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Dexamethasone N n° CAS 152121-30-7 SB202190 Molecular Weight: 475,62 Chemical Formula: C26H41N3O5 O H N O N H O H N O O O F H3C HO H n° CAS 133407-82-6 MG 132 Molecular Weight: 392,46 Chemical Formula: C22H29FO5 H Molecular Weight: 244,24 Chemical Formula: C14H12O4 HO H CH3 OH CH3 OH O OH OH OH n° CAS 50-02-2 Dexamethasone n° CAS 10083-24-6 Piceatannol Piceatannol n° CAS 50-02-2 Resveratrol OH CH3 HO H3C H F O H O OH CH3 NF-kB inhibitor OH Catalog # tlrl-resv For research use only Version # 12E22-MM content: MG 132 100 mg Resveratrol provided lyophilizedn° CAS 133407-82-6 HO OH Chemical Formula: C14H12O4 Molecular Weight: 244,24 Chemical Formula: C22H29FO5 Molecular Weight: 392,46 PrODucT iNFOrMaTiON n° CAS 10083-24 OH METHODS Preparation of stock solution (20 mg/ml): To obtain a 20 mg/ml stock solution: 1. Add 250 ml DMSO to 5 mg Resveratrol. This provides a Storage and stability: solution at 20 mg/ml (88 mM). - Resveratrol is shipped at room temperature. Store lyophilized 2. Vortex until complete solubilization. O O product at -20°C. Product is stable for 1 year. H 3. Aliquote and store at 4˚C. H -Upon resuspension in DMSO,OResveratrol isN stable for 4. Once resveratrol is solubilized, dilutions can be prepared by N N 3 H H months at 4°C. Protect from light. O O adding sterile water or culture medium. Aqueous dilutions of resveratrol should not be stored for more that 1 day. DEScriPTiON Working concentration: 10-100 µM (2.3 - 23 mg/ml) Resveratrol (3,4',5-trihydroxy-trans-stilbene) is a polyphenol Chemical Formula: C H N O 26 41 3 5 found in plants known to possess anti-inflammatory and 475,62 NFkB inhibition: chemopreventive properties. Molecular ResveratrolWeight: has been shown to To assess the role of NF-kB, pretreat cells, such as inhibit the expression of proinflammatory markers, including macrophages or HEK293 cells transfected with one or several inducible nitric oxide synthase and cyclooxygenase-2 in 1 TLR genes, for 1 hour with or without resveratrol SB202190 macrophages and cancer cells , block TRIF-dependent 2 at 10-100 µM and then incubate at 37°C with the appropriate signaling pathway of TLR3 and TLR4 and modulate bacterial 3 n° CAS 152121-30-7 TLR ligand for 1 to 6 hours. Detect NF-kB inhibition using the phagocytosis of macrophages . Resveratrol may exert these appropriate detection system. diverse effects by suppressing N NF-kB activation. H 1. lorne E. et al., 2009. Participation of Mammalian N Target of Rapamycin Complex 1 in Toll-Like Receptor 2– and 4–Induced Neutrophil Activation and Acute Lung Injury. Am. J. OHCancer Respir. Cell Mol. Biol. 41: 237 - 245. 2. Bhat KP. & Pezzuto JM., 2002. chemopreventive activity of resveratrol. Ann. NY Acad. N Sci.957:210.-229. 3. Youn HS et al., 2005. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. J Immunol. 175(5):3339-46. F Chemical Formula: C20H14FN3O cHEMical PrOPErTiES Molecular Weight: 331,34 caS number: 501-36-0 Formula: C14H12O3 Molecular weight: 228.24 appearance: Off-whiteResveratrol to pale yellow color Solubility: 20 mg/ml in DMSO provides a clearn° yellow CASsolution 501-36-0 Purity: >98% rElaTED PrODucTS Product catalog code HEK-Blue hTLR2 cells (SEAP reporter cells) pUNO1-hTLR2 (plasmid with human gene) pUNO-mTLR2 (plasmid with mouse gene) Pam3CSK4 (TLR2 ligand) hkb-htlr2 puno1-htlr2 puno-mtlr2 tlrl-pms OH HO OH TECHNICAL SUPPORT Toll free (US): 888-457-5873 Outside US: (+1) 858-457-5873 Europe: +33 562-71-69-39 E-mail: [email protected] Website: www.invivogen.com Chemical Formula: C14H12O3 Molecular Weight: 228,24 3950 Sorrento Valley Blvd. Suite 100 San Diego, CA 92121 - USA