei, Julien Renard, Martin R. Tramer, and Haran Burri 1299 Atrial fibrillation Antithrombotic therapy use in patients with atrial fibrillation before the era of non-vitamin K antagonist oral anticoagulants: the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF) Phase I cohort Menno V. Huisman, Chang Sheng Ma, Hans-Christoph Diener, Sergio J. Dubner, Jonathan L. Halperin, Kenneth J. Rothman, Christine Teutsch, Nils Schoof, Eva Kleine, Dorothee B. Bartels, and Gregory Y.H. Lip, for the GLORIA-AF Investigators 1308 Effectiveness and safety of dabigatran versus acenocoumarol in ‘real-world’ patients with atrial fibrillation Jennie Korenstra, E. Petra J. Wijtvliet, Nic J.G.M. Veeger, Christiane A. Geluk, G. Louis Bartels, Jan L. Posma, Margriet Piersma-Wichers, Isabelle C. Van Gelder, Michiel Rienstra, and Robert G. Tieleman 1319 Von Willebrand factor is associated with atrial fibrillation development in ischaemic patients after cardiac surgery Diana Hernández-Romero, Álvaro Lahoz, Vanessa Roldan, Eva Jover, Ana I. Romero-Aniorte, Carlos M. Martinez, Rubén Jara-Rubio, José Marı́a Arribas, Arcadio Garcia-Alberola, Sergio Cánovas, Mariano Valdés, and Francisco Marı́n 1328 Ablation for atrial fibrillation Five-year efficacy of pulmonary vein antrum isolation as a primary ablation strategy for atrial fibrillation: a single-centre cohort study Cas Teunissen, Wil Kassenberg, Jeroen F. van der Heijden, Rutger J. Hassink, Vincent J.H.M. van Driel, Nicolaas P.A. Zuithoff, Pieter A. Doevendans, and Peter Loh 1335 Outcomes after cryoablation vs. radiofrequency in patients with paroxysmal atrial fibrillation: impact of pulmonary veins anatomy Z. Khoueiry, J.-P. Albenque, R. Providencia, S. Combes, N. Combes, F. Jourda, P.A. Sousa, C. Cardin, J.-L. Pasquie, T.T. Cung, F. Massin, E. Marijon, and S. Boveda 1343 Who is the operator, that is the question: a multicentre study of catheter ablation of atrial fibrillation Akinori Sairaku, Yukihiko Yoshida, Yukiko Nakano, Mayuho Maeda, Haruo Hirayama, Haruki Hashimoto, and Yasuki Kihara 1352 Incidence and outcomes of cerebrovascular events complicating catheter ablation for atrial fibrillation Yang Liu, Xianzhang Zhan, Yumei Xue, Hai Deng, Xianhong Fang, Hongtao Liao, Jun Huang, Fangzhou Liu, Yuanhong Liang, Wei Wei, and Shulin Wu 1357 Sudden death and ICDs Battery drain in daily practice and medium-term projections on longevity of cardioverter-defibrillators: an analysis from a remote monitoring database Giuseppe Boriani, Philippe Ritter, Mauro Biffi, Matteo Ziacchi, Igor Diemberger, Cristian Martignani, Cinzia Valzania, Sergio Valsecchi, Luigi Padeletti, and Fredrik Gadler 1366 Downloaded from by guest on October 25, 2016 CLINICAL RESEARCH 1374 Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients Yiyi Zhang, Elena Blasco-Colmenares, Amy C. Harms, Barry London, Indrani Halder, Madhurmeet Singh, Samuel C. Dudley, Rebecca Gutmann, Eliseo Guallar, Thomas Hankemeier, Gordon F. Tomaselli, and Alan Cheng 1383 Pacing and resynchronization therapy Reduction of inappropriate anti-tachycardia pacing therapies and shocks by a novel suite of detection algorithms in heart failure patients with cardiac resynchronization therapy defibrillators: a historical comparison of a prospective database Maurizio Lunati, Alessandro Proclemer, Giuseppe Boriani, Maurizio Landolina, Emanuela Locati, Roberto Rordorf, Elisabetta Daleffe, Renato Pietro Ricci, Domenico Catanzariti, Luca Tomasi, Michele Gulizia, Maria Stella Baccillieri, Giulio Molon, and Maurizio Gasparini, on behalf of the ClinicalService Cardiological Centres 1391 Pacing and sensing optimization of permanent His-bundle pacing in cardiac resynchronization therapy/ implantable cardioverter defibrillators patients: value of integrated bipolar configuration Lan Su, Lei Xu, Sheng-jie Wu, and Wei-jian Huang 1399 Cardiac electrophysiology Evaluation of a new very low dose imaging protocol: feasibility and impact on X-ray dose levels in electrophysiology procedures Felix Bourier, Tilko Reents, Sonia Ammar-Busch, Alessandra Buiatti, Marc Kottmaier, Verena Semmler, Marta Telishevska, Amir Brkic, Christian Grebmer, Carsten Lennerz, Christof Kolb, Gabriele Hessling, and Isabel Deisenhofer 1406 Channelopathies Brugada syndrome: clinical presentation and genotype—correlation with magnetic resonance imaging parameters Boris Rudic, Rainer Schimpf, Christian Veltmann, Christina Doesch, Erol Tülümen, Stefan O. Schoenberg, Martin Borggrefe, and Theano Papavassiliu 1411 Novel electrocardiographic criteria for the diagnosis of arrhythmogenic right ventricular cardiomyopathy Velislav N. Batchvarov, Rachel Bastiaenen, Pieter G. Postema, Elaine N. Clark, Peter W. Macfarlane, Arthur A.M. Wilde, and Elijah R. Behr 1420 Syncope and event loop recorders Standardized algorithm for cardiac pacing in older patients affected by severe unpredictable reflex syncope: 3-year insights from the Syncope Unit Project 2 (SUP 2) study Michele Brignole, Francesco Arabia, Fabrizio Ammirati, Marco Tomaino, Fabio Quartieri, Martina Rafanelli, Attilio Del Rosso, Maria Rita Vecchi, Vitantonio Russo, and Germano Gaggioli, on behalf of the Syncope Unit Project 2 (SUP 2) investigators 1427 EP WIRE Implantation of subcutaneous implantable cardioverter defibrillators in Europe: results of the European Heart Rhythm Association survey Serge Boveda, Radoslaw Lenarczyk, Kristina Haugaa, Stefano Fumagalli, Antonio Hernandez Madrid, Pascal Defaye, Paul Broadhurst, and Nikolaos Dagres 1434 BASIC SCIENCE Sex-dependent alterations of Ca21 cycling in human cardiac hypertrophy and heart failure Thomas H. Fischer, Jonas Herting, Jörg Eiringhaus, Steffen Pabel, Nico H. Hartmann, David Ellenberger, Martin Friedrich, André Renner, Jan Gummert, Lars S. Maier, Markus Zabel, Gerd Hasenfuss, and Samuel Sossalla 1440 CASE EXPRESS REPORTS A useful irrigated tip to cannulate distal coronary sinus J. Fedida, C. Lepiece, and S. Knecht 1327 Cystic tumour of the atrioventricular node: can an electrophysiological study predict sudden death? Kazutaka Ueda, Osamu Tagusari, and Masashi Kasao 1334 High-density biatrial activation mapping during typical atrial flutter after bicavopulmonary bypass Philippe Maury, Stefano Capellino, and Sebastien Hascoet 1342 Twiddler’s syndrome with a baroreflex stimulator device Vincent Galand, Raphaël P. Martins, and Christophe Leclercq 1433 Downloaded from by guest on October 25, 2016 Reduced long-term overall mortality in heart failure patients with prolonged QRS treated with CRT combined with ICD vs. heart failure patients with narrow QRS treated with ICD only Pietro Palmisano, Michele Accogli, Ennio Carmine Luigi Pisanò, Maria Zaccaria, Sergio De Blasi, Maria Antonietta Ponzetta, Sergio Valsecchi, Giovanni Milanese, Maurelio Lauretti, and Francesco Magliari IMAGES IN ELECTROPHYSIOLOGY Intracardiac drifting iceberg: a worrisome incident during cryoablation Adolfo Fontenla, Lola Villagraz, and Marı́a López-Gil 1351 Downloaded from by guest on October 25, 2016 Open Access Paper Visit EP —EUROPACE’s mobile site http://m.europace.oxfordjournals.org/ www.europace.oxfordjournals.org