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Product Monograph for Herbal Magic
Probiotics
NPN 80055952
GENERAL INFORMATION
Herbal Magic’s Probiotics is a formulation of live micro-organisms
that helps restore the microbial balance in the gut flora. This
formula includes 8 strains, providing a total of 25 billion colony
forming units (CFU) per capsule. Probiotics should be taken daily
to contribute to a natural, healthy gut flora which plays an
important role in ensuring good digestive health and general
health.
The term probiotic refers to live microorganisms (bacteria) that
have beneficial effects on the host’s microflora. 1 More than 500
species of bacteria reside in the human intestinal tract, which
consists of organisms including Bifidobacterium and Lactobacillus.2
These bacteria have many functions, including supporting fibre
digestion, vitamin synthesis, dietary nutrient absorption, and
defence against harmful bacteria.3,4 If the delicate balance of the
microflora is disrupted, its regular and vital functions are affected
which may lead to harmful bacterial infection.
The human body relies on a healthy digestive flora for numerous
important functions including helping with food digestion and
metabolism, absorption of nutrients, toxin elimination and in the
prevention of pathogenic bacterial intestinal growth.5,6,7,8,9
RECOMMENDED USES

Primary Uses: Helps support intestinal/gastrointestinal health;
could promote a favorable gut flora.
MECHANISM OF ACTION
Research Suggests
The adult gastrointestinal flora is composed of two kinds of flora:
native symbiotic (mutual beneficial relationship for the bacteria
and host) bacteria, and potentially harmful bacteria. Good health
often results from a balance between the beneficial versus the
harmful bacteria. Several medical, dietary and lifestyle factors can
disturb the balance, such as inadequate dietary fibre, oral
antibiotic therapy, ingestion of environmental toxins, alcohol use
and/or stressful lifestyle. 10,11
Probiotics are considered beneficial and are referred to as "good"
bacteria. The World Health Organization defines probiotics as “live
microorganisms which when administered in adequate amounts
confer a health benefit on the host”.12 The intestinal microflora
consist of billions of bacteria that have two key functions: they
play a role in metabolism by aiding food digestion, and also help to
protect the body from developing infections. 13,14
Probiotics can also help reduce inflammation, a key contributor to
insulin resistance, resulting in destruction of insulin-producing
cells. 15,16 These bacteria help strengthen the intestinal wall,
preventing the passage of bad bacteria into the bloodstream that
can further increase inflammation and insulin resistance. 17
Probiotics can help alleviate stress, anxiety and improve mood;
overall reducing factors which can contribute to weight gain.
Research has demonstrated that probiotics can exert a noticeable
effect on GABA levels, an inhibitory neurotransmitter involved in
regulating many physiological and psychological processes, and
also can lower the stress-induced hormone corticosterone. Lower
levels of corticosterone result in reduced anxiety and depression
related behaviors, which can play a major role in weight gain.18,19
Furthermore, UCLA researchers found that consuming probiotics,
such as Bifidobacterium animalis subsp Lactis, for 4 weeks helps
reduce activity in parts of the brain that control central processing
of emotion and sensation—these areas are involved in mood,
sensitivity to pain, anxiety, and stress. Participants underwent
functional magnetic resonance imaging (fMRI) before and after the
treatment to measure brain response to an emotion-oriented
attention task and resting brain activity.20
Aside from supporting proper food digestion, researchers are also
finding evidence of a relationship between good bacteria and the
immune system. Certain bacteria in the gut influence the
development of aspects of the immune system, such as correcting
deficiencies and increasing the numbers of T cells.21 T cells are
responsible for maintaining a good immune response by
influencing the activity of other cell types throughout the body.22
Furthermore, researchers at Laval University in Quebec suggests
that certain probiotics, specifically the Lactobacillus rhamnosus
family, may help women lose twice as much weight compared to
those who do not consume the bacteria regularly. Results
demonstrate that the mean weight loss in the supplemented group
was significantly higher when compared to placebo group after 12
weeks. Overall the women in the probiotic supplementation group
lost on average 4.4 kilograms (nearly 10 lbs) compared to the
placebo group who only lost 2.6 kg (about 5.5 lbs).23
Lactobacillus
Lactobacillus is one of the major species of natural microflora
found in the human body and is used for treating diarrhea. It is
one of the most important, well established and well-researched
micro-organisms that occupies the gastrointestinal tract.
Lactobacillus probiotics offer a many health benefits, such as the
treatment of diarrhea and other gastrointestinal conditions, as well
as helping break down food.6,24
Bifidobacterium
Bifidobacterium lactis contribute to a natural healthy gut flora
which plays an important role in good digestive health. The
beneficial lactic acid-producing bacteria Bifidobacterium forms a
major part of the bacteria residing in the human intestinal tract.25
This particular strain of bacteria can help support a healthy
balance of intestinal microflora and stimulate the natural defenses
of the immune system.13,14 Bifidobacterium lactis are dominant in
the micro-ecosystem of the colonic microbiota,26 and are
recognized for their high oxygen resistance and ability to inhabit
the colon.27
RECOMMENDED DOSAGE
Youth and Adults aged 12+: 1 cap 2x/day with meals, at least 2-3
hours before or after antibiotics.
CAUTIONS AND WARNINGS
Consult a health care practitioner prior to use if you have fever,
vomiting, bloody diarrhoea or severe abdominal pain. Discontinue
use and consult a health care practitioner if symptoms of digestive
upset occur, worsen, or persist beyond 3 days. May contain gluten
and soybean.
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DISEASE/CONDITION INTERACTIONS
Immune compromised condition: Do not use.
DRUG INTERATIONS
Take at least 2-3 hours before or after taking antibiotics.
To prevent any interactions, all Herbal Magic centres offer our
unique Medication Cross-Reference System, designed to provide
evidence-based safe dosing options for Herbal Magic products
such as Probiotics with other medications that the client is taking.
FORMULATION
Medicinal Ingredients per capsule:
Probiotic blend……………………………………………………..25 billion CFU
Lactobacillus acidophilus (LA-14) ..........................12 X 109 CFU
Bifidobacterium animalis subsp. Lactis (BI-04) …..... 8 X 109 CFU
Lactobacillus rhamnosus (Lr-32) ......................... 0.6 X 109 CFU
Lactobacillus plantarum (Lp-115) …..................... 1.1 X 109 CFU
Lactobacillus casei (Lc-11) ................................. 0.6 X 109 CFU
Lactobacillus paracasei (Lpc-37) …...................... 1.1 X 109 CFU
Bifidobacterium longum subsp. Longum (BI-05) .. 0.3 X 109 CFU
Bifidobacterium bifidum (Bb-02) ......................... 1.3 X 109 CFU
Non-medicinal Ingredients:
Hypromellose, inulin, magnesium stearate, silica.
Features:

Non-GMO

Vegan friendly

Dye free
For further information, please contact the Herbal Magic
Scientific Advisory Team at 1-866-787-0050.
REFERENCES
1 World Health Organization. Guidelines for the Evaluation of
Probiotics in Food. Accessed May 22, 2015 from:
http://www.who.int/foodsafety/fs_management/en/probiotic_g
uidelines.pdf.
2 Leahy SC, et al. (2005). Getting better with bifidobacteria. J App
Micrbiol, 98: 1303-15.
10 Doron S & Gorbach SL. (2006). Probiotics: their role in the
treatment and prevention of disease. Expert Review of AntiInfective Therapy. 4(2):261–275.
11 Maity, TK, & Misra AK. (2009). Probiotics and human health:
synoptic review. African J Food , Agriculture, Nutrition and
Development 9.8: 1778(19).
12 Maity, TK, & Misra AK. (2009). Probiotics and human health:
synoptic review. African J Food , Agriculture, Nutrition and
Development 9.8: 1778(19).
13 Ezendam J & Van LH. (2006). Probiotics: Immuno-modulation
and Evaluation of Safety and Efficacy. Nutr Rev, 64(1):1-14.
14 Gill H & Prasad J. (2008). Probiotics, Immunomodulation, and
Health Benefits. Adv Exp Med Biol, 606:423-454.
15 Isolauri E, Kirjavainen PV, Salminen S. Probiotics: a role in the
treatment of intestinal infection and inflammation?.
Gut 2002;50:54-59.
16 National Diabetes Information Clearing.house (NDIC). Causes
of Diabetes. Accessed May 22, 2015 from:
http://diabetes.niddk.nih.gov/dm/pubs/causes.
17 British Journal of Nutrition; Effects of Lactobacillus acidophilus
NCFM on insulin sensitivity and the systemic inflammatory
response in human subjects; A. Andreasen, et al.; September
2010.
18 Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E.,
Savignac, H. M., Dinan, T. G., … Cryan, J. F. (2011). Ingestion
of Lactobacillus strain regulates emotional behavior and central
GABA receptor expression in a mouse via the vagus
nerve. Proceedings of the National Academy of Sciences of the
United States of America, 108(38), 16050–16055.
19 Mishima, Y., Shinoda, Y., Sadakata, T., Kojima, M., Wakana, S.,
& Furuichi, T. (2015). Lack of stress responses to long-term
effects of corticosterone in Caps2 knockout mice. Scientific
reports, 5.
20 Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat,
B., & Mayer, E. A. (2013). Consumption of fermented milk
product with probiotic modulates brain
activity. Gastroenterology, 144(7), 1394-1401.
3 National Center for Complementary and Alternative Medicine.
Oral Probiotics: An Introduction. Accessed May 21, 2015 from:
http://nccam.nih.gov/health/probiotics/introduction.htm.
21 Harvard Health Publication. How to boost your immune system:
What can you do?. http://www.health.harvard.edu/stayinghealthy/how-to-boost-your-immune-system. Accessed June 6,
2015.
4 Frenkel M, et al. (2013). Integrating dietary supplements into
cancer care. Integr Cancer Ther, 12(5):369.
22 Zou, W. (2006). Regulatory T cells, tumour immunity and
immunotherapy.Nature Reviews Immunology, 6(4), 295-307.
5 Rolfe RD. The role of probiotic cultures in the control of gastrointestinal health. J Nutr. 2000;130(2 Suppl):396S-402S.
23 Sanchez, M., Darimont, C., Drapeau, V., Emady-Azar, S.,
Lepage, M., Rezzonico, E., ... & Tremblay, A. (2014). Effect of
Lactobacillus rhamnosus CGMCC1. 3724 supplementation on
weight loss and maintenance in obese men and women. Br J
Nutr, 111(8), 1507-19.
6 de Vrese M, Schrezenmeir J. Probiotics, prebiotics, and
synbiotics. Adv Biochem Eng Biotechnology. 2008;111:1-66.
7 Douglas LC, Sanders ME. Probiotics and Prebiotics in dietetic
practice. J Am Diet Assoc. 2008;108(3):510-21.
8 Parvez S., Malik KA, Kang AH, et al. Probiotics and their fermented food products are beneficial for health. J Appl Microbiol.
2006;100(6):1171-85.
9 Collins D., Gibson G., Probiotics, prebiotics, and synbiotics:
approaches for modulating the microbial ecology of the gut
American Journal of Clinical Nutrition, 1999; 69(5): 1052S1057S.
24 Medline Plus. Lactobacillus. Accessed May 21, 2015 from:
http://www.nlm.nih.gov/medlineplus/druginfo/natural/790.htm
l
25 Wheatcroft PD, on behalf of Molecular and Cellular Research
Team Agriculture and AgriFood Canada, Guelph, Ontario.
Microorganisms in Foods and Around Them.
http://www.magma.ca/~pavel/science//Foodbugs. html.
26 Bifidiobacterium lactis. Danisco, Received 2012; Version 6-D04.
F OR PROFESSIONAL U SE O NLY
F OR P ROFESSIONALS TO RECEIVE A PRINTED COPY OF THIS MONOGRAPH , CONTACT HERBAL M AGIC CLINICAL
SUPPORT AT [email protected] OR 1-866-787-0050.
11/09/15 Rev 0
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27 Ventura M., Zink Ralf., Rapid Identification, Differentiation, and
Proposed New Taxonomic Classification of Bifidobacterium
lactis. Appl Environ Microbiol 2002; 68(12): 6429–6434.
LeBlanc, J. G., Milani, C., de Giori, G. S., Sesma, F., van
Sinderen, D., & Ventura, M. (2013). Bacteria as vitamin
suppliers to their host: a gut microbiota
perspective. Current opinion in biotechnology, 24(2),
160-168.
F OR PROFESSIONAL U SE O NLY
F OR P ROFESSIONALS TO RECEIVE A PRINTED COPY OF THIS MONOGRAPH , CONTACT HERBAL M AGIC CLINICAL
SUPPORT AT [email protected] OR 1-866-787-0050.
11/09/15 Rev 0
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