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3rd Edition (Revised in January, 2014)
[ Product Information ]
Name: Yohimbine
Catalog No.: CFN90147
Cas No.: 146-48-5
Purity: > 98%
M.F: C21H26N2O3
M.W: 354.44
Physical Description: Cryst.
Synonyms:
17alpha-Hydroxy-yohimban-16alpha-carboxylic acid methyl ester; Corynine; Corymbin;
Aphrodine; Hydroergotocin; Methyl 17-hydroxyyohimban-16-carboxylate;Quebrachine;
Yohimex; Yohimvetol
[ Intended Use ]
1. Reference standards;
2. Pharmacological research;
3. Synthetic precursor compounds;
4. Intermediates & fine chemicals;
5. Others.
[ Source ]
The barks of Corynante yohimbe
[ Aplications ]
Local anaesthetic.
Selective 2-adrenoceptor antagonist. Yohimbine was explored as a remedy for type 2
diabetes in animal and human models carrying polymorphisms of the α2A-adrenergic
receptor gene.
Yohimbine and its stereoisomers are used as tools for study of different adrenoceptor sites.
Antidepressant agent used clinically.
Shows antihypotensive activity, causes vasopressin release and shows antidiuretic
activity.
Alleged aphrodisiac. Yohimbine has been shown to be effective in the treatment of
orgasmic dysfunction in men. Yohimbine has also been used to treat hypoactive sexual
desire disorder (reduced libido) in women.
Anxiogenic activity in rodents.
[ Solvent ]
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
[ HPLC Method ]
Mobile phase: Methanol-0.02% Triethylamine H2O gradient elution;
Flow rate: 1.0 ml/min;
The wave length of determination: 280 nm..
[ Storage ]
2-8℃, Protected from air and light, refrigerate or freeze.
[ References ]
1. Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 614C.
2. Science, 2009, 327(5962), 217-220.
3. Asian Journal of Andrology, 2007, 9(3), 403-407.
4. The American Journal of Psychiatry, 1987, 144(8), 1030-1036.