Download TDS Resveratrol

Dexamethasone
N
n° CAS 152121-30-7
SB202190
Molecular Weight: 475,62
Chemical Formula: C26H41N3O5
O
H
N
O
N
H
O
H
N
O
O
O
F
H3C
HO
H
n° CAS 133407-82-6
MG 132
Molecular Weight: 392,46
Chemical Formula: C22H29FO5
H
Molecular Weight: 244,24
Chemical Formula: C14H12O4
HO
H
CH3
OH
CH3
OH
O
OH
OH
OH
n° CAS 50-02-2
Dexamethasone
n° CAS 10083-24-6
Piceatannol
Piceatannol
n° CAS 50-02-2
Resveratrol
OH
CH3
HO
H3C
H
F
O
H
O
OH
CH3
NF-kB inhibitor
OH
Catalog # tlrl-resv
For research use only
Version # 12E22-MM
content:
MG 132
100 mg Resveratrol provided lyophilizedn° CAS 133407-82-6
HO
OH
Chemical Formula: C14H12O4
Molecular Weight: 244,24
Chemical Formula: C22H29FO5
Molecular Weight: 392,46
PrODucT iNFOrMaTiON
n° CAS 10083-24
OH
METHODS
Preparation of stock solution (20 mg/ml):
To obtain a 20 mg/ml stock solution:
1. Add 250 ml DMSO to 5 mg Resveratrol. This provides a
Storage and stability:
solution at 20 mg/ml (88 mM).
- Resveratrol is shipped at room temperature.
Store lyophilized
2. Vortex until complete solubilization.
O
O
product at -20°C. Product is stable for 1 year. H
3. Aliquote and store at 4˚C.
H
-Upon resuspension in DMSO,OResveratrol
isN stable for
4. Once resveratrol is solubilized, dilutions can be prepared by
N
N 3
H
H
months at 4°C. Protect from light.
O
O adding sterile water or culture medium. Aqueous dilutions of
resveratrol should not be stored for more that 1 day.
DEScriPTiON
Working concentration: 10-100 µM (2.3 - 23 mg/ml)
Resveratrol (3,4',5-trihydroxy-trans-stilbene) is a polyphenol
Chemical
Formula:
C
H
N
O
26
41
3
5
found in plants known to possess anti-inflammatory and
475,62
NFkB inhibition:
chemopreventive properties. Molecular
ResveratrolWeight:
has been
shown to
To assess the role of NF-kB, pretreat cells, such as
inhibit the expression of proinflammatory markers, including
macrophages
or HEK293 cells transfected with one or several
inducible nitric oxide synthase and cyclooxygenase-2 in
1
TLR
genes,
for 1 hour with or without resveratrol
SB202190
macrophages and cancer cells , block TRIF-dependent
2
at
10-100
µM
and
then incubate at 37°C with the appropriate
signaling pathway of TLR3 and TLR4 and modulate bacterial
3
n°
CAS
152121-30-7
TLR
ligand
for
1
to
6 hours. Detect NF-kB inhibition using the
phagocytosis of macrophages . Resveratrol may exert these
appropriate
detection
system.
diverse effects by suppressing
N NF-kB activation.
H
1. lorne E. et al., 2009. Participation of Mammalian N
Target of Rapamycin Complex 1 in
Toll-Like Receptor 2– and 4–Induced Neutrophil Activation and Acute Lung Injury. Am. J.
OHCancer
Respir. Cell Mol. Biol. 41: 237 - 245. 2. Bhat KP. & Pezzuto JM., 2002.
chemopreventive activity of resveratrol. Ann. NY Acad.
N Sci.957:210.-229. 3. Youn HS et
al., 2005. Specific inhibition of MyD88-independent signaling pathways of TLR3 and
TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. J Immunol.
175(5):3339-46.
F
Chemical Formula: C20H14FN3O
cHEMical PrOPErTiES
Molecular Weight: 331,34
caS number: 501-36-0
Formula: C14H12O3
Molecular weight: 228.24
appearance: Off-whiteResveratrol
to pale yellow color
Solubility: 20 mg/ml in DMSO provides a clearn°
yellow
CASsolution
501-36-0
Purity: >98%
rElaTED PrODucTS
Product
catalog code
HEK-Blue hTLR2 cells (SEAP reporter cells)
pUNO1-hTLR2 (plasmid with human gene)
pUNO-mTLR2 (plasmid with mouse gene)
Pam3CSK4 (TLR2 ligand)
hkb-htlr2
puno1-htlr2
puno-mtlr2
tlrl-pms
OH
HO
OH
TECHNICAL SUPPORT
Toll free (US): 888-457-5873
Outside US: (+1) 858-457-5873
Europe: +33 562-71-69-39
E-mail: [email protected]
Website: www.invivogen.com
Chemical Formula: C14H12O3
Molecular Weight: 228,24
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