Download niacin hex (no flush) - Anabolic Laboratories

.
NIACIN HEX (NO FLUSH)
DESCRIPTION
The form of niacin providing all of the traditional benefits of
niacin without the flush and facial warmth that can sometimes
accompany large doses. Niacin Hex delivers free niacin over
several hours to keep bloodstream levels consistent.
FORMULA
Each Vegetarian Capsule Provides:
amount
Niacin (from 500 mg inositol hexanicotinate)………………..450 mg
Inositol (from 500 mg inositol hexanicotinate)……………….. 50 mg
Other ingredients: cellulose, magnesium stearate (vegetable source), silica.
INDICATIONS
Niacin Hex is for use to assist in the following:
• Healthy cholesterol support
o Lowers free fatty acid levels in the bloodstream
o Helps normalize the LDL/HDL ratio
• General cardiovascular health – may reduce incidence of CV lesions
• For patients currently taking niacin complaining of facial flushing and skin warmth
• Individuals who do not want to take nicotinic acid as timed-release niacin
KEY FEATURES
• Provides the benefits of conventional niacin therapy without the side effects
• Slowly and continuously metabolized, not reaching maximum serum levels for up to 10 hours
after ingestion
• Several decades of essentially risk-free clinical history
DIRECTIONS
Take one capsule up to four times daily with meals
BENEFITS
Most B vitamins are water soluble and many are eliminated from the body within hours after
consumption. To counter this problem some people take large doses of niacin and a significant
number experience the uncomfortable but harmless facial flushing. This is caused by histamine
release as an immediate reaction to niacin ingestion. Due to this uncomfortable side effect, some
people discontinue niacin therapy despite the many benefits. Inositol hexanicotinate (Niacin Hex) is a
unique combination of niacin bound to inositol. Free niacin is only slowly released into the
bloodstream from inositol in a slow reaction which may take up to 10 hours. Inositol hexanicotinate is
not considered a timed release niacin, but rather a form that eliminates the side effects but with the
same vascular supporting properties as simple niacin.
BACKGROUND
Niacin has been recognized as a vitamin since 1937 and is designated vitamin B3, nicotinic acid or
niacinamide. Once digested the body quickly transforms both nicotinic acid and niacinamide
(nutritionally equivalent) into the active coenzymes NicotinicAdenineDinucleotide (NAD) and
www.anaboliclabs.com
 2008
AN ABOLIC L ABORATORIES,LLC
All rights reserved.
*These statements are for educational purposes and have not been
evaluated by the Food and Drug Administration. This product is not
intended to diagnose, treat, cure or prevent any disease.
Product no. 0080
NicotinicAdenineDinucleotide Phosphate (NADP). These coenzymes are vital for cellular metabolism
of sugars and fats through their roles in many biochemical reactions, particularly within the
mitochondria, by assisting the oxidation of sugars and fats into energy as ATP and GTP. As a portion
of the reduced coenzymes, (NADH and NADPH) vitamin B3 cooperates in hundreds of biochemical
reactions by donating reducing power to oxidizing agents, often in reactions with molecular oxygen.
Important examples are the detoxifications of an array of noxious hydrocarbons and powerful
steroids by various cytochrome P450 enzymes.
Niacin, as nicotinic acid, has long been used to address many circulatory conditions; the most
common types being hyperlipidemia and dyslipidemia. It has been known for some time that
ingestion of high doses of niacin decreases bloodstream cholesterol, free fatty acids and
triglycerides, while raising the plasma level of HDL1. These powerful effects are due to the inhibition
of lipolysis by nicotinic acid but not other forms of vitamin B3. Lipolysis is the biochemical reaction
which releases free cholesterol and fatty acids (FFA) into the bloodstream.
Details of two important mechanisms for niacin inhibition of cholesterol deposition in arteries have
been recently uncovered. The first is the finding that niacin interacts with the protein ABCA 1, which
is responsible for releasing free cholesterol and FFA into the bloodstream from cholesterol esters in
adipose tissues. ABCA 1 is a member of a huge family of transport proteins (ABC transporters)
associated with cell membranes, especially adipose tissue cells. Nicotinic acid reduces the rate of
ABCA 1 release of free cholesterol and FFA thus lowering total bloodstream cholesterol and keeping
cholesterol esters in the adipose tissues. The concomitant reduction of bloodstream FFA lowers
both VLDL and LDL levels by inhibiting the initial biosynthesis of VLDL. Better control of the patient’s
free cholesterol and FFA are the reasons why people taking niacin exhibit improved plasma HDL as
well as lower LDL and VLDL parameters. These effects often combine to dramatically improve the
patient’s lipid ratio and the ability of vitamin B3 to reduce circulatory risk is published as a clinical
recommendation2.
The second discovered mechanism of protection is the niacin dependence of G protein coupled
receptor GPR-109A, found on the membranes of many cell types3. This key protein controls the
activities of very important immune neutrophil cells. These cells underlie the common problem of
uncomfortable side effects for those ingesting nicotinic acid. These include facial flushing, skin
reddening and some rare gastrointestinal difficulties, which all pass a few minutes after ingestion.
When bloodstream niacin levels are high, GPR-109A drastically modifies the internal neutrophil
functions causing the harmless but irritating facial flushing via histamine release and in the presence
of excessive nicotinic acid turns on controlled neutrophil death (apoptosis). These undesirable
effects of high nicotinic acid concentrations can be avoided by ingesting inositolhexaniacinamide,
Niacin Hex, which is quickly digested but only slowly releases the free and active nicotinic acid.
WARNINGS Pregnant women and lactating mothers should avoid inositol hexanicotinate. The
clinician should monitor use by patients with Raynaud’s disease1, diabetes, gout, renal
dysfunction, unstable angina and myocardial dysfunction. Inositol hexanicotinate in very high
doses may adversely affect glucose function. Niacin Hex should not be taken in large amounts
to attempt avoiding the positive results of a drug screening test.
References
1
Carlson LA (2005). Nicotinic acid: the broad-spectrum lipid drug. J. Intern. Med. 258: 94-114.
Chapman MJ, et al. (2004). Raising high-density lipoprotein cholesterol with reduction of cardiovascular risk: the role of nicotinic
acid –position paper developed by the European Consensus Panel on HDL-C. Curr. Med. Res. Opin. 20: 1253-1268.
3
Benyo Z, et al. (2005). GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J. Clin. Invest. 115: 3634.
2
www.anaboliclabs.com
 2008
AN ABOLIC L ABORATORIES,LLC
All rights reserved.
*These statements are for educational purposes and have not been
evaluated by the Food and Drug Administration. This product is not
intended to diagnose, treat, cure or prevent any disease.
Product no. 0080