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T H E R A P E U T I C I N D E X Avitron® V Tablet Description Avitron V tablet contains Vitamin B1 or Thiamine Hydrochloride USP. Thiamine Hydrochloride is a water soluble vitamin belongs to vitamin B complex family. Thiamine in the form of Thiamine Pyrophosphate (also known as cocarboxylase), is the co-enzyme for decarboxylation of α keto acids. Thiamine pyrophosphate also acts as the co-enzyme of transketolase in the direct oxidation pathway of glucose metabolism. In thiamine deficiency, pyruvic acid and lactic acid accumulate in tissues. Thiamine deficiency affects the peripheral nervous system, the gastrointestinal tract, and the cardiovascular system. Thiamine is not stored in the body, intracellular thiamine is present almost entirely as the co-enzyme moiety of active enzymes. Thiamine requirement is related to carbohydrate intake and the metabolic rate. A daily intake of 400 µg thiamine per 1000 kcal is recommended. The total requirement increases during periods of active growth or heavy physical labour, during pregnancy and lactation, in pathological conditions such as fever and hyperthyroidism and in other conditions causing increased metabolism. Indications Avitron V is indicated in the treatment of the various manifestations of thiamine deficiency such as beriberi (wet or dry) and Wernicke's encephalopathy, neuritis associated with pregnancy and pellagra. Supplementary thiamine may be indicated prophylactically in conditions where there is low dietary intake or low gastrointestinal absorption of thiamine, and increased thiamine requirement periods e.g. ♦ ♦ ♦ ♦ active growth heavy physical labour pregnancy and lactation in pathological conditions such as fever and hyperthyroidism and other conditions causing increased metabolism. 73 T H E R A P E U T I C I N D E X Dosage and Administration Mild chronic deficiency : 10-25 mg daily Severe deficiency : 200-300 mg daily or as advised by the physician Contraindication Thiamine is contraindicated in patients with known hypersensitivity to it. Side Effects Vitamin B1 does not have adverse effects when given orally. A feeling of warmth, pruritus, urticaria, weakness, sweating, nausea, restlessness etc. may occur. Use in Special Populations Pregnancy and lactation : Thiamine is safe in pregnant women and recommended for the treatment of neuritis in pregnancy. Although it is not known if thiamine is excreted in breast milk, the drug may be taken safely during lactation. Commercial Pack Avitron® V Tablet : Box containing 25 blister strips of 10 tablets. Each tablet contains Thiamine Hydrochloride USP 100 mg. 74